Browsing by Author "Senol, Serkan"

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Expression of Cd44s in Advanced Stage Esophageal Squamous Cell Carcinomas and Other Clinicopathological Prognostic Factors
(Akad Doktorlar Yayinevi, 2009) Izmirli, Mustafa; Bayram, Irfan; Senol, Serkan; Ilhan, Mahmut
CD44s is an adhesion molecule which is a member of the cell adhesion molecules family hyaladherins. CD44s has some effects including tumor-endothel interaction, cell motility and migration, cell adhesion and tumor invasion, tumor progression, and metastasing. In this study, we aimed to evaluate the CD44s expression and some other prognostic factors in patients with esophageal squamous cell carcinoma. Between 1999 and 2004, pathological specimens of 35 patients were examined by the Yuzuncu Yil University (YYU) Medical Faculty, Pathology Department and other clinical and laboratory findings were collected from Oncology Department patient files. CD44s staining was positive in 32 patients and negative in 3. The intensity of stained CD44s was positive in 30 and negative in 5 patients. Thirteen patients were well-differentiated, 18 were mid-differentiated, and 4 were poorly differentiated. Inflamatuary reactions were observed in 23 cases. The median survival was 5.3 months and the one year, two year and five year survival rates were 34.2%, 8.6% and 2.9% respectively. Treatment modality, clinical stage and tumour size at the diagnosis time was significant at univariate analysis and only treatment modality was significant in multivariate analysis. Very high CD44s expression was observed in sq cell osephageal cancer patients. CD44s may be an important marker in prognosis. Treatment modality was found as an independent factor on prognosis of osephageal cancer.
Placental Site Trophoblastic Tumor and Concomitant Primary Ovarian Leiomyoma in a Postmenopausal Woman
(Lippincott Williams & Wilkins, 2007) Bayram, Irfan; Senol, Serkan; Ozen, Suleyman; Sahin, Guler H.
Stromal Clues in Endometrial Carcinoma: Loss of Expression of Β-Catenin, Epithelial-Mesenchymal Transition Regulators, and Estrogen-Progesterone Receptor
(Lippincott Williams & Wilkins, 2016) Senol, Serkan; Sayar, Ilyas; Ceyran, Ayse B.; Ibiloglu, Ibrahim; Akalin, Ibrahim; Firat, Ugur; Aydin, Abdullah
Epithelial-stroma interactions in the endometrium are known to be responsible for physiological functions and emergence of several pathologic lesions. Periglandular stromal cells act on endometrial cells in a paracrine manner through sex hormones. In this study, we immunohistochemically evaluated the expression of epithelial-mesenchymal transition regulators (SNAIL/SLUG, TWIST, ZEB1), adhesion molecules beta-catenin and E-cadhenin), estrogen (ER)-progesterone (PR) receptor and their correlation with each other in 30 benign, 148 hyperplastic (EH), and 101 endometrioid-type endometrial carcinoma (EC) endometria. In the epithelial component, loss of expression in E-cadherin, ER and PR, and overexpression of TWIST and ZEB1 were significantly higher in EC than in EH (P<0.01). In the periglandular stromal component, beta-catenin and SNAIL/SLUG expression were significantly higher in normal endometrium and simple without atypical EH compared with complex atypical EH and EC (P < 0.01). In addition, periglandular stromal TWIST expression was significantly higher in EH group compared with EC (P<0.05). There was significantly negative correlation between beta-catenin and ER, TWIST and ER, and TWIST and PR in hyperplastic and carcinomatous glandular epithelium, whereas there was a significantly positive correlation between beta-catenin and SNAIL-SLUG, beta-catenin and TWIST, beta-catenin and ER, beta-catenin and PR, SNAIL -SLUG and ER, SNAIL SLUG and PR, TWIST and ER, TWIST and PR, in periglandular/cancer-associated stromal cells (P<0.01). In conclusion, the pattern of positive and negative correlations in the expression of epithelial-mesenchymal transition regulators (SNAIL -SLUG and TWIST), sex hormone receptors (ER and PR), and P-catenin between ECs and hyperplasia, as well as between epithelium and stroma herein, is suggestive of a significant role for these proteins and their underlying molecular processes in the development of endometrial carcinomas.