Browsing by Author "Seven, Erbil"

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Adherence To Drop Treatment in Glaucoma Patients and Its Relationship With Progression
(2021) Özer, Muhammet Derda; Seven, Erbil; Öcal, Halit; Tekin, Serek; Batur, Muhammed; Yaşar, Tekin
Purpose: To evaluate the adherence of glaucoma patients to eye drop therapy and determine the effects of treatment adherence on disease progression. Materials and Methods: A total of 147 patients followed at Van Yüzüncü Yıl University Department of Ophthalmology, between March 2019 and June 2019 were included in the study. Patients were examined and asked questions. Patients underwent peripapillary retinal nerve fi ber layer analysis via optical coherence tomography. Results: It was found that 66% of the patients adhered to eye drop treatment. The most common reasons for non-adherence were forgetting (40%) and running out of eye drop (38%). Correct instillation technique was demonstrated by 59% of the patients. There was signifi cantly less disease progression in adherent patients compared to non-adherent patients (p=0.002) and in patients with correct instillation technique compared to those without (p=0.001). Conclusion: This study showed adherence to eye drop therapy was 66% among glaucoma patients and 59% of patients showed correct drop instillation technique. More progression was observed in patients with poor adherence and patients who did not instill drops correctly.
Anterior Lens Capsule and Iris Thicknesses in Pseudoexfoliation Syndrome
(Taylor & Francis inc, 2017) Batur, Muhammed; Seven, Erbil; Tekin, Serek; Yasar, Tekin
Purpose: The aim of this study was to evaluate anatomic properties of the lens capsule and iris by anterior segment optical coherence tomography (AS-OCT) in patients with pseudoexfoliation (PEX).Methods: This prospective study included 62 eyes of 62 patients with PEX syndrome and 43 eyes of 43 age- and gender-matched controls. All subjects underwent full ophthalmologic examinations including AS-OCT. Pupillary diameter, midperipheral stromal iris thickness, central and temporal lens capsule thicknesses, and peripheral pseudoexfoliation material thickness on the anterior lens capsule surface were measured and recorded.Results: Mean age was 66.8 9.3 years in the PEX group and 65.5 +/- 8.9 years in the control group (p = 0.44). The PEX group consisted of 62 patients: 38 men (61.3%) and 24 women (38.7%); the control group included 43 subjects: 25 men (58.1%) and 18 women (41.9%). Pupillary diameter after pharmacologic mydriasis was 21% smaller in the PEX group than controls. Mean midperipheral iris thickness was 36 +/- 7.2 m (7.8%) thinner in the PEX group than that of control group (p = 0.047). The central anterior capsule was a mean of 3.40 +/- 0.51 m (18%) thicker in the PEX group compared to the control group (p = 0.0001). The temporal anterior lens capsule was a mean of 0.17 +/- 0.15 m thicker in the PEX group compared to the control group (p = 0.81).Conclusions: With high-resolution OCT imaging, it has become possible to evaluate the anterior lens capsule without histologic examination and demonstrate that it is thicker than normal in PEX patients.
Arka Kapsülotomi Yapılmayan Okul Öncesi ve Okul Çağı Pediatrik Katarakt Cerrahi Olgularında Arka Kapsül Kesafeti
(2016) Batur, Muhammed; Yaşar, Tekin; Gül, Adem; Seven, Erbil; Can, Ertuğrul
Amaç: Arka kapsülotomi ve ön vitrektomi yapılmadan katarakt cerrahisi yapılan okul öncesi ve okul çağı pediatrik hastalarımızın arka kapsül kesafeti (AKK) gelişme durumunu değerlendirmeyi amaçladık.Gereç ve Yöntem: Pediatrik katarakt nedeniyle ameliyat olup göz içi lens (GİL) implantasyonu yapılan 21 hastanın 30 gözüne ait kayıtlar retrospektif olarak incelendi. Olguların yaşı, AKK gelişme durumu, zamanı, optik aksı kapatma durumuna göre neodymiumdoped yttrium aluminium garnet (Nd:YAG) lazer ihtiyacı ve takip süreleri kaydedildi. Bulgular: Hastaların ortalama yaşı 7,6±2,83 yıl idi. On iki (%57,14) hastanın tek gözüne, dokuz hastanın (%42,86) her iki gözüne katarakt ameliyatı ve GİL implantasyonu uygulandı. Ortalama takip süresi 17,7±22,67 ay idi. Yirmi bir (%70) gözde AKK gelişti, bunlardan 15 (%50) gözde Nd:YAG lazer ile arka kapsülotomi gerektirecek düzeyde optik aksı kapatmaktaydı. Ameliyat sonrası AKK gelişme ortalama süresi 8,91±18,7 (1 hafta-71 ay) ay idi.Sonuç: Okul öncesi ve okul çağı pediatrik kataraktlarda cerrahi tecrübe de göz önüne alınarak hastanın özelliklerine göre katarakt ekstraksiyonu ile aynı seansta arka kapsülotomi (ve ön vitrektomi) kararının verilmesinin uygun olduğunu düşünüyoruz.
