Browsing by Author "Sahin, M."

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Anomaly of Left Main Coronary Artery Arising From the Right Sinus of Valsalva
(Elsevier Ireland Ltd, 2011) Simsek, H.; Sahin, M.; Islek, M.; Paker, S.; Gumrukcuoglu, H. A.
Comparison of Two Patients With Mitral Stenosis and Importance of Sinus Rhythm: Case Report
(2011) Sahin, M.; Simsek, H.; Gumrukcuoglu, H.A.; Akdag, S.; Ekici, B.
We present two woman patients have rheumatic mitral stenosis (MS). They complained of about shortness of breath and palpitation. First patient, she had had two stroke without any sequela (respectively 7 years and 4 years ago). And she has atrial fibrillation (AF) in electrocardiography (ECG). Another woman patient didn't have any complaint before. Latter patient has sinus tachycardia in ECG. Transthoracic echocardiography (TTE) disclosed severe mitral valve stenosis and left atrial dilatation in both patients. But first patient has multiple thrombus in left atrium. Mitral valve surgery was suggested for both patients. In conclusion maintenance of sinus rhythm, in the patients who had MS, is very important for both the protection of left atrial thrombus and the reduction of the development of systemic embolus related to it.
Effects of Illness Activity on Electrocardiographic Parameters in Patients With Multiple Sclerosis
(Elsevier Ireland Ltd, 2011) Gumrukcuoglu, H. A.; Tuncer, M.; Simsek, H.; Sahin, M.; Akdag, S.; Gunes, Y.; Tombul, T.
Maintenance of Sinus Rhythm and Treatment of Atrial Fibrillation in Mitral Stenosis
(2011) Sahin, M.; Simsek, H.; Ekici, B.; Akdag, S.; Tuncer, M.
Rheumatic fever is the most common cause of mitral stenosis. The most common complication of mitral stenosis is atrial fibrillation (AF). AF precipitates symptoms, greatly increases the risk of systemic embolisation, and reduces cardiac output and exercise capacity. Systemic embolization most often occurs in patients with both AF and mitral stenosis. Maintenance of the sinus rhythm in patients with mitral stenosis is very important because of reduce the risk of cerebral embolism, conservation of cardiac output and exercise capacity, and reduction of symptoms.
Molecular Epidemiology of the Bacillus Anthracis Isolates Collected Throughout Turkey From 1983 To 2011
(Springer, 2012) Durmaz, R.; Doganay, M.; Sahin, M.; Percin, D.; Karahocagil, M. K.; Kayabas, U.; Ertek, M.
The main perspective of this study was to determine cross-transmissions amongst anthrax cases and provide detailed information regarding the genotypes of Bacillus anthracis isolates circulating in Turkey. A total of 251 B. anthracis isolates were obtained from human (93 isolates), animal (155 isolates), and environmental (three isolates) samples in various provinces of Turkey. All isolates were susceptible to quinolones, vancomycin, tigecycline, and linezolid, but not to ceftriaxone. Excluding human isolates, one of the animal isolates was found to be resistant to penicillin, erythromycin, and doxycycline. Multiple-locus variable-number tandem repeats analysis including 8 loci (MLVA8) revealed 12 genotypes, in which genotype 43 was observed at the highest frequency (41.8 %), followed by genotype 35 (25.5 %) and genotype 27 (10.4 %). Major subtype A3.a was the predominant cluster, including 86.8 % of the isolates. The MLVA25 analysis for the 251 isolates yielded 62 different genotypes, 33 of which had only one isolate, while the remaining 29 genotypes had 2 to 43 isolates, with a total of 218 isolates (86.9 %). These findings indicate very high cross-transmission rates within anthrax cases in Turkey. The genotypes diagnosed in Turkey are populated in the A major cluster. Penicillin prescribed as the first-choice antibiotic for the treatment of anthrax is still effective.
A New Echocardiographic Parameter of Arterial Stiffness in End-Stage Renal Disease
(Urban & Vogel, 2014) Sahin, M.; Simsek, H.; Akyol, A.; Akdag, S.; Yaman, M.; Aydin, C.; Gumrukcuoglu, H. A.
