Browsing by Author "Sahin, Hanim Guler"

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Amniotic Fluid Oxidant-Antioxidant Status in Foetal Congenital Nervous System Anomalies
(Sage Publications Ltd, 2018) Cim, Numan; Tolunay, Harun Egemen; Karaman, Erbil; Boza, Baris; Bilici, Mustafa; Cetin, Orkun; Sahin, Hanim Guler
Objective This study aimed to evaluate the oxidant-antioxidant status of amniotic fluid in pregnant women with foetal congenital malformations of the central nervous system. Methods We studied pregnant women with foetal congenital nervous system anomalies at 16-22 weeks' gestation (n=36). The control group (n=30) consisted of pregnant women at the same gestational age who underwent amniocentesis, resulting in a normal karyotype. We analysed glutathione, catalase, and malondialdehyde levels in amniotic fluid. Enzyme activation was measured by spectrophotometry. Results The demographic features of the groups were similar in terms of age, parity, body mass index, and gestational weeks. We detected lower glutathione and catalase levels in the foetal congenital anomaly group than in the control group. We detected higher malondialdehyde levels in the foetal congenital anomaly group than in the control group. Conclusion In the organism, the rate of formation of free radicals and their rate of removal are balanced, and this is called oxidative balance. As long as oxidative stability is achieved, the organism is not affected by free radicals. This fact should be kept in mind to avoid any type of teratogenic agent that could lead to congenital disorders.
Angiogenic Factors and Evaluation of Vascular Status in Preeclampsia
(Bayrakol Medical Publisher, 2021) Aksin, Serif; Cim, Numan; Sahin, Hanim Guler; Balsak, Deniz
Aim: The aim of this study was to measure serum levels of the angiogenic factors nitric oxide (NO), soluble endoglin (s Eng), soluble fms-like tyrosine kinase-1 (s Flt-1), placental-derived growth factor (PIGF) and vascular endothelial growth factor (VEGF) and to measure uterine and umbilical arterial blood flow using Doppler ultrasonography to investigate the physiopathology of preeclampsia and endovascular dysfunction by comparing brachial artery dilatation and the thickness of the carotid artery with normal pregnant women. Material and Methods: Forty pregnant women with preeclampsia and 40 healthy pregnant women (control group) were recruited for the study in April 2011 and October 2011 at Van Yuzuncu Yil University. Systolic and diastolic blood pressure, urinary protein in spot urine samples, complete blood counts, aspartate transaminase (AST), alanine aminotransferase (ALT) levels of sEng, sFlt-1, VEGF, PIGF and NO, and APGAR scores at one and five minutes after birth were recorded and compared in all patients. Intima-media thickness of the carotid artery, brachial artery dilatation and umbilical artery Doppler parameters of all pregnant women were assessed and recorded. Results: When compared to the control group, systolic and diastolic blood pressures urinary protein in spot and 24-hour urine collection, levels of AST, ALT and sFlt-1, and uterine artery Doppler parameters were significantly higher, whereas VEGF, platelet count and APGAR scores at one and five minutes after birth were lower in the preeclampsia group (p<0.001). Brachial artery dilatation before obstruction was found to be insignificant in both groups, while post obstructive dilatation was found to be significantly higher in the control group. Discussion: Uterine artery Doppler evaluation, assessment of brachial artery dilatation and measurement of VEGF and sFlt-1 levels seem to be useful in preeclampsia.
Comparison of Maternal B12 and Folate Status in Prenatally Diagnosed Neural Tube Defects: a Case-Control Study
(Istanbul Univ, Fac Medicine, Publ off, 2020) Turkyilmaz, Gurcan; Kucukbas, Gokce Naz; Erturk, Emircan; Turkyilmaz, Esebnem; Karaaslan, Onur; Sahin, Hanim Guler
Objective: To evaluate folate and B12 levels in fetuses who had been diagnosed with neural tube defects (NTDs) and healthy fetuses in Van Yuzuncu Yil University and Van State Education and Research hospitals between March-August 2019. Material and Method: Thirty-eight pregnant women who had been diagnosed with fetuses with NTDs prenatally, and 40 healthy controls were recruited. The chi-square test and Mann-Whitney U test were employed to compare variables. Results: None of the women had taken folic acid preconceptionally in the NTD group. However, 4 (10%) women had taken folic acid supplementation in the preconception period in the control group, and this was significantly different among the groups (p=0.04). The women who had taken folic acid in the first trimester of pregnancy were 9 (23.6%) and 32 (80%) in cases and controls, respectively, and it was significantly different (p=0.01). The mean B12 level was 248.7 +/- 65.4ng/ml in cases and 239.3 +/- 27.5 ng/ml in controls, and there was no significance between the groups (p=0.78). The mean folate level was 9.6 +/- 4.8 ng/ml in cases and 9.8 +/- 3.9 ng/ml in controls, and it was similar between the groups (p=0.62). Conclusion: We did not show difference in folate and B12 levels. However, folic acid intake in preconception or in the first trimester of pregnancy was significantly higher in women who have healthy babies compared to the NTD group.