Assessment of Serum Catalase, Reduced Glutathione, and Superoxide Dismutase Activities and Malondialdehyde Levels in Keratoconus Patients
(Springernature, 2022) Tekin, Serek; Seven, Erbil
Background: The aim of this study was to investigate the relationship between keratoconus disease and the antioxidant activities of catalase (CAT), reduced glutathione (GSH) and superoxide dismutase (SOD) and the level of the oxidative stress marker malondialdehyde (MDA) in serum. Methods: The study included 50 patients diagnosed with keratoconus and 53 healthy age- and sex-matched control subjects. The keratoconus patients were grouped according to the four keratoconus stages based on the modified Krumeich keratoconus classification system. The CAT, GSH and SOD activities and MDA levels in the serum samples collected from the patient and control groups were compared. Results: The mean serum CAT, GSH, SOD and MDA levels in the keratoconus group were determined to be 0.075 (0.074-0.078)U/L, 0.002 (0.001-0.006) mmol/ml, 1.56 (1.51-1.62)U/L and 1.69 (1.65-1.99) mmol/L, respectively, and those in the control group were determined to be 0.024 (0.013-0.037)U/L, 0.029 (0.018-0.049) mmol/ml, 4.13 (4.01-4.17) U/L and 0.74 (0.65-0.82) mmol/L. The serum GSH levels and SOD activity were significantly lower in the keratoconus group (p < 0.001 for both) than in the control group while the CAT activity and MDA levels were significantly higher (p < 0.001 for both). Conclusion: The low serum GSH levels and SOD activity and the high CAT activity and MDA levels observed in this study suggest the presence of oxidative stress and inadequate antioxidant defence mechanisms in keratoconus patients. The studied parameters may offer auxiliary markers for use in the diagnosis and treatment of the keratoconus disease and in its potential therapeutic targets in the future.
Authors' Reply To: Using Anterior Segment Optical Coherence Tomography To Compare the Smoothness of Anterior Iris Surface Between Two Eyes in Unilateral Fuchs' Uveitis Syndrome
(Springer, 2019) Ozer, Muhammet Derda; Kebapci, Fatih; Batur, Muhammed; Seven, Erbil; Tekin, Serek
Bakteriyel Keratit Tedavisinde Koenzim Q10 Göz Damlasının Korneal Yara İyileşmesi Üzerine Etkisi: Prospektif Klinik Çalışma
(2024) Batur, Muhammed; Seven, Erbil; Tekin, Serek; Ozer, Muhammet Derda
Amaç: Bu çalışmada, bakteriyel keratitte Koenzim Q10 (KoQ10) göz damlasının korneal yara iyileşmesi üzerindeki etkinliğini ve güve- nilirliğini değerlendirmeği amaçladık. Gereç ve Yöntemler: Bakteri- yel keratit tanısıyla yatırılarak tedavisi yapılan hastalar çalışmaya alındı. Hastaların yaşı, cinsiyeti ve hangi gözün tutulduğu kaydedildi. Hasta- lara tam bir göz muayenesi yapıldı ve hipopiyon olup olmadığı kayde- dildi. Korneal ülser büyüklüğü yatay ve dikey olarak ölçüldü. Hastalar rastgele 2 gruba ayr ıldı. Her iki gruba da topikal antibiyotik ve siklo- pentolat damla verildi. Birinci gruba ek olarak KoQ10 göz damlası 4×1 tedaviye eklendi. Tedavi öncesi ve tedaviye ba şlandıktan sonra ülser iyileşene kadar günlük olarak korneal ülser görüntüleri al ındı ve kay- dedildi. Bulgular: Çalışmaya alınan toplam 32 hastanın yaş ortalaması 51,16±25,31 (7-90) yıl olup, 20’si (%62,5) erkek, 12’si (%37,5) kadın idi. KoQ10 göz damlası verilen grup (n=16) ile kontrol grubunun (n=16) yaş, cinsiyet, sağ-sol göz tutulumu, hipopiyon varlığı ve korneal ülser boyutu açısından istatistiksel olarak anlamlı farkı yoktu (p>0,05). Or- talama iyileşme süresi KoQ 10 göz damlası verilen grupta 12,25±6,02 gün ve kontrol grubunda 19±12,9 gün idi (p=0,076). Sonuç: KoQ10 göz damlası, bakteriyel keratite bağlı gelişen korneal ülser tedavisindeki etkisi istatistiksel olarak anlaml ı bulunamadı. Ancak iyile şme süresi- nin kısalması açısından adjuvan ajan olarak düşünülebilir. Bu konuda daha geniş serilere sahip randomize, prospektif klinik çalışmalara ihti- yaç vardır.
