Browsing by Author "Sener, S"

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Pharmacokinetics and Tissue Levels of Tilmicosin in Fowls
(Scientific Technical Research Council Turkey, 2001) Keles, O; Bakirel, T; Sener, S; Baktir, G; Dagoglu, G; Özkan, O
Tilmicosin is a long-acting macrolide antibiotic used in the treatment of respiratory disease. It was administered once (SO mg/kg b.wt) to fowls via the oral route for determination of kinetic properties and tissue levels. After oral administration, tilmicosin's pharmacokinetics conformed to a two compartment open model. Tilmicosin was slowly eliminated from the serum and lung with mean half-lives of 30.18 +/- 2.38 and 75.74 +/- 3.67 hours, respectively The mean maximum concentration of the drug in the lungs was found to be 6.2 times greater that of serum. Serum and lung tilmicosin concentrations reached peak Values 4.66 +/- 2 and 17.78 +/- 7.51 hours, respectively, after oral administration. In fowls, the apparent volume of distribution was found to be more than 1 L/kg, indicating extensive tissue distribution. The clearance Values were calculated to be 1.33 +/- 0.06 for serum and 0.11 +/- 0.004 Vh for lung. After oral administration, tilmicosin appeared to be retained at higher concentrations and for longer times in the edible tissue than in serum. The mean peak concentrations of tilmicosin were obtained in kidney 8 hours after dosing and in liver, heart and muscles 12 hours after dosing. Then, tissue concentrations decreased slowly over time and tilmicosin residues were only detected in the liver and kidney.
The Prevalence of Parasomnias in Preadolescent School-Aged Children: a Turkish Sample
(Oxford Univ Press inc, 2004) Agargun, MY; Cilli, AS; Sener, S; Bilici, M; Ozer, OA; Selvi, Y; Karacan, E
Study Objectives: To survey the prevalence of parasomnias in a population of children aged 7 to 11 years and to determine whether parasomnias are associated with medical and neurobehavioral properties. Design: Parents and children completed a pediatric sleep questionnaire that contains 27 items developed by the authors to assess parasomnias in children. Parents and children were also interviewed about the children's medical and sociofamilial history, schooling, psychological difficulties, medication intake, and the history of psychomotor and psychosocial development. Setting: NA Participants: 971 preadolescent school-aged children from 4 locations in Turkey participated in the study. Results: We found a 14.4% prevalence of parasomnia in preadolescent school-aged children. Almost every sixth child had about at least 1 parasomnia. When we examined parasomnias separately, bruxism, nocturnal enuresis, and night terrors were the most common parasomnias among both girls and boys. The prevalence of parasomnias was higher in the 9- and 10-year-old age groups than in the other age groups. Girls and boys did not differ. Children with parasomnias had higher rates of past physical illness, delays in toilet raining, behavior disturbances, adjustment problems, and learning difficulties. Conclusions: These results suggest that the prevalence of parasomnias was high in the 9- and 10-year-old age groups. Parasomnias are associated with a history of physical illness and neurobehavioral abnormalities.