Browsing by Author "Sahin, Irfan"

Now showing 1 - 4 of 4

Can the Efficacy of a Medical Treatment Be Predicted Based on the Type of Idiopathic Premature Ventricular Contraction
(Churchill Livingstone inc Medical Publishers, 2024) Atici, Adem; Sahin, Irfan; Dogan, Omer; Barman, Hasan Ali; Kup, Ayhan; Celik, Mehmet; Caliskan, Mustafa
Background: Premature ventricular contractions (PVCs) are common arrhythmias with diverse clinical implications. This retrospective study aimed to evaluate the efficacy of medical treatments using various clinical, imaging, and electrocardiographic parameters in patients with idiopathic PVCs. Methods: A total of 1051 patients with idiopathic PVCs were retrospectively analyzed. Patients were categorized into three groups based on treatment response: beta-blocker (BB) responders (479 patients), calcium-channel blocker (CCB) responders (335 patients), and class 1c antiarrhythmic (AA) responders (237 patients). Clinical, imaging, and electrocardiographic data were collected and analyzed to assess the factors influencing treatment response. Results: Age, left ventricular ejection fraction (LVEF), PVC QRS duration, CI variability, and multiple PVC morphologies were identified as significant factors affecting treatment response. Older age and lower LVEF were associated with better response to BB treatment, whereas CCB responders showed narrower QRS complexes. BB responders also exhibited higher CI variability, possibly linked to automaticity mechanisms. Moreover, the BB responder group had a higher frequency of multiple PVC morphologies. Conclusion: These findings emphasize the importance of tailored treatment approaches based on individual patient characteristics.
Hydroxyl Group Effect in Novel Nnn Type Pyridine Based Ruthenium (Ii) Complex for the Transfer Hydrogenation of Ketones
(Elsevier, 2016) Sahin, Irfan; Emir, Sedat; Ispir, Esin; Karakaya, Idris; Gumus, Selcuk; Ulusoy, Mahmut; Karabuga, Semistan
The new NNN type pyridine ligands were prepared by using low cost and readily available starting materials and metalated with RuCl2(PPh3)(3) to obtain ruthenium(II) complexes. All structures were illuminated by NMR, HRMS, and FT-IR spectroscopy. The complexes exhibited good catalytic activity in transfer hydrogen reaction of ketones and it was found that a hydroxyl group on beta-position of the pyridine ring had a dramatic effect on the catalyst efficiency. (C) 2016 Elsevier B.V. All rights reserved.
Predictive Ability of Inflammatory Markers on In-Hospital Outcomes in Patients Admitted To Coronary Care Unit (morcor-Turk Inflame)
(Sage Publications inc, 2024) Kumet, Omer; Ozgeyik, Mehmet; Topuz, Sahin; Tascanov, Mustafa Begenc; Dindas, Ferhat; Sahin, Irfan; Tanboga, Ibrahim Halil
We investigated the prognostic implications of the systemic immune-inflammatory index (SII), atherogenic index of plasma (AIP), C-reactive protein/albumin ratio (CAR), neutrophil-lymphocyte ratio (NLR), prognostic nutritional index (PNI), and triglyceride/glucose index (TGI) in the MORtality predictors in the CORonary Care Units in TURKey (MORCOR-TURK) population. This is the largest registry of coronary care unit (CCU) patients in Turkey (3157 patients admitted to CCU in 50 different centers). The study population was divided into two according to in-hospital survival status; 137 patients (4.3%) died in-hospital follow-up. A significant correlation was found between death and SII, CAR, NLR, and PNI but not for AIP and TGI in logistic regression. In Model 1 (combining parameters proven to be risk predictors), the -2 log-likelihood ratio was 888.439, Nagelkerke R2 was 0.235, and AUC (area under curve) was 0.814 (95% CI: 0.771-0.858). All other models were constructed by adding each inflammatory marker separately to Model 1. Only Model 3 (CAR + Model 1) had a significantly greater AUC than Model 1 (DeLong P = .01). Our study showed that CAR, but not other inflammatory index, is a significant predictor of in-hospital mortality in CCU patients when added to proven risk predictors.
Prognostic Significance of Cardiac Injury in Covid-19 Patients With and Without Coronary Artery Disease
(Lippincott Williams & Wilkins, 2021) Barman, Hasan Ali; Atici, Adem; Sahin, Irfan; Alici, Gokhan; Aktas Tekin, Esra; Baycan, Omer Faruk; Gungor, Baris
Objective COVID-19 is a disease with high mortality, and risk factors for worse clinical outcome have not been well-defined yet. The aim of this study is to delineate the prognostic importance of presence of concomitant cardiac injury on admission in patients with COVID-19. Methods For this multi-center retrospective study, data of consecutive patients who were treated for COVID-19 between 20 March and 20 April 2020 were collected. Clinical characteristics, laboratory findings and outcomes data were obtained from electronic medical records. In-hospital clinical outcome was compared between patients with and without cardiac injury. Results A total of 607 hospitalized patients with COVID-19 were included in the study; the median age was 62.5 +/- 14.3 years, and 334 (55%) were male. Cardiac injury was detected in 150 (24.7%) of patients included in the study. Mortality rate was higher in patients with cardiac injury (42% vs. 8%; P < 0.01). The frequency of patients who required ICU (72% vs. 19%), who developed acute kidney injury (14% vs. 1%) and acute respiratory distress syndrome (71%vs. 18%) were also higher in patients with cardiac injury. In multivariate analysis, age, coronary artery disease (CAD), elevated CRP levels, and presence of cardiac injury [odds ratio (OR) 10.58, 95% confidence interval (CI) 2.42-46.27; P < 0.001) were found to be independent predictors of mortality. In subgroup analysis, including patients free of history of CAD, presence of cardiac injury on admission also predicted mortality (OR 2.52, 95% CI 1.17-5.45; P = 0.018). Conclusion Cardiac injury on admission is associated with worse clinical outcome and higher mortality risk in COVID-19 patients including patients free of previous CAD diagnosis.