Comparison of Placental Elasticity in Normal and Pre-Eclamptic Pregnant Women by Acoustic Radiation Force Impulse Elastosonography
(Wiley-blackwell, 2016) Karaman, Erbil; Arslan, Harun; Cetin, Orkun; Sahin, Hanim Guler; Bora, Aydin; Yavuz, Alparslan; Akbudak, Ibrahim
AimThe aim of this research was to study and compare placental elasticity with acoustic radiation force impulse (ARFI) elastography in pre-eclamptic and normal pregnancies. MethodsA total of 107 singleton pregnancies in the third trimester (38 healthy control subjects, 34 patients with gestational hypertension, and 35 pre-eclampsia patients) were included in the study. ARFI elastography was used to determine the placental elasticity in the three predetermined regions of the placenta (the fetal edge, maternal edge, and central part of the placenta). The obstetrical data regarding grayscale and Doppler ultrasonography and perinatal outcomes were reviewed. A mean placental shear wave velocity cut-off value that predicts the presence of pre-eclampsia was determined. ResultsThe shear wave elasticity values in the pre-eclampsia group in all three regions were significantly higher than in the gestational hypertension and healthy control groups (P=0.001). The most significant difference was found in the peripheral edge of the placenta from the fetal surface in the pre-eclampsia group (P=0.001). ConclusionThe stiffness of the placenta determined by the ARFI technique is significantly higher in pre-eclampsia patients. ARFI elastography of the placenta might be used as a non-invasive and easy method in the diagnosis and evaluation of pre-eclampsia as a supplement to the already existing methods.
Doppler Analysis of Uterine Perfusion and Ovarian Stromal Blood Flow in Polycystic Ovary Syndrome
(Wiley, 2009) Adali, Ertan; Kolusari, Ali; Adali, Fulya; Yildizhan, Recep; Kurdoglu, Mertihan; Sahin, Hanim Guler
Objective: To investigate blood flow velocity in the ovarian stromal artery and uterine artery in women with polycystic ovary syndrome (PCOS) and to correlate these velocities with clinical and biochemical parameters. Methods: A prospective study was carried out in 55 patients with PCOS and 42 age-matched women who did not have PCOS. Clinical, biochemical, and hormonal characteristics, and utero-ovarian Doppler ultrasound blood flow parameters were determined, and correlations between the parameters were evaluated. Results: Ovarian stromal blood flow was higher (P<0.01) and uterine perfusion was lower (P<0.01) in women with PCOS compared with women who did not have PCOS. Ovarian stromal artery pulsatility index (PI) was inversely correlated with levels of dehydroepiandrosterone sulfate (DHEAS) and insulin-like growth factor-1, and with the luteinizing hormone/follicle-stimulating hormone ratio. There was a positive correlation between uterine artery PI and DHEAS level. Conclusion: Doppler analysis of the uterine and intraovarian arteries may provide additional information about the etiopathogenesis of PCOS and partly explain the clinical implications of the condition. (C) 2009 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Ectopic Intrauterine Device in the Bladder of a Pregnant Woman
(Hindawi Ltd, 2010) Kurdoglu, Zehra; Ceylan, Kadir; Kurdoglu, Mertihan; Guler, Ayse; Sahin, Hanim Guler
Background. Uterine perforation and transvesical migration of an intrauterine device are rare complications. Case. A 28-year-old woman who had an intrauterine device was admitted to our outpatient clinic with complaints of amenorrhea lasting 5 weeks and pelvic pain lasting a year. Transvaginal ultrasonography revealed embedding of the intrauterine device in the bladder. The misplaced device was removed by laparotomy. Conclusion. The followup of intrauterine device localization with transvaginal ultrasonography is essential for early detection of possible serious complications.
