Browsing by Author "Savucu, Yuksel"

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Changes in Nitric Oxide Levels and Erythrocyte Arginase Activities in Patient With Down Syndrome
(Academic Journals, 2012) Ozbey, Ulku; Seyran, Ayse; Erisir, Mine; Benzer, Fulya; Savucu, Yuksel
Down syndrome is a chromosome abnormality with specific clinical symptoms and mental retardation caused by trisomy of chromosome 21. There is evidence that oxygen free radicals play an important role in the pathophysiology of many neuropsychiatric disorders. Although, it has not been investigated yet, several recent studies proposed that nitric oxide related to oxidative stress and arginase may have a pathophysiological role in mental retardation. The purpose of this study was to determine plasma nitric oxide levels and erythrocyte arginase activities in patients with Down syndrome and in healthy children. Plasma nitric oxide levels and erythrocyte arginase activity were measured in 20 patients with Down syndrome (median age: 15.6 +/- 7.5) and 20 age-matched healthy subjects (median age: 16.2 +/- 7.4). Significant differences were found between erythrocyte arginase activity of the patients with Down syndrome (35.2 +/- 2.7 U/g hemoglobin (Hb)) and those of healthy children (43.5 +/- 2.9 U/g Hb), (P < 0.05). But we have not found any statistical difference between persons with Down syndrome and control group for nitric oxide (P > 0.05). It was concluded that the level of erythrocyte arginase activity could be considered as a useful marker for assessing the level of mental retardation in children with Down syndrome.
Oxidative Stress and Altered Levels of Antioxidants in Adolescents With Down Syndrome During Pre-Exercise and Post-Exercise
(Academic Journals, 2012) Ozbey, Ulku; Arslan, Cengiz; Savucu, Yuksel; Erisir, Mine; Seyran, Ayse
The aim of this study was to determine the influence of exercise on activity of erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and plasma malondialdehyde (MDA), beta-carotene, retinol levels in adolescents with Down syndrome (DS). Twenty adolescents with DS (14.86 +/- 7.07 years) performed a 12-week training program. Body composition was measured by bioelectric impedance method. SOD, GPx, CAT, MDA, retinol, beta-carotene levels was determined spectrophotometrically. When compared to baseline, MDA level was increased (P<0.05). SOD, GPx activities and beta-carotene level were decreased (P<0.05). There was no difference during pre-post exercise in terms of CAT activity and retinol level (P>0.05). The mean value of percentage of fat mass was reduced. Regular exercise decreased SOD, GPx activities and beta-carotene level and did not affect CAT activity and retinol level in individuals with DS. Exercise increases oxidative stress depending on level of training.