Background. Cardiovascular disease is the leading cause of death among patients with end-stage renal disease (ESRD). Arterial stiffness is an independent predictive parameter of overall and cardiovascular mortality in these patients. However, the defined procedures for the measurement of arterial stiffness are time consuming and not practical in daily practice. Methods. The study population included 50 patients with ESRD who were treated with hemodialysis (HD; n=23) or peritoneal dialysis (PD; n=27) and 70 age-and sex-matched control subjects. Aortofemoral pulse wave velocity (PWV), carotid intima-media thickness (CIMT), and color M-mode propagation velocity of the descending aorta (aortic propagation velocity, APV) were measured. Results. Compared to the control group, the patients with ESRD had significantly lower APV (46.4 +/- 12.4 vs. 58.5 +/- 8.5, p<0.01) and higher PWV (10.5 +/- 2.5 vs. 9.2 +/- 1.2, p<0.01) and CIMT (0.66 +/- 0.15 vs. 0.43 +/- 0.06, p<0.01) measurements. There were significant correlations between APV and CIMT (r=-0.769, p<0.001), APV and PWV (r=-0.682, p<0.001), and PWV and CIMT (r=0.564, p<0.001). There were no significant differences in APV and PWV between the PD and HD patients. Conclusion. Arterial stiffness is an important indicator of atherosclerosis and arterial aging in patients with ESRD. The measurement of APV is an easy and practical new echocardiographic method and may be used to identify arterial stiffness in these patients.
A Novel Echocardiographic Method as an Indicator of Endothelial Dysfunction in Patients With Coronary Slow Flow
(verduci Publisher, 2013) Simsek, H.; Sahin, M.; Gunes, Y.; Akdag, S.; Akil, M. A.; Akyol, A.; Yaman, M.
BACKGROUND: To improve clinical outcomes, noninvasive imaging modalities have been proposed to measure and monitor atherosclerosis. Endothelial dysfunction is considered the first stage in the development of atherosclerosis. Brachial artery flow-mediated dilatation (FMD) has been impaired in patients with coronary slow flow (CSF). Recently, color M-mode derived propagation velocity of descending thoracic aorta (aortic propagation velocity-AVP) was shown to be an ultrasonographic marker for atherosclerosis. AIM: To assess endothelial function in patients with CSF and the correlation of AVP with FMD. MATERIALS AND METHODS: FMD and AVP were measured in 90 patients with CSF and 39 patients having normal coronary arteries (NCA) detected by coronary angiography. RESULTS: Compared to patients with normal coronary arteries patients having CSF had significantly lower AVP (39.1 +/- 8.4 vs. 53.7 +/- 12.7 cm/s, p < 0.001) and FMD (5.6 +/- 3.2 vs. 17.6 +/- 4.4 %, p < 0.001) measurements. There were significant correlations between AVP and FMD (r = 0.524, p < 0.001). CONCLUSIONS: Transthoracic echocardio-graphic determination of color M-mode propagation velocity of descending aorta is a simple practical method and correlates well with coronary slow flow and brachial endothelial function.
Online Learners’ Navigational Patterns Based on Data Mining in Terms of Learning Achievement
(Springer International Publishing, 2019) Keskin, S.; Sahin, M.; Yurdugül, H.
The aim of this study is to explore navigational patterns of university students in a learning management system (LMS). After a close review of the literature, a scarcity of research on the relation between online learners’ navigational patterns and their learning performance was found. To contribute to this research area, the study aims to examine whether there is a potential difference in navigational patterns of the learners in terms of their academic achievement (pass, fail). The data for the study comes from 65 university students enrolled in online Computer Network and Communication. Navigational log records derived from the database were converted into sequential database format. According to students’ achievement (pass, failure) at the end of the academic term, these data were divided into two tables. Page connections of the users were transformed into interaction themes, namely homepage, content, discussion, messaging, profile, assessment, feedback, and ask the instructor. Data transformed into sequential patterns by the researchers were organized in navigational pattern graphics by taking frequency and ratio into consideration. The z test was used to test the significance of the difference between the ratios calculated by the researchers. The findings of the research revealed that although learners differ in terms of their achievement, they draw upon similar processes in the online learning environments. Nevertheless, it was observed that students differ from each other when considering their system interaction durations. According to this, learning agents, interventional feedbacks, and leaderboards can be used to keep failed students in the online learning environment. Studies were also proposed on the ordering of these LMS navigational themes, which are important in the e-learning process. Findings from these studies can guide designers and researchers in the design of adaptive e-learning environments, which are also called next-generation digital learning environments. © Springer Nature Switzerland AG 2019.
Online Learners' Navigational Patterns Based on Data Mining in Terms of Learning Achievement
(International Conference on Cognition and Exploratory Learning in Digital Age, 2016) Keskin, S.; Sahin, M.; Ozgur, A.; Yurdugul, H.
