Browsing by Author "Sarikaya, Mucahit"

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Antioxidant Effect of Chromium Picolinate on Chronic Exercise-Induced Oxidative Stress in Male Rats
(Nature Portfolio, 2025) Cibuk, Salih; Sarikaya, Mucahit; Ulema, Mustafa Sencer; Pancar, Zarife; Oge, Beyza; Embiyaoglu, Nuri Mert; Batrakoulis, Alexios
Chromium picolinate influences antioxidant mechanisms, potentially affecting oxidative stress levels during prolonged aerobic exercise. This study investigates the effects of chromium supplementation on Catalase (CAT) activity and Malondialdehyde (MDA), advanced oxidation protein products (AOPP), and reduced glutathione (GSH) levels in chronic aerobic exercise in male rats. Twenty-eight male Wistar albino rats were divided into 4 groups containing 7 mice each (control, exercise, chromium, and chromium + exercise). Supplemented rats received chromium picolinate (8 mu g/kg/day) daily for eight weeks. Exercise was performed on a rat treadmill at an average speed of 15 cm/s for 20 min, five days a week for eight weeks. At the end of the 8th week of the experimental period, blood samples were taken. CAT, MDA, AOPP, and GSH analyses were performed. It was observed that the chromium + exercise group induced a significant reduction in CAT activity compared to the other three groups (- 8.6 to - 12%, p < 0.05). MDA values meaningfully increased (18.2-25.7%, p < 0.001) in all groups, except the controls after the 8-week intervention. All groups demonstrated an increase in AOPP (8.1-12.3%, p < 0.001), but not the controls. In GSH, all experimental groups showed a significant elevation (30.3-45.8%, p < 0.001) compared to the control group (p < 0.001) following an 8-week intervention period. The present findings indicate that supplementation with chromium picolinate, whether administered alone or in conjunction with aerobic exercise, led to modulations in oxidative stress and redox status indices in male rats following an 8-week aerobic exercise regimen. The observed reduction in CAT activity may suggest a lowered oxidative challenge; however, this finding should be interpreted with caution, as decreased antioxidant enzyme activity can also reflect a potential limitation in defense capacity.
Determination of the Role of Aerobic and Anaerobic Training at Different Altitude on Hypoxia-Induced Factor 1, Hemoglobin, Iron, Erythropoietin, Hepcidin, and Nitric Oxide
(Oxford University Press, 2025) Onturk, Ugur; Cinar, Vedat; Sarikaya, Mucahit; Alp, Hamit Hakan; Akbulut, Taner; Chaverri, Diego; Migliaccio, Gian Mario
Introduction or background Altitude training is a well-established strategy for improving athletic performance, particularly in endurance sports. Hypoxic exposure induces physiological adaptations through oxygen sensing and erythropoietic mechanisms. However, the comparative effects of aerobic and anaerobic training on hematological and biochemical markers under different altitude conditions have not yet been adequately investigated.Sources of data This prospective cohort study included 24 trained male athletes (aged 19-23) who were randomly assigned to aerobic or anaerobic training groups (n = 12 per group). Training was conducted at simulated altitudes of 0 m, 1700 m, 2450 m, and 3200 m for 8 weeks. Biomarkers such as hypoxia-induced factor 1-alpha (HIF-1 alpha), hemoglobin, erythropoietin (EPO), iron, hepcidin, and nitric oxide (NO) were measured using ELISA and standard biochemical methods.Areas of agreement Consistent with previous literature, both aerobic and anaerobic training resulted in altitude-induced increases in hemoglobin levels. Aerobic training was associated with earlier activation of hypoxia-related markers such as HIF-1 alpha and NO, supporting the role of moderate altitude exposure in stimulating adaptive molecular responses.Areas of controversy While EPO is generally expected to increase with altitude exposure, this study found a decrease in EPO levels across altitudes in the aerobic group, while a significant increase was observed only at 3200 m in the anaerobic group. Interpretation of hepcidin dynamics also differs between training modalities, highlighting the complexity of iron regulation under hypoxic stress.Growing points This study highlights the different timing and magnitude of biomarker responses to aerobic and anaerobic training at various altitudes. It suggests that aerobic exercise triggers earlier molecular responses, while anaerobic training elicits delayed or blunted adaptations.Areas timely for developing research Further research is needed to optimize altitude training protocols tailored to specific exercise modalities and targeted physiological adaptations. Future studies could examine gender differences, longer training durations, and additional markers of oxidative stress and inflammation to expand on these findings.
