Browsing by Author "Sevim, M."

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Can the Irisin Be a Biomarker for Prostate Cancer? a Case Control Study
(Asian Pacific Organization for Cancer Prevention, 2020) Aslan, R.; Alp, H.H.; Eryılmaz, R.; Huyut, Z.; Sevim, M.; Araz, S.; Taken, K.
Aim: There is much evidence of an association between cancer and irisin that is an adipokine. This study researched on the relationship between prostate cancer (PCa) and irisin levels, and whether irisin can be used as a biomarker in the diagnosis of PCa. Materials and Methods: For the study groups, 50 primary PCa patients and 30 healthy male subjects were included in the PCa and healthy control groups, respectively. All volunteers in the healthy control group were screened for prostate cancer and other malignancies and chronic diseases. Volunteers who were determine to be completely healthy were included for healthy control group. In the serum samples of the subjects were measured free PSA, total PSA and irisin levels. Irisin levels were compared separately in terms of the Gleason scores and T stage. In addition to intergroup comparisons, the ROC curve for the irisin was plotted and power analysis was performed. Results: Free and total PSA levels in the PCa group were significantly higher compared to the healthy control group (p<0.05). In addition, irisin levels in the PCa group were significantly lower than in the healthy control group (p<0.05). There was no significant difference between irisin levels in the groups classified in terms of Gleason scores (p>0.05). When the cut-off value was taken as 8.1, the sensitivity and specificity of irisin for PCa were as 80.5% and 90%, respectively. Conclusion: The results of this study indicate that the levels of irisin in the PCa group are considerably reduced and irisin may be used as a biomarker as well as free and total PSA. © This work is licensed under a Creative Commons Attribution Non Commercial 4.0 International License.
Evaluation of Renal Colic Patients Attending the Emergency Department When the Covid 19 Pandemic Was First Announcement
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Ertaş, K.; Gizli, G.; Demir, M.; Sevim, M.; Eryılmaz, R.; Aslan, R.; Taken, K.
Renal colic cases, which have an important place among patients presenting to the emergency department with pain complaints, have an important place in urological emergencies. In this study, patients who applied to the emergency department with suspected renal colic diagnosis during the Covid-19 pandemic were compared with those in the pre-pandemic period. Patients who applied to the Emergency Department with the colic type flank pain between March 2020 and May 2020 were included in the study. Diagnostic and treatment parameters of 1699 patients, inclu ding 199 pandemic and 1500 pre-pandemic control group, were evaluated in this study. As a result of the evaluation made, it was seen that emergency physicians preferred ultrasonography less during the pandemic period, and mostly resorted to computer tomography method, and in this period, a decrease in the rate of observed kidney stones, an increase ureter stones were observed. During the pandemic period, there has been a considerable decrease in the rate of hospital admissions As a result of postponing treatment of patients with urinary system stones, secondary pyonephrosis and pyelonephritis rates increased approximately 10 times compared to the pre-pandemic period. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
A Prospective Analysis of the Efficacy and Safety of Caudal Block for Transrectal Ultrasound Guided Prostate Biopsy in Patients With Anorectal Disorders
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Aslan, R.; Günes, H.Y.; Erbin, A.; Eryilmaz, R.; Sevim, M.; Ertaş, K.; Taken, K.
In this study, the efficacy and safety of the caudal block technique for transrectal ultrasonography-guided biopsy (Trus-guided biopsy) in patients with anorectal problems were investigated. A total of 31 consecutive patients with anal-rectal problems underwent prostate needle biopsy. All patients included in the study were examined by an experienced general surgeon, and the presence of anorectal problems was confirmed. The majority of patients (61%) were referred from the outer center to our clinic beca use a biopsy could not be performed due to severe pain felt during rectal probe insertion despite local anesthesia (topical prilocaine or lidocaine cream). A 12-core biopsy protocol was applied to all patients under the caudal block. Pain perception was se parately assessed during caudal anesthesia, probe insertion, and sampling stages using a visual analog scale (VAS) score. The mean age was 64.1 ± 9.1 years. The mean VAS score during caudal anesthesia was 1.8 ± 0.81. At probe insertion, the mean VAS score was 1,44 ± 012. During the needle penetration into prostate tissue and sampling, the mean VAS score was 2.44± 013. All of the patients did not state any bothersome pain at any stage. We did not find any complications related to the anesthesia method. Topical creams and/or periprostatic nerve block (PNB) do not provide adequate analgesia in patients with anorectal disorders undergoing Trus-guided biopsy. Caudal block technique can be performed effectively and reliably in this selected patient group. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.