Browsing by Author "Sekeroglu, R"

Now showing 1 - 11 of 11

Blood and Tissue Findings in the Diagnosis of Mesenteric Ischaemia: an Experimental Study
(Walter de Gruyter Gmbh, 1998) Aydin, M; Guler, O; Ugras, S; Bakir, B; Sekeroglu, R
In this experimental study, after inducing mesenteric ischaemia in dogs, we investigated routine blood biochemistry, serum malondialdehyde (MDA) levels, histopathological changes and tissue MDA levels in the liver and intestines. The study group included 10 dogs. Six dogs which underwent sham operation served as controls. In the study group, the MDA level in liver tissue increased after superior mesenteric artery (SMA) ligation. Various degrees of necrosis were seen in the ileal biopsies 10 hours after the ligation. Hyperaemia and focal necrosis in the liver accompanied the intestinal necrosis if it was limited within the mucosa. However, massive or centrilobular necrosis was observed in the liver of those dogs which had intestinal necrosis that extended into muscular layers. MDA levels in intestinal tissue measured after SMA ligation were significantly higher than the preligation levels. On the other hand, the difference between serum and tissue MDA levels was not significant. The alterations in MDA were not significant in the sham group. Thus it is concluded that the serum MDA levels are valuable markers of diagnosis in intestinal ischaemia.
A Further Study of Seminal Plasma: Lactate Dehydrogenase and Lactate Dehydrogenase-X Activities and Diluted Semen Absorbance
(Walter de Gruyter & Co, 1997) Aydin, S; Yilmaz, Y; Odabas, O; Sekeroglu, R; Tarakcioglu, M; Atilla, MK
Activities of total lactate dehydrogenase, which plays an important role in providing energy for cell metabolism, lactate dehydrogenase-X, an isoenzyme of lactate dehydrogenase supposed to be specific for germinal epithelium activity, diluted semen absorbance and some other properties have been measured in 51 seminal plasma samples. Aiming to study its clinical use as a marker of seminiferous epithelium activity, determination of isoenzyme-X and investigation of correlation between it and the spermiogram properties were carried out. Besides lactate dehydrogenase and lactate dehydrogenase-X activity, their ratio and diluted semen absorbance were correlated with the different properties of the spermiogram, the best correlation of the enzymes being obtained with the total sperm count and motile sperm count. Correlation of diluted semen absorbance with the total sperm count and motile sperm count was also noted, whereas it did not correlate with sperm concentration and motility rate. The data suggests the clinical utility of these properties as reliable markers for both germinal activity and spermatozoid quality when ''total sperm count'' and ''motile sperm count'' are used to define sperm properties instead of just sperm concentration and motility rate.
The Inhibition Effects of Some Pesticides on the in Vitro Activity of Five Serum Enzymes
(Taylor & Francis inc, 1997) Arslan, O; Sekeroglu, R; Celik, J; Tarakci, M
The effect of some pesticides on alkaline phosphatase (ALK-P) (E.C 3.1.3.1), Amylase (E.C. 3.2.1.1) creatine kinase (CK) (E.C. 2.7.3.2), delta-glutamyltransferase (GGT-P) (E.C. 2.3.2.1) and lactate dehydrogenase (LDH) (E.C. 1.1.1.27) were investigated. These pesticides were baytroid [Cyano-(4-fluoro-3-phenoxyphenyl)-methly-3-(2,2-dichloroethenly)-2,2-dimetylcyclopropancarboxylate], imperator [cyano-3-phenoxy-benzyl-cis,trans-3-(2,2-dichloroethenyl)-2,2- dimetylcyclopropancarboxylate]. Meothrin [cyanophenoxybenzyl- 2,2, 3,3-tetramethyl cyclopropanecarboxylate], Sumicidin [cyano-3-phenoxybenzylcyclopropane carboxylate] T C A (trichloroacetic acid) and talstar. ISO values of chemicals caused inhibition were determined by means of activity percentage [I] diagrams. Pesticides having the strongest inhibitory effects on each enzyme were found to be talstar (I-50 = 7,3 x 10(-4) M) for ALK-P; talstar (I-50) = 7,1 x 10(-4) M) and baytroid (I-50 = 8.8 x 10(-4) M) For amylase; baytroid (I-50 = 1,25 x 10(-4) M) for CK. baytroid (I-50 = 8.8 x 10(-4) M and I-50 = 9,7 x 10(-4) M) for GGT-P and LDH. Baytroid and talstar In general caused a high inhibition for all enzymes. pollutants such as TCA, meothrin, imparator, sumicidin weakly inhibed each enzymes.
Low Cholesterol Level in Patients With Panic Disorder
(Elsevier Science Bv, 1998) Agargün, MY; Algün, E; Sekeroglu, R; Kara, H; Tarakçioglu, M
Background: The purpose of this study was to examine whether an association exists between low cholesterol level and major depression in patients with panic disorder. Methods: The subjects of the study were 16 patients panic disorder only, 16 panic disorder patients had also current major depressive episode, and 16 normal control subjects. An automated enzymatic colorimetric method was used for cholesterol determination. Results: Panic disorder patients had higher serum cholesterol than panic disorder patients with major depression and normal controls. Conclusion: There is an association between low cholesterol level and the presence of major depression in patients with panic disorder. Limitation: Future studies with large sample are needed to confirm this finding. Clinical Relevance: A low serum cholesterol level might serve as biological marker of major depression in patients panic disorder. (C) 1998 Elsevier Science B.V.
