Browsing by Author "Sehitogullari, Abidin"

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Altered Serum Levels of Elements in Acute Leukemia Cases in Turkey
(Asian Pacific Organization Cancer Prevention, 2011) Demir, Cengiz; Demir, Halit; Esen, Ramazan; Sehitogullari, Abidin; Atmaca, Murat; Alay, Murat
Objective: The purpose of the study was to compare serum concentrations of some elements [zinc (Zn), copper (Cu), manganese (Mn), magnesium (Mg), lead (Pb), iron (Fe), cadmium (Cd) and cobalt (Co)] in acute leukemia patients with those of healthy subjects. Methods: The study group consisted of newly diagnosed acute leukemia patients and the controls were matched for socioeconomic stauts and eating habits. The elements levels in the patient group were measured before treatment with an atomic absorption spectrophotometer. The selection criteria for the patients and controls were the lack of recent blood transfusion history and taking any medication with mineral supplement. Results: The acute leukemia group composed of 42 patients and there were 40 persons in the control group. There was no difference between the age of the two groups (p=0.239). Serum levels of Zn, Mg and Mn were significantly lower with acute leukemia than in controls (p<0.001, p=0.011, p<0.001, respectively), while Cu, Pb and Cd were significantly elevated (p=0.003, p<0.001, p<0.001, respectively). There were no significant differences regarding Co and Fe (p=0.323 and p=0.508, respectively) Conclusion: In this study, we found levels of Zn, Mg and Mn to be lowered and of Cu, Pb and Cd to be elevated in patients with leukemia. Further studies are needed to clarify the role of these elements in pathogenesis of acute leukemia.
Clinical Analysis of Pneumonectomy for Destroyed Lung: a Retrospective Study of 32 Patients
(Springer Japan Kk, 2019) Sayir, Fuat; Ocakcioglu, Ilhan; Sehitogullari, Abidin; Cobanoglu, Ufuk
ObjectiveDestroyed lung is whole lung destruction secondary to chronic or recurrent lung infections. This clinical condition can result in irreversible changes in the lung parenchyma. In this study, we aimed to evaluate patients undergoing pneumonectomy with a diagnosis of lung destruction in terms of surgical technique, post-operative morbidity and mortality, and long-term outcomes.MethodsA total of 32 patients that underwent pneumonectomy due to a destroyed lung between 2005 and 2017 were retrospectively reviewed. Age, gender, presenting symptoms, etiologies, localization of the destruction, pre-operative medical history, pre- and post-operative respiratory function tests, intraoperative complications and bleeding volume, morbidity and mortality, length of hospital stay, and long-term follow-up outcomes were reviewed for each patient.ResultsThe study included 32 patients with a mean age of 31.710.8years. All the patients presented with persistent cough, whereas sputum production was presented by 25, hemoptysis by 18, and chest pain by 11 patients. The underlying primary diseases included nonspecific bronchiectasis in 20 (62.5%), tuberculosis in 9 (28.1%), left pulmonary hypoplasia accompanied by Bochdalek hernia in 2 (6.2%), and aspiration of a foreign body lodged in the left main bronchus in 1 (3.1%) patient. Mean operative time was 220.6 +/- 40.2min and mean perioperative bleeding was 450.9 +/- 225.7ml. Post-operative complications occurred in 14.2% of the patients, most commonly including atelectasis associated with stasis of secretions and wound site infection. Mean post-operative hospital stay was 11.8 +/- 2.8days and mean follow-up period was 35.5 +/- 28.3months. A significant clinical improvement was observed in 81.2% of the patients post-operatively.Conclusions Favorable long-term outcomes were obtained in our patients through careful patient selection and appropriate pre-operative work-up and surgical technique.
