Browsing by Author "Sahin, A"

Now showing 1 - 6 of 6

The Effect of Nigella Sativa (Black Seed) and Vit. E Plus Selenium in the Prevention of Liver Necrosis Experimentally Induced With Carbon Tetrachloride (Ccl4) in Rats
(Tubitak Scientific & Technological Research Council Turkey, 2003) Sahin, A; Yener, Z; Dagoglu, G; Dede, S; Oto, G; Alkan, M
The preventive effect of Nigella sativa (black seed) was investigated in rats with hepatic necrosis experimentally induced by carbon tetrachloride (CCl4). To compare the antioxidant effect of black seed, well-known antioxidants, vitamin E and selenium mineral, were used. This study was conducted on 40 rats that were divided into five groups of eight. Group A was separated as a control group and treated intraperitoneally (i.p.) with only liquid paraffin. Group B was administered i.p CCl4 in liquid paraffin. Group C was administered i.p. CCl4 in liquid paraffin and intramuscularly (i.m.) treated with vitamin E + selenium. Group D was administered i.p. CCl4 in liquid paraffin, i.m. treated with vitamin E + Se and fed ad libitum with standard rat pellets containing 10% black seed. Group E was administered i.p. CCl4 in liquid paraffin and fed ad libitum with standard rat pellets containing 10% black seed. Blood samples were drawn from the heart of the rats four times for the experimental groups and five times for the control group, one of which was at the beginning of the experiment. In blood samples, malondialdehyde (MDA), glutathione peroxidase (GSH-px), superoxide dismutase (SOD), alanine transaminase (ALT), aspartic transaminase (AST), intracellular glutathione (GSH) and ceruloplasmin analyses were performed. In group B blood samples, lipid peroxidation and antioxidant enzymes were significantly increased. The closest enzyme activities to those of the control group were found in group E. The least weight loss percentages were in group E. The least necrosis was detected in the liver samples of group D. Histopathological results were consistent with biochemical results. In conclusion, a liver necrosis preventive effect of vitamin E + selenium and black seed was observed.
Effect of Propofol Anaesthesia in Calves
(indian veterinary Journal, 2005) Genccelep, M; Aslan, L; Sahin, A; Sindak, N
Effects of Nigella Sativa and Vitamin E+se in Ccl4 Treated Rats
(indian veterinary Journal, 2004) Deger, Y; Sahin, A; Dede, S; Kilicalp, D; Cemek, M
Carbontetrachloride (CCl4), a selective hepatotoxic chemical agent has been utilized to produce liver cirrhosis in experimental animals (Parola et al., 1992). Vitamin E and Se are well-known liver preservative and hepatotrophic compounds (Zhang et al., 1996). Nigella sativa (black seed) is a seed of capsulated plants and belongs to the Ranunculaceae spp. Recently researches have shown the therapeutic effect of N. Sativa extracts such as bronchodilator, immunomodulative, antibacterial, hypotensive, choleretic, antitumoral, antifungal and anthelmentic (Salomi et al., 1992). The trace elements such as copper and zinc are co-factors of some enzymes, such as SOD which participate in antioxidant process by inhibiting reactive oxygen production (Bray and Bettger, 1990). The aim of this study was to determine the effect of N. sativa, well known therapeutic agent, vitamin E+Se administration on serum antioxidant vitamins (vitamin E, vitamin C, vitamin A, beta-carotene and retinol) and trace elements (Zn, Cu) concentrations on CCl4 treated rats.
Effects of Scorpion Envenomation on Blood Constituents in Rats
(indian veterinary Journal, 2004) Sahin, A; Ozbek, H; Dulger, H; Ozturk, G; Dagoglu, G
The Efficacy of Moxidectin and Doramectin Against Gastrointestinal Nematode Infection in Cattle
(Scientific Technical Research Council Turkey, 2003) Ayaz, E; Sahin, A
The efficacy of doramectin (Dectomax, Pfizer) and moxidectin (Cydectin, Abfar) against gastrointestinal nematode infection was evaluated in cows which were naturally infected with these nematodes. For that purpose over 100 cows' faeces were tested for gastrointestinal nematodes with the saturated salt solution method. Infected cows were selected according to the McMaster criteria. To establish whether the cows were infected with gastrointestinal nematodes, their coprocultures were screened for the presence of Ostertagia, Haemonchus, Nematodirus and Trichostrongylus species. Thirty cows which had acquired nematodes naturally were allocated to three groups of 10. The cows in the first and second group were administered subcutaneous 1% doramectin and moxidectin in injectable form at 0.2 mg/kg, respectively. The third group was separated as a control. Faecal samples from animals were examined one week before the start of treatment and on days 0, 7 and 14 of treatment. One and two weeks after the treatment, the examination of faecal samples from both treated groups showed that doramectin and moxidectin were 100% effective against gastrointestinal nematode infection. In contrast, the egg numbers in the control group were variable but not lower.
Ureteroscopic Treatment of Ureteral Lithiasis With Pneumatic Lithotripsy
(Springer, 2005) Ceylan, K; Sünbül, O; Sahin, A; Günes, M
Ureteroscopes and different lithotripsy methods have greatly improved the urologist's ability to treat ureteral stones, regardless of their location in the ureter. We retrospectively reviewed our experience with ureteroscopic pneumatic lithotriptor in 287 patients with ureteral calculi. Ureteroscopic stone treatment was performed between October 1999 and May 2004. Of 221 patients with distal ureteral calculi, 209 (group 1), and 58 of 66 patients with upper ureteral calculi (group 2) were treated successfully by ureteroscopy alone. In group 1, seven migrated stones (to the upper urinary tract) were successfully treated by ESWL later. There were five-treatment failures due to ureteral perforation which consequently required open ureterolithotomy. In group 2, there were five patients with migrated stones; two of them were sent to a percutaneous nephrolithotomy center because of previously unsuccessful ESWL attempts. Three of these with migrated stones were treated by ESWL later. In three patients, we switched to open ureterolithotomy because of ureteral rupture that required surgical repair. Ureteroscopic pneumatic lithotripsy is a safe and effective treatment modality for ureteral calculi.