Browsing by Author "Sancak, T."

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Comparative Effects of Intra-Articular Administration of Vitamin C, Vitamin D, and Hyaluronic Acid in an Experimental Osteoarthritis Model in Rats
(Arquivo Brasileiro Medicina veterinaria Zootecnia, 2025) Sancak, T.; Yildiz, F.; Gurbuz, H. O.; Ozmen, V.; Ari, H. H.; Alkan, I.
Osteoarthritis (OA) is a chronic disease characterized by inflammation or cartilage deterioration in joints, leading to debilitating, movement-associated pain and degenerative changes in joint cartilage, bone, and other surrounding tissues, caused by factors such as joint injury, aging, obesity, and heredity. Various agents are used in OA treatment. In this study, hyaluronic acid, vitamin C and vitamin D were used in different combinations. A total of 32 rats were used in the study. After osteoarthritis was experimentally induced in the rats under general anesthesia, they were randomly divided into eight groups. Then, the preparations were administered intra-articularly as a single dose according to the groups. The study was terminated after 21 days. The tissues collected post-study were examined histopathologically. According to the histopathological findings of the study, the preparations provided mild cartilage tissue regeneration when applied individually, moderate regeneration when used in pairs, and significant regeneration and new bone trabecula formation when used in a triple combination.
Effect of Castration and Vasectomy on Some Oxidative Stress Parameters and Blood Hormone Levels in Rats
(Arquivo Brasileiro Medicina veterinaria Zootecnia, 2023) Sancak, T.; Kosal, V.; Okulmus, C.
Vasectomy and castration are the most preferred surgical methods to control reproduction in males. While sexual functions are terminated reversibly in vasectomy, they are removed irreversibly in castration. After these processes, changes are observed in hormones and oxidative stress parameters. In this study, we investigated the effects of vasectomy and castration operations on blood follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone, nitric oxide (NO) and malondialdehyde (MDA) levels in rats. As a result of the analysis, it was determined that FSH, LH, NO, and MDA levels increased (p<0.05) and testosterone levels decreased (p<0.05) in the castration group compared to the sham and vasectomy groups. Considering the data obtained from the present study, when the two operations (vasectomy and castration) are compared in rats, which are preferred for the control of reproduction, it is thought that vasectomy is a healthier method because it is reversible, does not affect hormone levels, and does not increase oxidative stress.