Browsing by Author "Sahin, H. G."

Now showing 1 - 8 of 8

Is There Any Association Between Fetal Nervous System Anomalies and Heavy Metal-Trace Element Levels in Amniotic Fluid
(I R O G Canada, inc, 2018) Cim, N.; Tolunay, H. E.; Boza, B.; Bilici, M.; Karaman, E.; Cetin, O.; Sahin, H. G.
Aim: In this study the authors aimed to evaluate whether there are any causal relationship between heavy metals-trace elements and fetal malformations of central nervous system (CNS). Materials and Methods: The study group consisted of pregnancies with fetal congenital nervous system anomaly (anencephaly, acrania, neural tube defects, etc.) in 16-22 weeks (n=36). Pregnancies with the same weeks of pregnancy who underwent amniocentesis due to high risk in triple test with the result of normal karyotype constituted the control group (n=30). In the both groups the authors analyzed the heavy metals and trace elements in amniotic fluid. Metals and elements were measured by using atomic absorption spectrophotometer technique with a UNICAM-929 spectrophotometer. Results: When compared, the groups were similar in terms of age, parity, BMI, and gestational week (p > 0.05). In fetal congenital anomaly group the authors detected low levels of copper (Cu) and zinc (Zn) rather than control groups (p < 0.05). In fetal congenital anomaly group they detected high levels of lead (Pb) and cadmium (Cd) rather than control groups (p < 0.05). Iron (Fe), manganese (Mn), cobalt (Co), nickel (Ni), and Cd levels were similar and there was no significantly difference between the groups (p > 0.05). Conclusion: This study can contribute benefits to the literature in terms of clarifying the pathogenesis of fetal congenital nervous system anomalies.
Ovarian Stimulation in Obese and Non-Obese Polycystic Ovary Syndrome Using a Low-Dose Step-Up Regimen With Two Different Starting Doses of Recombinant Follicle-Stimulating Hormone
(Sage Publications Ltd, 2008) Yildizhan, R.; Adali, E.; Kolusari, A.; Kurdoglu, M.; Yildizhan, B.; Sahin, H. G.; Kamaci, M.
Sixty-seven infertile women with polycystic ovary syndrome (PCOS) were divided into two groups, obese and non-obese, according to their body mass index. Waist-to-hip ratio, insulin resistance, total testosterone and dehydroepiandrosterone sulphate levels were significantly elevated in obese, compared with non-obese, patients. Both groups were treated with a low-dose step-up protocol of recombinant follicle-stimulating hormone (rFSH) with a starting dose of 50 IU/day and, every third day, a 25-IU increase in the dose until the appropriate dose was achieved for each individual, up to a maximum of 175 IU/day. In the obese group only, repeat therapy commenced in the second ovulatory cycle in women who had not become pregnant, however a starting dose of 75 IU/day was then used, with incremental and maximum dose as before. The results of the starting dose of 75 IU/day rFSH were compared with the results of a 50 IU/day rFSH starting dose in the obese group. A starting dose of 50 IU/day rFSH in a low-dose step-up regimen was found to be effective, safe and well-tolerated for inducing follicular development in non-obese infertile women with PCOS. However, for obese PCOS patients, a starting dose of 75 IU/day rFSH is recommended.
Prevalence of High Risk Human Papillomavirus (Hpv) Infection and Abnormal Cervical Cytology and Knowledge About Hpv Vaccine in Eastern Turkey
(Imr Press, 2017) Sahin, H. G.; Kolusari, A.; Guducuoglu, H.
Purpose of investigation: The aim of the present study was to gather data on the high risk human papillomavirus (HPV) frequency and the distribution of HPV types in Eastern Turkey in relation to cervical cytology and to assess the knowledge about cervical cancer, HPV, and vaccination. Materials and Methods: The study population included 1,000 women aged between 20-65 years who attended the outpatients clinics of Department of Obstetrics and Gynecology of the Medical School of Yuzuncu Yil University Hospital. Results: The overall prevalence of high risk HPV-DNA was 2.8 %. Abnormal cytology was observed in 12.9% of the cases. Abnormal cytology consisted of cervical cancer: 0.1%, LSIL: 1.6%, HSIL: 0.5%, ASC-H: 2.1%, atypical glandular cells: 0.4%, and ASCUS: 8.3 %. Conclusion: The prevalence of HPV was low in Eastern Turkey and the most common HPV types are similar to the literature. However, the prevalence of HPV infection is a growing worldwide and the awwreness of the women in the region is limited.
