Browsing by Author "Sertogullarindan, Bunyamin"

Now showing 1 - 20 of 36

Assessments of the Associations of Thrombus Localization With Accompanying Disorders, Risk Factors, D-Dimer Levels, and the Red Cell Distribution Width in Pulmonary Embolism
(Hospital Clinicas, Univ Sao Paulo, 2015) Sunnetcioglu, Aysel; Sertogullarindan, Bunyamin; Ozbay, Bulent; Asker, Selvi; Ekin, Salemi
Objective: Pulmonary embolisms occur as a wide spectrum ranging from clinically asymptomatic thrombi to massive thrombi that lead to cardiogenic shock. The purpose of this study was to determine the associations of thrombus localization with risk factors, accompanying disorders, D-dimer levels and the red blood cell distribution width in patients with pulmonary embolism. MATERIAL AND METHODS: In 148 patients diagnosed with pulmonary embolism, the presence and anatomical localization of the thrombus were assessed via computed tomographic pulmonary angiography. The accompanying disorders, risk factors, serum D-dimer levels, and red blood cell distribution width of the patients were retrospectively evaluated. ClinicalTrials. gov: NCT02388841. RESULTS: The mean age of the patients was 54 +/- 16.0 years, and 48 patients were >= 65 years of age. The most frequent accompanying disorders were chronic obstructive pulmonary disease (22%) and malignancy (10.1%), and the most frequent risk factors were recent operation (14.1%) and immobilization (18.2%). Thrombi were most frequently observed in the right pulmonary artery (37.8%). In 31% of the patients, the thrombus was localized to the main pulmonary arteries. Immobile patients exhibited a higher proportion of thrombi in the main pulmonary arteries than mobile patients. The mean D-dimer level and the mean red blood cell distribution width in the patients with thrombi in the main pulmonary arteries were higher than those in the patients with thrombi in more distal pulmonary arterial branches. CONCLUSION: Significant associations of proximally localized thrombi with immobilization, the D-dimer levels, and the red blood cell distribution width were observed.: Pulmonary embolisms occur as a wide spectrum ranging from clinically asymptomatic thrombi to massive thrombi that lead to cardiogenic shock. The purpose of this study was to determine the associations of thrombus localization with risk factors, accompanying disorders, D-dimer levels and the red blood cell distribution width in patients with pulmonary embolism. MATERIAL AND METHODS: In 148 patients diagnosed with pulmonary embolism, the presence and anatomical localization of the thrombus were assessed via computed tomographic pulmonary angiography. The accompanying disorders, risk factors, serum D-dimer levels, and red blood cell distribution width of the patients were retrospectively evaluated. ClinicalTrials. gov: NCT02388841. RESULTS: The mean age of the patients was 54 +/- 16.0 years, and 48 patients were >= 65 years of age. The most frequent accompanying disorders were chronic obstructive pulmonary disease (22%) and malignancy (10.1%), and the most frequent risk factors were recent operation (14.1%) and immobilization (18.2%). Thrombi were most frequently observed in the right pulmonary artery (37.8%). In 31% of the patients, the thrombus was localized to the main pulmonary arteries. Immobile patients exhibited a higher proportion of thrombi in the main pulmonary arteries than mobile patients. The mean D-dimer level and the mean red blood cell distribution width in the patients with thrombi in the main pulmonary arteries were higher than those in the patients with thrombi in more distal pulmonary arterial branches. CONCLUSION: Significant associations of proximally localized thrombi with immobilization, the D-dimer levels, and the red blood cell distribution width were observed.