A Case: Abscess Formation in the Sub-tenon's Space After Strabismus Surgery
(2017) Batur, Muhammed; Çağlar, İsmail Çağatay; Gül, Adem; Yaşar, Tekin; Seven, Erbil
A five-year-old boy was examined in follow-up in our strabismus department due to exotropia and amblyopia in the right eye. Recession to both lateral recti muscles was performed. When the patient was examined one week, postoperatively, he complained of pain in the right eye. Upon physical examination, hyperemia and minimal swelling of the surgical area were observed. The situation was diagnosed as an abscess. The abscess was drained and the eye was irrigated with cefazolin and gentamicin solutions. All signs and symptoms were determined to be resolved in subsequent postoperative visits.
Choroid Vascularity Index as a Parameter for Chronicity of Fuchs' Uveitis Syndrome
(Springer, 2020) Ozer, Muhammet Derda; Batur, Muhammed; Tekin, Serek; Seven, Erbil; Kebapci, Fatih
Purpose This study aimed to compare the choroidal vascularity index (CVI) of eyes having Fuchs' uveitis syndrome (FUS) with healthy fellow eyes (N). Methods This prospective, cross-sectional study included unilateral FUS cases and an age- and gender-matched healthy control group. Thirty-nine participants were included in the FUS group, and 24 age- and gender-matched individuals were randomly selected for the control group. Endothelial cell density (ECD) was measured using Tomey specular microscopy. Spectral-domain optical coherence tomography was used to acquire the choroidal images, and binarization was applied to the images. Two blinded investigators analyzed the CVI in both eyes of the FUS cases and the right eyes of the healthy control group. Results CVI was found to be significantly decreased in FUS (p < 0.001). Additionally, ECD had a strong positive correlation with CVI (r = 0.383, p = 0.008). Conclusion CVI may provide information about the chronicity of the disease.
Comparative Analysis of Oxidative Stress Biomarkers in 50 Primary Open-Angle Glaucoma Patients
(int Scientific information, inc, 2025) Seven, Erbil; Tekin, Serek
Background: Glaucoma, a leading cause of irreversible blindness, is associated with increased oxidative stress and impaired antioxidant defense mechanisms. This study compared serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) in 50 patients with primary open-angle glaucoma (POAG) and 52 healthy controls. Material/Methods: Fifty patients in the POAG group and 52 age-and sex-matched individuals in the control group were included in the study. SOD activity was evaluated using the optical density of the blue formazan dye formed at 560 nm due to the interaction of nitroblue tetrazolium with xanthine and superoxide radicals generated by xanthine oxidase. CAT activity in serum was assessed using hydrogen peroxide and phosphate buffer solution. Measurement of GSH levels was performed using a phosphate buffer and DTNB (Ellman's reagent) solution. MDA levels were quantified by measuring the colored complex formed with thiobarbituric acid. All biomarkers were measured using spectrophotometric methods. Results: The results indicated significantly higher serum MDA levels (P<0.001) and CAT levels (P<0.001), along with lower SOD levels (P<0.001) and GSH levels (P<0.001) in patients with POAG compared to the controls. Conclusions: These findings suggest that POAG patients experience increased oxidative stress and have an insufficient antioxidant defense system. The imbalance in the oxidant-antioxidant equilibrium in POAG patients suggests a role of oxidative stress in pathogenesis of the disease. Evaluating serum levels of these biomarkers could be valuable for diagnosing and treating POAG.