Clinical Profile of Thorax and Lung Injuries Associated With the 2011 Van Earthquake in Turkey
(Modestum Ltd, 2013) Sehitogullari, Abidin; Kahraman, Ali; Sayir, Fuat; Akin, Oral; Sevilgen, Gokcen; Cobanoglu, Ufuk; Aktas, Serdar
The 7.2 and 5.6 magnitude earthquake that struck Turkey on October 23 and November 9, 2011, was one of the deadliest earthquakes in recent decade. Our aim is to determine the clinical profile of crush thoracic traumas resulting from the massive Van earthquake. A retrospective review was undertaken of 39 intervention for chest traumas. Sex distrubition was 21 female and 18 male patients. Thoracic cage, pulmonary parenchyma, and pleura traumas were included in the study. Among the total of 425 hospitalized patients, 39 (9.1%) were thorax and lung injuries. Pneumothorax and rib fractures were the two most frequent pathologies. There were pneumothorax or hemothorax in 31 (79%) patients, bronch ruptures in 2 (5.1%) patients, diaphragmatic ruptures in 2 (5.1%) patients, flail chest in 2 (5.1%) patients and sternal fracture was detected in 2 (5.1%) patients. Totally, 76 ribs fractures were found in 27 (69%) patients, There were 36 (92%) patients with pulmonary parenchymal injuries and 31 (79%) with pleural injuries. Thoracotomy was performed in 4 (10%) patients, while 37 (95%) patients underwent tube thoracostomy. Carinal reconstruction was performed in a patient with bronchus and trachea injuries. Four patients (10%) with severe trauma developed Acute Respiratory Distres Syndrome (ARDS) and two of them died because of developing ARDS. After the patients are admitted to the hospital, we should use an individualized treatment according to the patients recent clinical history and examination. At the same time, traumatic chest injury should be considered in planning the medical response strategies.
Conventional Osteosarcoma of the Rib: a Case Report
(Baycinar Medical Publ-baycinar Tibbi Yayincilik, 2012) Sehitogullari, Abidin; Bulut, Gulay; Cobanoglu, Ufuk; Bayram, Irfan
Primary tumors of the rib are relatively uncommon in adults and rare in children. In this article, we present a case who was operated due to conventional osteosarcoma of the rib in the light of the literature review. A 17-year-old female patient had been operated due to a rib tumor 54 months ago. There was no local recurrence or metastatic disease. Chest wall tumors, particularly those arising from bones, require histologic assessment to be considered benign; the differential diagnosis of malignant neoplasms should not be based on clinical and radiographic features, only.
Erythrocyte Catalase and Carbonic Anhydrase Activities in Lung Cancer
(Asian Pacific Organization Cancer Prevention, 2010) Cobanoglu, Ufuk; Demir, Halit; Duran, Memet; Sehitogullari, Abidin; Mergan, Duygu; Demir, Canan
Aim: To study the relationship between the pathogenesis of lung cancer and antioxidant status and acidic media by measuring the activities of erythrocyte catalase (CAT) and carbonic anhydrase (CA). Methods: A total of 26 patients with lung cancer and 15 healthy individuals were included in the study. The CAT and CA activities of erythrocytes were defined. The catalase (CAT) activity of erythrocytes was measured using Aebi's method. Carbonic anhydrase (CA) activity was analyzed by CO2 hydration. Results: It was found that erythrocyte CA and CAT activities were significantly lower in patients with lung cancer compared to controls (p<0.05). Of the 26 patients with lung cancer, seven (26.9%) had metastasis, and the CA and CAT levels in patients with metastasis were significantly decreased (p=0,0001). Conclusions: Development of oxidative stress due to lung cancer may be related to the balance between prooxidant and antioxidant reactions. Catalase may have a preventive effect for malignant lung cancers and the gene of the antioxidant enzymes may be one of the anti-oncogenes, and inactivation of one of these genes in the process of carcinogenesis may lead to tumor development. This may be an explanation for the very low levels of antioxidant CAT in patients with lung cancer compared to healthy individuals. Carbonic anhydrase (CA) in tumor cells may be an indicator of the acid-base balance in lung cancer. Decreased levels of CA in patients with lung cancer may provide a convenient media for tumor development, growth and metastasis by creating an acidic media.