Betatrophin Association With Serum Triglyceride Levels in Obstructive Sleep Apnea Patients
(Wolters Kluwer Medknow Publications, 2019) Sertogullarindan, Bunyamin; Komuroglu, Ahmet Ufuk; Ucler, Rifki; Gunbatar, Hulya; Sunnetcioglu, Aysel; Cokluk, Erdem
Background: Obstructive sleep apnea (OSA) is a common sleep problem, in which patients are at increased risk for metabolic and cardiovascular problems, including metabolic syndrome, diabetes mellitus (DM), and dyslipidemia. Betatrophin is a novel protein that regulates fatty acid and triglyceride (TG) metabolism and is related to obesity and metabolic abnormalities, including metabolic syndrome, DM, and dyslipidemia. Although OSA and betatrophin share common abnormalities, their relationship has not been investigated. AIM: The aim of this study is to investigate the relationships among betatrophin, OSA, and the serum lipid profile. METHODS: Ninety consecutive patients with suspected OSA underwent polysomnography (PSG) to confirm OSA. Plasma betatrophin, leptin, adiponectin, and the full lipid profile were analyzed. The patients were categorized as OSA or control based on the apnea-hypopnea index (AHI). RESULTS: About 61% of patients had OSA, and 39% had normal PSG. The levels of betatrophin, leptin, and adiponectin were higher in patients with OSA (256.59 +/- 29.35, 374.20 +/- 37.93, and 17.86 +/- 2.63 mu g/mL, respectively) compared to the controls (141.86 +/- 26.20, 205.53 +/- 14.75, and 7.52 +/- 1.02 mu g/mL, respectively). Betatrophin levels were correlated with the AHI, leptin (r = 0.413, P = 0.002, r = 0.782, P = 0.000). TG levels were significantly higher, and high-density lipoprotein cholesterol (HDL-C) levels were lower, in OSA patients compared to controls (244 +/- 20.33 vs. 138 +/- 14.89, and 37.21 +/- 1.26 vs. 43.78 +/- 1.62, respectively). The TG level was correlated with betatrophin (r = 0.353, P = 0.013). Multiple regression analysis showed that the AHI, leptin, and arousals were independent predictors of betatrophin level (B = 1.70 P = 0.046 95%, B = 0.56 P < 0.005, and B = 1, 2, P = 0.003, respectively). CONCLUSIONS: Our results suggest a complex relationship between OSA, betatrophin, TG, and HDL, as well as other adipokines. Our results require further investigation to assess this complex association and re-evaluate previous related studies.
A Case of Sarcoidosis With Pleural Involvement
(Wiley, 2018) Sunnetcioglu, Aysel; Sertogullarindan, Bunyamin; Batur, Abdussamet; Bayram, Irfan
Sarcoidosis is a chronic, multisystem inflammatory disorder of unknown etiology that is characterized by noncaseating granulomas. Although lung involvement is common in sarcoidosis, pleural involvement is rare. Pleural involvement may manifest as a pleural effusion, pneumothorax, pleural thickening and nodules, hydropneumothorax, hemothorax, or chylothorax. Here, we describe a case of sarcoidosis with pleural nodular thickening.
Chronic Effects of Environmental Biomass Smoke on Lung Histopathology in Turkish Non-Smoking Women: a Case Series
(inst Medical Research & Occupational Health, 2012) Gunbatar, Hulya; Sertogullarindan, Bunyamin; Ozbay, Bulent; Avcu, Serhat; Bulut, Gulay; Kosem, Mustafa
Biomass is widely used for fuel in developing countries. Particles and gases of biomass burning may cause changes in the lung. In this prospective study we investigated histopathological changes in the lungs of 42 non-smoking women [mean age (59 +/- 10) years] caused by biomass smoke. We valuated exposure to biomass smoke, case histories, and the findings of physical examination, radiology, bronchoscopy, and lung histopathology. Mean exposure to biomass smoke was (28 +/- 9) hour-year (1 hour-year equals 365 hours of exposure per year with average exposure of 1 hour a day). The radiological findings were mass (42 %), reticulonodular opacities (31 %), mediastinal lymphadenopathy (26 %), pleuro-parenchymal fibrotic banding (19 %), widening of the pulmonary artery (14 %), ground glass (11 %), mosaic perfusion (9 %), consolidation (9 %), segmental or subsegmental atelectasis (7 %), and bronchiectasis (7 %). The patients were diagnosed with lung cancer (35 %), interstitial lung disease (31 %), sarcoidosis (9 %), tuberculosis (9 %), chronic obstructive pulmonary disease (4 %), chronic bronchitis (9 %), and metastasis (4 %). Bronchoscopy showed pilies, oedema, erythema, bronchus narrowing, endobronchial tumour, mucosal irregularity, increased vascularisation, blue-black anthracotic plaques, mucosal oedema, and purulent secretion. Transbronchial biopsies revealed neutrophil and lymphocyte leucocytes in the perivascular, peribronchiolar, and interalveolar septa, slightly enlarged connective tissue, thickening of the basal membrane, thickening of interalveolar septa, intimal and medial thickening of the vascular wall and vascular lumen narrowing, anthracosis between the cells and in the bronchiole epithelium. These findings confirm that biomass smoke has important toxic effects on the lung parenchyma, interstitium, and pulmonary vessels that may result in malignancies.