The aim of this study is to determine navigational patterns of university students in a learning management system (LMS). It also investigates whether online learners' navigational behaviors differ in terms of their academic achievement (pass, fail). The data for the study comes from 65 third grade students enrolled in online Computer Network and Communication lesson in a state university. As the online learning environment, Moodle, an open source software, is used in this study. Navigational log records derived from database were converted into sequential database format. According to students' achievement (pass, failure) at the end of the academic term, these data were divided in two tables. Page connections of the users were transformed into interaction themes namely, homepage, content, discussion, messaging, profile, assessment, feedback and ask the instructor. Data transformed to sequential patterns by the researchers were organized in navigational pattern graphics by taking frequency and ratio into consideration. To test the difference between obtained patterns ratio test was conducted by means of z statistics. The findings of the research revealed that first and second order navigational patterns of passed and failed students in the online learning environment had similar features, but passed students allocated more time to interaction process.
Papillary Muscle Rupture Due To Myocardial Infarction in a Patient Presenting With Clinical Features of Acute Pulmonary Oedema
(Elsevier Ireland Ltd, 2011) Simsek, H.; Sahin, M.; Gumrukcuglu, H. A.; Caglayan, C. E.; Akdag, S.; Dogan, A.
Percutaneous Transluminal Angioplasty in Haemodialysis Patients With Central or Peripheral Venous Stenosis
(Ondokuz Mayis Universitesi, 2016) Yaman, M.; Sahin, M.; Simsek, H.; Gumrukcuoglu, H.A.; Tuncer, M.; Gunes, Y.; Akdag, S.
Dysfunction of arteriovenous fistulae (AVF), which result from peripheral or central venous occlusive illness, occurs very often in haemodialysis patients. In therapy, endovascular open procedures are prefered. Our study illustrated the clinical success of percutaneous transluminal angioplasty (PTA) for the treatment of these patient. A retrospective analysis was applied on patients presenting during a 2-years term with haemodialysis failure and ipsilateral arm swelling coherant with peripheral and/or central venous stenosis. PTA was performed as clinically and angiografically indicated. Technical success of PTA was defined less than 30% residual stenosis and clinical success was illustrated by resolution of pain and edema along with preservation of the AVF. Our study shows a subgroup of 26 patients that presented with symptomatic peripheral or central venous occlusive disease. Mean follow-up was 12.4 months (range, 3-24 months). PTA was successful in 26 patients 11 of whom were with central lesions and 15 of whom were with peripheral lesions. We were stated for central lesions PTA had a priority patency rates of 81.8%, 60%, 37.5% and supported primary patency rates of 90.9%, 70%, 62.5% at 3, 6, 12 months. For peripheral lesions, primary patency rates of 86.7%, 78.5%, 66.6% at 3, 6 and 12 months and assisted primary patency rates of 93.3%, 85.7% and 75%, separately. PTA for central and peripheral venous stenosis is be a successful and safe procedure in hemodialysis patients. In patients with lesions that are responsible for dilation, continuous functional access in the affected extremity is sustained, especially for patients with peripheral venous stenosis. © 2016 OMU.
A Rare Cause of Myocardial Infarction: Blunt Chest Trauma
(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Kul, Ş.; Akyol, A.; Aşker, M.; Sahin, M.; Kucukdagli, O.T.; Uyarel, H.
Blunt chest trauma is a rare cause of myocardial infarction. If the diagnosis is delayed, serious complications may occur. To prevent them, electrocardiography should be performed to all patients with chest pain after blunt chest trauma. In the event of myocardial infarction, coronary angiography should be performed as soon as possible and appropriate management interpreted according to clinical situation. © 2015, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Recurrence of Primary Cardiac Rhabdomyosarcoma Without Methastasis Two Years After Surgery
(TIP ARASTIRMALARI DERNEGI, 2012) Simsek, H.; Sahin, M.; Gumrukcuoglu, H.A.; Tuncer, M.; Gunes, Y.
Primary malignant cardiac tumors are rare. Rhabdomyosarcoma is the most common of these lesions. These tumors usually arise from the ventricular walls. They sometimes arise from the atrial walls and mimic atrioventricular valve stenosis. A case of recurrence of primary cardiac rhabdomyosarcoma without metastasis to other organs in a 34 year old woman is presented. The tumor arose from the posterior wall of the left atrium and extended to the posterior mitral valve leaflet. Histopathology confirmed recurrence of the cardiac rhabdomyosarcoma. Although cardiac rhabdomyosarcomas are highly lethal, operation indicated. Clarify diagnosis, relieve symptoms and improve survive intracardiac mass must be excision as as extensively as possible in these cases in order to prevent recurrence of tumor.
Regional Functions of the Left Ventricle in Patients With Coronary Slow Flow and the Effects of Nebivolol
(2009) Gunes, Y.; Tuncer, M.; Guntekin, U.; Ceylan, Y.; Sahin, M.; Simsek, H.
