Browsing by Author "Purut, Yunus Emre"

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Comparison of Anterior Uterocervical Angle in Unexplained Primary Infertile and Primigravid Cases
(Bayrakol Medical Publisher, 2022) Kaya, Firat; Babayeva, Gulchin; Purut, Yunus Emre; Gul, Abdulaziz
Aim: The aim of this study was to investigate the hypothesis that narrow angle may prevent sperm passage and thus cause infertility by comparing anterior uterocervical angle (A-UCA) in patients with unexplained infertility and primigravid cases at early gestational week.Material and Methods: This study included 126 cases, including 75 cases of unexplained infertility and 51 cases with a diagnosis of primigravid at early gestational week, who applied to the Van Yuzuncu Yil University Gynecology and Obstetrics Clinic between February 2021 and October 2021. A-UCA values of infertile cases were reviewed. Primigravid cases with beta-hCG values of < 1000 mIU/ml were included in the study. A-UCAs were measured with transvaginal ultrasonography and while the bladder was empty.Results: In our study, no statistically significant difference was found between the increase in beta-hCG value and A-UCA value in the pregnant group (p > 0.05). Discussion: It was found that the A-UCA did not show a significant difference between primigravid cases at early gestational weeks and unexplained primary infertile cases.
Could Hpv Type 33 Be More Risky Than We Thought
(Sage Publications inc, 2023) Purut, Yunus Emre; Uckan, Kazim
Objective: The distribution of human papilloma virus (HPV) genotypes varies by country and region. HPV is the most important risk factor for cervical cancer and HPV 16/18 is the most common genotype. Other high risk HPVs (hrHPVs) other than HPV 16 and 18 contribute significantly to invasive disease. In this study, we aimed to reveal the frequency of association of HPV 16, 18 and other high-risk-HPV types with CIN 2 + (CIN 2 and above) cervical lesions in patients with cervical intraepithelial neoplasia (CIN) and to support the literature especially on the management of high-risk-HPV types other than 16 and 18. Materials and Methods: This retrospective study, which was conducted on 264 patients and 202 patients after the exclusion criteria, was conducted in the gynecology oncology outpatient clinic of the tertiary care hospital between March 2020 and May 2022. HPV 16, HPV 18 and other high-risk-HPV types with negative cytology between the ages of 25-65 were compared by taking a biopsy accompanied by colposcopy performed by the same gynecologist. As a result of colposcopy, CIN2 + patients who underwent excisional procedure were distributed according to HPV type. During this procedure, the patients who were positive for more than one HPV type were considered positive for the group with all subtypes (For example, if the patient was type 31 and 33 positive, they were included in both the 31 and 33 positive groups). The genotype distribution in the high-risk-HPV group was examined. Results: Colposcopy results showed HPV 16 positivity in 43.3%, HPV 33 positivity in 30% and HPV 18 positivity in 10% of the patients with CIN2 + and above lesions. It was observed that the incidence of CIN2 + lesions in the patients with HPV 33 positive was higher than the incidence of a lower-grade lesion (such as CIN1, chronic cervicitis) (p < 0.05). While HPV 33 (r = 0.290, p < 0.000) results were positively correlated with CIN2 + and above lesions, there was a negative correlation with HPV 45 (r = - 0.172, p < 0.015) results (p < 0.05). It was observed that HPV 33 and HPV 45 positivity was a statistically significant variable in predicting the probability of CIN2 + lesions in colposcopy results. It was determined that a HPV 33 positive patient increased the probability of having a CIN2 + lesion by 4.999 times (p < 0.000). Conclusion: In the literature, the role of high-risk -HPV types other than HPV 16 and HPV 18 with negative cytology in the women at risk of cervical preinvasive lesions has still not been fully determined. According to the results of the stuy, especially in women infected with high-risk -HPV types other than HPV 16/18, the relationship between HPV 33 type and CIN 2 + lesions was found to be high, and it was seen that colposcopic biopsy should be performed immediately instead of follow-up after 1 year.