Comparison of the Efficacy of Cis-Platin - Gemcitabine Combination With Cis-Platin - Etoposide in Advanced and Locally Advanced Nonsmall Cell Lung Cancer
(Bilimsel Tip Publishing House, 2007) Ozbay, Bulent; Altinoz, Orhan; Islek, Ayten; Sertogullarindan, Bunyamin
In this study, we aimed to compare the efficay and toxicity of cis-platin - gemcitabine (PG) combination with cis-platin - etoposide (PE) in advanced and locally advanced nonsmall cell lung cancer. PG treatments were given to 18 patients (2 females, 16 males) and PE to 17 patients (5 females, 12 males), totally 35 patients stage III b or IV. Combination chemotherapies of cis-platin at a dose of 80 mg/m(2) on day 1, gemcitabine 1250 mg/m2 on day 1 and 8, and etoposide 100 mg/m(2) 1st, 2nd, and 3rd days, were administered. Overall response rates were found 33.3% and 41.1% in PG and PE, respectively (p > 0.01). Median survival was 5 months in both groups. One year survival was found to be 16.6% in PG group and 17.6% in PE group. Nausea and vomiting were the most frequent side effects of PE group in a rate of 64.7% (in 11 cases) followed by anemia 38.8% (in 7 cases) in PG group, and nefrotoxicity 5.8% (in one case) in PE group. As a result although we have found partial response advantage for PE combination, but not statistically significant, there was no median or one year survival advantage between both groups.
Endobronchial Tumors Presenting as Asthma
(Daedalus Enterprises inc, 2014) Arisoy, Ahmet; Ekin, Selami; Gunbatar, Hulya; Sertogullarindan, Bunyamin; Akdeniz, Huseyin; Bulut, Gulay; Demirkiran, Hilmi
Evaluation of Oxidative Damage and Antioxidant Mechanisms in Copd, Lung Cancer, and Obstructive Sleep Apnea Syndrome
(Daedalus Enterprises inc, 2016) Sunnetcioglu, Aysel; Alp, Hamit H.; Sertogullarindan, Bunyamin; Balaharoglu, Ragip; Gunbatar, Hulya
BACKGROUND: Oxidative damage is a major contributing factor to carcinogenesis and obstructive disorders in lungs. Current evidence suggests that the inflammatory processes yield to oxidative mechanisms, which underlie COPD, lung cancer, and obstructive sleep apnea syndrome (OSAS). This study aimed to evaluate the oxidative damage in these diseases by evaluating the oxidative and antioxidant biomarkers. METHODS: Malondialdehyde, 8-oxo-7,8-dihydro-2'-deoxyguanosine, and coenzyme Q10 levels were evaluated in the blood samples of subjects with COPD, lung cancer, and OSAS by high-pressure liquid chromatography. RESULTS: A total of 111 participants (35 females, 76 males) with OSAS (n = 29), COPD (n = 26), and lung cancer (n = 28) and healthy controls (n = 28) were included in the study. The malondialdehyde and coenzyme Q10 levels were significantly higher in all 3 diseases when compared with controls (P < .01), whereas 8-oxo-7,8-dihydro-2'-deoxyguanosine levels were only significantly higher than in healthy controls in subjects with lung cancer (P = .005). The highest levels of malondialdehyde and coenzyme Q10 were determined in subjects with OSAS and lung cancer, respectively. The highest 8-oxo-7,8-dihydro-2'-deoxyguanosine levels were also observed in subjects with lung cancer, but the differences of this biomarker with other diagnoses were not statistically significant (P = .56). CONCLUSION: Oxidative damage was observed in all 3 diagnoses, and, as a response to oxidative stress, antioxidant mechanisms were also active in these diseases. Malondialdehyde and 8-oxo-7,8-dihydro-2'-deoxyguanosine were found to be efficiently usable in the evaluation of oxidative damage in chronic respiratory diseases.