The Evaluation of Maternal Systemic Thiol/Disulphide Homeostasis for the Short-Term Prediction of Preterm Birth in Women With Threatened Preterm Labour: a Pilot Study
(Taylor & Francis inc, 2022) Cetin, Orkun; Karaman, Erbil; Alisik, Murat; Erel, Ozcan; Kolusari, Ali; Sahin, Hanim Guler
The aim of this study was to investigate maternal systemic thiol/disulphide homeostasis (TDH) for the short-term prediction of preterm birth in women with threatened preterm labour (TPL). This prospective study included 75 pregnant women whose pregnancies were complicated by TPL. Thirty-seven of them delivered within 7 days and 38 of them delivered beyond 7 days. Maternal serum samples were collected at the day of diagnosis and the TDH was measured. The maternal disulphide level was significantly higher in pregnant women who delivered within 7 days (25.0 +/- 9.8 mu mol/L vs 19.4 +/- 9.8 mu mol/L, p: .015). The threshold value of 22.1 mu mol/L for maternal disulphide level predicted delivery within 7 days with 62.2% sensitivity and 60.5% specificity (area under curve 0.651, confidence interval 0.53-0.78). The likelihood ratios for short cervix (<= 25 mm) and maternal disulphide level (>= 22 mu mol/L) to predict delivery within 7 days was found to be 8.7 and 7.3, respectively. The likelihood ratio of combining two tests to predict delivery within 7 days was found to be 11.4. The maternal TDH, which is an indicator of oxidative stress status in maternal compartment, is disturbed in TPL cases who delivered within 7 days. Elevated maternal disulphide level along with cervical length screening predicts a short latency period in pregnancies with TPL. IMPACT STATEMENT What is already known on this subject? Spontaneous preterm delivery is one of the major complication of pregnancy and the common cause of neonatal morbidity and mortality. Threatened preterm labour (TPL) is also a frequent complaint in obstetric emergency care units in all around the world. Triaging women with TPL is mandatory for planning further management therapies, since the most of them will eventually deliver at term. Only the measurement of cervical length in symptomatic women has moderate accuracy in predicting preterm delivery. Short cervix is described as an independent predictor of preterm delivery in women with TPL, its predictive accuracy as a single measurement is relatively limited. On this account, several potential markers like foetal fibronectin in the cervicovaginal fluid, salivary oestriol, prolactin in vaginal discharge, maternal serum calponin and interleukin-6 in the amniotic fluid were examined to predict preterm delivery in previous studies. However, none of them represented an excessive predictive accuracy like high sensitivity, PPV or NPV. What do the results of this study add? We report a method which has higher diagnostic and predictive performance to identifying TPL women with high risk of preterm delivery. According to the current literature, there are accumulated data about the correlation between oxidative stress (OS) and preterm delivery regardless of the amniotic membrane status. However, it is still debated whether OS is a trigger or a consequence of preterm delivery. Our study provides evidence for the first time that maternal serum thiol/disulphide homeostasis, which is an indicator of OS in maternal compartment, is disturbed in TPL cases who delivered within 7 days. The high disulphide level in maternal serum, along with cervical length measurement (short cervix) accurately predicts a short latency period in TPL cases. What are the implications of these findings for clinical practice and/or further research? This novel test combination (maternal serum disulphide level and cervical length measurement) could be used clinically to triage pregnant women presenting with TPL, avoiding overtreatment, unnecessary hospitalisations and increased medical costs. The future research would be addressed on reducing maternal OS by using new antioxidant treatment strategies to improve perinatal and long-term childhood outcomes.
Evaluation of Periodontal Status and Interleukin Levels in Pregnant Women With Hellp Syndrome
(Kerman Univ Medical Sciences, 2022) Aydinyurt, Hacer Sahin; Cetin, Orkun; Aydogdu, Hasan Murat; Karaman, Erbil; Taskin, Cem; Sahin, Hanim Guler; Alkhatib, Mohammed F. A.
