Browsing by Author "Simsek, M."

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The Effect of Adenosine Triphosphate on Sunitinib-Induced Cardiac Injury in Rats
(Sage Publications Ltd, 2020) Aldemir, M. N.; Simsek, M.; Kara, A., V; Ozcicek, F.; Mammadov, R.; Yazici, G. N.; Suleyman, H.
In this study, we aimed to show the effect of adenosine 5 '-triphosphate (ATP) on sunitinib-induced cardiac injury in rats. The rats (n = 30) were divided equally into three groups as sunitinib group (SG), sunitinib plus ATP group (SAG), and healthy group (HG); 2 mg/kg ATP was injected intraperitoneally (ip) to the SAG group. Same volume normal saline as solvent was administered ip to the other two groups. After 1 h, 25 mg/kg sunitinib was applied orally via catheter to stomach in the SAG and SG groups. This procedure was repeated once daily for 5 weeks. At the end of this period, all animals were sacrificed and their cardiac tissue was removed. Malondialdehyde (MDA), total glutathione (tGSH), tumor necrosis factor alpha (TNF-alpha), and nuclear factor kappa B (NF-kappa B) levels in rats' cardiac tissues and troponin I (Tp-I) levels in rats' blood samples were evaluated. Histopathological analysis was also performed in cardiac tissues of the animals. MDA, TNF-alpha, NF-kappa B, and Tp-I levels were higher in the SG group compared to the SAG and HG groups (p < 0.001). tGSH levels of the SG group were lower than the SAG and HG groups (p < 0.001). The structure and morphology of cardiac muscle fibers and blood vessels were normal in the control group. In the SG group, obvious cardiac muscle tissue damage with dilated myofibers, locally atrophic myofibers, and congested blood vessels were observed. In the SAG group, marked amelioration in these findings was observed. We showed this for the first time that ATP administration exerts a protective effect against cardiac effects of sunitinib.
Fatty Acid, Mineral and Proximate Compositions of Various Genotypes and Commercial Cultivars of Sweet Almond From the Same Ecological Conditions
(Corvinus Univ Budapest, 2018) Simsek, M.; Gulsoy, E.; Yavic, A.; Arikan, B.; Yildirim, Y.; Olmez, N.; Boguc, F.
This study was carried out on the fatty acid, mineral and proximate compositions of ten sweet almond genotypes and two commercial varieties named as Ferragnes and Ferraduel grown in the same ecological conditions known as the Firat riverside region during two consecutive years. In this context, the crude oil (Co), crude protein (Cp), total sugar (Ts), total ash (Ta) and moisture (Mo) contents from the almond genotypes and cultivars ranged from 48.69 to 55.8%, 20.41 to 25.82%, 2.92 to 5.27%, 3.29 to 4.66% and 2.52 to 3.75%, respectively. The genotypes and cultivars showed a varied mineral content as well. Potassium (K) was the main mineral in all genotypes and cultivars, ranging from 679.53 to 986.63 mg100 g(-1) ; phosphorus (P) was the second most abundant mineral, ranging from 584.57 to 697.31 mg100 g(-1) ; followed by magnesium (Mg) and calcium (Ca), ranging from 325.27 to 381.93 mg100 g(-1) , 250.15 to 332.19 mg100 g(-1) , respectively. Of the identified fatty acids, oleic acid (Oa) (69.76-72.02%) was the predominant fatty acid, followed by linoleic acid (La) (18.82-21.62%), palmitic acid (Pa) (5.627.76%), and stearic acid (Sa) (1.20-1.69%). Other fatty acids were present at trace amounts. The unsaturated (Ufa)/saturated fatty acid (Sfa) ratios ranged from 9.29 to 12.12. From the results of the present study, we can conclude that the kernels of almond genotypes and cultivars are being potential sources of valuable oil which might be used for edible and other industrial purposes.