Browsing by Author "Sahin, Idris"

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Analysis of 3065 Cancer Cases in an Eastern Part of Turkey: the Results of Hospital-Based Registries From Van Region
(Oxford Univ Press, 2004) Topcu, Nazan; Ilhan, Mahmut; Koca, Dogan; Kosem, Mustafa; Sahin, Kevser; Sahin, Idris; Yetkin, Aysin
Are Serum Lipid Levels Associated With Depression in Hemodialysis Patients
(Turk Nefroloji Diyaliz Transplantasyon dergisi, 2006) Sahin, Idris; Kiran, Umit Kemal; Sahin, Huseyin Avni; Ustun, Yusuf; Agargun, Mehmet Yucel; Erkoc, Reha
Background: Recent study suggested a relation between low levels of serum lipids and depression. The aim of this study was to assess the association between serum lipid levels and depression in patients with end-stage renal disease (ESRD). Methods: All the patients who were attending Yuzuncu Yil University Faculty of Medicine Training Hospital Hemodialysis Unit, in Turkey, from August 2000 to July 2001, were prospectively studied. Serum TC, LDL-c, HDL-c, VLDL-c and triglyceride levels were measured and Beck Depression Inventory (BDI) was administered to all patients. Diabetic patients were excluded. Results: There were 46 patients (25 males and 21 females). Mean duration of hemodialysis was 28.1 +/- 30.2 months. Mean Kt/V was 1.2 +/- 0.4. The mean age of study group was 45.2 +/- 16.3 years and the age range was 15-73 years. Mean serum albumin concentration was 3.63 +/- 0.55 (2.5-4.7) g/dL. The patients' mean BDI was 15.9 +/- 6.2 (431). There was association between serum TC (total cholesterol), LDL-c (low density lipoprotein cholesterol), HDL-c (high density lipoprotein cholesterol) and depression but no association between serum VLDL-c (very-low density lipoprotein cholesterol) and triglyceride levels and depression in patients with ESRD. Conclusion: Depression is the most common psychological finding in patients with ESRD. Our study demonstrate that there were associations between low serum TC, LDL-c, HDL-c levels and depression but there was no association between depression and serum triglyceride and VLDL-c levels in patients with ESRD.
Brucellosis Induced Acute Renal Failure in an Elderly Patient
(Gunes Kitabevi Ltd Sti, 2011) Sahin, Idris; Sahin, Huseyin Avni; Eminbeyli, Lokman; Kaba, Ismet
Although subclinical renal involvement in brucellosis is not rare, brucellosis is a rare cause of acute renal failure. Here, we present an uncommon case of Brucella-induced acute renal failure in a previously healthy 85-year-old male farmer. He was admitted with acute renal failure and vasculitic rash on his legs. He had a 20-day history of fever, malaise, anorexia, and vomiting, and a 10-day history of vasculitic rash on his legs. He had no history of reduced urine output in this period The diagnosis was established by serological tests. Skin biopsy was concordant with leucocytoclastic vasculitis. Steroid and antibiotherapy was started. The serum creatinine began to decrease slowly after starting the specific antibiotherapy. On day 15, the renal parameters and urinalysis returned to normal. Antibiotic therapy was continued for six weeks. Brucella infection must be considered as a rare cause of acute renal failure in endemic areas.
The Effects of Hcv Infection on Serum Lipid Profile in Hemodialysis Patients
(Turk Nefroloji Diyaliz Transplantasyon dergisi, 2010) Sahin, Idris; Eminbeyli, Lokman; Sahin, Huseyin Avni; Kaba, Ismet
Objective: We aimed to investigate effects of hepatitis C virus infection on serum lipid profile in hemodialyzed patients. Method: The serum lipid profile was determined in 108 patients who had been on regular hemodialysis for at least two months. Serum total cholesterol (TC), triglyceride (TG), HDL (high density lipoprotein), VLDL (very low density lipoprotein) and LDL (low density lipoprotein) levels were compared between two groups. Results: The study included 55 HCV- negative (% 58 male) and 53 HCV-positive (% 64 male) hemodialysed patients. Mean age was 43 +/- 16 years in the HCV- negative group and 43 +/- 14 years in the HCV- positive group. There were no significant differences between the two groups with respect to age and gender. Mean duration of HD was 20 +/- 16 months in the HCV (-) group and 50 +/- 32 months in the HCV (+) group. Mean hemodialysis time was longer in HCV (+) patients than HCV (-) patients (p<0.0001). Mean serum TC (129 +/- 27 vs 148 +/- 42 mg/dL; p=0.006), TG (137 +/- 55 vs 162 +/- 64 mg/dL; p=0.032), and HDL levels (32 +/- 11 vs 36 +/- 11 mg/dL; p=0.036) were significantly lower in the HCV-ositive group than in the HCV- negative group. Mean serum LDL and VLDL levels were similar in the two groups. Although we did not find a statistical difference between serum lipid levels and ALT levels; there was a statistically significant correlation between serum AST level and TC, TG, and VLDL-c levels. Serum TC, VLDL levels were significantly higher in patients with AST >30 iu/dL than in patients with AST <30 iu/dL. Conclusion: The present study suggests that HCV infection is associated with lower TC, TG and VLDL-c levels in hemodialysed patients. An increase in serum AST levels was associated with a decrease in lipid levels.
