Browsing by Author "Ozturk, Murat"

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Assessment of Hla-A, Hla-Dr, and Hla-Dq Alleles in Patients With Pemphigus Vulgaris From Eastern of Turkey
(Wiley, 2020) Dere, Gokturk; Yavuz, Ibrahim Halil; Ozaydin Yavuz, Goknur; Bayram, Yasemin; Gunes Bilgili, Serap; Ozturk, Murat
Background Pemphigus vulgaris (PV) is a chronic progressive autoimmune bullous disease caused by the interaction of pathogenic factors, genetic, and environmental factors. HLA alleles, which are considered as protective factors against disease or predisposing factors, may be different in various populations and ethnic groups. Aims The purpose of this study is to examine the HLA-A, HLA-DR, and HLA-DQ alleles in patients that are diagnosed with PV in and around eastern of Turkey and to determine the alleles that create predisposition to disease or protect against the disease. Patients/Methods Thirty patients diagnosed as PV with clinical, histopathological, and immunofluorescence findings and 30 healthy subjects were included in this study. The HLA-A, HLA-DR, and HLA-DQ typology in the DNA samples that were obtained from the blood samples of the groups was performed by using the PCR-SSP low-resolution gene panels. Results The HLA-A*03 allele was found to be significantly higher in patient group than the control group (P-value: .020). HLA-DRB1*04 and HLA-DRB1*14 alleles in PV patients were found to be significantly higher than the control group (P-value = .000). Conclusion It was concluded that the HLA-DRB1*03, HLADQB1*02, and HLA-DQB1*06 alleles in and around eastern of Turkey showed protective effects against pemphigus vulgaris. It was also concluded that the HLA-A*03, HLA-DRB1*04, HLA-DRB1*14, HLA-DRB4, HLA-DQB1*03, and HLA-DQB1*05 alleles could cause predisposition to the disease.
Bahri Efendi'nin Letâifnâme'si ve Letâifnâme'sinden Mizah Örnekleri
(2017) Ozturk, Murat
Letâifnâmeler, hikmet, mizah, yergi ve sosyal hadiselere dair yaşanmış veyarivayet edilmiş bazı kısa olayların ele alındığı bir türdür. Genellikle derlemehikâyelerden oluşturulurlar. Eserlerde birbirinden bağımsız çok sayıda kısa anlatıbulunur. Letâifnâmelerde bazı tiplerin gülmece üslubunda yergileri de yapılır. Butüre dair yazılan eserler manzum veya mensur bazen de manzum-mensur olarakyazılır. Bu türde yazılmış eserlerden biri de Bahrî Efendi'ye aittir. BahrîEfendi'nin Letâifnâme'si türe dair özellikleri ihtiva eder.Bahrî Efendi on altıncı asrın ikinci yarısında yaşamıştır. Onun Letâifnâme'sihakkında bugüne kadar herhangi bir çalışma yapılmamıştır. Eserden birkaççalışmada oldukça kısa bir şekilde bahsedilmiştir.Bahrî Efendi eserini dört bölüme ayırmıştır. Bu bölümlerden ikisi oldukçamüstehcendir. Latifelerden bazıları dinî, ahlakî ve hikmet içeriklidir. Tamamenmanzum olan hikâyelerde ise müstehcenlik mensur kısımlara göre çok dahaazdır.Eserde, sosyal hayatta karşılaşılan pek çok tipe dair mizahi hikâyeler vardır.Çoğu mutayebe başlığı taşıyan bu latifelerde derviş, köylü, cimri, dilenci, bencil,âlim, zen-pare, gulam-pare, mahbup-perest gibi tiplerle tarihte yaşamış bazı ünlüsultanlar ve tasavvuf büyükleriyle ilgili hikâyelere yer verilmiştir. Bu latifelerdeöne çıkan unsurlar hiciv, mizah ve sövgüdür.Bu çalışmada Bahrî Efendi'nin Letâifnâme'sinin tanıtılması, eserinletâifnâmeler içindeki yerinin belirlenmesi ve eserden manzum ve mensur latifeörnekleri sunulması amaçlanmaktadır.