Factors Affecting Survival in Non-Small Cell Lung Cancer Invading the Chest Wall
(Scientific Publishers india, 2017) Sehitogullari, Abidin; Aydemir, Yusuf; Sayir, Fuat
Aim: The current study aimed to evaluate the factors affecting survival in non-small cell lung cancer invading the chest wall. Method: A total of 45 cases operated on for Non-Small Cell Lung Cancer invading the chest wall (NSCLC) were followed-up for five years. The effects of factors such as depth of tumor invasion of the chest wall (parietal pleura, extra pleural fatty tissue, intercostal muscles, and rib involvement), perinodal involvement, "N" involvement, surgical margin of the resection, and adjuvant chemotherapy on prognosis and survival were evaluated. Results and discussion: The number of males and females among the cases was 38 (84%) and seven (16%), respectively, with a mean age of 55 +/- 8 years (42-74). Chest wall resection and extra-pleural resection was performed in 36 (80%) and nine (20%) cases, respectively. In the multivariate analysis, factors positively affecting survival were depth of invasion, tumor dimension less than 5 cm, N0 lymph node status, complete resection, and complete adjuvant chemotherapy. Full-thickness resection of the chest wall was an important prognostic factor for long-term survival in all patients with NSCLC invading the chest wall. Conclusion: The stage of the tumor and histopathological factors such as lymphatic involvement, extrapleural invasion, and rib invasion have been shown to gain importance in improvement of survival, in addition to advancements in surgical techniques. Although there is no consensus on the surgical approach in presence of chest wall invasion, we suggest that "en bloc" resection should be preferred to extra-pleural resection.
Impact of Lymph Node Metastases in Esophageal Carcinoma Patients Is Independent of Patient Age
(Asian Pacific Organization Cancer Prevention, 2011) Sehitogullari, Abidin; Cikman, Oztekin; Sayir, Fuat; Cobanoglu, Ufuk; Demir, Cengiz; Demir, Halit
Objective: The purpose of the present study was to define the clinicopathological features and prognosis of esophageal cancer. Methods: Between 2004 and 2009, 128 patients with esophageal cancer were enrolled in a retrospective database and divided into two groups on the basis of number positive lymph nodes with the cutoff as four. Results: The findings for 18 patients (14.0%) Group A were compared with those of 110 patients Group B. In the group A, there were significantly more women (12/6 vs. 54/56, P < 0.001). In both groups, the most frequent histological morphology was squamous cell carcinoma (83% and 75%, respectively), although the percentages were significantly different (P < 0.005). In the group A, lesions were more frequently located in the middle one-third of the esophagus than in the group B (61% vs. 28%, P < 0.001). Group A was more likely to be Stage IIa. Survival rates in group A patients at 5 years after resection were 15.8%, similar to those in group B patients (12.1%, difference not significant). Local lymph node metastases and microscopic residual tumor at the line of resection were also more prevalent in the young patients, but not to a statistically significant degree. Conclusions: These findings suggested that the clinical and pathologic features of carcinomas of the esophagus in young patients do not significantly differ from those in older patients.
A Long-Term Study Assessing the Factors Influencing Survival and Morbidity in the Surgical Management of Bronchiectasis
(Biomed Central Ltd, 2011) Sehitogullari, Abidin; Bilici, Salim; Sayir, Fuat; Cobanoglu, Ufuk; Kahraman, Ali
Background: Although the prevalence of bronchiectasis decreased significantly in developed countries, in less developed and in developing countries, it still represents a significant cause of morbidity and mortality. The aim of this retrospective study is to present our surgical experiences, the morbidity and mortality rates and outcome of surgical treatment for bronchiectasis. Methods: We reviewed the medical records of 129 patients who underwent surgical resection for bronchiectasis between April 2002 and April 2010, at Van Training and Research Hospital, Thoracic Surgery Department. Variables of age, sex, symptoms, etiology, and surgical procedures, mortality, morbidity and the result of surgical therapy were analyzed retrospectively. Results: Mean age was 21.8 year (the eldest was 67 year, the youngest was 4 years-old). Male/female ratio was 1.86 and 75% of all patients were young population under the age of 40. Bilateral involvement was 14.7%, left/right side ratio according to localization was 2.1/1. The most common reason for bronchiectasis was recurrent infection. Surgical indications were as follows: recurrent infection (54%), hemoptysis (35%), empyema (6%), and lung abscess (5%). There was no operative mortality. Complications occurred in 29 patients and the morbidity rate was 22.4%. Complete resection was achieved in 110 (85.2%) patients. Follow-up data were obtained for 123 (95%) of the patients. One patient died during follow-up. The mean follow-up of this patient was 9 months. Mean postoperative hospitalization time was 9.15 +/- 6.25 days. Significantly better results were obtained in patients who had undergone a complete resection. Conclusions: Surgical treatment of bronchiectasis can be performed with acceptable morbidity and mortality at any age. The involved bronchiectatic sites should be resected completely for the optimum control of symptoms.