The Effect of 6-Week Zinc Supplement and Weight Training on the Blood Lipids of the Sedentaries and Athletes
(C M B Assoc, 2018) Cinar, Vedat; Akbulut, Taner; Kilic, Yakup; Ozdal, Mustafa; Sarikaya, Mucahit
In this study, we aimed to investigate the effect of 6 weeks of zinc supplementation and weight training on blood lipids of sedentary and athletes. Research group consists of total 40 males; 20 athletes who do regularly physical exercises and 20 sedentary volunteers. The volunteers were divided into four groups. These groups were constituted in that way: the first group is a natural sedentary group which called control group as well (S); the second group is another sedentary group which is supplied with only zinc (Z+S); the third group is training group which composing of athletes and is supplied with zinc (Z+T); the fourth group is the natural training group or athletes (T). From the beginning of the study to the end of 6-weeks of training, the participants gave blood samples before and after every application order to measure the total cholesterol, LDL cholesterol and HDL cholesterol and the levels of Triglyceride. This study identifies that the values of the total cholesterol, LDL cholesterol and Triglyceride of the groups which were supplied with zinc supplement decreased, whereas the levels of HDL cholesterol increased in these groups. Consequently, this work demonstrates that the 6-weeks zinc supplement and training can make a significant contribution to the performance by changing positively the levels of blood lipid.
Effect of Calisthenics Exercise Program on Some Liver Enzyme Values and Blood Lipids
(Edusoft Publishing, 2020) Turgut, Mine; Sarikaya, Mucahit
The purpose of this study is to research the effect of the eight week calisthenics exercise, applied to sedentary males, on some liver enzymes. 20 volunteer males, the age average of whom is 29,40 +/- 3, 47 years and height average of whom is 177,45 +/- 4, 89 cm, participated in the research. The body weight, fat percentage and, fasting blood sample were taken by the expert persons in the suitable laboratory, environment in the healthcare institutions, determined, before and after the application of the exercise program. SPSS 22. 0 package program was used for analyzing the data obtained and independent groups test (Wihoxon Test) was applied for comparing the descriptive statistics and the values before and after the exercise. As a result of the findings we obtained, it was found out that there is a significant difference between the blood lipids, triglyceride, HDL, LDL, and total cholesterol levels before and after the calisthenics exercise program applied (p > 0. 05). Similarly, it was determined that there is also a significant change between the pre-test-post-test liver enzyme values (AST, ALT) (p > 0.05). In conclusion, it is understood that the calisthenics exercise program, we applied, provides a significant and efficient change on sedentary males physiologically, from the results of the study. Starting from these findings, not needing roper level materials fir applying the calisthenics exercises suggests that it is efficient to guide the sedentary males to exercise. At the same time, this exercise program being easily applicable home is important because it is thought that obtaining a healthy body mass index can also protect from cardiovascular diseases, caused by sedentary life style and the risk factors causing these diseases.
The Effect of Long-Term Exercise Training With Omega-3 Fatty Acid Supplement on Serum Iris and Some Blood Parameters
(Discovery Publication, 2022) Aslan, Mehdi; Sarikaya, Mucahit
This research; the effects of omega-3 fatty acids and exercise on irisin, leptin and ghrelin hormone total cholesterol, HDL, LDL and triglyceride levels when applied separately or in combination were investigated. Method; A total of 28 male Wistar albino rats, 8 weeks old, were randomly divided into 4 groups of seven each as control, exercise, omega (400 mg/kg) and exercise + omega-3. After starting the omega-3 fatty acid diet, rats were subjected to a 20-minute jog test 5 days a week for 10 weeks. Results; It was determined that exercise and omega-3 supplementation decreased the total cholesterol level in the groups in which they were applied separately, and increased the total cholesterol level when they were applied together. When we examined the triglyceride levels, it was determined that while there was an increase in the exercise group, there was a decrease in the omega group, and when the exercise and omega-3 supplementation were combined, it decreased similarly to the omega group. In addition, when we examined HDL and LDL cholesterol levels, it was found that exercise and omega-3 fatty acids increased HDL levels separately and in combination, LDL levels decreased in omega-3 and exercise groups, but there was no change in cholesterol levels. Conclusion; positive effects of exercise on lipid profile and iris, moderate positive correlation between irisin and leptin; It can be said that irisin and ghrelin show a highly positive relationship and omega-3 fatty acids have positive effects on the lipid profile.