A Case of Linear Syringocystadenoma Papilliferum of the Axilla: A Rare Location
(deri Zuhrevi Hastaliklar dernegi, 2019) Bilgili, Serap Gunes; Yavuz, Ibrahim Halil; Yavuz, Goknur Ozaydin; Ozturk, Murat; Erten, Remzi
Divan Edebiyatı Aynasında Memurlar
(2010) Ozturk, Murat
Bu makalede divan şairlerinin Osmanlı devletindeki memuriyet zihniyetine ve hayatına dair bakış açıları edebi eserler ışığında değerlendirilmeye çalışılmıştır. Şairler, memurları görevlerine ve makamlarına göre çoğunlukla hicvetmiş, nadiren de övmüşlerdir. Özellikle yüksek kademedeki memurlara ve bu memurların biçimlendirdikleri devlet sistemine yönelik tenkitler bütün divan edebiyatı tarihinde mevcuttur. Memur şairlerin kendi memuriyet hayatlarına ve meslektaşlarına dair yorumları, yakınmaları ve arzuları da memuriyet hayatının yüzyıllardır süren özelliğini yansıtır. Bu eleştiriler bazı divanlarda ve mesnevilerde tespit edilen şiirlerden hareketle 16. asırdan 20. asra kadar kronolojik bir sıra takip edilerek değerlendirilmiştir.
Evaluation of Hirsutism and Hormonal Parameters in Acne Vulgaris Patients Treated With Isotretinoin
(Wiley-hindawi, 2021) Aktar, Rojda; Gunes Bilgili, Serap; Yavuz, Ibrahim Halil; Ozaydin Yavuz, Goknur; Aktar, Sirac; Ozturk, Murat; Karadag, Ayse Serap
Background Although the effect of isotretinoin use on hormonal changes in acne pathogenesis is not fully known, there are limited studies on its effects on the development of hirsutism. In this study, it was aimed to evaluate the effect of isotretinoin use on hirsutism and hormonal parameters in patients with acne vulgaris. Methods In this study, 30 female acne patients and 30 healthy females were evaluated prospectively. Menstrual irregularity, LH, FSH, prolactin, progesterone, 17-OH progesterone, oestradiol, total testosterone, DHEA-S, insulin, glucose, TSH levels, Ferriman-Gallwey (FG) score and ultrasonography (USG) findings of control group and patient group were recorded. Results Pre-treatment progesterone (P = .007) and oestradiol (P = .001) levels of the patients were statistically lower than the control group. In the patient group, menstrual irregularity (P < 001) and FG hirsutism score at the third month of treatment were significantly higher than before treatment. In 10% of the patients, there were abnormal findings on pelvic USG in the third month of treatment. Conclusion In our study, it could not be revealed that isotretinoin has a significant effect on pituitary, adrenal hormones and insulin resistance. We found that 3 months of isotretinoin treatment caused an increase in menstrual irregularity and FG hirsutism score.
Evaluation of Some Chronical Diseases in Etiopathogenesis of Demodicosis
(Elsevier Taiwan, 2017) Cengiz, Zeynep Tas; Ozkol, Hatice Uce; Beyhan, Yunus Emre; Ozturk, Murat; Yilmaz, Hasan
Background: The aim of this study is to assess the effect of chronic diseases on the etiopathogenesis of demodicosis through the determination of Demodex sp. positivity in the face and eyelashes of the people with the chronic disease. Methods: This study is conducted on the patients who were referred to the Laboratory of Parasitology from the Yuzuncu Yil University, Faculty of Medicine, Outpatient Clinic of Dermatology. The samples were taken from the patients with standard skin surface biopsy. Furthermore, eyelashes of the patients were examined for Demodex sp. Result: When the patient groups are considered, demodicosis was found in the ratio of 18.5% of the patients with diabetes mellitus (p < 0.05), in 27% of those with hypertension (p < 0.01), in 25% of those with cancer (p < 0.01), in 32.5% of those with chronic renal failure (p < 0.01), in 23.7% of those with hypothyroidism (p < 0.05) and in 22.2% of the patients with hepatitis B (p < 0.05). Demodex sp. positivity was determined in the eyelashes of eight patients (p > 0.05). Conclusion: It is concluded that, in such patients the presence of this parasite should be taken into consideration in case of dermatoses occurring on the face, and these patients could be under the risk of occurring blepharitis as well. Copyright (C) 2017, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC.