A Comparative Evaluation of Cataract Classifications Based on Shear-Wave Elastography and B-Mode Ultrasound Findings
(Springer international Publishing Ag, 2019) Ozgokce, Mesut; Batur, Muhammed; Alpaslan, Muhammed; Yavuz, Alpaslan; Batur, Abdussamet; Seven, Erbil; Arslan, Harun
In this study, a comparison is made of the findings of B-mode ultrasound and ultrasound elastography with the Lens Opacities Classification (LOCS) grade in patients with senile cataracts. A total of 74 patients with cataracts and 32 age-matched healthy volunteers as the control group were evaluated in the departments of ophthalmology and radiology between 2016 and 2017. In the patient group, cataracts were graded according to LOCS, and B-mode sonographic appearance and elasticity measurements were recorded, after which the cataract grade and sonoelastography/B-mode ultrasound findings were compared using statistical methods. Among the 74 patients with cataracts, 38 were females (51.4%) and 36 were males (48.6%), and the mean age was 62.05 +/- 7.95 (43-78) years. A Chi-square test revealed a significant relationship between ultrasound echogenicity of cataract and grade of cataract (p < 0.005). The ultrasound elastography revealed a mean shear-wave velocity of 2.90 m/s +/- 0.371 (2.13-3.53) among patients with grade 3 cataracts, 3.1 m/s +/- 0.45 (2.26-3.98) among patients with grade 4, 3 m/s +/- 0.58 (2.35-4.60) among patients with grade 5 and 3 m/s +/- 0.528 (2.31-4.50) among patients with grade 6 cataracts, and 3 m/s +/- 0.258 (2.36-3.58) among the normal subjects. No statistically significant difference was noted in the analysis of variance (p > 0.005). While cataract grade and B mode echogenicity were directly proportional, there was no significant difference in lens elasticity.
Comparison of the Efficacy of Accelerated Corneal Cross-Linking Therapy in Different Pediatric Age Groups Having Progressive Keratoconus
(Springer, 2020) Ozer, Muhammet Derda; Batur, Muhammed; Mesen, Selma; Tekin, Serek; Seven, Erbil; Yasar, Tekin
Purpose To report a comparison analysis of accelerated corneal cross-linking (A-CXL) treatment for progressive keratoconus patients in different pediatric age groups. Study design Retrospective, cross-sectional. Methods Patients with progressive keratoconus aged <= 18 were retrospectively reviewed. Forty-one eyes of 41 patients were included in the study. Patients were divided into two groups according to their age (<= 14 years and 15-18 years). All patients underwent epithelium-off A-CXL protocol. Acquired data were compared between the two groups. Results The mean age was 14.3 +/- 1.8 (10-18) years. Twenty-five (61%) of the participants were male, and 16 (39%) were female. Twenty (49%) patients were separated into group 1 (<= 14 years of age), and 21 (51%) were in group 2 (15-18 years). Age at presentation was found to be the only factor in anticipating the progression of keratoconus at the second postoperative year visit (p < 0.001). Progression in keratometric values was detected in seven (35%) of the 20 eyes in group 1, and one (4%) of the 21 patients in group 2 (Z = - 2.44, p = 0.014). Conclusion Even if proper treatment is applied, the progression of keratoconus is likely in patients younger than 14 years of age. Instead of evaluating pediatric patients as a whole, closer follow-up and early treatment may be useful in younger age groups (<= 14 years).