Do the Levels of Hepcidin and Tenascin-C Change in Patients With Preterm Premature Rupture of Membranes? Can These Markers Help in Diagnosis? Hepcidin and Tenascin-C Levels in Preterm Premature Rupture of Membranes
(Bayrakol Medical Publisher, 2023) Ildogan, Betul Tuncer; Ercan, Fedi; Saglam, Ceren; Purut, Yunus Emre; Kaya, Firat; Karaaslan, Onur
Aim: In this study, it was aimed to investigate the role of tenascin-C and hepcidin levels in the diagnosis of preterm premature rupture of membranes (PPROM). Material and Methods: This study is a prospective cohort study conducted at Van Yuzuncu Yil University (YYU), Dursun Odabasi Medical Center Gynecology and Obstetrics outpatient clinic between 31.03.2021 and 15.03.2022. One hundred patients aged 18 to 45 years diagnosed with PPROM at 24 to 37 weeks of gestation were included in the study as the "case group", and 100 healthy pregnant women were included as a "control group". Demographic data and laboratory parameters of the patients, such as C-reactive protein (CRP), leukocyte, neutrophil, hepcidin, and tenascin-C levels, were recorded. Results: Compared to the control group, CRP, leukocytes, and neutrophil levels were statistically significantly higher in the PPROM group (p<0.05). Hepcidin value was statistically significantly lower in the PPROM group compared to the control group (p = 0.003); tenascin-C levels between the two groups were not statistically different (p = 0.161). Discussion: Hepcidin levels can be used in the diagnosis of PPROM. Multicenter randomized controlled studies with more cases and parameters are needed.
Letrozol ve Klomifen Sitrat Birlikteliğinin Açıklanamayan İnfertil Hastalardaki Etkinliği
(2023) Giray, Burak; Okyay, Tuba Yangılar; Sağlam, Ceren; Purut, Yunus Emre; Dirik, Deniz
Amaç: Çalışmamızda açıklanamayan primer infertilite tanılı hastaların tedavisinde klomifen sitrat (CC), aromataz inhibitörü (letrozol) ve letro- zol ile CC birlikte kullanılarak ovulasyon indüksiyonu ve intrauterin inseminasyon (IUI) yapılan hasta gruplarının karşılaştırılması hedeflenmiştir. Gereç ve Yöntemler: Çocuk istemiyle müracaat eden, açıklanamayan infertilite tanısı konmuş 90 primer infertil çift ile yapılan bir çalışmadır. Hastalar ovulasyon indüksiyonunda kullan ılacak ajana göre 3 gruba ayr ıldı. 1. grup; CC ve letrozol; 2. Grup yaln ızca letrozol ve 3. Grup ise yalnızca CC ile tedavi edildi. Dominant follikül geli şen hastalarda 6500 IU koryogonadotropin-alfa ile ovulasyon tetiklendi. Ovulasyondan yaklaşık 36-38 saat sonra IUI i şlemi yapıldı. Takiplerde β-hCG değeri pozitif gelen ve fetal kalp at ımı olan gebelikler kaydedildi. Bulgular: Gruplar arasında IUI günü bakılan estradiol artış miktarlarında ve endometrial kalınlıklarında anlamlı fark bulunmadı. Ovulasyon indüksiyonu zamanında kombine tedavi alan ilk grupta 14-18 mm arası folikül sayısı 2, diğer iki grupta ise 1 olarak bulundu ancak dominant follikül sayısına bakıldığında (>18 mm) gruplar aras ında istatistiksel fark bulunmad ı. Gebelik oranlar ı bakımından 3 grup aras ında istatistiksel olarak anlaml ı fark saptanmadı. Sonuç: CC ve letrazol ile kombine, yalnız CC ve yalnız letrozol ile ovulasyon indüksiyonu ve IUI yapılmış hastalarda gruplar arasında gebelik oranları açısından birbirlerine üstünlükleri görülmemiştir.