Immunohistochemical Evaluation of the Effect of Acitretin and Systemic Steroid Treatments on Ki-67, Bcl-2, and Cox-2 Levels in Cutaneous Lichen Planus Patients
(Wiley, 2019) Ozturk, Murat; Yavuz, Goknur Ozaydin; Yavuz, Ibrahim H.; Erten, Remzi; Bilgili, Serap Gunes; An, Isa
Background Lichen planus (LP) is an inflammatory disease that affects skin, hair follicles, mucous membranes, and nails. Ki-67 is an antigen associated with the proliferation of cells in all stages of cell cycle except G0. Bcl-2 is a protooncogene that protects cells from apoptosis. COX-2 is an antiapoptotic protein that increases in inflammation. The infiltration of T cells in LP seems to be responsible in the apoptosis of the basal keratinocytes. Objective The purpose of this study was to investigate the effects of prednisolone and acitretin treatments on Ki-67, Bcl-2, and COX-2 expression and apoptosis in patients with LP and the role of Ki-67, Bcl-2, and COX-2 proteins in LP. Methods Fifty-eight patients with clinically and histopathologically diagnosed LP who had not been treated with systemic treatment before and 15 healthy volunteers were evaluated prospectively. Pretreatment and posttreatment biopsies were immunohistochemically stained with Ki-67, Bcl-2, and COX-2. The percentage of the stained cells were calculated and recorded. Results Although the percentage of staining with Ki-67 and Bcl-2 after treatment with prednisolone and acitretin decreased significantly (P < 0.05) in both groups, there was no significant difference between groups (P > 0.05). COX-2 decreased but was not statistically significant. Conclusions With this study in cutaneous lichen planus, prednisolone and acitretin treatments reduced Bcl-2 and Ki-67 levels and did not effect COX-2 levels. It should be clarified whether these results can be obtained with any treatment effective in cutaneous lichen planus.
Molluscum Contagiosum in Interdigital Area of Foot in a Pregnant Patient
(Wolters Kluwer Medknow Publications, 2019) Ozturk, Murat; Aktar, Rojda; Erten, Remzi
Ocular Surface Characteristics in Acne Vulgaris
(Taylor & Francis Ltd, 2022) Muhafiz, Ersin; Ozturk, Murat; Erten, Remzi
Background: To evaluate the ocular surface features, meibomian glands, and tear parameters of patients with acne vulgaris. Methods: The right eyes of 70 individuals (34 patients with acne vulgaris, 36 healthy volunteers) were evaluated. The tear break-up time of participants was measured, and the Schirmer test was performed. Then, to determine ocular surface characteristics, samples were taken from the conjunctiva for impression cytology. Finally, the loss rates of the upper and lower eyelid meibomian glands were determined by taking meibography (Sirius, CSO, Florence, Italy). Results: Tear break-up time was significantly lower in the study group compared to the control group (p < 0.001). No statistically significant difference was determined between the groups in respect of Nelson grade in the conjunctival impression cytology (p = 0.141). Grade 3 cytological changes were not observed in either group. The median value of the loss rate in the meibomian glands in the upper eyelid of patients with acne vulgaris was 19.10% (IQR: 18%), while it was 8.75% (IQR: 9.53%) in the control group (p = 0.001). The median value of the loss rate in the meibomian glands in the lower eyelid was 15.70% (IQR: 15.13%) and 7.70% (IQR: 6.53%) in the acne vulgaris and control groups, respectively (p < 0.001). Conclusion: Our study shows that patients with acne vulgaris may have a predisposition to meibomian gland damage and tear instability. Therefore, we consider that a more detailed ophthalmologic examination should be performed in patients with acne vulgaris.
Sağ Bacakta Asemptomatik Verrüköz Yüzeyli Plak: Dermatofibrom
(2018) An, Isa; Ozturk, Murat; Uçmak, Derya; İbiloğlu, İbrahim
Dermatofibrom sık görülen benign fibrohistiyositik bir neoplazidir. Etiyolojisi halen belirsizliğini korumaktadır fakat böcek ısırması ve follikül rüptürü gibi bir travmadan kaynaklanabileceği kabul edilmektedir. Dermatofibrom klinikte genellikle düzgün yüzeyli nodüler lezyonlar şeklinde görülmektedir. Burada sağ bacakta asemptomatik verrüköz yüzeyli plağı olan bir hastayı sunuyoruz.
Tradition and Four Modern Mersiye (Dirge) Written To the Ottoman Dynasty
(2018) Ozturk, Murat
Mersiye is the type of poem in which the sadness after the death of the classical Turkish poetry is expressed. This type of poetry is mostly written in sultans and princes in our literary history. In these poems, on the one hand, the anguish caused by death was expressed and explained to the forehead, while the positive qualities of the deceased were explained. In this study, one of the four princes of the last century (Muhsin Macit, Ahmet Efe, Bülent), who wrote to the overturned sultans (because of their sentences - Sultan II Osman), four princes (Prince Cem, Prince Mustafa, Prince Cihangir and Prince Bayezid) Ecevit and Ali Ural) will be discussed in terms of the continuation of the tradition of mersiye. The four names of the dynasty were tragically dead, and they did not die with their ego. Other poems written in their rights in the context of short historical information about the tragic deaths of these sultans and prince poets who are also poets will be given examples of traditional mercies and their own poems. Thus, both the influence of the tradition of classical poetry on modern poetry will be briefly mentioned, and the feature of the poetry of traditional poetry will evolve from the tradition to the moderne. The poems and tallies of the poets we dealt with will be given in the same context to the living tragedies of the dynastic names.