Browsing by Author "Pinar, Suleyman Mesut"

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Antioxidant Capacity and Phylogenetic Analysis of Twenty Native Grape Cultivars in Siirt Province, Turkey
(C M B Assoc, 2018) Fidan, Mehmet; Erez, Mehmet Emre; Inal, Behcet; Pinar, Suleyman Mesut; Altintas, Serdar
The quality of grape cultivars not only depends on the grape cultrvar but also is influenced by the molecular concepts and agro-climatic factors. For this purpose, four different grape cultivars were collected from five different locations in Siirt province (Turkey). Totally twenty different grape cultivars were investigated. In the present study, the antioxidant activity (total phenolic, flavonoid, proanthocyanidin content, DPPH and FRAP activity) in seeds were indicated and phylogenetic analysis (cpDNA;trnL-F region) of twenty native grape cultivars were imestigated to construct their phylogenetic tree. According to reported data on antioxidant activity and content of phytochemicals, all cultivars exhibited different values from each other, but Rutik and Gad?v cultivars were found as significantly higher in comparison to others According to bioinformatics analysis, twenty grape cultivars were distributed into six different major groups. Rutik and Sevkeye cultivars exhibit significant distinction from other grape cultivars. The phylogenetic analysis was also associated and supported with the results of obtained data from bioactivity. The bioactivity and phylogenetic analysis were firstly identified and quantified in these grape cultivars, however, with regard to obtained data from the current study, the grape cultivars grown in Siirt province were indicated significant and valuable results and as a result, these cultivars have to be evaluated before extinction.
Bellevalia Behcetii Sp Nov (Asparagaceae): a New Species From South Eastern Anatolia, Turkey
(Magnolia Press, 2016) Pinar, Suleyman Mesut; Eroglu, Huseyin; Fidan, Mehmet
Bellevalia behcetii (Asparagaceae) is described and illustrated as a new species from Sirnak province in South Eastern Anatolia (Turkey). It is morphologically similar to B. paradoxa but easily differs in several morphological characters. Diagnostic morphological characters, a full description and detailed illustrations of the new species are provided. A quantitative morphometric analysis was carried out to check the diagnostic characters of Bellevalia behcetii with respect to morphologically related species. The somatic chromosome number was determined as 2n = 2x = 8 in B. behcetii. In addition, the ecology and phenology of the new species, as well as its etymology and the pollen characteristics, are presented and discussed. The conservation status of B. behcetii was assessed according to IUCN protocol. A distribution map of B. behcetii and related species is also presented.
Bellevalia Turcica Sp. Nov. (Asparagaceae): a New Species From South Anatolia, Turkey
(Springer, 2019) Pinar, Suleyman Mesut; Eroglu, Huseyin
Bellevalia turcica was described as a new species in the Pozant district, Adana province in the south of Turkey. The palynological, ecological, and phenological characteristics were determined. Bellevalia turcica is similar to Bellevalia fominii Woronow, but can easily be distinguished from the differences in the flower and leaf trait characteristics. Full description and detailed photographs of this new species were provided. The somatic chromosome number of B. turcica was determined to be 2n=2x=8. B. turcica was attributed into the "Vulnerable" category after assessment based on the International Union for Conservation of Nature (IUCN) Categories. The distribution patterns of B. turcica and other related Bellevalia species were also presented.
Chemical Profiling by Lchrms, Antioxidant Potential, Enzyme Inhibition, Molecular Docking and Molecular Dynamics Simulations of Acantholimon Acerosum
(Elsevier, 2025) Kiziltas, Hatice; Ortaakarsu, Ahmet Bugra; Bingol, Zeynebe; Erturk, Adem; Goren, Ahmet Ceyhan; Pinar, Suleyman Mesut; Gulcin, Hami
The principal objective of this study is to evaluate phenolic content and biological activity in vitro and silico properties of A. acerosum (Willd.) Boiss. subsp. acerosum's (A. acerosum). The antioxidant activity of A. acerosum was assessed in a variety of bioanalytical methods. Strong antioxidant activity was shown for both water (WEAA) and ethanol (EEAA) extracts of the aerial parts of A. Acerosum. Also, it was shown that hyperoside is the most prevalent phenolic compound in EEAA (12,940.83 mg kg(-1)) and WEAA (5409.67 mg kg(-1)) by LCHRMS. The enzyme inhibitory abilities of the EEAA were then realised. The IC50 values of EEAA against acetylcholinesterase (AChE) (E.C.3.1.1.7), alpha-glycosidase (E.C.3.2.1.20), and alpha-amylase (E.C.3.2.1.1) were determined as 1.828 mu g mL(-1), 0.615 mu g mL(-1), and 1.081 mu g mL(-1), respectively. Subsequently, the alpha-amylase, alpha-glycosidase, and AChE enzymes were subjected to molecular docking and molecular dynamic interactions using major compounds of EEAA as ligands. High enzyme-inhibiting properties of EEAA were also determined in silico. It has been reported that numerous traditional and contemporary medical applications of A. acerosum. It can be said that the effective antioxidant results obtained in our study are the basis of previously performed traditional or contemporary medical practices.