Comparison of Three Different Intraocular Lens Implantation Method for Eyes With Defi Cient Capsular Support
(2021) Tekin, Serek; Özer, Muhammet Derda; Yavuzer, Beyza; Yaşar, Tekin; Batur, Muhammed; Seven, Erbil
Purpose: The aim of this study was to compare three different intraocular lens (IOL) implantation methods performed primary or secondary in eyes with defi cient capsular support. Materials and Methods: The records of patients who underwent IOL implantation due to defi cient capsular support were analyzed. The patients were fi rst separated into primary and secondary IOL implantation group (PIG and SIG, respectively), then divided into three subgroups among themselves as iris-claw IOL (IC-IOL), scleral fi xated IOL (SF-IOL), and anterior chamber IOL (AC-IOL). Data were compared according to the groups. Results: The most important cause of IOL implantation was perioperative capsule rupture and insuffi cient capsular support (61.7%, n=29) in PIG, aphakia (55.8%, n=24) in SIG. The most preoperative comorbid condition was iridodonesis (30.4%, n=14) in PIG and IOL subluxation (93.8%, n=15) in SIG. The mean BCVA in the 3rd months was signifi cantly better in the IC-IOL subgroup than AC-IOL subgroups (p=0.001) in PIG. The mean BCVA at the last follow-up was signifi cantly better in the SF-IOL group than the AC-IOL group (p<0.001) in PIG. Postoperative complication rate was 38.3% in PIG and 27.9% in SIG. There was no signifi cant difference among subgroups in postoperative complications in both groups (p>0.05, Chi-square test). Conclusion: All three methods have advantages and disadvantages. The surgeon should consider the patient’s condition when determining the implantation method to be chosen. Future long-term studies comparing the different methods with a large number of patients may provide more information about the most appropriate method to use in eyes with insuffi cient capsular support.
Conjunctival Lymphangiectasis: Successful Surgical Resection of an Idiopathic Case
(Ophthoscience Publ, 2019) Seven, Erbil; Batur, Muhammed; Tekin, Serek; Bulut, Gulay; Yasar, Tekin
Conjunctival lymphagiectasis is a topical ocular condition characterized by swelling of conjunctiva as a result of dilated lymphatics of the bulbar conjunctiva. In this case report, a 51-year-old man presented with conjunctival swelling in the left eye. Conjunctival lymphangiectasis was diagnosed and a conjunctival resection was performed. No recurrence was found in follow-up examination at 9 months.
Corneal Parameters, Ocular Biometers, and Retinal and Choroidal Thickness in Acromegaly Patients
(Elsevier, 2023) Batur, Muhammed; Ozer, Muhammet Derda; Ucler, Rifki; Seven, Erbil; Tekin, Serek; Unal, Fikret
Background: To compare ocular findings of acromegaly patients with healthy individuals and investigate the relation of serum levels of insulin-like growth factor (IGF-1) along with growth hormone (GH) and pituitary tumor (adenoma) dimensions (TD) with specific ocular parameters. Methods: The ocular parameters of acromegaly patients (n = 38) were compared with those of healthy subjects (n = 36). These parameters were intraocular pressure, keratometric (K1-K2) values, central corneal thickness (CCT), total axial length along with anterior chamber-lens-vitreous length, retinal nerve fiber layer (RNFL) thickness, central foveal thickness (CFT), choroidal thickness (CT), ganglion cell layer thickness (GCLT), and inner plexiform layer thickness (IPLT). Also investigated was whether there was a correlation between disease duration, TD, GH, IGF-I, CCT, RNFL, CFT, GCLT, IPLT, and CT. Results: The lens length of the acromegaly group was increased (p = 0.014). GH and IGF-1 levels were positively correlated with CT and CCT, respectively (p = 0.041, r = 0.343) (p = 0.03, r = 0.347). Analysis of TD also found a highly negative correlation with the mean RNFL thickness of the acromegaly patients (p < 0.01, r = -0.603). The mean value of the inner parts of GCLT and IPLT was negatively correlated with TD (p = 0.041, r = -0.343 and p = 0.025, r = -0.379, respectively). Conclusion: Serum IGF-1 and GH levels might be determinant factors in CCT and CT, respectively. The pituitary adenoma size increasing may be prone to lead RNFL, ganglion cell layer, inner plexiform layer thinning. Increased lens thickness was found in the acromegaly group.
