Browsing by Author "Palabiyik, Onur"

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The Effects of Dexmedetomidine on Liver Injury in Rats With Experimental Sepsis: a Histopathological and Immunohistochemical Study
(Turkish Assoc Trauma Emergency Surgery, 2025) Keles, Omer Faruk; Kaplan, Havva Sayhan; Cicek, Haci Ahmet; Palabiyik, Onur; Yener, Zabit
BACKGROUND: In the rat sepsis model, the protective effect of dexmedetomidine (Dex) in sepsis-induced tissue injuries by reducing inflammation is still unclear. Research is ongoing to determine whether Dex modulates sepsis-induced tissue injury. The aim of this experimental study was to investigate the effect of Dex on liver injury in sepsis rats histopathologically and immunohistochemically. METHODS: In this study, sepsis was induced in rats by a 10 ml/kg E. coli injection, and the protective efficacy of Dex against liver damage was investigated through histopathological and immunohistochemical findings by the intraperitoneal administration of 100 mu g/ kg Dex. RESULTS: In our results, the most striking and basic morphological changes in the liver tissues of sepsis group rats were neutrophil leukocyte infiltrations in and around the vessels. In Dex-treated groups, neutrophil leukocyte infiltrations were more prominent, and marked dilatations were observed in the vessels. The fact that inflammatory reactions were more prominent in the Dex-treated groups was thought to be related to the increase in vascular permeability due to Dex's vasodilation effect. CONCLUSION: According to the histopathological and immunohistochemical findings obtained in the present study, we conclude that Dex did not alleviate sepsis-induced liver inflammation in a rat sepsis model.
Effects of Sugammadex and Neostigmine on Renal Biomarkers
(int Scientific information, inc, 2016) Isik, Yasemin; Palabiyik, Onur; Cegin, Bilal Muhammed; Goktas, Ugur; Kati, Ismail
Background: Neostigmine, the currently commonly used agent for reversal of neuromuscular blockade. Sugammadex is a novel and unique compound designed as an antagonist of steroidal neuromuscular blockers. In this study, we evaluated the effects of sugammadex or neostigmine on kidney functions in patients scheduled for elective surgery. Material/Methods: Patients scheduled for a surgical procedure under desflurane/opioid anesthesia received an intubating dose rocuronium. Patients were divided into 2 groups receiving either sugammadex or neostigmine atropine to reverse neuromuscular blockade. Cystatin C, creatinine, urea, blood urea nitrogen, sodium, potassium, and calcium levels in the blood and alpha(1)microglobulin, beta(2)microglobulin, and microalbumin levels in the urine were measured. Results: There was no significant difference between the groups with regard to the demographic data. In the Neostigmine Group, although beta(2)microglobulin and microalbumin were similar, a significant increase was found in the postoperative alpha(1)microglobulin and cystatin C values. In the Sugammadex Group, although beta(2)-microglobulin and cystatin C were similar, a significant increase was found in the postoperative alpha(1)-microglobulin and microalbumin values. The only significant difference was cystatin C value variation in the Neostigmine Group compared to the Sugammadex Group. Conclusions: We believe that the use of more specific and sensitive new-generation markers like cystatin C to evaluate kidney function will provide a better understanding and interpretation of our results. Sugammadex has more tolerable effects on kidney function in patients than does neostigmine. However, when compared to preoperative values, there is a negative alteration of postoperative values. Neostigmine and sugammadex do not cause renal failure but they may affect kidney function.
Efficiency of Hematocrit, Lymphocyte, C-Reactive Protein and Transferrin Levels in Predicting Mortality in Intensive Care Unit Patients
(Modestum Ltd, 2015) Palabiyik, Onur; Isik, Yasemin; Cegin, Muhammed Bilal; Goktas, Ugur; Kati, Ismail
The effectiveness of many physiological parameters and laboratory tests was investigated in predicting mortality. In this study, we investigated hematocrit, C-reactive protein, transferrin and total lymphocyte count along with Acute Physiology and Chronic Health Evaluation II and Glasgow Coma Scores of patients who were hospitalized in the intensive care unit. The data were retrospectively analyzed from hospital information management system, doctors' records and nurse observing forms. The mortality rate was 42.6%. The Acute Physiology and Chronic Health Evaluation II scores were significantly higher in cases with mortality compared to those without mortality. The admission and discharge Glasgow Coma Scores were significantly lower in patients who showed mortality compared with patients without mortality. Admission and discharge hematocrit and transferrin values were significantly lower in cases with mortality compared to those without mortality. Discharge C-reactive protein values were significantly higher in cases with mortality compared to those without mortality. Discharge total lymphocyte count values were significantly lower in cases with mortality compared to those without mortality. Consequently, we believe that hematocrit and transferrin values at the time of admission to the intensive care unit and total lymphocyte count and C-reactive protein at the time of discharge from the intensive care unit can be effective in predicting mortality.
Reexpansion Pulmonary Edema
(Galenos Yayincilik, 2011) Isik, Yasemin; Kati, Ismail; Palabiyik, Onur; Goktas, Ugur
Reexpansion pulmonary edema is a rare but life threating complication which is occurring during the treatment of lung collapse secondary to pleural effusion, pneumothorax or atelectasis. We presented a 68 year-old case with hypertension, heart failure, cerebrovascular disease and diabetes mellitus who had developed reexpansion pulmonary edema three hours after the application of unilateral thoracentesis.