Browsing by Author "Saglamtas, Ruya"

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Anti-Alzheimer, Antiglaucoma, and Antidiabetic Activities of Sainfoin (Onobrychis Buhseana Boiss.)
(Wiley-v C H verlag Gmbh, 2025) Jafarova, Shahla; Aydin, Tuba; Isayev, Javanshir; Saglamtas, Ruya; Ozgokce, Fevzi; Kazaz, Cavit; Cakir, Ahmet
Onobrychis Adans. species, known as 'sainfoin,' are commercially valuable plants cultivated to produce high-protein animal feed. In this study, the ethanol extract of Onobrychis buhseana Boiss., which is widely distributed in Azerbaijan, was subjected to silica gel column and thin-layer chromatography for the first time, leading to the isolation of a new natural hydroquinone oligomer, named buhseanol (1), along with two known compounds, beta-arbutin (2) and an inositol derivative (3). The chemical structure of buhseanol (1) was characterized by proton nuclear magnetic resonance (1H-NMR), carbon-13 NMR, Attached Proton Test NMR, and liquid chromatography-tandem mass spectrometry. Buhseanol (1), beta-arbutin (2), and the ethanol extract were evaluated for their anti-Alzheimer's, anti-glaucoma, and anti-diabetic effects, with both the extract and buhseanol (1) potentially showing these activities. The inositol derivative (3) did not exhibit any of these activities.
Isatis Glauca Aucher Ex Boiss. Subsp. Glauca (Indigo) Extracts as Enzyme Inhibitors: a Biochemical Study
(Wiley-v C H verlag Gmbh, 2025) Nezir, Beyza Sevdenur; Dasdemir, Edanur; Aydin, Tuba; Saglamtas, Ruya; Kaya, Elife; Ozgokce, Fevzi
Isatis glauca Aucher ex Boiss. subsp. glauca is a species of indigo that grows naturally in T & uuml;rkiye. In this study, the in vitro biological activities of I. glauca were evaluated for the first time. The inhibitory effects of I. glauca's methanol, ethanol, dichloromethane/methanol (50:50), acetone, ethyl acetate, dichloromethane, and n-hexane extracts were investigated on the enzymes human carbonic anhydrase I (hCAI), human carbonic anhydrase II (hCAII), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glycosidase. IC50 values were calculated to determine the inhibitory effect of the extracts. Among the extracts, the ones with the strongest inhibitory activity against hCAI, hCAII, AChE, BChE, and alpha-glucosidase were found to be ethyl acetate extract (IC50: 75.77 mg/mL), methanol extract (IC50: 102.89 mg/mL), n-hexane extract (IC50: 61.11 mg/mL), ethyl acetate extract (IC50: 22.79 mg/mL), and ethyl acetate extract (IC50: 77.12 mg/mL), respectively. The study findings suggest that all extracts of I. glauca may have promising therapeutic properties. In particular, it can be suggested that these extracts have the potential to be used in the treatment of diseases or the alleviation of symptoms. However, additional research and clinical trials are required to determine its efficacy. The isolation of I. glauca phytochemicals should be addressed in future studies.