Comprehensive Appraisement of Antioxidant Potential and Phytochemical Profile of Native Botanicals From Turkey
(Springer, 2019) Erez, Mehmet Emre; Dalar, Abdullah; Fidan, Mehmet; Pinar, Suleyman Mesut
This study presents the first comprehensive evaluation of antioxidant potential and phytochemical profiling of nine plant taxa utilized in southeastern and eastern parts of Turkey for various medicinal purposes, in order to contribute the scientific database, which was focused on exploring novel candidates of antioxidant agents from natural sources for industry and complementary medicine. Sequential extracts were prepared from plant materials were prepared through treating different solvents (acetone, ethanol, and water) based on polarity index. According to antioxidant assays via hydrogen atom transfer (HAT) and single atom transfer (SET) mechanisms, acetone extracts were found as the efficient antioxidant sources. Chromatographic studies revealed that phenolic compounds (mainly 5-O-Caffeoylquinic acid, luteolin hexoside, quercetin and rutin) were characterized as major hydrophilic phytochemical compounds and fatty acids (princibally linolenic, palmitic, and linoleic acids) were found as the major volatile compounds that dominantly contribute to the pronounced antioxidant capacities. According to the chemical structure, catechol moiety containing plant extracts had superior antioxidant capacity both for HAT and SET mechanisms. Data obtained from this study showed that among native botanicals, Crepis hakkarica, Crepis gemicii, Laserpitium carduchorum and Hedysarum vanaense might serve bioactive antioxidant agents both for industrial and pharmaceutical use.
Determination of Biological Activity and Active Substances of Thecocarpus Carvifolius (Boiss.) Hedge & Lamond
(Springer, 2021) Pinar, Suleyman Mesut; Erez, Mehmet Emre; Fidan, Mehmet; Erodlu, Huseyin; Dalar, Abdullah
We have studied the antioxidant activity and analyzed active substances of the aqueous and methanol extracts of endemic species Thecocarpus carvifolius Hedge and Lamond. The antioxidant activity was identified and assessed using the DPPH, FRAP and iron chelating capacity assay. Active substances were detection, total phenolic, flavonoids and volatile compounds were analyzed. According to DPPH analyzes, the inhibition percentage was 48.57% for aqueous extract and 76.34% for methanol extract. The FRAP reduction capacity was determined as 3.32 mg/mL for aqueous extract and 11.75 mg/mL FESO4 for methanol extract. The total concentrations of phenolics and flavonoids were calculated as 64.08 - 35.29 mu g/mL and 146.84 - 555.66 mu g/mL in aqueous and methanol extracts, respectively. Finally, five volatile compounds were detected in methanol extracts. The results indicated that the endemic species of T. carvifolius can be evaluated as a natural antioxidant plant.
Karyomorphological Analysis of Eight Allium L. (Amaryllidaceae) Species From Turkey
(Univ Tokyo Cytologia, 2022) Kiran, Yasar; Arikboga, Gulsah; Dogan, Gulden; Eroglu, Huseyin; Pinar, Suleyman Mesut
The chromosome numbers and karyotypes of eight species of the genus Allium distributed in Turkey were analyzed. These taxa are A. armerioides Boiss., A. orientale Boiss., A. stamineum Boiss., A. tuncelianum (Kollmann) Ozhatay, B.Mathew & Siraneci, A. subakaka Razyfard & Zarre, A. muratozelii Armagan, A. duma-nii Koyuncu & Kocyigit and A. colchicifolium Boiss. Four of them (A. armerioides, A. tuncelianum, A. mura-tozelii and A. dumanii) are endemic in Turkey. The chromosome numbers of all studied taxa were determined as 2n=2x=16, while A. dumanii had the chromosome number 2n=2x=16+2B. A basic number of x=8 was confirmed for all investigated species. Haploid chromosome lengths varied from 91.48 mu m (A. armerioides) to 176.16 mu m (A. colchicifolium) among species. Karyotype analysis indicated that Allium taxa generally are sym-metrical, consisting of metacentric and submetacentric chromosome pairs. Only A. stamineum has subtelocentric chromosomes. Satellites were observed in three species; A. tuncelianum, A. subakaka, and A. armerioides. The karyotypes of A. muratozelii and A. armerioides were determined for the first time in this study.