Managing Postpneumonic Empyema Thoracis in Children: Comparison of Different Treatment Options
(Kowsar Corp, 2019) Sehitogullari, Abidin; Sayir, Fuat; Aydemir, Yusuf; Anbar, Ruchan; Sayhan, Havva
Objectives: To compare various treatment methods of postpneumonic empyema (PPE) in children. Methods: Six hundred eighty one (302 females and 379 males) pediatric PPE patients were studied at two different centers between 2000 and 2016. The average age was 4.8 years that ranged from 30 days to 15 years. The patients were considered in six groups. The initial treatments, thoracentesis (group A), chest tube drainage (group B), fibrinolytic therapy (group C), decortication following chest tube drainage (group D), video-assisted thoracoscopic surgery (VATS) (group E) and primary operation without chest tube drainage (group F), were applied to the patients. Results: Success rates were 100%, 47.3%, 82.7%, 100%, 100%, and 100% for thoracentesis, chest tube drainage, fibrinolytic treatment, chest tube drainage, decortication following chest tube drainage, VATS and primer operation, respectively. The overall response rate of fibrinolytic therapy was 82.7% (n = 67). Fourteen of 81 (17.2%) patients who went through fibrinolytic instillation did not respond to treatment; these recovered after the application of thoracotomy and VATS. In addition to decortication pulmonary resections were performed in 15 patients. Overall mortality rate was 1.32%. There was no operative mortality. Postoperative morbidity included wound infection in 22, delayed expansion in 17, and atelectasis in 40 patients. Conclusions: Chest tube drainage can be said to be an efficient and safe primary treatment for PPE in children. In cases when chest tube drainage fails to satisfy, decortication with thoracotomy can be applied well with low mortality and morbidity rates.
Nonspecific Infectious Bilateral Chylothorax and Cyhloabdomen With Symptoms of Acute Abdomen
(Aves, 2011) Sayir, Fuat; Cobanoglu, Ufuk; Sehitogullari, Abidin
Co-existence of chylothorax and chyloabdomen is a rare clinical entity. Apart from surgery and extra-surgical trauma, malignancies, liver cirrhosis, nephrotic syndrome, thrombosis in the superior vena cava and acute pancreatitis play roles in the etiology. The case presented in this article was a 35-year-old woman, and the chronic infectious pathology in the cytology, plus the other supportive nonspecific infection parameters prompted us in establishing this diagnosis. Obstruction in the abdominal lymphatics leads to chylous ascites and chylothorax develops in due course. Similar to our case, the clinical entities of chylothorax and chyloabdomen of nonspecific infectious origin may co-exist in the same patient.
Our Eight-Year Surgical Experience in Patients With Pulmonary Cyst Hydatid
(E-century Publishing Corp, 2012) Sayir, Fuat; Cobanoglu, Ufuk; Sehitogullari, Abidin; Bilici, Salim
Background: In this clinical retrospective study, we aimed to investigate our experinces and whether capitonnage is an effective therapy method for a pulmonary hydatid cyst or not. Material and methods: A total of 412 patients with hydatid cyst operated in our hospitals were evaluated retrospectively between January 2003 and January 2011. In order to create a study group to compare the hydatid cyst operations with and without capitonnage in our department, 60 uncomplicated patients with the diagnosis of hydatid cyst who had undergone operations in the previous two years, were divided into two groups; while no capitonnage was performed and bronchial leaks were closed in one group, standard cystotomy plus the capitonnage operation was performed in the second group. All patients underwent surgery. Results: In many patients, one or more symptoms were present on admission (339 cases, 82%). Perforated cysts/nonperfore cysts rate was statistically significant (p = 0.001). There was no statistical difference between patients with or without capitonnage in terms of morbidity rates between patients with or without capitonnage (p = 0.041). However, morbidity rates were higher in the group without capitonnage. There were found statistically significant between capitonnage and non capitonnage groups in terms of length of hospital stay (p = 0.001). Conclusions: In the surgical treatment, resection should be avoided as much as possible. An average time of 3-5 minutes should be allocated and capitonnage should be performed. Capitonnage should always be performed in the surgical treatment of hydatid cyst. We believe that povidone iodine per se provides sufficient disinfection.