Evaluation of Tuberculosis Cases Detected in Our Region Between 1999 and 2003
(Turkish Assoc Tuberculosis & Thorax, 2008) Ozbay, Bulent; Sezgi, Cengizhan; Altinoz, Orhan; Sertogullarindan, Bunyamin; Tokgoz, Necla
This study investigates the extent of tuberculosis, its clinical features, the specification of the patients with tuberculosis, and evaluates diagnosis, treatment and their effectiveness in our region. The records of 645 patients admitted to the Tuberculosis Control Dispensary in our between January 1999 and December 2003 were evaluated retrospectively. The incidence of the disease was 0.012% and it was more common among young men and diagnosed mostly by individual examination. Twenty-six percent of the patients had a history of physical contact with a tuberculosis patient. The pulmonary and extra pulmonary involvement of the disease was 51.8% and 48.2%, respectively. Bacteriologic examination of the patients was as follows; 42.2% did not have a bacteriologic examination, 21.7% was smear and culture positive, 26.8% was smear and culture negative, and 8.7% was smear negative and culture positive. Diagnosis of tuberculosis by bacteriologic examination increased from 39.7% to 73.6% within years. Cure rates of the disease were between 12.5% and 34.4%. Completion rates of tuberculosis therapy were between 53.5% and 72.6% and treatment success rates were between 82% and 95% whereas mortality rates varied between 1.7% and 2.8%. In conclusion, we observed that new cases and smear positive cases of tuberculosis were more common among the young and among the people with low socioeconomic status, bacteriologic examination increased over time and the rate of successful treatment was high but the cure rate was low.
Frequency of Pulmonary Hypertension in Patients With Copd Due To Biomass Smoke and Tobacco Smoke
(Ivyspring int Publ, 2012) Sertogullarindan, Bunyamin; Gumrukcuoglu, Hasan Ali; Sezgi, Cengizhan; Akil, Mehmet Ata
Objectives; Pulmonary hypertension (PH) is a common and well established complication of chronic obstructive pulmonary disease (COPD). Its presence is associated with decreased survival. This study was designed to investigate the PH frequency and its relations in hospitalized tobacco and biomass related COPD patients. Methods and Results; The study was a retrospective review of inpatients with COPD defined as a history of tobacco or biomass smoking, Pulmonary function tests (PFT) within stable status, an echocardiogram within stable status. PH was defined as systolic pulmonary artery pressure (sPAP) > 35 mmHg. Of the 694 individuals, 600 had suitable aspects for inclusion of study. All Females were biomass exposer and males were tobacco smoker. The Prevalence of PH was found more frequent in females than males. It was more prominent in moderate level COPD cases (56,2% and 37,5%, P<0,002). Both groups had airflow limitation, hypercapnia and hypoxemia, but no differences were found in terms of PaCO2 and PaO2. However, FEVI % was lower in males than females (p<0,005). On the other hand, FVC % was lower in the females compared with the males (p < 0.02). When analyzing the influence of PFT and demographic parameters on PH in separate COPD level groups, the results a bit varied among the groups. Conclusion; Our study demonstrated that PH frequency is higher in female COPD cases due to biomass smoke than in male COPD cases due to tobacco smoke. The influence of FVC % on the risk of a person having PH increased with increasing COPD level.