Karyomorphological Investigation of the Eight Species of the Muscari Genus Botryanthus Subgenus Growing in Turkey
(Univ Tokyo Cytologia, 2023) Kiran, Yasar; Yildirim, Leyla; Dogan, Gulden; Eroglu, Huseyin; Pinar, Suleyman Mesut
The chromosome numbers and karyotypes of eight species, the subgenus Botryanthus of the genus Muscari distributed in Turkey were analyzed. These taxa are M. adilii M.B. Guner & H. Duman, M. anatolicum Cowley & Ozhatay, M. bourgaei Baker, M. latifolium, J. Krik, M. inconstrictum Rech. f. M. microstomum P.H. Davis & D.C. Staurt, M. parviflorum Desf. and M. sandrasicum Karlen. Five of them (M. adilii, M. anatolicum, M. bourgaei, M. latifolium, M. sandrasicum) are endemic in Turkey. While the chromosome number of the examined taxa was generally determined as 2n= 2x= 18, the somatic chromosome number was determined as 2n= 4x= 36 in M. anatolicum and M. parviflorum. Haploid chromosome lengths varied from 26.00 mu m (M. adilii) to 101.74 mu m (M. parviflorum) among species. Karyotype analysis indicated that Muscari taxa generally have median point (M), median (m), submedian (sm), and subterminal (st) chromosomes. In addition, satellites were observed in two species, M. adilii and M. latifolium.
A Karyomorphological Study on the Genus Muscari Miller Growing in Turkey
(Univ Tokyo Cytologia, 2020) Kiran, Yasar; Pinar, Suleyman Mesut; Dogan, Gulden; Eroglu, Huseyin
The chromosome numbers and karyotypes of eight species of the genus Muscari distributed in Turkey were analyzed. These taxa are M. macrocarpum Sweet, M. racemosum Mill., M. aucheri (Boiss.) Baker, M. armeniacum Leichtlin ex Baker, M. sivrihisardaghlarensis Yildirimli & B. Selvi, M. discolor Boiss. & Hausskn, M. botryoides (L.) Mill. and M. neglectum Guss. Five of them (M. racemosum, M. aucheri, M. sivrihisardaghlarensis, M. discolor, and M. botryoides) are endemic in Turkey. The chromosome number of all studied taxa were determined as 2n=2x=18, while M. neglectum had the chromosome number of 2n=4x=36. Haploid chromosome lengths varied 24.94 mu m (M. armeniacum) to 119.85 mu m (M. racemosum) among species. Karyotype analysis indicated that Muscari taxa generally have a median point (M), median (m), and submedian (sm) chromosomes. In addition, only M. racemosum has one subterminal (st) chromosome pair. Satellites were observed in M. racemosum and M. botryoides. The karyotypes of M. sivrihisardaghlarensis was determined for the first time in this study.
A Karyomorphological Study on the Subgenus Leopoldia of the Genus Muscari Growing in Turkey
(Univ Tokyo Cytologia, 2020) Kiran, Yasar; Pinar, Suleyman Mesut; Dogan, Gulden; Eroglu, Huseyin
The chromosome numbers and karyotypes of 11 species the subgenus Leopoldia of the genus Muscari distributed in Turkey were analyzed. These taxa are M. comosum (L.) Miller, M. weissii Freyn, M. caucasicum (Griseb.) Baker, M. tenzeorum Tausch, M. babachii Eker & Koyuncu, M. erdalii Ozhatay & Demirci, M. longipes Boiss., M. massayanum Grunert, M. mirum Speta, M. elmasii Yildirim, and M. haradjiani Briq. ex Rech., and six of them (M. babachii, M. erdalii, M. massayanum, M. mirum, M. elmasii, M. haradjiani) are endemic species in Turkey. The somatic chromosome number of all studied taxa were determeined as 2n=2x=18. Haploid chromosome lengths varied 44.06 (M. massayanum) to 67.50 mu m (M. babachii) among species. Karyotype analysis indicated that Muscari taxa generally have median (m), submedian (sm) and subterminal (st) chromosomes. In addition, only M. comosum has one terminal (t) chromosome. Satellites were observed in five species, M. tenuiflorum, M. erdalii, M. longipes, M. mirum and M. haradjianii. This study is the first in terms of revealing the karyotypes of all taxa of subgenus Leopoldia on the genus Muscari.
