Browsing by Author "Sener, MK"

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A Simple Synthesis of 5-Ethoxycarbonyl and Ethyl 3-Benzoyl
(Hetero Corporation, 2003) Sener, A; Genç, H; Sener, MK
4-Ethoxycarbonyl-5-phenyl-2,3-dihydrofuran-2,3-dione 1 reacts with aldehydes via the acylketene intermediate 2 giving the 1,3-dioxin-4-ones 3a-e and the 1,4-bis(5-ethoxycarbonyl-4-oxo-6-phenyl-4H-1,3-dioxin-2-yl)benzene 4, and a one step reaction between dibenzoylmethane and oxalylchloride gave 3,5-dibenzoyl-2,6-diphenyl-4-pyrone 7. The reaction of 1 with dibenzoylmethane, a dicarbonyl compound, provided ethyl 3-benzoyl-4-oxo-2,6-diphenylpyran-5-carboxylate derivative 9. Compound 9 was converted into the corresponding ethyl 3-benzoyl-4-hydroxy-2,6-diphenylpyridine-5-carboxylate derivative 10 via its reaction with ammonium hydroxyde solution in 1-butanol.
Studies on Reactions of Cyclic Oxalyl Compounds With Hydrazines or Hydrazones -: 2.: Synthesis and Reactions of 4-Benzoyl Acid
(Khimiya Geterotsiklicheskikh Soedineniya, 2004) Sener, A; Kasimogullari, R; Sener, MK; Genç, H
4-Benzoyl-1-(4-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid, obtained from corresponding furan-2,3-dione and N-benzylidene-N'-(4-nitrophenyl)hydrazine, was converted via reactions of its acid chloride with various alcohols or N-nucleophiles into the corresponding ester or amide derivatives. Nitrile of the starting acid 1-(4-aminophenyl)-4-benzoyl-5-phenyl-1H-pyrazole-3-carboxylic acid was also obtained. While cyclocondensation reactions of two acids and nitrile mentioned hydrazines lead to pyrazolo[3,4-d]pyridazine derivatives, the reaction of starting acid with 2-hydrazino-pyridine provided hydrazono-pyrazole acid derivative.
Studies on the Reactions of 4-Ethoxycarbonyl With Some Nh Nucleophiles
(Tubitak Scientific & Technological Research Council Turkey, 2004) Sener, A; Genç, H; Tozlu, I; Sener, MK
4-Ethoxycarbonyl-5-phenyl-2,3-dihydro-2,3-furandione 1 was reacted with o-phenylenediamine, substituted ureas and methylcarbamate or acetamide to give quinoxaline 2, pyrimidine 3 and benzoylmalonic acid 4 derivatives, respectively. Benzoylmalonic acid derivative 4a was converted into a new oxozinedione derivative, 5, by refluxing its solution in xylene containing a catalytic amount of p-toluene sulfonic acid. In addition, triphenylpyrazole carboxylic acid derivative 6 was obtained from the reaction of 4a with diphenylhydrazine.
Studies on the Reactions of Cyclic Oxalyl Compounds With Hydrazines or Hydrazones
(Wiley, 2002) Sener, A; Kasimogullari, R; Sener, MK; Bildirici, I; Akçamur, Y
The 1H-pyrazole-3-carboxylic acid 2, obtained from the furan-2,3-dione 1 and N-Benzylidene-N'-(3-nitrophenyl) hydrazine, was converted via reactions of its acid chloride 3 with various alcohols or N-nucleophiles into the corresponding ester or amide derivatives 4 or 5, respectively. Nitrile 6 and anilino-pyrazole acid 7 derivatives of 2 were also obtained by dehydration of 5a in a mixture of SOCl2 with DMF and reduction of 2 with sodium polysulphide, respectively. While cyclocondensation reactions of 2 or 7 with phenyl hydrazine or hydrazine hydrate and 6 with only anhydrous hydrazine lead to derivatives of pyrazolo[3,4-d]pyridazinone 8 and pyrazolo[3,4-d]pyridazine amine 9, respectivel. The reaction of 2 with 2-hydrazino-pyridine provided hydrazono-pyrazole acid derivative 10, which was decarboxylated to give hydrazono-pyrazole derivative 11. Pyrazolo[4,3-d]oxazinone 12 and 2-quinolyl pyrazolo[3,4-d]pyridazine 13 derivatives were also prepared by cyclocondensation reactions of 2 with hydroxylamine hydrochloride and 7 with acetaldehyde, respectively.
Synthesis and Some Reactions of 4-Benzoyl Acid
(Tubitak Scientific & Technological Research Council Turkey, 2004) Sener, A; Akbas, E; Sener, MK
The 1H-pyrazole-3-carboxylic acid 2, obtained from the furandione 1 and 2-hydrazinopyridine, was decarboxylated to give 4-benzoyl-5-phenyl-1-pyridin-2-yl-pyrazole derivative 3. Some ester 4 derivatives of 2 were prepared by the Fischer esterification reactions of 2 with various alcohols. Cyclocondensation reactions of 2 with phenyl hydrazine or hydrazine hydrate led to the formation of derivatives of pyrazolo[3,4-d]pyridazine 5 derivatives.