Primary Gestational Choriocarcinoma of the Uterine Cervix and Fallopian Tube: the Diagnosis of Ectopic Pregnancy Is Not Always a Benign Condition
(Bmj Publishing Group, 2019) Karaman, E.; Kolusan, A.; Alkis, I.; Karaaslan, O.; Sahin, H. G.; Gul, A.
Rectal Cancer and Pregnancy: Report of Two Cases
(I R O G Canada, inc, 2009) Kolusari, A.; Ugurluer, G.; Kotan, C.; Sahin, H. G.; Kamaci, M.
Colorectal cancers are rare during pregnancy and the management is controversial and challenging. Prognosis is usually unfavorable due to late diagnosis since the presenting symptoms of colorectal cancer are attributable to the usual manifestations of pregnancy. Management depends on the patient's age and desire for future pregnancy, gestational age, cancer stage and religious principles. Thus, the treatment should be individualized. We present two cases of rectal cancer during pregnancy.
The Relationship Between Clinico-Biochemical Characteristics and Psychiatric Distress in Young Women With Polycystic Ovary Syndrome
(Sage Publications Ltd, 2008) Adali, E.; Yildizhan, R.; Kurdoglu, M.; Kolusari, A.; Edirne, T.; Sahin, H. G.; Kamaci, M.
The relationship between clinico-biochemical characteristics and self-reported psychological parameters in 42 women with polycystic ovary syndrome (PCOS) and 42 age-matched healthy controls was examined. The General Health Questionnaire was used (GHQ-12) to ascertain emotional distress and the Beck Depression Inventory (BDI) to determine depressive symptoms. Emotional distress, depressive symptoms, hirsutism score, body mass index (BMI), waist-to-hip ratio (WHR), luteinizing hormone/follicle-stimulating hormone ratio, serum total testosterone, dehydroepiandrosterone sulphate levels and the insulin resistance index were significantly greater in women with PCOS than in healthy women. The BDI and GHQ-12 scores of the women with PCOS were significantly higher than those of the control group (BDI, 11.69 +/- 9.49 vs 5.80 +/- 4.58; GHQ-12, 3.38 +/- 3.38 vs 1.54 +/- 1.97, respectively), and BMI and WHR were positively correlated with the BDI and GHQ-12 scores. Clinicians should be aware of the increased risk of emotional distress and depression in women with PCOS, especially those who are obese, and of the need to screen these patients for such symptoms.
Serum Trace Elements and Heavy Metals in Polycystic Ovary Syndrome
(Sage Publications Ltd, 2012) Kurdoglu, Z.; Kurdoglu, M.; Demir, H.; Sahin, H. G.
Objective: We aimed to investigate the serum levels of essential trace elements copper (Cu), zinc (Zn), manganese (Mn), magnesium (Mg) and heavy metals cadmium (Cd), cobalt (Co) and lead (Pb) in the patients with polycystic ovary syndrome (PCOS). Methods: A total of 65 (35 patients with PCOS and 30 healthy controls) women were included in the study. Serum Cu, Zn, Mn, Pb, Mg, Co and Cd levels were analyzed using atomic absorption spectrophotometric method. Results: Serum Cu and Zn levels were significantly higher, but Mn and Pb levels were lower in patients with PCOS compared with the healthy participants (p<0.01). There was no difference between patients with PCOS and the controls with respect to the serum levels of Mg, Co and Cd. Conclusions: This is the first study investigating serum Cu, Zn, Mn, Pb, Co, Mg and Cd levels in the patients with PCOS. The serum levels of trace elements and heavy metals might change in patients with PCOS. The findings in this study should be investigated with further trials in order to obtain new insights into PCOS.
Torsioned Adnexal Masses: a 7 Year Clinical Analysis
(Galenos Yayincilik, 2012) Kamaci, Mansur; Sahin, H. G.; Kolusari, Ali; Adali, Ertan; Yildiz, Muhammet; Yildizhan, Recep; Guler, Ayfle
In the last seven year, 24 patients who had pelvic localized pain or which was expansive to abdomen who applied to emergency service were included into the study. In this study, we aimed to determine the management of torsioned adnexal masses in our clinic on the light of the literature. After vaginal and pelvic color-power Doppler ultrasound examination, torsioned masses due to fallopian tube, ovarium or both were noted. The mean ages of the patients were 31. Eighteen of these were married, 6 women were single. Three of the patients had first trimester pregnancy. The most common complaints were pelvic and abdominal pain. Laparoscopy and laparotomy were performed on 6 and 18 patients, respectively. As a result, each patient thought torsioned adnexal mass should evaluate indivudially and management should be planned according to patient's age, fertility and pregnancy situation.