Browsing by Author "Sekeroglu, Nazim"

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Antioxidant Capacity and Bioactive Contents of Mulberry Species From Eastern Anatolia Region of Turkey
(Assoc Pharmaceutical Teachers india, 2018) Gundogdu, Muttalip; Tuncturk, Murat; Berk, Selma; Sekeroglu, Nazim; Gezici, Sevgi
In this study, we aimed to determine biochemical contents of white (Morus alba L.) and black (Morus nigra L.) mulberry genotypes grown in the Hakkari region. At the end of the study, organic acids, phenolic compounds, sugars, vitamin C and antioxidant capacities of mulberry species were determined. Black mulberry genotypes were found to contain higher antioxidant capacity than white mulberry genotypes. The highest antioxidant capacity was detected in the 30YK03 (25.55 mu moITE/g) black mulberry genotype. While phenolic compounds varied in mulberry species, especially gallic acid (57.78 mg/100g), chlorogenic acid (53.13 mg/100g), and rutin (37.77 mg/100g) had the highest values. Malic acid was found to be higher than other organic acids and was found to be 13.51 g/100g in the highest 30HK03 genotype. Although sugar contents varied in mulberry species, glucose was determined higher than fructose and sucrose in mulberries.
Essential Oil Composition of Some Sage (Salvia Spp.) Species Cultivated in Izmir (Turkey) Ecological Conditions
(Assoc Pharmaceutical Teachers india, 2018) Karik, Unal; Cinar, Orcun; Tuncturk, Murat; Sekeroglu, Nazim; Gezici, Sevgi
Background: Salvia L., the largest genus of Lamiaceae, includes about 1000 species, widespread throughout the world. This genus is represented, in Turkish flora, by 99 species and 113 taxa, 58 of which are endemic. Some members of this genus are of economic importance since they have been used as herbal tea, flavouring agents in perfumery and cosmetics. Some sage (Salvia L.) species has been credited with a long list of medicinal uses: e.g. spasmolytic, antiseptic, astringent. Objective: In present study, essential oil composition of some sage (Salvia L.) species cultivated in Izmir (Turkey) was investigated. Sage species have recently become more common in Turkey and sage cultivation is increasing especially in the Aegean Region. Material and Methods: The species of Salvia fruticosa Mill., Salvia officinalis L., Salvia sclarea L., hybrid (Salvia fruticosa Mill. x Salvia officinalis L.) and Salvia dichroantha L. were used in the study. Essential oils were extracted according to hydro distillation method with clevenger type apparatus and analyzed using GC-FID and GC-MS system. Results: Essential oil contents of Salvia fruticosa MM. was 3.86%, Salvia officinalis L. 2.42%, Salvia sclarea L. 0.5%, Salvia fruticosa Mill. x Salvia officinalis L. 2.84% and Salvia dichroantha L. 0.19%. The number of components in essential oils were detected 22, 16, 14, 20 and 16 respectively. The chemical composition of the essential oils in Salvia fruticosa Mill. 1,8-cineole (57.18%), Salvia officinalis L. beta-thujone (34.59%), Salvia sclarea L. linalyl acetate (46.77%), Salvia fruticosa MM. x Salvia officinalis L. 1,8-cineole (21.42%) and beta-thujone (18.37%) and Salvia dichroantha L. beta- caryophyllene (23.11%) and sabinyl acetate (21.87%).
Limonotu (Lippia Citriodora H.b.k.) Uçucu Yağının Morfolojik ve Gün İçindeki Değişimi
(2019) Çınar, Orçun; Tunçtürk, Murat; Sekeroglu, Nazim; Karik, Ünal
Bu çalışmanın amacı, Menemen-İzmir/Türkiye’de kültürü yapılan limonotu (Lippia citriodora H.B.K.) bitkisinin yaprak ve çiçeklerindeki uçucu yağların bileşimini analiz etmek ve morfolojik ve gün içindeki değişiminin uçucu yağların bileşimine etkisini belirlemektir. Yaprak ve çiçeklerdeki uçucu yağlar Clevenger tipi aparey ile hidrodistilasyon yöntemine göre çıkarılmıştır. Uçucu yağların analizi gaz kromatografisi (GC-FID) ve gaz kromatografisi-kütle spektrometrisi (GC-MS) sistemleri kullanılarak belirlenmiştir. Yapraklardaki uçucu yağlar en yüksek %1,64 ile öğleden sonra saat 16.00’da, en düşük %0,78 ile sabah 10.00’da bitkinin dip kısımlarından alınan yapraklardan elde edilmiştir. Çiçeklerdeki uçucu yağlar 16.00’da alınan örneklerde %1,17, 10.00’da alınan örneklerde %0,86 olarak belirlenmiştir. Bütün uçucu yağlardaki ana bileşenler limonen, neral ve geranial olarak bulunmuştur. Bu bileşenlerin oranı günün farklı zamanı ve alındığı bitki bölümüne göre değişim göstermiştir. Limonen, neral ve geranial’ın en yüksek en düşük oranları yaprak uçucu yağ örneklerinde %12,2-22,6, %15,6-23,6, %22,7-35,8 ve çiçek uçucu yağ örneklerinde %16,3-28,5, %20,2-16,2, %30,3-23,8 arasında saptanmıştır.
Uncommon Terpenoids From Salvia Species: Chemistry, Biosynthesis and Biological Activities
(Mdpi, 2022) Hafez Ghoran, Salar; Taktaz, Fatemeh; Mozafari, Ali Akbar; Tunctuerk, Murat; Sekeroglu, Nazim; Kijjoa, Anake
The search for new bioactive compounds from plant sources has been and continues to be one of the most important fields of research in drug discovery. However, Natural Products research has continuously evolved, and more and more has gained a multidisciplinary character. Despite new developments of methodologies and concepts, one intriguing aspect still persists, i.e., different species belonging to the same genus can produce different secondary metabolites, whereas taxonomically different genera can produce the same compounds. The genus Salvia L. (Family Lamiaceae) comprises myriad distinct medicinal herbs used in traditional medicine worldwide that show different pharmacological activities due to the presence of a variety of interesting specialized metabolites, including mono-, sesqui-, di-, sester-, tri-, tetra-, and higher terpenoids as well as phenylpropanoids, phenolic acid derivatives, lignans, flavonoids, and alkaloids. We herein summarize the research progress on some uncommon terpenoids, isolated from members of the genus Salvia, which are well recognized for their potential pharmacological activities. This review also provides a current knowledge on the biosynthesis and occurrence of some interesting phytochemicals from Salvia species, viz. C-23-terpenoids, sesterterpenoids (C-25), dammarane triterpenoids (C-30), and uncommon triterpenoids (C-20+C-10). The study was carried out by searching various scientific databases, including Elsevier, ACS publications, Taylor and Francis, Wiley Online Library, MDPI, Springer, Thieme, and ProQuest. Therefore, 106 uncommon terpenoids were identified and summarized. Some of these compounds possessed a variety of pharmacological properties, such as antibacterial, antiviral, antiparasitic, cytotoxic and tubulin tyrosine ligase inhibitory activities. Due to the lack of pharmacological information for the presented compounds gathered from previous studies, biological investigation of these compounds should be reinvestigated.