Browsing by Author "Sayarlioglu, Mehmet"

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Comparison of Argon Laser Photocoagulation-Induced Cutaneous Inflammation and Skin Pathergy Test in Behcet's Disease
(Springer, 2010) Sayarlioglu, Mehmet; Calka, Omer; Cinal, Adnan; Sayarlioglu, Hayriye; Akdeniz, Necmeddin; Topcu, Nazan; Gul, Ahmet
Nonspecific increased inflammatory response is an important feature of Behcet's disease (BD). The skin pathergy reaction (SPR) which tests this hyperreactivity in the skin is frequently used as a diagnostic tool. This study aims to investigate the argon laser photocoagulation (ALP)-induced cutaneous inflammation in BD patients and controls and also to compare the results with the skin pathergy test (SPT). The study group consisted of 35 patients with BD and 28 healthy volunteers. The ALP was applied to the left forearms of all cases from 20-cm distance (2,000 mW, 100 A mu m) with exposure times ranging from 0.2 to 0.7 s with 0.1-s increments. Also, a SPT with three prics was performed to both forearms of all cases. The ALP-induced cutaneous inflammation and SPT were evaluated and scored with the same method at 48 h, and the SPR scores of 2+ and above was accepted as positive. Positive results as defined above were found in eight cases (23%) with the ALP and in nine (26%) with the SPT in patients with BD. There was no clear correlation between the ALP and SPT results and also between the exposure time to laser beam and SPR scores. The preliminary results of this study reveal that ALP can induce a skin hyperreactivity similar to the needle prick-induced SPR in patients with BD. We, herein, showed that ALP can induce skin inflammation with its thermal effect and without any inoculation of antigen in BD. This method would help to develop another experimental method to investigate the cutaneous inflammation in BD.
Effects of Low Sodium Dialysate in Chronic Hemodialysis Patients: an Echocardiographic Study
(Taylor & Francis Ltd, 2007) Sayarlioglu, Hayriye; Erkoc, Reha; Tuncer, Mustafa; Soyoral, Yasemin; Esen, Ramazan; Gumrukcuoglu, Hasan Ali; Sayarlioglu, Mehmet
Background. Chronic kidney disease (CKD) and hemodialysis (HD) patients who cannot restrict sodium consumption in their diets sometimes develop significant saline excess and hypertension between dialyses. This study assessed the effect of relatively low sodium dialysate dialysis on changes of echocardiography in hemodialysis patients. Methods and Results. Eighteen patients with end stage renal failure on chronic HD were studied (8 females, 10 males) with a mean age 48.3 +/- 14.6 (24-70) years. The mean time on HD was 30.8 +/- 14.0 (12-60) months. Patients with hematocrit levels under 24% were excluded from the study. In all patients, echocardiography was performed thrice weekly before and after eight-week HD treatment with low sodium dialysate hemodialysis by the same operator (135 mEq/L for patients with sodium levels less than 137, 137 for patients with sodium levels over 137). Left atrium (LA) and left ventricle (LV) volumes and ejection fractions were measured, specifically: LV systolic diameter (LVSD), LV diastolic diameter (LVDD), interventricular septum (IVS), tricuspid regurgitation (TR), mitral regurgitation (MR), pulmonary artery pressure (PAP), and inferior vein cava diameter (IVCD). Results. In terms of echocardiographic parameters, LVSD, TR, PAP, and IVCD were statistically decreased after low-sodium dialysate treatments (p = 0.002, 0.04, 0.013, and 0.00, respectively). Predialysis systolic and diastolic blood pressure (BP), post-dialysis systolic blood pressure, and interdialytic weight gain was statistically decreased when compared to basal levels (p = 0.00, p = 0.011, p = 0.022, p = 0.001, respectively). Conclusion A reduction of the dialysate sodium concentration based on the predialysis sodium levels of the patients could reduce the systolic BP and decrease the volume load on the heart as assessed by echocardiography. Within this short period, postdialysis diastolic BP could not be lowered. The effect of this approach should be studied in broad and lengthy series.
Nutritional Status and Immune Functions in Maintenance Hemodialysis Patients
(Hindawi Ltd, 2006) Sayarlioglu, Hayriye; Erkoc, Reha; Demir, Cengiz; Dogan, Ekrem; Sayarlioglu, Mehmet; Oner, Ahmet Faik; Dilek, Imdat
Epidemiological studies suggest various kinds of immune dysregulation in hemodialysis (HD) patients. The aim of this study was to investigate the relationship between immune functions and nutritional status of HD patients. We studied 54 patients with ESRD on chronic HD, included 34 females and 20 males with mean age 46.6 +/- 16.3 (18-77) years. We measured the height and dry weight of all patients. The BMI was calculated by dividing weight (kg) by height squared (m(2)). In all patients serum urea, creatinine, albumin, iron, cholesterol, triglyceride, CRP, IgG, IgM, IgA, CD4, CD8, CD19, CD16-56 lymphocytes were measured. Kt/V values were calculated according to DOQI guideline. In this study, a positive correlation between albumin, cholesterol, and triglyceride levels as nutritional parameters and immune functions in terms of total and subtype lymphocyte counts was observed. Further prospective studies are needed to determine the clinical importance of this finding and the appropriate means of measurement and effects of nutrition on immune function in hemodialysis patients. Copyright (c) 2006 Hayriye Sayarlioglu et al.
Rheumatoid Arthritis and Pulmonary Carcinoid Tumor
(Modestum Ltd, 2005) Sayarlioglu, Mehmet; Izmirli, Mustafa; Uzun, Kursat; Alici, Suleyman; Erkoc, Reha
A 40-yearold woman was admitted with a history of elbow, wrist, knee pain and prolonged morning stiffness. Rheumatoid arthritis (RA) diagnosed before five years, had been treated with non-steroidal anti-inflammatory agents and low dose corticosteroid. On hospital admission, routine chest x-ray showed a 4x4 cm solitary mass in the right pulmonary. A diagnostic thoracotomy was performed. The histological examination showed a typical carcinoid tumor. This is the third carcinoid tumor case reported to be associated with RA.