Effects of Long-Term Exercises on Element Metabolism and Markers of Muscle Damage in Athletes
(int Journal Applied Exercise Physiology, 2020) Erdogan, Ramazan; Sarikaya, Mucahit
Regular and long-term exercises create changes in the physical and physiological characteristics of athletes. As a result of the exercises, it forms important changes especially in the muscle and element metabolism of the athletes and affects the performance of the athletes. In this context, it is determined to detect the changes of the long-term exercises in the muscle damage and element metabolism of the athletes. The study consists of 16 male volunteer athletes in the field of athletics. In the research, an exercise program for competitions was applied to the athletes for 3 times a week during 12 weeks. Blood samples were taken from the athletes at rest, before the exercises were started and at the end of the exercises. In the samples taken from athletes, muscle damage markers and element metabolism levels were determined. The data obtained from the research were analyzed by using SPSS 22 package program. Significance was accepted as p<0,05.When the data obtained from the research were analyzed; in the element metabolism of the athletes participating in the research, statistically differences were observed in sodium, calcium, potassium, chlorine, phosphorus, magnesium, glucose and creatinine levels (p<0,05), however there was no statistically significant difference in urea level (p> 0,05). When the muscle damage values of the athletes were examined; a statistically significant difference was found in the pretest-posttest values of CK and CK-MB values (p<0,05). As a result; the changes that occur by performing long-term and regular exercise programs in muscle damage markers and element metabolism of athletes were determined. We believe that considering the changes that occur in athlete's metabolism, the exercise programs to be applied will positively affect the performance of athletes.
El Kavrama Kuvveti Basketbolda Şut İsabetini Etkiler Mi
(2019) Seyhan, Sinan; Igdir, Emre Can; Temur, Hacı Bayram; Sarikaya, Mucahit; Gencer, Yıldırım Gökhan
Bu araştırmada, Van ili erkek lisanslı basketbolcuların şut vedestek eli kavrama kuvveti ile şut isabeti arasındaki ilişkinin incelenmesiamaçlanmıştır. Araştırmaya gönüllü olarak Van ilinde lisanslı olarakbasketbol oynayan ve şut atış elleri sağ olan, 13-17 yaş arasında 40 erkekbasketbolcu katılmıştır. Çalışmaya katılan basketbolculara şut ve elkavrama kuvveti testleri yapılmış ve şut eli ve destek eli kavramakuvvetinin şut isabet oranına etkisi incelenmiştir. Elde edilen verilerinnormal dağılım sağladıkları tespit edildikten sonra gruplar arasındakiilişkiyi belirlemek için Pearson Korelasyon Testi uygulanmıştır. Eldeedilen verilere göre; basketbolcuların yaş ortalamaları 15,15±1,44, boyortalamaları 174,08±9,88 cm, kilo ortalamaları 63,07±11,90 kg olarakbulunmuştur. Basketbolculara uygulanan serbest atış şut testininortalamaları ise 16,97±5,04 olarak ölçülmüştür. Çalışmaya katılanbasketbolcuların şut eli kavrama kuvveti ile serbest atış isabet oranıarasında anlamlı bir ilişki bulunmuştur (p<0,05). Ancak destek elikavrama kuvveti ile serbest atış şut testi arasında anlamlı bir ilişkibulunamamıştır (p>0,05). Sonuç olarak araştırmaya katılanbasketbolcuların şut atışı için topu dengede tutan destek (nondominant)ellerine ait kavrama kuvvetinin şut isabetine anlamlı bir etki etmemesi(p>0,05), basketbolcuların şut ellerinin dominant el olması ve kuvvetdeğerlerinin nondominant el aleyhine anlamlı derecede farklı olması, basketbolda yalnızca şut eli el kavrama kuvvetinin şut isabetinidolayısıyla müsabakalarda başarıyı etkileyebileceğini göstermektedir.