A Patient With Pleural Effusion Related To Dasatinib
(Aves, 2013) Demir, Cengiz; Turan, Nedim; Sehitogullari, Abidin; Esen, Ramazan
Dasatinib is a tyrosine kinase inhibitor which is used for the treatment of patients with chronic myeloid leukemia (CML) resistant or intolerant to imatinib. Dasatinib can cause fluid retention in some patients, leading to peripheral edema and pleural effusion. Recognition of these symptoms as a potential complication of dasatinib will help prevent unnecessary investigations and facilitate adequate management. We report a patient with blastic phase CML. In patients with advanced phase CML an initial dose of dasatinib is recommended as 70 mg twice daily. We observed that 100 mg once daily dose of dasatinib could control the blastic phase of CML with less toxicity.
Serum Paraoxonase-1 Enzyme Activities and Oxidative Stress Levels in Patients With Esophageal Squamous Cell Carcinoma
(Taylor & Francis Ltd, 2014) Sehitogullari, Abidin; Aslan, Mehmet; Sayir, Fuat; Kahraman, Ali; Demir, Halit
Objectives: Oxidative stress is well recognized to play a role in the pathogenesis of many diseases, including cancers. Paraoxonase-1 (PON1) is implicated in the elimination of carcinogenic lipid-soluble radicals produced by lipid peroxidation. Reports on PON1 activities in patients with cancer are conflicting. The aim of this study was to investigate serum antioxidant enzyme activities and oxidative stress levels in patients with esophageal squamous cell carcinoma (ESCC). Patients and methods: Thirty-two patients with ESCC and 33 healthy controls were enrolled. Serum malondialdehyde (MDA) levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione reductase (GR), paraoxonase, and arylesterase activities were measured spectrophotometrically. Results: Serum paraoxonase, arylesterase, SOD, activities, GSH-Px, and GR activities were significantly lower in patients with ESCC than in controls (all, P < 0.05), whereas serum MDA levels were significantly higher (P < 0.05). Serum MDA levels were significantly correlated with paraoxonase (r = -0.572, P < 0.001) and arylesterase activities (r = -0.597, P < 0.001) in patients with ESCC. Conclusions: This study indicated that ESCC is associated with increased oxidative stress and decreased antioxidant enzyme activities. Decreased serum PON1 enzyme activities may play a role in the progression and/or development of ESCC. Further studies are required to clarify these results.
Surgical Treatment of Pulmonary Hydatid Cysts, Which Perforated To the Pleura
(Aves, 2012) Sayir, Fuat; Cobanoglu, Ufuk; Sehitogullari, Abidin
Objective: Hydatid cyst disease, endemic in Eastern region of Turkey, is a significant parasitic public health problem. In this study, pleural complications of hydatid cysts were presented in 76 cases. Materials and Methods: In our study, of the 412 pulmonary hydatid cyst cases operated on between 2003 and 2011, 76 cases had ruptured into the pleura for various reasons, and the different clinicoradiological presentations were evaluated retrospectively. The age distribution of the cases was between 7 and 56 years, and the mean age was 26.20+/-13.04. Results: The most frequent symptom due to pleural rupture in patients was dyspnea (44 cases, 57.8%). Etiologically, iatrogenic perforation was detected in four cases and thoracic trauma in nine cases (six car accidents and three falls from a height). An anthelmintic drug use history was found in three cases of ruptured pleura. Spontaneous perforation was detected in the other 60 (78.9%) cases. Two cases that were admitted to the emergency unit and were immediately administered a tube thoracostomy developed tension pneumothorax. In addition, 21 cases had hydropneumothorax, 17 had pneumothorax, and 36 had pleurisy. Morbidity was observed in 30 cases (39.4%). Atelectasis was the most frequent cause of morbidity in these patients (10 cases). The mean duration of hospitalization was determined to be 12.26+/-2.90 days. Conclusion: This disease can progress asymptomatically for a long time and can sometimes lead to life-threatening emergency situations, such as tension pneumothorax. The delayed admission of a patient to a physician causes the disease to become more complicated and to increase the morbidity and mortality rates. Treatment of the disease is in the form of surgery. Possible parenchymal protection should be applied in surgical treatment, and anatomic resection should not be performed unless necessary.
