Browsing by Author "Selçuk, M."

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Antioxidant Effect of Omega-3 Fatty Acids on Exercise-Induced Oxidative Stress in Rats
(Verduci Editore s.r.l, 2023) Sarikaya, M.; Aslan, M.; Çinar, V.; Çibuk, S.; Selçuk, M.; Embiyaoğlu, N.M.; Öğe, B.
OBJECTIVE: The aim of this study is to examine the effects of omega-3 supplementation on Catalase (CAT) activity, Malondialdehyde (MDA), advanced oxidation protein products (AOPP) and reduced glutathione (GSH) levels in long-term aerobic exercises in rats. MATERIALS AND METHODS: 28 male Wistar albino rats (8 weeks old, 220-350 g body weight) were included in the study. The rats were given treadmill exercise for 20 minutes at an average speed of 15 cm/s, 5 days a week, for 8 weeks. The experiment was terminated at the end of the eighth week. Blood samples were taken. CAT, MDA, AOPP and GSH analyses were performed. SPSS v. 21 package program was used in the analysis of the data. The distribution of the data was examined with the normality homogeneity test, and it was determined that it was a normal distribution. As a result, the One-Way ANOVA test, one of the parametric tests, was used. Tukey test was used to determine the difference between groups. Significance levels were evaluated as (p < 0.05). RESULTS: Statistical analysis showed a statistically significant difference between groups in CAT, MDA and GSH levels (p < 0.05), while there were no differences between the groups in AOPP levels (p > 0.05). CONCLUSIONS: In the conclusion of the study, it was determined that omega-3 supplementation caused a decrease in MDA level, an increase in CAT activity and GSH level in rats exposed to chronic long-term exercise. Thus, it can be said that omega-3 supplementation in chronic long-term exercise will provide antioxidant protection against potential oxidative damage. © 2023 Verduci Editore s.r.l. All rights reserved.
Effects of Stress Produced by Adrenocorticotropin (Acth) on Ecg and Some Blood Parameters in Vitamin C Treated and Non-Treated Chickens
(2006) Çinar, A.; Belge, F.; Donmez, N.; Taş, A.; Selçuk, M.; Tatar, M.
The aim of this study was to examine the effects of vitamin C on ECG and some blood parameters in chickens stressed by ACTH. Sixty Leghorn chickens were randomly allotted to control and experimental groups. Prior to the experimental period ECG's were recorded and blood samples were taken from both groups of chickens; some blood parameters were also determined. In the control group, isotonic sodium chloride solution was administered at a dose of 2.5 mL per chicken per day for a period of 5 days. In the experimental group, vitamin C (Redoxon Amp, Roche) was administered intramuscularly at the same dose (containing 250 mg vitamin C) and period of time. On the 5th day of the experiment chickens in both groups received 50 IU ACTH intramuscularly. Three hours following this application ECGs were recorded and blood samples were taken from both groups of chickens; some blood parameters were also determined. In conclusion, sinusoidal tachycardia was observed and an increase was determined (P<0.05) in the level of corticosterone and heterophil/lymphocytes (H/L) ratio after ACTH application in the control group.
The Protective Effects of Naringin on Some Blood Paremeters and Kidney Histopathology in Cyclophosphamide Induced Nephrotoxicity in Rats
(Ataturk Universitesi, 2018) Dağ, Y.; Şengül, E.; Selçuk, M.; Yildirim, S.; Çelebi, F.; Çinar, A.
In this study, it was aimed to investigate the protective effects of Naringin on nephrotoxicity by Cyclophosphamide (CYP)-induced rats. In our study, forty male adult Sprague Dawley rat weighing approximately 200-250 g were used and 5 gropus formed. Measurement of hematologic and biochemical parameters were done in the rat mode on the Abocus Junior Vet 5 hemogram and on Modular PP autoanalyzer instruments. In the CYP groups, Neutrophil (%) and monocyte (%) increase despite red blood cell count, white blood cell count, hematocrit value, thrombocyte count and lymphocyte (%) decrease (P<0.05). While there were a decrease in potasium and sodium levels (P<0.05), but no decrease in other parameters such as phosphorus, magnesium, chlorine and calcium. Altough glucose, creatinine and uric acid levels from renal function tests were statistically significantly increased at (P<0.05), the increase in urea, BUN and lactate dehydrogenase (LDH) values were not significant. In the histopathological exemination; It was determined that severly hydropic degeneration and coagulation necrosis in tubule ephitelia, dilatation in Bowman capsule, hyperemia in interstitial vein and glomerulus of kidney tissue by the effects of CYP. These damages in the kidney were found to be reduced as dose-dependent due to cytoprotective effects of Naringin. It was determined that different doses of Naringin suppress nephrotoxicity and the negative effect of CYP. © 2018 Ataturk Universitesi.All Rights Reserved.