Incidence of Palmoplantar Keratoderma Has Been Increased in Esophageal Cancer in Van Region of Turkey: the Early Results of a Case-Control Study
(Oxford Univ Press, 2004) Ilhan, Mahmut; Akdeniz, Necmettin; Arslan, Sefket; Sahin, Idris; Sahin, Kevser
Investigating Effects of Hepatitis C Virus on Platelet Parameters in Hemodialysis Patients
(Turk Nefroloji Diyaliz Transplantasyon dergisi, 2006) Sahin, Idris; Eminbeyli, Lokman; Dolu, Funda; Melek, Yasin; Guler, Hasan; Ozturk, Vechettin
Aim: In this study, we aimed to investigate the effects of hepatitis C virus on platelet parameters in hemodialysis patients. Materials and Methods: We included patients who received hemodialysis in Van region in Turkey. Platelet counts, mean platelet volume (MPV), platelet distribution width and plateletcrit, antiHCV antibodies were measured. Relations between anti-HCV antibodies and platelet parameters were investigated. Results: We included a total of 142 patients, 76 anti-HCV antibodies positive (30 female, 46 male) and 66 negative (25 female, 41 male). Mean age was 42 +/- 16 years in HCV (-) and 44 +/- 13 in HCV (+) patients. There were no significant associations between age, gender in two groups. The ratio of thrombocytopenia was 43.6%. Platelet counts was 178 +/- 73 000/mm(3) in patients with anti-HCV positive and 219 +/- 76 000/mm(3) in anti-HCV negative. We found statistically significant differences between the two groups (p<0.0001). Moderate thrombocytopenia was seen in 14.7% in anti-HCV(+) patients group and 3% in anti-HCV negative patients. There were negative correlations between anti-HCV (+) and low-platelet counts (Pearson correlation coefficient, r=-0.261, p<0.001). Mean platelet volume was 8.27 +/- 1.21 fl in patients with anti-HCV (+) and 7.60 +/- 1.10 fl in anti-HCV (-). Statistically significant differences were found between the two groups (p< 0.001). Conclusion: HCV infection can cause decreasing in platelet counts in hemodialysis patients. MPV increased in hemodialysis patients who were anti-HCV (+).
The Patient Presenting With Renal Failure Due To Multiple Myeloma Associated With Celiac Disease: Case Report
(Akad Doktorlar Yayinevi, 2011) Sahin, Idris; Demir, Cengiz; Alay, Murat; Eminbeyli, Lokman
Celiac disease (CD) is an autoimmune disorder induced by gluten intake in susceptible individuals, and characterized by intestinal and extraintestinal findings due to malabsorption caused by intestinal mucosa inflammation and villus atrophy. CD is an important risk factor for the development of malignancy including lymphoma and gastrointestinal tumors and renal failure. In this paper we present a 65 years old male patient with multiple myeloma, who was monitored for chronic renal failure (CRF) and diagnosed with CD. He is the first case with multiple myeloma associated with CD in the literature.
Screening for Celiac Disease Among Patients With Chronic Kidney Disease
(informa Healthcare, 2012) Sahin, Idris; Eminbeyli, Lokman; Andic, Safak; Tuncer, Ilyas; Koz, Suleyman
Aim: Celiac disease (CD) is considered to be a risk factor for chronic kidney disease (CKD) but there is no study determining the prevalence of CD, among patients with CKD. We aim to determine the prevalence of CD in patients with CKD. Materials and methods: Anti-endomysial IgA (EMA) antibody was screened in patients with CKD (glomerular filtration rate <60 mL/min). Patients who were EMA positive underwent upper gastrointestinal system endoscopy and intestinal biopsy for confirmation of definite diagnosis for CD. Results: Two hundred and ninety-two patients (161 males, mean age was 47.3 +/- 16.3 years) with CKD were included. The EMA testing was positive in 10 patients (6F/4M). Of these, eight underwent upper gastrointestinal endoscopy and biopsies, two of them rejected endoscopy. Biopsy specimen of one of the patients was not appropriate for histopathological examination. Specimens of remaining cases (4F/3M) were compatible with CD on histopathological examination. The EMA-positive CKD patients were 3.42% (1/29 cases) and frequency of CD was 2.39% (1/42 cases). Frequency of CD was 3.1% in females and 1.85% in males. Female/male ratio was 1.67. We did not find statistically significant difference between two groups according to age and gender. Apparent chronic gastrointestinal symptoms such as abdominal pain, distension, constipation, dyspepsia, and diarrhea were absent in patients diagnosed with CD. Differences between some laboratory parameters (such as complete blood count, albumin, calcium, phosphate, total cholesterol, ferritin, parathormone) of CD and non-CD patients were not significant statistically. Conclusion: Our results showed increased frequency of CD among patients with CKD and screening for CD in CKD population can be helpful.