Browsing by Author "Sen, Ahmet"

Now showing 1 - 3 of 3

Association of Mild Hyperbilirubinemia With Decreased Ecg-Based Ventricular Repolarization Parameters in Young Men
(Oxford Univ Press, 2021) Sengul, Cihan; Sen, Ahmet; Barutcu, Suleyman; Cakir, Cayan; Sarikaya, Remzi
Objective: Hyperbilirubinemia is associated with protection against various oxidative stress-mediated diseases. We aimed to investigate the association between bilirubin and novel electrocardiography (ECG)-based ventricular repolarization parameters. Methods: We enrolled 201 healthy men with mild hyperbilirubinemia (group 1) and 219 healthy men with normal bilirubin levels (group 2). The Tpeak-Tend (Tp-e) interval (defined as the interval from the peak of the T wave to the end of the T wave), corrected (c) Tp-e interval, QT interval, cQT interval, and Tp-e interval/QT interval ratio were measured from leads V-5 and V-6 with 20 mm/mV amplitude and 50 mm/second rate. Results: The Tp-e interval, cTp-e interval, and Tp-e interval/QT interval ratio were significantly lower in group 1 compared with group 2. The cTp-e interval showed a significant negative correlation with total bilirubin, conjugated bilirubin, and unconjugated bilirubin. The cTp-e interval (odds ratio [OR], 0.900; P=.002) and Tp-e interval/QT interval ratio (OR, 0.922; P=.04) were significantly associated with mild hyperbilirubinemia. Conclusion: We showed the association of mild hyperbilirubinemia with decreased novel ECG-based ventricular repolarization parameters.
Copeptin as a Diagnostic Ph Marker in Acute Pulmonary Embolism
(Marmara Univ, inst Health Sciences, 2022) Baykan, Necmi; Yakar, Sule; Ozkan, Seda; Sen, Ahmet; Salt, Omer; Durukan, Polat
Objective: The present study aimed to investigate the effectiveness of copeptin levels in detecting increased pulmonary artery pressure and right ventricular dysfunction in patients with acute pulmonary embolism. Methods: A total of 116 patients who presented to the emergency department with chest pain or dyspnea and were diagnosed with acute pulmonary embolism and 30 healthy controls were included in the study. Plasma copeptin levels of patients and healthy control group were measured. Right ventricular functions and pulmonary artery pressures were evaluated in echocardiography of patients diagnosed with acute pulmonary embolism. Results: Copeptin levels were significantly higher in patients with right ventricular dysfunction than in those without right ventricular dysfunction [median 1.06(0.03-7.14) vs. 0.59(0.31-2.50), p= 0.01]. Conclusion: Copeptin can be used as a new biomarker in the diagnosis of acute pulmonary embolism and in predicting right ventricular dysfunction and increased pulmonary artery pressure in patients with acute pulmonary embolism.
The Role of Plasma Copeptin Level in Determining The Severity and Mortality of Subarachnoid Hemorrhage
(Sestre Milosrdnice Univ Hospital, 2023) Ozkan, Seda; Baykan, Necmi; Salt, Omer; Yakar, Sule; Sen, Ahmet; Durukan, Polat
The study aimed to investigate the role of plasma copeptin level in setting the diagnosis, severity and mortality of patients with subarachnoid hemorrhage (SAH) admitted to the emergency department. We included patients aged >= 18 years who were diagnosed with SAH. Blood samples were collected from patients at the time of admission to the emergency department for assessment of plasma copeptin levels. The Glasgow Coma Scale (GCS), World Federation of Neurological Surgeons (WFNS), modified Fisher score, in-hospital mortality and one-year mortality rates were determined in patients. There was a statistically significant difference in plasma copeptin levels between the patients (mean: 0.78 +/- 0.41 ng/mL) and healthy controls (mean: 0.48 +/- 0.27 ng/mL) (p=0.001). There was no significant correlation of plasma copeptin levels with the GCS, WFNS, and modified Fisher scores. There was no significant difference in copeptin levels between the patients who died in the hospital (mean: 0.73 +/- 0.42 ng/mL) and those who did not (mean: 0.80 +/- 0.41 ng/mL) (p=0.41). Although plasma copeptin level may be used in the diagnosis of SAH, it does not have a role in determining the patient condition severity and mortality.