BACKGROUND AND AIM: Hemolysis, elevated liver enzymes and low platelet (HELLP) syndrome is a pregnancy-specific disease that affects many systems of the body. Its etiopathogenesis has not been fully elucidated. HELLP syndrome is characterized by hemolysis, elevated liver enzymes, and low platelet counts. It has a prevalence of 0.2%-0.8% in pregnant women. This study aimed to compare periodontal status as well as interleukin (IL)-6 and IL-37 levels in gingival crevicular fluid (GCF) of healthy pregnant women and pregnant women with HELLP syndrome. METHODS: This study included 20 patients with HELLP and 20 healthy pregnant women. The clinical periodontal parameters [plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL)] were recorded and GCF samples were collected. IL-6 and IL-37 levels were measured in GCF samples using the enzyme linked immunosorbent assay (ELISA) method. The data collected from healthy pregnant women and patients with HELLP were compared with statistical analysis. RESULTS: There was no statistically significant difference between healthy pregnant women and pregnant women with HELLP in terms of periodontal clinical parameters. There was a statistically significant difference in terms of IL-6 levels (P < 0.05); however, no statistically significant difference was determined in terms of IL-37 levels in GCF. CONCLUSION: This is the first study to evaluate periodontal status as well as IL-6 and IL-37 levels in GCF in pregnant women with HELLP syndrome. The results of the study showed that IL-6 levels were significantly higher in pregnant women with HELLP syndrome, but there was no significant difference in terms of other parameters. Further research is needed to evaluate the relationship between HELLP syndrome and periodontal disease.
A Five-Year Audit of Cases With Ectopic Pregnancy in Our Clinic
(Galenos Yayincilik, 2010) Adali, Ertan; Kurdoglu, Mertihan; Kolusari, Ali; Yildizhan, Recep; Cim, Numan; Sahin, Hanim Guler; Kamaci, Mansur
Objective: The aim of this study was to review the ectopic pregnancy cases that were administered to our clinic in the last five years. Materials and methods: According to the dermographic features, risk factors, clinical signs and treatment approaches, ninetyone cases with ectopic pregnancies were evaluated retrospectively between 2004-2009. For statistical analysis, SPSS was used. Results: The average age of the patients were 28,38 +/- 6,47 years and ectopic pregnancies were mostly seen between the ages of 26-35. The mean gravida and parity were 3,86 +/- 2,55 and 2,34 +/- 2,16, respectively. The mean serum beta-hCG level of the patients on admission to our clinic was 3085,41 +/- 6346,84 mIU/L. The risk factors in the order of frequencies were previous abdomino-pelvic surgery (16 %), the use of intrauterine device (12 %), previous ectopic pregnancies (7 %) and previous pelvic inflammatory disease (2 %). The most common complaint on admission were abdominal pain (40 %) and following that in the order of frequencies were vaginal bleeding with pain (38 %) and only vaginal bleeding (15 %). As a treatment option, surgery, methotrexate and expectant management were applied to 66 %, 20% and 10% of the patients respectively. Conclusion: Ectopic pregnancies are important health problems since they may interfere with fertility capability of the patient in her future life and may even cause maternal mortality. Especially, women who had abdomino-pelvic surgery before are at risk. Early diagnosis enables conservative management approaches.
Gestational Trophoblastic Diseases: Fourteen Year Experience of Our Clinic
(Galenos Yayincilik, 2011) Kurdoglu, Mertihan; Kurdoglu, Zehra; Kucukaydin, Zehra; Sahin, Hanim Guler; Kamaci, Mansur
Objective: To evaluate the patients followed and treated with a diagnosis of gestational trophoblastic disease in our clinic retrospectively. Design: The files of the patients followed and treated in our clinic between 1996 and 2010 with a diagnosis of gestational trophoblastic disease were examined. Setting: Yuzuncu YIl University, Faculty of Medicine, Department of Obstetrics and Gynecology, Van. Patients: The 147 patients with satisfactory information in their files within 173 patients treated and followed in our clinic between 1996 and 2010 with a diagnosis of gestational trophoblastic disease. Interventions: No intervention to the patients. Main outcome measures: Demographic and obstetric parameters, blood group, obstetric history in the previous pregnancy, contraceptive method, gestational week and complaints on admission, hystological type, stage, treatment and complications of gestational trophoblastic disease and presence of associated clinical problems. Results: In our clinic, 18.324 deliveries occured and 173 cases had a diagnosis of gestational trophoblastic disease between 1996 and 2010. Out of 147 patients, 72 (49%), 61 (41.5%), 3 (2%), 7 (4.8%) and 1 (0.7%) had diagnoses of complete mole, partial mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor, respectively. In 3 patients ( 2%), subtype could not be determined. Mean age was 31.45 +/- 10.29 years and the most common complaint was vaginal bleeding (77.6%). As the primary therapy, suction curettage with oxytocin infusion or hysterectomy was appplied to 140 and 7 patients, respectively. A single agent chemotherapy was performed to 26 patients while a multiagent chemotherapy was given to 6 patients. All patients were followed up by serial serum beta-hCG measurements. Conclusions: The incidence of gestational trophoblastic disease in our clinic was calculated as 8.1 per 1000 deliveries and socio-economic and educational status of majority of the patients were low. Lowering the high birth rate in our region may contribute to decrease of disease incidence.