The Depigmentation Degree of Iris Pigment Epithelium in Pseudoexfoliation Syndrome
(Elsevier, 2021) Ozer, Muhammet Derda; Batur, Muhammed; Tekin, Serek; Seven, Erbil; Kebapci, Fatih; Bilmez, Rumeysa
Background: To compare the optical density of iris pigment epithelium (ODIPE) and iris stromal thickness (IST) measurements in patients having pseudoexfoliation syndrome (PXS) and age-gender matched participants. Methods: This is a cross-sectional study. Patients with PXS were enrolled in the study group. Age and gendermatched healthy subjects with no evidence of PXS were recruited as controls. After a comprehensive ophthalmological evaluation, the anterior segment images were acquired using anterior segment spectral-domain optical coherence tomography (AS SD-OCT). The acquired pictures were further analyzed using the ImageJ program. Two investigators measured the ODIPE and the IST of the subjects, and the repeatability and reproducibility were checked. SPSS program was used for statistical analysis. Results: The PXS group was comprised of twenty-two eyes (n = 22 patients), and the control group contained twenty-six eyes of 26 age and gender-matched healthy subjects. The mean temporal ODIPE of the study group was found to be decreased significantly in comparison to the mean temporal ODIPE of the control eye (p = 0.018). Both the mean nasal (N) and temporal (T) ISTs of the PEX eyes were thinner than the control eyes (p = 0.006 and p = 0.002, respectively). The mean baseline IOP was found to significantly negatively correlate with the ODIPE in the PEX group at both N and T sides (r = -0.531, p = 0.011 and r = -0.685, p < 0.001, respectively). Conclusion: The pupillary margin IPE was found more depigmented, and the mean N and T IST were significantly thinner in the PEX group by comparison with the age-gender matched healthy controls. The mean baseline IOP was negatively correlated with the pupillary margin's IPE pigmentation degree in patients with PXS.
Effect of Insulin Therapy on Ocular Biometric Parameters in Diabetic Patients
(Mary Ann Liebert, inc, 2020) Seven, Erbil; Yildiz, Saliha; Tekin, Serek; Altas, Ahmet Serkan; Ozer, Muhammet Derda; Batur, Muhammed; Yasar, Tekin
Purpose: To evaluate effects of insulin on ocular parameters in patients with type 2 diabetes mellitus who start insulin therapy. Methods: In this prospective study, ocular biometric parameters were obtained using optical biometer (Lenstar LS900; Haag-Streit AG) and refraction test (ARK-510A Auto refracto-keratometer; Nidek Co. Ltd, Aichi, Japan) before and at 3 months after initiating insulin therapy. In addition, patients' fasting blood glucose (FBG), glycosylated hemoglobin (HbA1C), and blood lipid levels were measured at the same time points. Pretreatment and post-treatment results were compared. In addition, associations between ocular parameters with initial dose and type of insulin treatment regimen, HbA1C, and FBG levels were evaluated. Results: The patients' mean age was 51.2 +/- 12.9 (18-73) years. Post-treatment HbA1C and FBG levels (8.5% +/- 2.5% and 188.1 +/- 111.2 mg/dL, respectively) were significantly lower than pretreatment values (12% +/- 1.4% and 325.3 +/- 95.7 mg/dL, respectively; P < 0.001 for both). There was a significant positive correlation between the change in HbA1C and the change in lens thickness (P = 0.03), and a significant negative correlation between the change in FBG and the change in the spherical equivalent refraction (P = 0.045). Insulin dose and treatment regimen type were not significantly correlated with ocular parameters (P > 0.05). Conclusion: HbA1C-lowering glycemic effect of insulin was correlated with a small decrease in lens thickness. Long-term, randomized controlled trials including larger patient numbers are needed to shed light on the long-term effects of insulin use and glycemic control on ocular parameters.
