Browsing by Author "Sengul, Cihan"

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Association of Mild Hyperbilirubinemia With Decreased Ecg-Based Ventricular Repolarization Parameters in Young Men
(Oxford Univ Press, 2021) Sengul, Cihan; Sen, Ahmet; Barutcu, Suleyman; Cakir, Cayan; Sarikaya, Remzi
Objective: Hyperbilirubinemia is associated with protection against various oxidative stress-mediated diseases. We aimed to investigate the association between bilirubin and novel electrocardiography (ECG)-based ventricular repolarization parameters. Methods: We enrolled 201 healthy men with mild hyperbilirubinemia (group 1) and 219 healthy men with normal bilirubin levels (group 2). The Tpeak-Tend (Tp-e) interval (defined as the interval from the peak of the T wave to the end of the T wave), corrected (c) Tp-e interval, QT interval, cQT interval, and Tp-e interval/QT interval ratio were measured from leads V-5 and V-6 with 20 mm/mV amplitude and 50 mm/second rate. Results: The Tp-e interval, cTp-e interval, and Tp-e interval/QT interval ratio were significantly lower in group 1 compared with group 2. The cTp-e interval showed a significant negative correlation with total bilirubin, conjugated bilirubin, and unconjugated bilirubin. The cTp-e interval (odds ratio [OR], 0.900; P=.002) and Tp-e interval/QT interval ratio (OR, 0.922; P=.04) were significantly associated with mild hyperbilirubinemia. Conclusion: We showed the association of mild hyperbilirubinemia with decreased novel ECG-based ventricular repolarization parameters.
The Epicardial Fat Thickness Is Associated With Fragmented Qrs in Patients With Newly Diagnosed Metabolic Syndrome
(Assoc Medica Brasileira, 2022) Akbulut, Tayyar; Saylik, Faysal; Sengul, Cihan
OBJECTIVE: The metabolic syndrome involves both metabolic and cardiovascular risk factors and is associated with cardiovascular mortality. Epicardial fat tissue plays a crucial role in deleterious effects of metabolic syndrome on the heart, including myocardial fibrosis. The fragmented QRS reflects heterogeneous depolarization of the myocardium and occurs as a result of fibrosis. Thus, we aimed to investigate whether there is an association between fragmented QRS and epicardial fat tissue in patients with metabolic syndrome. METHODS: This study enrolled 140 metabolic syndrome patients, of whom 35 patients with fragmented QRS (+) and 105 patients with fragmented QRS (-). The two groups were compared with respect to clinical, laboratory, electrocardiographic, and echocardiographic indexes. RESULTS: Fragmented QRS (+) patients had higher waist circumference, red cell distribution width, creatinine, left ventricular end-systolic diameter, left atrium diameter, septal a velocity, QRS duration, and epicardial fat tissue compared with fragmented QRS (-) patients. Waist circumference, red cell distribution width, QRS duration, left ventricular end-systolic diameter, left atrium diameter, septal a velocity, and epicardial fat tissue were significantly associated with the presence of fragmented QRS. The QRS duration and epicardial fat tissue were independently associated with the presence of fragmented QRS on surface electrocardiographic in metabolic syndrome patients. CONCLUSIONS: Epicardial fat tissue and QRS duration were independently associated with the presence of fragmented QRS. Basic echocardiographic and electrocardiographic parameters might be used for the risk stratification in metabolic syndrome patients.
Fragmented Qrs in Inferior Leads Is Associated With Non-Alcholic Fatty Liver Disease, Body-Mass Index, and Interventricular Septum Thickness in Young Men
(Aves, 2022) Sarikaya, Remzi; Sengul, Cihan; Kumet, Omer; Imre, Gurkan; Akbulut, Tayyar; Oguz, Mustafa
Objective: Fragmented QRS (fQRS) has been shown to be related to coronary heart disease, heart failure, hypertension, cardiac arrhythmia, and metabolic syndrome. Although fQRS in lateral leads is shown to be associated with a poor outcome in patients with a known cardiac disease, the knowledge about the significance and prevalence of fQRS in inferior leads is scarce. This study aimed to investigate the prevalence and predictors of fQRS in inferior leads in healthy young men. Methods: A total of 1,155 men underwent electrocardiography (ECG), hepatic ultrasonography, and routine biochemical tests. A total of 210 eligible men with fQRS in inferior leads (group 1) and 770 eligible men without fQRS in inferior leads (group 2) were compared with each other in terms of clinical, demographic, and laboratory parameters. Results: The prevalence of fQRS in inferior leads was found to 21.4%. Body mass index (BMI), systolic blood pressure (BP), creatinine, and alanine aminotransferase levels; non-alcoholic fatty liver disease (NAFLD) percentage; and interventricular septum thickness (IVST) were significantly greater in group 1 than those in group 2. BMI, IVST, NAFLD, creatinine, ALT, and systolic BP were entered in a model of multiple regression analyses to predict fQRS, a dependent variable. NAFLD was the best independent predictor of fQRS (beta=6.115, p=0.001). BMI (beta=1.448, p=0.014) and IVST (beta=1.058, p=0.029) were the other independent predictors of fQRS in inferior leads. Conclusion: This study demonstrated the association of fQRS in inferior leads with NAFLD, BMI, and IVST in young men.
The Prevalence and Correlates of T-Wave Inversion in Lead Iii in Non-Obese Men
(Churchill Livingstone inc Medical Publishers, 2020) Sengul, Cihan; Cakir, Cayan; Barutcu, Suleyman; Sarikaya, Remzi
Background: T-wave inversion in lead III was linked to displacement of the base of the heart due to abdominal adipose tissue in early electrocardiography (ECG) trials. The observation of T-wave inversion in lead III in some of the pathological and physiological conditions other than obesity suggests the possibilities of different mechanisms. We aimed to investigate the prevalence and correlates of T-wave inversion in lead III in non-obese men. Method: A total of 1240 men underwent ECG, blood pressure measurement, hepatic ultrasonography, and biochemical tests from January 2019 to December 2019. We excluded 220 subjects due to predetermined criteria. The eligible 105 non-obese men with T-wave inversion in lead III and 915 non-obese men without T-wave inversion in lead III were compared with each other in terms of clinical, demographic and laboratory parameters. Results: The mean age was 27.9 years with a range of 20 to 46 years. The prevalence of T-wave inversion in lead III was 10.3%. Body mass index (BMI), blood urea nitrogen, creatinine, alanine aminotransferase, hematocrit, and the percentage of non-alcoholic fatty liver disease (NAFLD) were significantly higher in Group with T-wave inversion while alkaline phosphatase was significantly higher in Group without T-wave inversion. In multivariable analysis, NAFLD was the best independent correlate of inverted T-wave in lead III (beta = 6.215, p < 0.0001). BMI (beta = 1.448, p b 0.001) and hematocrit (beta = 1.179, p = 0.021) were the other independent correlates of T-wave inversion in lead III. Conclusion: We demonstrated the association of T-wave inversion in lead III with NAFLD, BMI, and hematocrit in non-obese men. (C) 2020 Elsevier Inc. All rights reserved.