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Browsing by Author "Sati, L."

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    Nk Cells in Prostate Cancer
    (Elsevier, 2021) Acikgoz, E.; Sati, L.; Soner, B.C.; Oktem, G.
    Advanced modalities in the treatment of prostate cancer, an important health problem among men, draw attention to the field of cancer immunotherapy. Although the immune system holds promise for prostate cancer treatment, the biological processes associated with prostate cancer cells and immune cells have not yet been fully elucidated. The prostate cancer microenvironment is a complex system containing a large number of immune cells. Among multiple immune cells, natural killer (NK) cells have enormous potential in targeting various cancer cells. NK cells, which are an important part of the innate immune system, play a very important role as a first-line defense against prostate cancer cells. Various strategies have been adopted by researchers to increase the efficiency of NK cells. However, there are many difficulties to increase the therapeutic relevance of NK cells. This review will provide a perspective on the phenotypic and functional properties of NK cells, molecular links between NK cells and prostate cancer cells, and the therapeutic and prognostic significances of NK cells in both advanced hormone naïve prostate cancer and castration-resistant prostate cancer. © 2021 Elsevier Inc. All rights reserved.
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    Yy1 Involvement in Embryonic Development and Cancer
    (Elsevier, 2020) Acikgoz, E.; Sati, L.; Oktem, G.
    Despite numerous advances in the field of cancer cell biology, the origin of cancer cells and the systemic disruptions in the cancer process of normal cells have not yet been fully identified. However, we certainly know that cancer cells carry genetic and molecular similarities of the early embryonic development indicating an interesting relationship between “birth” and “death.” During the embryonic development process, the software of system codes to determine cell fate has been designed. Then, cells containing embryonic residues can be directed as a normal cell, cancer cell, or a stem cell. The transcription factor Yin Yang 1 (YY1) has been reported to play critical roles in many biological processes, such as the embryonic development, cell fate specification, regulation of pluripotency, and oncogenesis. In view of these activities, YY1 has been implicated in both the embryonic development and oncogenesis by acting as a bridge linking these two important biological processes. Therefore, in this review, we primarily focus on YY1 investigations linking the embryonic development, oncogenesis, and stem cell biology. © 2021 Elsevier Inc. All rights reserved.