Karyotype Analysis of Five Bellevalia Lapeyr. Species (Asparagaceae) From Turkey
(Univ Tokyo Cytologia, 2022) Eroglu, Huseyin; Pinar, Suleyman Mesut; Dogan, Gulden; Paksoy, M. Yavuz; Kiran, Yasar
The chromosome numbers and karyotypes of five species of the genus Bellevalia distributed in Turkey were analyzed. These taxa are B. anatolica B. Mathew & Ozhatay, B. fominii Woronow, B. kurdistanica Feinbrun, B. rixii Wendelbo, B. turcica Pinar & Eroglu. Three of them (B. anatolica, B. rixii and B. turcica) are endemic in Turkey. The chromosome numbers of all studied taxa were determeined as 2n=2x= 8. Haploid chromosome lengths varied from 57.78 mu m (B. fominii) to 68.17 mu m (B. anatolica) among species. Karyotype analysis showed that Bellevalia taxa generally have median (m), submedian (sm), and subterminal (st) chromo-somes, but not subterminal chromosomes in B. fominii species.
Lc-Hrms Profiling of Phytochemicals, Antidiabetic, Anticholinergic and Antioxidant Activities of Evaporated Ethanol Extract of Astragalus Brachycalyx Fischer
(Acg Publications, 2021) Kiziltas, Hatice; Bingol, Zeynebe; Goren, Ahmet C.; Pinar, Suleyman Mesut; Alwasel, Saleh H.; Gulcin, Ilhami
Astragalus is a perennial plant that has existed for about 2500-3000 years and consists of more than 250 taxonomic parts. Twenty species of Astragalus are endemic to Turkey, as well as the richest genus with 425 taxa. The roots of Asfragalus species are used in folk medicine as hepatoprotective, antioxidant, antibacterial, antihypertensive, antidiabetic and diuretic. Also, it is used to treat diabetes mellitus, leukemia, nephritis and uterine cancer. It is known that in Anatolia, Astragalus roots are traditionally used against leukemia and wound healing. For the purpose, the measuring of antioxidant activity of evaporated ethanol extract of Asfragalus brachycalyx FISCHER (EEAB), some bioanalytic methods including DPPH center dot and ABTS(center dot+) scavenging effects, ferric ions (Fe3+) and cupric ions (Cu2+) reducing abilities, and metal (Fe') chelating activity were realized. alpha-Tocopherol, ascorbic acid, and BHT were used as the standard antioxidants. On the other hand, some phenolic compounds, which responsible for antioxidant activities of EEAB was determined by liquid chromatography-high resolution mass spectrometry (LC-HRMS). At the similar concentration, EEAB exhibited efficient antioxidant effects when compared to standard compounds. Additionally, EEAB showed IC50 values of 1.985 mu g/mL toward acetylcholinesterase (AChE), 0.620 mu g/mL on alpha-glycosidase and 0.306 mu g/mL against alpha-amylase enzymes.
Morphological, Anatomical, Palynological and Ecological Data on the Local Endemic Dianthus Vanensis (Caryophyllaceae) From Turkey
(Magnolia Press, 2019) Karaismailoglu, Mehmet Cengiz; Erez, Mehmet Emre; Pinar, Suleyman Mesut; Fidan, Mehmet; Eroglu, Huseyin
A first detailed taxonomical, palynological, and ecological study of the Turkish endemic Dianthus vanensis is shown based on field data collected at locus classicus. A revised morphological description, including data of seed and pollen by using Scanning Electron Microscope, is provided. Seed surface displays elongated cells, which are lobate with 14-28 teeth, I, S shaped or irregular, and papillate. Pollen grains are radially symmetric, apolar, pantoporate and spheroidal shape (size: 40.38 +/- 0.64 x 37.98 +/- 0.36 mu m), with scabrate ornamentation, and 9-12 pores elliptical (different margin), and operculate (size: 6.17 +/- 0.23 x 4.17 +/- 0.39 mu m). The anatomy of root, stem and leaf are also investigated. On the outer surface of the root is placed a multi-layered periderm. The cortex consists of multi-layered parenchymatic cells under periderm, and its thickness is 176.49 +/- 7.85 mu m. In the stem cross-sections, it is noticed one epidermis layer, comprising of flat cells in outermost. Its thickness ranged between 28.13 and 35.29 mu m. The type of vascular bundle is hadrocentric. In the abaxial and adaxial surfaces of the leaf are located 1-layer epidermis cells, comprising of the flat or rectangular cells. The leaf is equifacial. Leaves have collateral vascular type. IUCN category of the taxon is assessed CR (Critical Endangered) based on criterion B2a,b(iii).