Background: Microvascular and endothelial dysfunction have been implicated for coronary slow flow (CSF). Nebivolol, besides its beta-receptor blocking activity, causes an endothelium-dependent vasodilatation through increased nitric oxide release. Methods: This study included 27 patients with CSF and 27 subjects with normal coronary arteries. Segmental functions of the left ventricle (LV) were assessed using myocardial tissue Doppler velocities before and 3 months after treatment with nebivolol 5 mg/day. Results: Compared with the control group, mitral deceleration time (DT) was significantly longer, and E/A ratio, systolic velocity of lateral mitral annulus (Sm) and regional myocardial peak systolic and early diastolic velocities (Vs, Vd) were significantly lower in patients with CSF. The reason for coronary angiography was typical angina in 21 (77.8%) and positive treadmill test in six (22.2%) CSF patients. There were significant correlations between presence of CSF in left anterior descending artery (LAD) with Sm (r =-0.404, p =0.002) and Vs in anterior (r =-0.531, p < 0.001 ) and lateral (r =-0.495, p < 0.001 ) segments and between presence of CSF in RCA and Vs in posterior segments (r =-0.501, p < 0.001). Treatment with nebivolol significantly decreased blood pressures (128.5±12.5/82.5±8.8 to 119.8± 12.6/76.4± 7.4 mmHg, p < 0.001), DT (252.3±53.6 to 222.0±41.0 ms, p < 0.001 ) and IVRT (115.7±19.9 to 103.3±17.0 ms, p <0.001), and increased exercise capacity (8.7±1.3 to 10.4±0.9 METs, p < 0.001), E/A ratio (0.87±0.26 to 1.08±0.23, p <0.001) and myocardial velocities (p < 0.001). All the patients were free of angina after treatment. Patients with CSF had impaired diastolic and regional LV functions. Conclusions: Nebivolol may therefore be useful in improving angina, exercise capacity and LV functions in patients with CSF. © 2009, SAGE Publications. All rights reserved.
Resolution of Atrial Thrombus With Adjusted Dose Warfarin Therapy in Patient With Nonvalvular Atrial Fibrillation
(Elsevier Ireland Ltd, 2011) Simsek, H.; Dogan, A.; Sahin, M.; Gumrukcuoglu, H. A.; Akdag, S.
Retrospective Analysis of Cardiac Manifestations of Our Patients With Marfan Syndrome
(2011) Simsek, H.; Sahin, M.; Gumrukcuoglu, H.A.
Marfan syndrome (MS) is an autosomal dominant connective tissue disorder affecting mainly cardiovascular system, eyes and skeleton. However, the most serious complication in patients with MS is progressive aortic root dilatation, aortic dissection or regurgitation. We have reviewed all patients with MS in our hospital over a six year period to determine the symptoms, clinical aspects, treatment modalities and long term follow-up. The medical records of all patients with MS in Yuzuncu Yil University Department of Cardiology from January 2004 to May 2010 were reviewed. MS was defined by Ghent criteria. Individuals without a family history of MS require major criteria in at least two different organ systems and involvement of a third organ. Individuals carrying an FBN1 mutation known to cause MS or cases with a positive family history require one major criterion and involvement of an additional organ to diagnosis of MS. Eleven patients have diagnosis of MS according to Ghent criteria. Patients with mean age of 37.5 years. In our patient group wasn't a presence woman. Main complaint of patients was dispnea. Primary findings in physical examination were apical systolo-diastolic murmur, mediastinal enlargement at chest X-ray. Aortic root dilatation, aortic regurgitation was seen echocardiographically. Mean follow-up time was 3.8 years. During follow-up six patients died. Main cause of die was aortic complication. Early detection and close monitoring of the MS are very important for prevent complications. MS patients should be followed closely especially in terms of cardiovascular complications.
Severe Mitral and Aorta Insufficiency in Patient With Acute Rheumatismal Fever
(Elsevier Ireland Ltd, 2011) Akdag, S.; Sahin, M.; Simsek, H.; Gumrukcuoglu, H. A.; Tuncer, M.
Treatment of Gigantic Left Ventricular Thrombus: Case Report
(Elsevier Ireland Ltd, 2011) Sahin, M.; Simsek, H.; Gumrukcuoglu, H. A.; Akdag, S.; Ekici, B.
Vascular Endothelial Function in Patients With Coronary Slow Flow and the Effects of Nebivolol
(Elsevier Ireland Ltd, 2011) Gunes, Y.; Gumrukcuoglu, H. A.; Akdag, S.; Simsek, H.; Sahin, M.; Tuncer, M.