The Impact of Low Molecular Weight Heparin on Obstetric Outcomes Among Unexplained Recurrent Miscarriages Complicated With Methylenetetrahydrofolate Reductase Gene Polymorphism
(Via Medica, 2017) Cetin, Orkun; Karaman, Erbil; Cim, Numan; Dirik, Deniz; Sahin, Hanim Guler; Kara, Erdal; Esen, Ramazan
Objectives: The association between methylenetetrahydrofolate reductase gene polymorphisms and unexplained recurrent miscarriage is elusive. The recommendations for improving pregnancy outcomes in these patients keep changing based on the available evidence. The aim of this study is to analyze the impact of low molecular weight heparin on obstetric outcomes of recurrent miscarriage patients complicated with methylenetetrahydrofolate reductase gene polymorphism. Material and methods: We reviewed medical records of 121 patients with a history of recurrent miscarriage complicated by methylenetetrahydrofolate reductase gene polymorphisms, retrospectively. From among them, 68 patients were treated only with folic acid and iron. The remaining 53 patients were treated with folic acid, iron and prophylactic doses of low molecular weight heparin. The subsequent pregnancy outcomes of these patients were noted. Results: The live birth rate was higher in patients with anticoagulant therapy than in patients without anticoagulant therapy (48.5% vs. 69.8%, respectively, p: 0.015) and the congenital anomaly rate was lower in anticoagulant therapy group (17.6% vs. 3.8%, respectively, p: 0.022). The other obstetric outcomes were found to be similar between the two groups. Conclusions: The current study demonstrated that low molecular weight heparin improved the live birth rates among unexplained recurrent miscarriage patients complicated with methylenetetrahydrofolate reductase gene polymorphisms. However, the routine use of low molecular weight heparin did not improve the late pregnancy complications in these selected patients in the eastern region of our country. Further studies are needed to discriminate the effect of anticoagulation on the live birth rate of each of methylenetetrahydrofolate reductase gene polymorphism type.
Increased Nuchal Translucency and Pregnancy Outcomes: a Tertiary Center Data
(Duzce Univ, Fac Medicine, 2024) Bagci, Mustafa; Uckan, Kazim; Sahin, Hanim Guler; Karaaslan, Onur; Karaman, Erbil
Aim: This study aimed to evaluate the pregnancy outcomes of patients who applied to our clinic between the 11th and 14th weeks of pregnancy and whose nuchal translucency (NT) measurement was >= 1.5 multiples of the median (MoM). Material and Methods: The study included 85 patients whose NT measurement was determined >= 1.5 MoM and pregnancy results were available. Demographic characteristics of the patients, prenatal invasive diagnostic test results, fetal anomaly screening, fetal echocardiography (ECHO) results, and neonatal and obstetric results were evaluated. Results: Abnormal karyotype was detected in 10.6% (n=9) of the patients. Trisomy 21 was the most common chromosomal anomaly. Fetal structural anomaly was detected in 29.4% (n=25) of the patients. A structural fetal anomaly was detected in 21% (n=13) of fetuses with normal karyotypes and 66.7% (n=6) of fetuses with abnormal karyotypes. Cardiac anomalies were found to be the most common anomalies with 9.7% (n=6) in patients with normal karyotype. NT and NT MoM values in patients with fetal structural (both p=0.001) or chromosomal anomalies (p=0.011, and p=0.019, respectively) were found significantly higher than those without. NT and NT MoM values in patients whose pregnancies resulted in fetal loss were found significantly higher than in patients who had a live birth (both p=0.001). Conclusion: Increasing NT or NT MoM values indicate an increase in the risk of chromosomal anomalies, structural anomalies, and poor pregnancy outcomes in the fetus. Fetal anomaly screening and fetal ECHO should be recommended in patients with increased NT, even if a normal karyotype is detected.