Traumatic and Atraumatic Sternal Fractures: Analysis of 13 Cases
(Bilimsel Tip Publishing House, 2012) Cobanoglu, Ufuk; Hiz, Ozcan; Sayir, Fuat; Ediz, Levent; Sehitogullari, Abidin
Objective: Sternal fracture (SF) occurs as a result of trauma or a pathological process. In this study, patients with SF were evaluated in terms of traumatic and atraumatic etiology, diagnosis and treatment. Material and Methods: Between 2006-2010; fracture etiology, location, shape, associated pathology, treatment modalities, complications and length of hospital stay were reviewed retrospectively in 13 patients with SF. In all cases, the lateral chest X-ray and electrocardiogram (ECG) had been performed. Cardiac enzymes had been measured in patients with traumatic etiology. Results: Of SF subjects, 11 had a traumatic etiology and 2 had an atraumatic etiology (osteoporosis). Sternal fracture was located in the corpus of the sternum in 9 patients, and in the manubrium in 4 cases, while it was displaced in 5 patients, and non-displaced in 8 cases. The ECG changes in five patients, elevated cardiac enzymes in 7 patients and pathology in echocardiography in 3 cases were detected. The most common injuries were associated with rib fractures (54.5%) and extremity fractures (27.3%), respectively. There was a vertebral osteoporotic fracture in two patients with atraumatic SF. One case underwent surgical fixation, while three patients underwent tube thoracostomy. Conclusion: Whether or not accompanying trauma, SF should be considered and sternum X-ray should be requested in patients presenting with chest pain, and especially when an atraumatic fracture is detected, osteoporosis should be kept in mind among the etiological causes. ECG monitoring of patients for cardiac injury, cardiac enzyme monitoring and echocardiography should be done if necessary.
Traumatic Hemothorax: Analysis of 282 Patients
(Bilimsel Tip Publishing House, 2012) Sayir, Fuat; Cobanoglu, Ufuk; Sehitogullari, Abidin
Objective: The approaches and results of the treatment were evaluated in the cases treated on admission to our clinic because of traumatic hemothorax. Materials and Methods: Of the cases admitted after trauma between 2002-2011, 282 patients treated in our clinic due to hemothorax were included. The cases were retrospectively analyzed in terms of age, gender, cause of trauma, treatment methods, indications of thoracotomy, the location of coexisting trauma in addition to thoracic trauma and treatment outcomes. Results: Motor-vehicle accidents were the most important cause of hemothorax (168 cases, 59.5%). penetrating injury in 58 cases (20.5%) and gunshot wounds in 32 cases (11.3%). Effective and adequate treatments were provided with tube thoracostomy in 165 cases (58.5%). The number of patients under 15 years was 22 (7.8%). Emergency thoracotomy was applied to 35 (12.4%) cases. The mean duration of stay of the cases at the hospital was 8.3 days. Mortality occurred in 9 cases (3.1%) and morbidity in 43 cases (15.2%). Conclusion: Tube thoracostomy was sufficient to treat the vast majority of the cases. Benefit can be obtained from video thoracoscopy as the first step of treatment in cases with isolated hemothorax who are hemodynamically stable because of traumatic hemothorax. Thoracotomy has been less necessary than the tube thoracostomy. However, thoracotomy should not be avoided even in the emergency department when necessary.
The Use of Ligasure Vessel Sealing System in Ivor Lewis Esophagectomy
(Bmc, 2012) Sayir, Fuat; Cobanoglu, Ufuk; Sehitogullari, Abidin
Background: This study investigated the results of the LigaSure Vessel Sealing System (LVSS), which has been routinely used in esophageal resections in our clinic since 2006. Methods: For this purpose, 60 patients who underwent Ivor Lewis esophagectomy were included in the study. The results were compared with the patients who underwent stomach mobilising procedure and esophagectomy with conventional methods (conventional group) before 2006 and the patients who underwent LVSS (group of LigaSure) in surgical cases after 2006. The cases were compared particularly in terms of intraoperative bleeding, operative time, duration of postoperative hospital stay, intraoperative complications, mortality, and morbidity. Results: Of the patients, 34 (% 56.6) were female and 26 (43.3%) were male, and the range of the age was between 33 and 78, and the mean age of the patients was 52.73 +/- 11,617. While the amount of intraoperative bleeding was 321.864 +/- 575.00 ml in the conventional group, this was found to be 370.31 +/- 238.456 ml in the LigaSure group (p = 0.007). In the statistical evaluation of the operative time, the mean duration was determined as 310.00 +/- 24.795 minutes in the conventional group, whereas it was determined as 265.16 +/- 31.353 minutes in the LigaSure group (p = 0.001). Conclusions: The use of LVSS was associated with a significant reduction in the operative time and the rate of intra-operative complications.