Malondialdehyde Levels in Serum of Patients With Skin Cancer
(Springer, 1998) Bekerecioglu, M; Aslan, R; Ugras, S; Kutluhan, A; Sekeroglu, R; Akpolat, N; Karakok, M
The relationship of free radicals with some types of carcinomas is known, these studies have been performed on samples taken from the tumor tissue. In this study, the malondialdehyde levels in the serum of patients with skin cancer were studied and compared with a control group. The differences between malondialdehyde levels in these two groups were evaluated using Mann Whitney-U. There was a very statistically significant increase in malondialdehyde levels in serum of the skin cancer patients compared with the control group (p=0.0095, z=-2.59). Thus, increased serum malondialdehyde levels may be a sign of carcinoma.
Maternal Serum Ceruloplasmin in Preectampsia
(Wiley, 2005) Engin-Üstün, Y; Üstün, Y; Kamaci, M; Sekeroglu, R
Nightmares and Serum Cholesterol Level: a Preliminary Report
(Canadian Psychiatric Assoc, 2005) Agargun, MY; Gulec, M; Cilli, AS; Kara, H; Sekeroglu, R; Dulger, H; Inci, R
Objective: To examine whether there is a relation between nightmares and serum lipid levels. Methods: Fifteen subjects who met DSM-IV criteria for the diagnosis of nightmare disorder and 15 healthy control subjects participated in the study. We used an enzymatic colorimetric method for cholesterol and triglyceride determination. We measured high-density lipoprotien (HDL) cholesterol using the direct HDL-cliolesterot method. Low-density lipoprotein (LDL) was calculated according to the Friedewald formula. Results: Patients with nightmare disorder had. lower serum triglyceride, lower total cholesterol, and lower LDL levels than healthy control Subjects. Conclusion: These findings suggest that nightmares are associated with low serum lipid levels.
Note on Histamine Levels in Turkish Style Fermented Sausages
(Elsevier Sci Ltd, 2004) Ekici, K; Sekeroglu, R; Sancak, YC; Noyan, T
The histamine contents of Turkish style fermented sausages were determined on 46 samples of five different brands obtained from retail stores in Van in Turkey. Histamine was found in all samples in the range 19.64-87.47 mg/kg (mean 32.13 mg/kg). Histamine levels in the brands differed significantly (P < 0.01). The results suggest that the histamine levels in the sausages were not hazardous in terms of public health although they may be a potential risk to sensitive individuals. (C) 2004 Elsevier Ltd. All rights reserved.
The Role of Antioxidant Vitamins (C and E), Selenium and Nigella Sativa in the Prevention of Liver Fibrosis and Cirrhosis in Rabbits
(M H Schaper Gmbh Co Kg, 2001) Türkdogan, MK; Agaoglu, Z; Yener, Z; Sekeroglu, R; Akkan, HA; Avci, ME
This experiment was carried out to investigate the role of antioxidants such as vitamin C and E, selenium and Nigella sativa (NS) on the prevention of carbon tetrachloride (CCl4)-induced liver fibrosis in rabbits. It was found that superoxide dismutase (SOD) values in ail of the treated groups were significantly lower than those of the control at 12(th) week of experiment (p < 0.05), while at 6(th) week and 12(th) week of experiment glutathione peroxidase (GSH-Px) values in the vitamin C treated group were significantly different from the control (p < 0.05). Histopathologically, hepatocellular necrosis, degeneration and advanced fibrosis were found in the control group. Lesions were minor and only confined to midzonal regions without centrilobular necrosis and fibrosis in the NS treated animals (group B). The lesions observed in the vitamin C treated animals (group C) were similar to that of the control group. Parenchymal changes with fibrosis were less in selenium and vitamin E treated animals (group D) than in those of the control group, but more obvious than in NS group. Histopathological findings demonstrate that NS might, at least partly, be successful in the prevention of liver fibrosis in rabbits. Vitamin E plus selenium had little therapeutic effect and vitamin C seemed to be ineffective, as far as the results of this study are concerned.
Serum Lipid Levels in Patients With Dissociative Disorder
(Amer Psychiatric Publishing, inc, 2004) Agargun, MY; Özer, OA; Kara, F; Sekeroglu, R; Selvi, Y; Eryonucu, B
Objective: There may be an association between a low serum cholesterol level and dissociative disorders. Method: The subjects of the study were 16 patients with dissociative disorder and 16 normal comparison subjects (two men and 14 women in each group). Total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, and very low density lipoprotein levels were compared. Results: Patients with dissociative disorders had lower serum triglyceride, total cholesterol, low-density lipoprotein, and very low density lipoprotein levels than normal comparison subjects. Conclusions: Low serum lipid concentrations may be related to a high incidence of self-injurious behaviors and borderline features in patients with dissociative disorders.
A Study on the Determination of Histamine Levels in Herby Cheese
(A V A Agrarverlag, 2005) Sancak, YC; Ekici, K; Isleyici, O; Sekeroglu, R; Noyan, T
Cheese, like other fermented foods, may contain histamine as result of decarboxylation of histidine by microorganisms. Histamine is either psychoactive or vasoactive and may cause problems to some consumers. Histamine, has been implicated as the causative agent in several outbreaks of food poisoning. This study was conducted to determine the histamine contents of Herby cheese marketed in Van area, Turkey. Histamine levels of 47 Herby cheese samples purchased from retail stores were quantified by fluorometric o-phthalaldehyde method. Histamine was found in all samples. Histamine concentration varied from 25.62 to 957.62 mg/kg. Mean was 211.82 +/- 206.74 mg/kg. It can be said that the histamine levels in Herby cheeses of 6.38% examined in this study may be hazardous for public health. In conclusion, histamine formation should be controlled by strict use of good hygiene in both raw material and manufacturing environment, with corresponding inhibition of spoiling microorganisms.