Browsing by Author "Sekeroglu, M. Ramazan"

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Evaluation of Plasma Agmatine Level and Its Metabolic Pathway in Patients With Bipolar Disorder During Manic Episode and Remission Period
(Taylor & Francis Ltd, 2019) Yilmaz, Emine; Sekeroglu, M. Ramazan; Yilmaz, Ekrem; Cokluk, Erdem
Objectives: Agmatine is a cationic amine resulting from the decarboxylation of l-arginine. Agmatine has neuroprotective, anti-inflammatory, anti-stress, and anti-depressant properties. In this study, plasma agmatine, arginine decarboxylase, and agmatinase levels were measured during manic episode and remission period in patients with bipolar disorder. Methods: Thirty healthy volunteers and 30 patients who meet Bipolar Disorder Manic Episode diagnostic criteria were included in the study. Additionally, the changes in the patient group between manic episode and remission period were examined. We evaluated the relationship between levels of l-arginine and arginine decarboxylase in the agmatine synthesis pathway, and level of agmatinase that degrades agmatine. Results: Levels of agmatine and l-arginine were significantly increased than control group during manic episode (p < .01). All parameters were increased during manic episode compared to remission period (p < .05). Agmatinase was significantly decreased both during manic episode (p < .01) and remission period (p < .05) in comparison to the control group. Arginine decarboxylase levels did not show a significant difference between the groups (p > .05). Conclusions: This study indicate that there may be a relationship between bipolar disorder and agmatine and its metabolic pathway. Nonetheless, we believe more comprehensive studies are needed in order to reveal the role of agmatine in etiology of bipolar disorder.
The Investigation of Relationship Between Secondary Hyperparathyroidism and Oxidative Stress in Patients With Chronic Kidney Disease
(Turk Nefroloji Diyaliz Transplantasyon dergisi, 2009) Noyan, Tevfik; Avci, Gulendam; Sekeroglu, M. Ramazan; Erkoc, Reha
OBJECTIVES: Our aim was to investigate the changes of the oxidant and antioxidant systems in chronic kidney disease patients who had increased parathyroid hormone (PTH) levels in the present study. PATIENTS and METHODS: A total of fifty hemodialysis patients were divided into two equal groups based on the PTH levels; > 300 pg/mL (Group 1) and < 300 pg/mL (Group 2). A total 20 healthy subjects were included in the study as the control group (Group 3). The measurement of malondialdehyde (MDA), advanced protein oxidation products level (AOPP), ascorbic acid (AA) levels, and activities of myeloperoxidase (MPO) and catalase (CAT) were performed by colorimetric methods. PTH measurement was also performed by chemiluminescent method. RESULTS: As compared with control group, MDA level was significantly higher in Groups 1 and 2 (p<0.05), and the AOPP level was higher in Group 2 (p<0.05) only. The MPO activity was significantly lower in Group 1 as compared to the control group (p<0.05). The CAT activity and AA levels were significantly lower in Groups 1 and 2 than in the control group (p<0.05). CONCLUSIONS: This study has shown that patients with chronic kidney disease are characterized by increased oxidative stress and decreased antioxidant defense systems. However, increased PTH levels did not have an additional effect on the oxidant and antioxidant mechanisms in these patients.