Increased Visfatin and Leptin in Pregnancies Complicated by Pre-Eclampsia
(Taylor & Francis Ltd, 2009) Adali, Ertan; Yildizhan, Recep; Kolusari, Ali; Kurdoglu, Mertihan; Bugdayci, Guler; Sahin, Hanim Guler; Kamaci, Mansur
Objective. To evaluate the role of the adipokines, visfatin and leptin in the pathophysiology of pre-eclampsia and how their concentrations correlate with the severity of the disease and abnormal Doppler velocimetry. Methods. A cross-sectional study was carried out in 72 pregnant women (30 patients with mild pre-eclampsia, 20 patients with severe pre-eclampsia and 22 healthy normotensive pregnant women) during the third trimester of pregnancy. The maternal levels of plasma visfatin and serum leptin were determined in all cases by enzyme immunoassay and enzyme-linked immunosorbent assay, respectively. The uterine artery and umbilical artery RI were determined by Doppler analysis in all cases. Results. Plasma visfatin levels and serum leptin levels were higher in patients with pre-eclampsia than in the normotensive pregnant women. Six patients with mild pre-eclampsia and five patients with severe pre-eclampsia had abnormal Doppler velocimetry. Visfatin and leptin levels of pre-eclamptic patients with abnormal Doppler velocimetry were significantly higher than they were in those with normal Doppler velocimetry. Serum leptin levels were positively correlated with plasma visfatin level in cases of pre-eclampsia. Conclusions. These findings suggest that increased maternal levels of leptin and visfatin may be involved in the pathogenesis of pre-eclampsia, and measurement of these adipokines may be useful in assessment of the severity of disease.
Investigation of Maternal Psychopathological Symptoms, Dream Anxiety and Insomnia in Preeclampsia
(Taylor & Francis Ltd, 2017) Cetin, Orkun; Ozdemir, Pinar Guzel; Kurdoglu, Zehra; Sahin, Hanim Guler
Purpose: The aim of the current study was to investigate the psychopathological symptoms, psycho-emotional state, dream anxiety, and insomnia in healthy, mild and severe preeclamptic postpartum women and their relation to the severity of preeclampsia (PE).Materials and methods: This observational study included 45 healthy, 41 mild preeclamptic and 44 severe preeclamptic postpartum women. The 90-item Symptom Checklist Revised, Hospital Anxiety and Depression Scale, Insomnia Severity Index, and Van Dream Anxiety Scale (VDAS) were used to evaluate the psychopathological symptoms, psycho-emotional state, insomnia, and dream anxiety of the participants after delivery.Results: Severe preeclamptic women had higher VDAS scores than mild preeclamptic and healthy postpartum women (p: 0.001). The psychopathological symptoms were more frequent in preeclamptic women than in healthy controls (p: 0.001). Severe preeclamptic women had the highest scores in Hospital Anxiety-Depression Scale and Insomnia Severity Index (p: 0.001, p: 0.001, respectively).Conclusion: Preeclampsia negatively affects the psycho-emotional state, psychopathological symptoms and sleep patterns. Further, disturbed dreaming was more frequent in PE and also, all of these conditions became worse with the severity of PE. We speculated that the obstetricians should offer their preeclamptic patients an appropriate mental health care at bedside and postpartum period as needed.