Effect of Intravitreal Bevacizumab That Applied in Exudative Age-Related Macular Degeneration on Intraocular Pressure and Ocular Pulse Amplitude
(2012) Seven, Erbil; Yaşar, Tekin
Eksüdatif Yaşa Bağlı Maküla Dejenerasyonunda Uygulanan İntravitreal Bevasizumabın Oküler Nabız Amplitüdü ve Göz İçi Basıncına EtkisiEksüdatif yaşa bağlı maküla dejenerasyonu (YBMD) gelişmiş ülkelerde 50 yaş üzerinde santral görme kaybının ve körlüğün en yaygın sebebidir. Bu çalışmada, eksüdatif YBMD hastalarının tedavisinde kullanılan bir anti-vasküler endotelyal büyüme faktörü (anti-VEGF) olan bevasizumabın intravitreal enjeksiyonunun oküler nabız amplitüdü (ocular pulse amplitude, OPA) ve göz içi basıncı (GİB) üzerine etkilerini değerlendirme amaçlanmıştır.Çalışma Eylül 2011- Şubat 2012 tarihleri arasında prospektif olarak yürütülmüştür. Çalışmada lezyon tipine bakılmaksızın, YBMD'ye sekonder gelişen koroid neovaskülarizasyonlarına (KNV) intravitreal bevasizumab enjeksiyonu uygulanmıştır. Çalışmaya 39 hastanın 39 gözü dahil edildi. Enjeksiyon öncesi, sonrası 1. gün,1. hafta ve 4. haftada Goldmann aplanasyon tonometresi (GAT) ile GİB, Paskal dinamik kontur tonometre (DKT) ile GİB ve OPA ölçümleri yapıldı. Hastaların santral kornea kalınlığı (SKK) ve aksiyel uzunluk ölçümleri yapıldı. Tedavi öncesi ve sonrası ortalama en iyi düzeltilmiş görme keskinlikleri (EİDGK) karşılaştırıldığında enjeksiyon sonrası 1. hafta ve 4. haftada istatistiksel olarak anlamlı bir görme keskinliği artışı saptandı (p<0.05). Enjeksiyon öncesi ile sonrası GAT-GİB değişimi enjeksiyon sonrası 1.gün ve 1. haftada istatistiksel olarak anlamlı idi (p<0.05). Enjeksiyon öncesi ile sonrası DKT-GİB değişimi enjeksiyon sonrası 1.gün, 1. hafta ve 4. haftada istatistiksel olarak anlamlı idi (p<0.05). Enjeksiyon öncesi ile sonrası DKT-OPA değişimi enjeksiyon sonrası 1.gün ve 1. haftada istatistiksel olarak anlamlı idi (p<0.05). Hastaların DKT-OPA değerleri ile yaş, aksiyel uzunluk ve SKK arasında herhangi bir korelasyon bulunamadı.Çalışmamızdaki sonuçlar, bevasizumabın eksüdatif YBMD'li hastalarda görme keskinliğini arttırdığını göstermiştir. Ancak, enjeksiyon sonrası erken dönemde, OPA (toplam koroidal kan dolaşımının indirekt bir göstergesidir) daki anlamlı düşüşün, her ne kadar ciddi yan etki ortaya çıkmasa da oküler hipoperfüzyonla ilişkili olabileceği ve gelişebilecek olası komplikasyonlar unutulmamalıdır. Bu yüzden, tedavi için uygun hasta seçimi yapılmalıdır.
Effectiveness of Pulmonary Surfactant in the Treatment of Corneal Edema
(Mary Ann Liebert, inc, 2021) Artuc, Tuncay; Batur, Muhammed; Seven, Erbil; Tekin, Serek; Ozer, Muhammet Derda
Purpose: To compare the effectiveness of topical surfactant and 3% sodium chloride (NaCl) in the treatment of corneal edema occurring after cataract surgery. Methods: Ninety eyes of 90 patients with no corneal disease who underwent cataract surgery were included in the study. Thirty eyes without corneal edema comprised group 1. Patients with corneal edema were divided into two groups: those treated with 3% NaCl (group 2, 30 eyes) and those treated with surfactant drop (group 3, 30 eyes). Results: The mean age was 70.8 +/- 6.6 years, with no significant age difference between the groups. Preoperatively, there was no significant difference in mean central corneal thickness (CCT) or mean endothelial cell count (ECC) among the groups (P = 0.999). On postoperative day 1, CCT was significantly lower in group 1 (P < 0.001) but did not differ between groups 2 and 3 (P = 0.999). There was no significant difference between groups in terms of ECC (P > 0.05). At postoperative day 7 and 14, CCT differed significantly between groups 1 and 2 (P < 0.001) and between groups 2 and 3 (P = 0.001), with no significant difference between groups 1 and 3 (P = 0.474). ECC was significantly higher in group 1 (P < 0.05), whereas there was no significant difference between groups 2 and 3 (P > 0.05). Conclusion: Topical pulmonary surfactant may be a more effective treatment option than 3% hypertonic NaCl for the treatment of corneal edema that develops after cataract surgery.