A New Leopoldia (Asparagaceae, Scilloideae) Species From South Anatolia-Türkiye: Leopoldia Oztasii
(Magnolia Press, 2024) Eroglu, Huseyin; Pinar, Suleyman Mesut; Eker, Ismail
Leopoldia oztasii sp. nov. (Asparagaceae, Scilloideae) is described as a new species in this study. It spreads on the stony slopes of Konya province in the south of Turkiye. Leopoldia oztasii is similar to L. tenuiflora, but it is easily distinguished from it, by having larger bulbs, falcate leaves, shorter scape, conical inflorescence, longer pedicels, and larger capsules. In this study, the morphology, seed surface characteristics and ecology of L. oztasii were studied. A detailed description of the new species, a comparison table between the two species, and detailed photographs showing their differences are provided. The distribution areas of L. oztasii and L. tenuiflora in Turkiye are also presented on the map.
A New Record for the Flora of Türkiye: Cousinia Mazu-Shirinensis Rech.f
(Kahramanmaras Sutcu Imam Univ Rektorlugu, 2024) Fidan, Mehmet; Pinar, Suleyman Mesut; Eroglu, Huseyin; Armagan, Metin
Cousinia mazu-shirinensis taxon was recorded for the first time in the Flora of T & uuml;rkiye from & Scedil;& imath;rnak province, located in the southeast of T & uuml;rkiye. The morphological characteristics of the C. mazu-shirinensis, the map of the distribution area, and the photographs of its natural habitat are also presented in the study.
A New Species of Gladiolus From Southeastern Turkiye, Gladiolus Siirtensis (Iridaceae, Crocoideae)
(Magnolia Press, 2023) Pinar, Suleyman Mesut; Eroglu, Huseyin; Fidan, Mehmet
Gladiolus siirtensis (Iridaceae) is described as a new species from the Pervari district, Siirt province in the southeast of Turkiye. Gladiolus siirtensis is similar to G. humilis, but it is easily distinguished by its shorter stem, oblong or oblanceolate first leaves, dense spike with secund flower arrangement, absence of fusiform blotch on the lower segments of perigone, shorter anthers, style and stigma lobes and obovoid capsule. A detailed morphological study, including pollen and seed surface characteristics was undertaken for the new species. A complete morphological and palynological description is provided, including distribution data of the new species and related ones.
Onopordum Hasankeyfense (Asteraceae), a New Species From South-Eastern Turkey
(Tubitak Scientific & Technological Research Council Turkey, 2014) Pinar, Suleyman Mesut; Behcet, Lutfi
Onopordum hasankeyfense Pinar & Behcet (Asteraceae: Cardueae) from south-eastern Anatolia, Turkey, is described. This species grows on the rocky slopes beneath the Hasankeyf castle in the Hasankeyf District (C8, Batman province). Morphologically, the new species is related to Onopordum anatolicum (Boiss.) Boiss. & Heldr. ex Eig, a species endemic to central and western Anatolia, and O. acanthium L. This new species differs from the others in its indumentum, capitulum shape, phyllary colour and shape, unequal corolla lobes, and pappus. The ecology and phenology of the new species, as well as its etymology and diagnostic features, are presented and discussed. Images of the new species are provided and compared with O. anatolicum and O. acanthium. In addition, the pollen characteristics and achene features of the species were examined using both light and scanning electron microscopy. The conservation status of O. hasankeyfense was assessed according to IUCN criteria. A distribution map of O. hasankeyfense and related species is also presented.
