Browsing by Author "Pasa, S."

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Effect of Curcumin Enema Dosage Regimes on the Reduction of Giardia Cyst Among Calves
(Pusat Penelitian Dan Pengembangan Peternakan, 2023) Ural, K.; Erdogan, H.; Ural, Da; Pasa, S.; Erdogan, S.; Ayan, A.; Balikci, C.
Giardiasis is one of the most significant and neglected parasitic infestations among calves, resulting in intestinal infections. This protozoan agent gained diagnostic and therapeutical importance because of its zoonotic potential, in which novel alternative/substitute therapeutical interventions are important, and this is because commonly used anti-parasitic drugs for control and eradication for battling this infection commonly presented side effects. Therefore, the present project evaluated the antiprotozoan activity of curcumin at different dose regimes used via the rectal route, the main constituent of turmeric. Rectal enema groups [Group I: 2 gr/kg, Group II: 80 mg/kg, and Group III: 10 mg/kg] and oral treatment Group IV: 2 gr/calf consisted of curcumin treatment at appropriate dosages showed herein in which the control group V were untreated. All treatment groups showed a statistically significant decrease in cyst counts on day 10, compared to day 10 values of the control group (p<0.005). Among the treatment groups, the highest cyst reduction was evident at 99.86% in curcumin 10 mg/kg rectal enema-administered calves (Group III), which received the lowest dose of the study. Curcumin at all dosages, primarily used in the rectal route at the lowest dosage regimen of 10 mg/kg, could have hastened clinical and parasitological efficacy via probable inhibition of Giardia proliferation and adhesion, as described previously. This treatment modality via the rectal route can change the game, highlighting novel treatment protocols.
Noninvasive Assessment of Subclinical Atherosclerosis in Normotensive Gravidae With Gestational Diabetes
(Urban & Vogel, 2014) Atay, A. E.; Simsek, H.; Demir, B.; Sakar, M. N.; Kaya, M.; Pasa, S.; Sit, D.
Carotid artery intima-media thickness (CIMT), hyperhomocysteinemia, microalbuminuria, and nitric oxide reflect subclinical atherosclerosis and predict the risk of future cardiovascular events. We aimed to evaluate the presence of subclinical atherosclerosis and endothelial dysfunction in normotensive patients with gestational diabetes mellitus (GDM) noninvasively. We enrolled 41 normotensive patients with GDM and 44 healthy gravidae in the study. Serum homocysteine and nitric oxide levels, urinary albumin excretion (microalbuminuria), and CIMT were evaluated along with lipid parameters and anthropometric measurements. Patients with GDM had significantly higher levels of serum homocysteine, urinary albumin excretion, and increased CIMT (p < 0.001, p=0.005, and p < 0.001, respectively). Nitric oxide levels were significantly reduced in the patient group (p < 0.001). There was a significant difference between groups in terms of low-density lipoprotein (LDL) but not of high-density lipoprotein (HDL) and triglyceride levels. A significant correlation was observed between CIMT and serum LDL, HDL, homocysteine, nitric oxide levels, and urinary albumin excretion. Microalbuminuria was significantly correlated with serum homocysteine levels (p=0.03) but not with nitric oxide. Independent of elevated blood pressure, subclinical atherosclerosis and endothelial dysfunction exist in normotensive patients with GDM. Further studies with a large number of participants are required to clarify these data.