Maternal Serum Calponin 1 Level as a Biomarker for the Short-Term Prediction of Preterm Birth in Women With Threatened Preterm Labor
(Taylor & Francis Ltd, 2018) Cetin, Orkun; Karaman, Erbil; Boza, Baris; Cim, Numan; Sahin, Hanim Guler
Purpose: To assess the utility of maternal serum calponin 1 level in the prediction of delivery within 7 days among pregnancies complicated with threatened preterm labor.Materials and methods: Eligible women who presented at 24-34 weeks of gestation with threatened preterm labor underwent sampling for serum calponin 1 level and cervical length measurement. They were followed up until delivery prospectively and the perinatal outcomes of the patients were recorded.Results: Of 73 women included in the study, 36 women delivered within 7 days and 37 women delivered beyond 7 days after admission. The maternal serum calponin 1 level was significantly high in women who delivered within 7 days (p: 0.031). The threshold value of 2ng/mL for maternal serum calponin 1 predicted delivery within 7 days with 61.1% sensitivity and 62.2 specificity (area under curve, 0.658, confidence interval 0.53-0.79). The general accuracy values for maternal cervical length measurement (25mm), serum calponin 1 level (>2ng/mL) and the combination of two tests to predict delivery within 7 days was found to be 64.4%, 61.6% and 72.1%, respectively.Conclusions: The maternal serum calponin 1 level may be a useful biomarker in short-term prediction of preterm birth among pregnancies complicated with threatened preterm labor, in addition to cervical length measurement.
Maternal Serum Thiol/Disulfide Homeostasis in Pregnancies Complicated by Neural Tube Defects: Report of a Preliminary Study
(Taylor & Francis Ltd, 2017) Karaman, Erbil; Cetin, Orkun; Boza, Baris; Alisik, Murat; Erel, Ozcan; Cim, Numan; Sahin, Hanim Guler
Objective: To determine and evaluate the maternal serum thiol/disulfide homeostasis in pregnancies complicated by neural tube defects (NTD) via a novel method.Methods: Seventy-three pregnant women with NTD (study group) and seventy-one healthy control pregnant women (control group) were included in the study. A new and fully automated method was used to measure plasma native thiol, total thiol and disulfide levels, based on the reduction of dynamic disulfide bonds to functional thiol groups by sodium borohydrate.Results: The study and control groups were gestational age-matched. There were no statistical differences in demographic variables regarding age, gravidity, parity and body mass index. The serum native thiol levels (-SH) were 360.550.3 and 353.3 +/- 31.0mol/l in study and control groups, respectively, which was not statistically different (p=0.308). The native thiol/total thiol, disulfide/native thiol and disulfide/total thiol ratios were not statistically significantly different (p>0.05).Conclusion: Our preliminary results show that maternal serum thiol/disulfide homeostatis does not change in pregnancies complicated by NTD. Larger further studies are required to evaluate the relation of oxidative stress and development of NTD.
The Maternal Serum Thiol/Disulfide Homeostasis Is Impaired in Pregnancies Complicated by Idiopathic Intrauterine Growth Restriction
(Taylor & Francis Ltd, 2018) Cetin, Orkun; Karaman, Erbil; Boza, Baris; Cim, Numan; Alisik, Murat; Erel, Ozcan; Sahin, Hanim Guler
Purpose: To investigate the maternal serum thiol/disulfide homeostasis in pregnancies complicated by idiopathic intrauterine growth restriction (IUGR) and to compare the results with healthy pregnancies.Materials and methods: This descriptive cohort study included 55 pregnant women complicated by idiopathic IUGR and 57 similar gestational aged healthy pregnant women in the third trimester of gestation. Maternal serum samples were collected at the day of diagnosis and the thiol/disulfide homeostasis was measured by using an automated assay method. The patients were followed up until delivery and perinatal outcomes were recorded.Results: Maternal serum native thiol (308.140.7mol/L vs. 282.4 +/- 60.6mol/L) and total thiol (346.8 +/- 48.1mol/L vs. 324.0 +/- 62.2mol/L) concentrations were significantly lower in IUGR group compared with healthy controls (p: .010 and p: .032, respectively), whereas disulfide (19.3 +/- 8.7mol/L vs. 20.8 +/- 7.8mol/L) concentrations were similar between the groups (p: .350). Maternal serum disulfide/native thiol and disulfide/total thiol ratios were higher in IUGR group compared with healthy controls (p: .014 and p: .017, respectively), whereas native thiol/total thiol ratio was significantly lower in IUGR group compared with healthy controls (p: .016).Conclusions: This study suggests that there is an impaired maternal thiol/disulfide homeostasis in pregnancies complicated by idiopathic IUGR during the third trimester of gestation.
