Browsing by Author "Sekin, S."
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Article The Importance of Serum Creatine Kinase (Ck), Aspartate Aminotransferase (Ast) and Lactate Dehydrogenase (Ldh) Activities in the Diagnosis and Prognosis of Subclinic and Clinic White Muscle Disease in Lambs(Scientific and Technical Research Council of Turkey, 1996) Sekin, S.; Voyvoda, H.; Bildik, A.; Yur, F.In this study ; the importance of serum CK, AST and LDH activities in the diagnosis and prognosis of subclinic and clinic White Muscle Disease in lambs was searched in consideration of the effect of vitamin E+selenium application on these enzyme values. Akkaraman 26 lambs (8 healthy, 8 subclinically and 10 clinically affected with White Muscle Disease) were used in investigation. Serum CK, AST and LDH activities were measured according to kinetic procedure with commercial test kits. Serum CK, AST and LDH activities were significantly higher in lambs with subclinical and clinical White Muscle Disease compared to healthy lambs (p<0.01). A prophylactic or therapeutic intramuscular dosage of 1mg selenium+300 IU vitamin E for subclinically and clinically affected lambs had the effect that within one week the increased enzyme activitiy had dropped again into the normal values (p<0.05, p<0.01). It has been concluded that, the joint evaluating of serum CK, AST and LDH activities will be useful in the diagnosis, prognosis and taking prophylactic measures of subclinic and clinic White Muscle Disease in lambs.Article Modifications of Serum Iron, Copper Concentration (Si, Cu), Total and Latent Iron-Binding Capacity (Tibc, Libc), and Transferrin Saturation (Ts) in Natural Babesia Ovis Infection of Sheep(Scientific and Technical Research Council of Turkey, 1997) Voyvoda, H.; Sekin, S.; Kaya, A.; Bildik, A.The aim of this research is to find out the relationship between body temperature and serum iron parameters (SI, TIBC, LIBC and TS), copper as well as progression of a true iron deficiency in naturally Babesia ovis infected sheep. No etiologic or symtomatic therapy applied 15 Akkaraman sheep with rectal temperature above 40°C had been used for this study. Acaprin, a babesiacidal drug, had been used for treatment of the disease. Hematological and biochemical parameters were determined in blood samples collected prior and after treatment (day 1 and 7). Hematocrit (Htc) value and hemoglobin concentration (Hb) have been considered for presence and degree of anemia. Serum total, direct and indirect bilirubin (TB, DB and IB), lactate dehyldrogenase (LDH) and total protein (TP) values have been considered for the determination of anemia type. A significant negative correlation between body temperature and SI. TIBC and TS (p<0.001, p<0.01 and p<0.001, respectively) and positive correlation between body temperature and Cu (p<0.001) had been observed. Since change in serum iron parameters related to body temperature, appearances of these parameter in B. ovis infected sheep correspond to infection type rather than hemolytic anemia. In the disease, a true iron deficiency required iron preparats as an antianemic drug was not found out. It has been demonstrated that these results should be considered for the diagnosis and treatment of disturbance in iron metabolism of B. ovis infected sheep.Article Therapeutic Efficacy of Doramectin as a New Endectocid on Natural Scabe and Trichostrongylose and Changes for Some Blood Parameter of Akkaraman Sheep in Van(Scientific and Technical Research Council of Turkey, 1996) Sekin, S.; Voyvoda, H.; Testereci, H.Two studies were conducted to evaluate the endectocidal therapeutic efficacy of Doramectin on Akkaraman Sheep naturally infested with S. ovis and P. ovis in Van. PCV, Hb and TP values were evaluated for infestation status. Doramectin (1%) was administered to sarcoptic sheep as a single 200 μg/kg dosage and to psoroptic sheep as a single 300 μg/kg dosage. The control groups received a single equivalent dosage of NaCl (0.9%). The complete recovery of clinical signs on sarcoptic sheep was observed in the third week. While initial improvement of the clinical sings of psoroptic sheep was more apparent in the second week, total recovery was seen on the fourth week. In the first week 53.3% and in he second week 93.3% of the sheep tested negative for the S. ovis mite. Similary P. ovis mites had disappeared in 43.3% of the animals in the first week and in 86.7% in the second week after treatment. Three weeks after Doramection application, sarcoptic and psoroptic mites had been completely eliminated for the sheep. Doramection was also found to be 97.9% effective on nematoe eggs of the Thrichostrongylidae family (P<0.001). There were significant (P<0.001) increases in PCV and Hb, and a decrease (P<0.05 - 0.01) in TP for sarcoptic and psoroptic sheep on the 27th day of treatment. All these differences were found significant as comparied to the control groups.