Eksüdatif Yaşa Bağlı Maküla Dejenerasyonunda Uygulanan İntravitreal Bevacizumab Tedavisi Sonrası Oküler Nabız Amplitüdü ve Göz İçi Basıncında Değişimler
(2015) Batur, Muhammed; Yaşar, Tekin; Seven, Erbil
Amaç: Bu çalışmada eksüdatif Yaşa Bağlı Maküla Dejenerasyonu (YBMD) hastalarının tedavisinde kullanılan İntravitreal Bevacizumab enjeksiyonu (İVB)'nun oküler nabız amplitüdü (Ocular Pulse Amplitude, OPA) ve Göz İçi Basıncı (GİB) üzerine etkilerini değerlendirme amaçlanmıştır.Gereç ve Yöntem: Çalışma prospektif olarak yürütüldü. Lezyon tipine bakılmaksızın, YBMD'ye sekonder gelişen Koroid Neovaskülarizasyonları (KNV)'na İVB uygulandı. Çalışmaya 39 hastanın 39 gözü ve kontrol grubu için enjeksiyon yapılmayan diğer 39 gözü dahil edildi. Enjeksiyon öncesi ve enjeksiyon sonrası 1. gün, 1. hafta ve 4. haftada Goldmann Aplanasyon Tonometresi (GAT) ile GİB, Paskal Dinamik Kontur Tonometre (DKT) ile GİB ve OPA ölçümleri yapıldı. Tedavi öncesi ve sonrası alınan ölçümler istatistiksel olarak karşılaştırıldı.Bulgular: GAT-GİB değeri enjeksiyon sonrası 1. günde ve 1. haftada enjeksiyon öncesine göre istatistik olarak anlamlı derecede azaldı (p<0.05). DKT-GİB değeri enjeksiyon sonrası 1. günde, 1. haftada ve 4. haftada enjeksiyon öncesine göre istatistik olarak anlamlı derecede azaldı (p<0.05). DKT-OPA değeri enjeksiyon sonrası 1. günde ve 1. haftada enjeksiyon öncesine göre istatistik olarak anlamlı derecede azaldı (p<0.05). Tartışma: İVB sonrası erken dönemde OPA'daki anlamlı düşüş, birçok neden yanı sıra global koroid dolaşımındaki azalmaya da bağlı olabilir.
Epidemiology of Adult Open Globe Injury
(Lippincott Williams & Wilkins, 2016) Batur, Muhammed; Seven, Erbil; Esmer, Oktay; Akaltun, Mahmut Nedim; Yasar, Tekin; Cinal, Adnan
Objective:The aim of this study was to evaluate the epidemiology and outcomes of adult open globe injuries (OGI) in the eastern part of Turkey.Methods:The retrospective study included all the patients who were diagnosed with OGI (436 eyes in 425 patients) at our clinic between 1997 and 2015. The OGI patients aged over 16 years were included into the study. Open globe injuries were classified according to the Ocular Trauma Classification. Age, gender, medical history, time between trauma and hospital admission, and mechanism of injury were recorded for each patient.Results:The incidence of OGI in adults was found to be 3.40/100,000, with 5.00/100,000 in males and 1.67/100,000 in females. Open globe injuries were mostly seen in the age group of 17 to 29 years and in October and November. The patients included 79.5% males and 20.5% females. Intraocular foreign body was detected in 99 (22.7%) eyes. A strong, linear, negative correlation was found between the Ocular Trauma Classification values and final visual LogMAR (r(p) = -0.602, P = 0.0001). The most common mechanism of injury was occupational accident (38.4%).Conclusion:Open globe injuries remain a serious public health problem, resulting in significant vision loss. Open globe injuries are mostly seen in the young, middle-aged, and male working population. Additional preventive measures should be taken for the individuals in these groups.