The Maternal Thiol/Disulfide Homeostasis Does Not Change in Pregnancies Complicated by Preterm Prelabor Rupture of Membranes
(Taylor & Francis Ltd, 2018) Cetin, Orkun; Karaman, Erbil; Boza, Baris; Cim, Numan; Erel, Ozcan; Alisik, Murat; Sahin, Hanim Guler
Purpose: To evaluate the maternal thiol/disulfide homeostasis in pregnant women complicated by preterm prelabor rupture of membranes (PPROM) and to compare the results with healthy pregnancies. Materials and methods: This cohort study consisted of thirty-nine pregnancies complicated by PPROM and 44 gestational age-matched healthy pregnancies in the third trimester of gestation. Maternal serum samples were obtained at the day of diagnosis, and thiol/disulfide profiles were measured by using an automated assay method. The patients were followed till delivery, and perinatal outcomes were noted. Results: The maternal native thiol (319.9 +/- 30.5 mu mol/L versus 305.1 +/- 49.2 mu mol/L, p:.100), total thiol (379.2 +/- 38.8 mu mol/L versus 363.6 +/- 56.4 mu mol/L, p: .142) and disulfide (29.7 +/- 11.7 mu mol/L versus 29.3 +/- 10.1 mu mol/L, p: .864) levels were similar between the groups. Maternal disulfide/native thiol, disulfide/total thiol and native thiol/total thiol ratios were similar between the groups (p: .610, p: .565 and .562, respectively). The maternal serum thiol/disulfide profiles were not significantly correlated with maternal serum C-reactive protein, white blood cell count values and ongoing pregnancy outcomes (p>.05). Conclusions: The current study demonstrated that there was not any disturbance in maternal thiol/disulfide homeostasis in pregnancies complicated by PPROM at the time of initial diagnosis. Follow-up studies with larger sample size are needed to confirm our results.
The Neurological Monitoring and Treatment of a Case Diagnosed With Postpartum Cerebellar Infarction
(Professional Medical Publications, 2012) Sayin, Refah; Kamaci, Mansur; Sahin, Hanim Guler; Kurdoglu, Zehra; Aksin, Serif
A 32-year-old female patient with a'previous history of cesarean section, who was referred to our clinic due to pre-eclampsia, was administered a cesarean section due to fetal distress. Consultation with the Neurologic Department was performed upon the development of complaints including headache, dizziness and blurred vision. Upon detection of acute infarction in the left cerebellar region on cerebral diffusion magnetic resonance imaging (MRI), she was referred to the Neurology Clinic. To investigate the etiology of stroke occurring at an early age, various biochemicals, hematological analyses, vasculitis, infection markers and radiological imaging methods (carotis, vertebral artery color Doppler ultrasonography, cerebral arteriography-venography MR angiography, and cervical MR angiography) were used. Treatment included anti-lipid and anti-aggregant therapies for hypertriglyceridemia and infarction respectively. The patient was discharged upon improvement in her complaints.
The Prevalence and The Determinants of Contraceptive Use Among Men and Women in Eastern Turkey
(Parlar Scientific Publications (p S P), 2017) Karaaslan, Selver; Sahin, Hanim Guler; Yesilova, Abdullah; Gunbatar, Nizamettin; Keskin, Siddik; Orhun, Reyhan; Akyigit, Elif
A variety of individual and community level determinants affect contraceptive usage. Traditionally the researches focus on women. The aim of this study was to investigate the prevalence and factors that are related to the use of contraception and the choice of contraceptive method among men and women in eastern Turkey which has a high fertility rate. The randomly selected study respondents were privately interviewed face-to-faces. A total of 3292 (676 men and 2616 women) respondents between 15 and 50 years of age were interviewed. The prevalence of the use of any form of family planning was 74%. Male condoms were used by 22.9% of the respondents, followed by intrauterine devices (16.7%), oral contraceptives (13.7%) and withdrawal (13%). Lower education level, maternal age at first birth, belief that lactation protects against getting pregnant, incorrect knowledge about contraceptive methods and efficacy were significantly associated with a preference for using less effective traditional methods (p < 0.05). Governments should focus on increasing the education level of men and women, creating greater awareness of family planning methods and their side effects, and increasing male involvement, which can decrease male opposition and thus increase rates of contraceptive use.