Onopordum Nezaketianum Sp. Nov. (Asteraceae: Cardueae): a New Species From Central Anatolia, Turkey
(Tubitak Scientific & Technological Research Council Turkey, 2019) Pinar, Suleyman Mesut; Eroglu, Huseyin
Onopordum nezaketianum sp. nov. (Asteraceae: Cardueae) from the Central Anatolia region of Turkey is described based on morphological and palynological features. The new species is morphologically related to O. davisii Rech. f. and O. turcicum Danin, and is characterized by its capitula solitary or 2-4 on leafy 2-20 cm long peduncles, phyllaries 5-6 seriate, outer phyllaries sparsely arachnoid pubescent, ovate-lanceolate, flat or nearly reflexed; median phyllaries sparsely arachnoid pubescent, narrowly ovate-lanceolate, reflexed; inner phyllaries glabrous, linear-lanceolate, erect, flowers 20-25 mm; 4 corolla lobes equal, 4-5 mm long, and 5th lobe 6-7 mm long, pappus barbellate. Achenes 4.0-5.1 x 2.0-2.5 mm, grayish, obovate, deeply transverse rugose, with finely and irregularly undulate surface. Pollen grains of O. nezaketianum are trizonocolporate, oblate-spheroidal, and ornamentation microreticulate.
Phytodermatitis in Eastern Turkey: a Retrospective, Observational Study
(Lippincott Williams & Wilkins, 2014) Ozkol, Hatice Uce; Calka, Omer; Akdeniz, Necmettin; Pinar, Suleyman Mesut
Background: Plant life is extremely diverse, with a great deal of geographic and seasonal variation. Consequently, the range of reported adverse reactions is large, and there are important differences worldwide in the incidence and prevalence of these reactions. Systemic ingestion of some plants containing furocoumarins can cause erythema, edema, vesicle and bulla formation and later hyperpigmentation, after exposure to sunlight. They may at times exhibit clinical manifestations that mimic angioedema, and rarely progress to necrosis. This condition is named phyto-phototoxic reaction. Objective: Our aim was to identify plant dermatitis such as allergic contact dermatitis, irritant contact dermatitis, and phyto-phototoxic dermatitis in eastern Turkey and to add new data to the literature. Methods: Thirty patients diagnosed with plant dermatitis were evaluated retrospectively. The demographic and clinical characteristics of the patients (age, gender, the type of dermatitis, and the name of the causative plant) were recorded. Conclusions: A phyto-phototoxic reaction to Chenopodium album (Chenopodiaceae) developed in 12 cases. Irritant contact dermatitis developed due to Ranunculus kotschyi (Ranunculaceae) in 11 cases. The other plants studied were Malva neglecta Wallr (Malvaceae), Mandragora autumnalis (Solanaceae), Eryngium billardieri (Apiaceae), Ceratocephalus falcatus (Ranunculaceae), Ranunculus damascenus (Ranunculaceae), and Plantago lanceolata (Plantaginaceae).
Sage (Salvia Macrochlamys): Lc-Hrms for Phytochemical Analysis, Cytotoxicity, Enzyme Inhibition, Antioxidant Activity, Molecular Docking and Molecular Dynamics Simulations
(Taylor & Francis Ltd, 2024) Kiziltas, Hatice; Ortaakarsu, Ahmet Bugra; Bingol, Zeynebe; Goren, Ahmet Ceyhan; Pinar, Suleyman Mesut; Gulcin, Ilhami
This study primarily aims to evaluate the phenolic content and biological activity of Salvia macrochlamys both in vitro and in silico. The antioxidant activities of Salvia macrochlamys were assessed using various methods. Additionally, cytotoxic effects and the alpha-amylase, alpha-glucosidase, and acetylcholinesterase (AChE) enzyme inhibitory abilities of ethanolic extract of the aerial parts of Salvia macrochlamys (EESM) were evaluated. Then, the molecular docking interactions and molecular dynamic calculations of EESM against alpha-amylase, alpha-glycosidase, and AChE enzymes were carried out. High antioxidant activity was determined in both ethanol and water extracts. The IC50 values of EESM against AChE (EC 3.1.1.7), alpha-glycosidase (E.C.3.2.1.20), and alpha-amylase (E.C.3.2.1.1) were determined as 1.622 mu g/mL, 0.530 mu g/mL, and 1.320 mu g/mL, respectively. High enzyme-inhibiting properties of EESM were determined in also in silico. Rosmarinic acid was identified as one of the most abundant phenolic compounds in both EESM and water extract of the aerial parts of Salvia macrochlamys (WESM) (3919.65 mg/kg and 10520.77 mg/kg, respectively). Their high level of flavonoids and phenolics, as well as the potent antioxidant and enzyme-inhibitory properties displayed by extracts, may contribute to broadening the use of Salvia macrochlamys in both traditional and modern therapeutic applications.