Hydrocarbon Pneumonitis; Clinical and Radiological Variability
(derman Medical Publ, 2015) Sertogullarindan, Bunyamin; Bora, Aydin; Sayir, Fuat; Ozbay, Bulent
Aspiration of hydrocarbons causes respiratory pathologies from simply to critical. Our aim is to attract attention to clinical and radiological variability in these cases. We presented a 22-year old young case exposed to diesel fuel by accidental aspiration. Three days after the aspiration, because of clinical deterioration, he was admitted to our emergency clinic. In the chest radiograph on admission showed infiltration in the right middle lobe. But a right lower lobe atelectasis emerged two days later. Bronchoscopy revealed inflamed and hyperemic mucosa and no bronchial obstruction. No secondary bacterial pneumonia was seen. The patient was treated with systemic steroids and antibiotics. After two weeks of treatment there was complete clinical improvement and significant radiologic regression. In the hydrocarbon aspiration cases clinical picture is variable. Radiological picture may develop with a delay. Unless there is a new evidence for an important complication, the steroid treatment should be followed.
Influenza-Associated Pneumonia in a Turkish Area With Endemic Avian Influenza
(Wiley, 2008) Ozbay, Buelent; Sertogullarindan, Bunyamin; Tekin, Murat; Altinoz, Orhan
Background and objective: The aim of the study was to describe the effects of influenza associated with community-acquired pneumonia (CAP) on the outcome of patients in an area characterized by endemic avian influenza. Methods: Sixty patients diagnosed with CAP and requiring hospitalization were studied for the presence of influenza. Based on the presence or absence of influenza, patients were divided into two groups: group 1 were CAP patients positive for influenza and group 2 included CAP patients negative for influenza. Laboratory investigations, CXR findings and prognosis were compared. Results: Nasopharyngeal swabs or deep tracheal aspirates were tested for viral aetiology, and seven patients were positive for influenza AH3; one was positive for influenza AH1; seven were positive for influenza B; and one was positive for parainfluenza. Group 1 patients (n = 16) had a mean age of 56 years and group 2 patients (n = 45) had a mean age of 55 years. Significant increases in creatinine kinase and lymphopaenia were seen in group 1 patients. On CXR, interstitial infiltration was more marked in group 1. There was significantly higher mortality in group 1 than in group 2. Conclusion: CAP associated with influenza had a different clinical picture and outcome compared with patients without evidence of influenza.
Interestingly Foreign Bodies in Esophageal and Bronchial System: Analysis of 9 Cases
(derman Medical Publ, 2012) Sayir, Fuat; Cobanoglu, Ufuk; Sertogullarindan, Bunyamin
Aim: Foreign body aspiration and ingestion foreign body is usually seen in childhood but can occur at any age. When the diagnosis of foreign bodies are delayed, this may lead important complications. Complet or partial obstruction of the main bronchial system produces different findings. Death may occur if emergency treatment is not given. The nine interesting foreign body aspiration and ingestion cases in our clinic were evaluated. Material and Method: In our study, 9 foreign bodys aspiration and ingestion cases were treated with interesting clinical and radiological findings were reviewed for the last 1.5 years. The distribution of age of the patients ranged from 9 months-54 years. 5 male patients, 4 were female. The period between aspiration and ingestion and treatment varied from 1.5 hour and 20 years. Results: All patients underwent broncoscopy or esophagoscopy. In five cases broncoscopy or esophagoscopy were insufficient and thoracotomy or VATS was performed. In all cases, foreign bodies were removed. Mortality was not observed. Discussion: The definite diagnosis of foreign body aspiration and ingestion is confirmed by esophagoscopy or broncoscopy. History, physical examination and radyological findings is very important for diagnosis of foreign body aspiration. Othervise, the morbidity and mortality may be unavoidable.
Invasive Mechanical Ventilation Requiring Varicella Pneumonia
(Turkish Assoc Tuberculosis & Thorax, 2011) Ozbay, Bulent; Sertogullarindan, Bunyamin
We aimed to report a case of varicella pneumonia that resulted in respiratory failure requiring mechanical ventilation. The patient was a 40-year-old man whose rashes started after his childeren. developed varicella and who had a high fever, sputum and sputum with blood, cough, cold and shiver four days before admission. A treatment was commenced by an antiviral acyclovir and arnpiric ampiallin-sulbactam therapy. Although a supporting oxygen treatment, the patient whose oxygen saturation did not increase and respiratory rate was high was commenced by an invasive mechanical ventilation because of a respiratory failure. The patient that had a recovery in clinical symptoms after 36 hours was extubated and was discharged from hospital by the following week.
