Browsing by Author "Silav, Gokalp"

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Paraoxonase and Prolidase Activity in Patietns With Malignant Gliomas
(Journal Neurological Sciences, 2012) Gonullu, Edip; Silav, Gokalp; Kaya, Miktat; Arslan, Mehmet; Gonullu, Hayriye; Arslan, Harun; Demir, Halit
Aim: We aimed to determine the relationship both paraoxonase and prolidase activitys in the patients with malignant glioma. Methods: In this study, serum paraoxonase and prolidase activitys were measured on 25 healthy human and 25 patients with malignant glioma. Paraoxonase activity was measured using diethyl-p-nitrophenylphosphate as substrate, as previously described. The prolidase activity was used for measurement of proline by the method proposed by Myara et al., which is a modification of Chinard's method (Myara et al., 1982). Results: The paraoxonase and prolidase activitys were significantly lower in serum of patients with malignant glioma as a whole compared to controls. Conclusions: In the current study, the activity paraoxonase and prolidase decreased in the patients with malignant glioma. As a result the paraoxonase and prolidase decreased seems to play a major role in the pathophysiology of malignant glioma. This is the first report on serum paraoxonase and prolidase decreased activities in patients with malignant gliomas.
Relationship of Dorsal Root Ganglion To Intervertebral Foramen in Lumbar Region: an Anatomical Study and Review of Literature
(Edizioni Minerva Medica, 2016) Silav, Gokalp; Arslan, Mehmet; Comert, Ayhan; Acar, Halil I.; Kahilogullari, Gokmen; Dolgun, Habibullah; Tekdemir, Ibrahim
BACKGROUND: The purpose of this study was to clarify the morphologic features, location and variations of the dorsal root ganglion (DRG). METHODS: Fifteen formalin fixed cadavers for the current study were included. Total of 150 DRGs were examined from L1 to L5. The relationships of the nerve root DRGs to the intervertebral foramen were noted. Position of the DRG was classified by the location of the ganglia in relation to the pedicle. The relationship of the DRG to the intervertebral foramen was evaluated. RESULTS: The distance between the midpoint of the DRG to the cross section of the root with the medial border of the pedicle gradually increased from L1 to L5. The medial border of the foramen distances along the nerve root were L1, 1.77 mm; L2, 2.79 mm; L3, 3.23 mm; L4, 7.28 mm and L5, 8.31 mm. The mean width of the lumbar DRGs were L1, 4.36 mm; L2, 4.56 mm; L3, 4.99 mm; L4, 5.22 mm and L5, 5.82 mm. The mean length of DRGs were as follows: L1, 5.39 mm; L2, 5.83 mm; L3, 7.24 mm; L4, 7.97 nun and L5, 10.83 mm. The mean width and length of DRGs gradually increased from Ll to L5. CONCLUSIONS: The DRG in the lumbar region play a key role in the occurence of low-back pain and sciatica; therefore, it is important to understand the anatomy of DRG. The accurate anatomic information about the position of DRGs would be useful to perform a safe surgical intervention in the lumbar foraminal region.