The Relationship Between Mother and Infant Plasma Trace Element and Heavy Metal Levels and the Risk of Neural Tube Defect in Infants
(Taylor & Francis Ltd, 2019) Demir, Nihat; Basaranoglu, Murat; Huyut, Zubeyir; Deger, Ibrahim; Karaman, Kamuran; Sekeroglu, M. Ramazan; Tuncer, Oguz
Objective: To determine levels of trace elements [copper (Cu), zinc (Zn), selenium (Se), and cobalt (Co)] and heavy metals [arsenic (As), mercury (Hg), lead (Pb), and cadmium (Cd)] in the plasma of mothers and infants and investigate the relationship between those levels and neural tube defects (NTD). Methods: A total of 100 neonates diagnosed with NTD and placed in the Neonatal Intensive Care Unit of Yuzuncu Yil University, Turkey between May 2013 and December 2016 comprised the study group. The control group consisted of 70 healthy neonates not diagnosed with NTD or any other congenital anomalies. For both the groups, mother and infant plasma levels of Cu, Zn, Co, Cd, Se, Hg, As, and Pb were measured and compared. Plasma levels of Cu, Zn, Co, Cd, Se, Hg, As, and Pb were measured and compared between two groups of mothers and infants. Findings: Mother and infant plasma levels of trace elements Zn and Se were determined to be significantly lower in the study group compared with the control group, while Cu levels were significant elevated in the study group (all p values < .05). Plasma levels of heavy metals As, Pb, and Cd were found to be significantly higher in the NTD control group (p < .05 for all). There was no association between maternal infection, maternal smoking status, history of miscarriage, or history of NTD with the development of NTD (p > .05). Differences in maternal age, birth weight, length of gestation, and infant gender for the two groups were also determined not to be statistically significant. Results: High plasma levels of heavy metals As, Pb, and Cd and trace element Cu were identified as risk factors for the development of NTD. At the same time, low plasma levels of trace elements Zn and Se were also found to be risk factors for NTD. However, no association between Hg and Co plasma levels and increased risk for the development of NTD was observed. This study, while being the most comprehensive case study to date investigating the relationship between heavy metals and trace element levels and increased risk of NTD, nonetheless highlights the need for further research in order to make definite statements regarding this relationship.
Roles of the Oxidative Stress and Adma in the Development of Deep Venous Thrombosis
(Hindawi Ltd, 2014) Ekim, Meral; Sekeroglu, M. Ramazan; Balahoroglu, Ragjp; Ozkol, Halil; Ekim, Hasan
Venous thromboembolism has multifactorial origin and occurs in the context of complex interactions between environmental and genetic predisposing factors. Oxidative stress plays an important role in the physiopathology of venous thrombosis. Current study examined the role of oxidative stress and asymmetric dimethylarginine in the development of DVT with the parameters such as serum malondialdehyde (MDA), glutathione peroxidase (GSH-Px), catalase, ADMA, homocysteine, folic acid, vitamin B 6, and vitamin B 12 levels. Serum MDA levels were found significantly (p < 0.005) high in patients with DVT compared with control group. Additionally, serum B 6 levels were found significantly (p < 0.009) low in patients with DVT compared with healthy volunteers. There were no significant differences between the groups in terms of the other parameters (p > 0.05). This study showed that patients with DVT have increased oxidative stress compared with the healthy volunteers whereas there was no significant difference between the groups in terms of serum ADMA levels. Thus serum ADMA levels seemed to be not related with development of DVT.
Serum Cytokines and Bone Metabolism in Patients With Thyroid Dysfunction
(Health Communications inc, 2006) Sekeroglu, M. Ramazan; Altun, Z. Busra; Algun, Ekrem; Dulger, Haluk; Noyan, Tevfik; Balaharoglu, Ragip; Ozturk, Mustafa
Hyperthyroidism is associated with increased bone turnover. Besides the hormones of calcium metabolism , locally produced factors are important in maintaining normal bone metabolism. Interleukin-6 (IL-6), in particular, has a major influence on bone turnover. In this study, serum IL-6 and tumor necrosis factor-alpha (TNF-alpha) levels, as well as bone turnover markers and relationships between them, were investigated in hyperthyroidism and hypothyroidism. A total of 20 female patients with hyperthyroidism, 15 with subclinical hyperthyroidism, 16 with hypothyroidism, and 15 with subclinical hypothyroidism constituted the patient groups. In all, 15 age-matched healthy female volunteers were recruited as controls. When compared with controls, serum TNF-a levels showed no significant difference in any of the patient groups (P >.05). In the groups with hyperthyroidism and subclinical hyperthyroidism, IL-6 levels were significantly higher compared with control group values (P <.05). Hyperthyroid patients showed higher levels of alkaline phosphatase (ALP) and osteocalcin, and a higher urinary deoxypyridinoline/creatinine ratio, compared with controls (P <.05). In subclinical hyperthyroidism, only ALP was found to be higher compared with control values. No significant correlations were made in any group between serum IL-6 or TNF-a level and bone turnover markers. Results suggest that serum IL-6 level and markers of bone turnover rate seem to be increased in hyperthyroidism. This finding may support the role of IL-6 in induction of bone turnover in hyperthyroid states.