Investigation of Frequency of Osas in Patients With Pulmonary Hypertension by Polysomnography
(European Respiratory Soc Journals Ltd, 2013) Sunnetcioglu, Aysel; Sertogullarindan, Bunyamin; Gunbatar, Hulya; Ozbay, Bulent
Investigation of Lung Involvement With Dlco in Women Exposed To Biomass Smoke
(European Respiratory Soc Journals Ltd, 2012) Arisoy, Ahmet; Sertogullarindan, Bunyamin; Ozbay, Bulent; Ekin, Selami; Yildiz, Hanifi
Loeffler's Syndrome: an Interesting Case Report
(Wiley, 2016) Ekin, Selami; Sertogullarindan, Bunyamin; Gunbatar, Hulya; Arisoy, Ahmet; Yildiz, Hanifi
Loeffler's syndrome is an acute pneumonia with an unclear cause. One fourth of Loeffler's syndrome patients are idiopathic, although the most common etiologic causes include parasites. Asymptomatic form is usually a reversible, self-limited disease, which does not require a specific treatment regimen. We presented a 17-year-old young man with diagnosis of Loeffler syndrome.
Multiple Lung Metastases From Parotid Adenoid Cystic Carcinoma With Respiratory Failure
(derman Medical Publ, 2013) Gunbatar, Hulya; Ekin, Selami; Sertogullarindan, Bunyamin; Yavuz, Alpaslan; Bulut, Gulay
Adenoid cystic carcinoma (ACC) is one of the most common malig-nancy in secretory glands. It accounts for about 15% -25% of all malignant salivary gland carcinomas. Typically, ACC is slow growing tumors and develops distant metastasis via haematogenous. We report a case who presented with respiratory failure and multiple metastases. A 52-year-old male, underwent a radical craniofacial resection for a right parotid gland, followed by postoperative radiotherapy. He was followed-up with head CT scans for 5 years with no signs of locoregional recurrence. Physical examination was normal. Blood gases analyses showed moderate hypoxemia. pH; 7,49 pCO2; 31,8 Po2; 38,9 HCO3; 24,1 sat O2; 79,1. Thorax CT showed multiple lesions ranging in size from 5 mm to 4 cm distributed diffusely in both lungs. CT-guided fine-needle aspiration of the lung lesion was performed. Pathological analysis reported adenoid cystic carcinoma. Multiple pulmonary metastases may cause respiratory failure and requires constant vigilance by medical practitioners.
Obstructive Sleep Apnea Related To Rapid Eye Movement or Non-Rapid Eye Movement Sleep: Comparison of Demographic, Anthropometric and Polysomnographic Features
(Soc Brasileira Pneumologia Tisiologia, 2016) Sunnetcioglu, Aysel; Sertogullarindan, Bunyamin; Ozbay, Bulent; Gunbatar, Hulya; Ekin, Selami
Pulmonary Hypertension Frequency in Patients With Chronic Obstructive Pulmonary Disease Exposed To Biomass or Tobacco Smoke
(European Respiratory Soc Journals Ltd, 2012) Sertogullarindan, Bunyamin; Gumrukcuoglu, Hasan Ali; Sezgi, Cengizhan; Akil, Mehmet Ata
Pulmonary Thromboembolism in a Patient With Active Ulcerative Colitis and Lung Abscess Secondary To Pulmonary Infarction
(Pakistan Medical Assoc, 2014) Asker, Selvi; Gunbatar, Hulya; Ekin, Selami; Sertogullarindan, Bunyamin; Sunnetcioglu, Aysel
Crohn's disease and ulcerative colitis are inflammatory bowel diseases and they primarily involve intestines. Herein we report the case of a young man who, during a clinical recurrence of ulcerative colitis, presented with symptoms suggestive of a lung abscess. When the patient was re-evaluated because of unexplained shortness of breath, an area of infarction was detected that had led to the development of cavitation secondary to submassive embolism and foci of infection contained within. The patient was managed with subcutaneous heparin and he was asymptomatic during 2 months of follow-up. He completed six months of anti-coagulation therapy and any recurrence was not detected during 3 months of post-treatment follow-up.