Browsing by Author "Ragip, Balahoroglu"

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Lipid Peroxidation in Patients With Brain Tumor
(Taylor & Francis Ltd, 2006) Yilmaz, Nebi; Dulger, Haluk; Kiymaz, Nejmi; Yilmaz, Cahide; Bayram, Irfan; Ragip, Balahoroglu; Oger, Muzaffer
Molecular and genetic signatures may predict brain tumor behavior and may soon guide tumor classification, diagnosis, and tumor-specific treatment strategies. Free oxygen radicals ( FOR) are thought to take part in oncogenesis and cellular differentiation. This article explored the state of FORs and antioxidant system in patients with cerebral tumor. The serum concentrations of malondialdehyde (MDA), catalase, and glutathione peroxidase (GSH-Px) enzyme activities were measured in the serum of 35 patients with cerebral tumors ( 21 glioma, 14 meningioma) and 11 controls. MDA measurement was done with fluorometric method and catalase and GSH-Px enzyme activities were done with photometric method. Mean serum MDA levels, catalase, and GSH-Px enzyme activities were significantly higher for both glial and meningiomal tumor cases when compared to controls (p < .05). There is no significant difference between glioma and meningioma groups in terms of the aforementioned parameters ( p > .05). In conclusion, lipid peroxidation and antioxidant enzymes as assessed by MDA, catalase, and GSH-Px were increased in patients with brain tumors, for this respect there is no difference between gliomas and meningiomas.
Oxidative and Immunohistochemical Changes in Various Tissues of Rats Exposed To Cigarette Smoking
(Sci Printers & Publ inc, 2018) Ahmet, Donder; Hamdiye, Turan; Ragip, Balahoroglu; Zubeyir, Huyut; Hamza, Aslanhan; Serkan, Yildirim; Engin, Deveci
OBJECTIVE: To investigate whether exposure to cigarette smoke causes histopathological changes in tissues of the heart, liver, kidney, testis, spleen, brain, and lung just after exposure, and whether smoke and smoking termination affect malondialdehyde (MDA) levels and catalase activities. STUDY DESIGN: Forty rats were divided into 5 groups: control, rats exposed to cigarette smoke, and rats previously exposed to smoke that stopped smoking for 1 month, for 3 months, and for 5 months. Tissue samples from all groups were collected to measure MDA and catalase activities. RESULTS: MDA levels in heart tissue of rats exposed to smoke were relatively higher than those of the control group. Rats that stopped smoking for 1 and 3 months also had significantly higher MDA levels. Catalase activity in liver and kidney tissues of rats exposed to smoke was significantly lower than that of the control group. Histopathologic changes were observed only in the lung. There was a statistically significant difference only between the lungs of the smoking group and all other groups. CONCLUSION: Cigarette smoke exposure results in reduced catalase activity in liver and kidney tissues, elevated catalase activity in spleen tissue, and increased MDA levels in heart tissue. The lung is the primary target organ affected by smoking.