Browsing by Author "Sogutlu, Inci"

Now showing 1 - 3 of 3

Renal Protective Effect of Grape Seed Extract in Streptozotocin-Induced Diabetic Rats
(Parlar Scientific Publications (p S P), 2022) Sogutlu, Inci; Irak, Kivanc; Mert, Handan; Yildirim, Serkan; Mert, Nihat
It was aimed to investigate the effects of grape seed extract (GSE) on structural changes that occur in renal tissues of rats with streptozocin (STZ)-induced diabetes. Rats were randomly divided into four groups (Control, Diabetes Mellitus (DM), GSE, Diabetes Mellitus+ GSE (DM + GSE) groups) each containing 8 rats. When GSE was given, the values of serum creatinine, BUN and uric acid in diabetics were decreased. Kidneys of diabetic group were found to have mild interstitial nephritis, tubular dilatation, hydropic degeneration, clotting necrosis in the tubular epithelium, dilatation in glomerulus and Bowman capsule, and hyperemia in glomerular capillaries. In the DM + GSE group, the glomeruli were normal, but hydropic degeneration was observed in some of the tubule epithelium. Only a few 8-OhDG positive cells were detected in tubule epithelium in the diabetes + grape seed group. The administration of GSE to diabetic patients helped to heal the deteriorated of kidney condition and DNA damage.
Substituent Effects on the Stability of Cyclic - Unsaturated Remote N-Heterocyclic Hammick Carbenes Using Density Functional Theory
(Elsevier, 2021) Sogutlu, Inci; Soltanzadeh, Mehdi; Mert, Handan; Mert, Nihat; Vessally, Esmail
We investigated the structure, stability and chemical properties of novel singlet (s) and triplet (t) Hammick carbenes with different fused aromatic rings, at (U)B3LYP/6-311+G*, (U)M06-2X/6-311+G*, (U)B3LYP/AUG-cc-pVTZ and (U)M06-2X/AUG-cc-pVTZ levels of theory. It is observed that: (1) All singlet and triplet structures appear as minima on their energy surfaces and each singlet carbene displays more thermodynamic stability than its corresponding triplet state; (2) Regarding to the relationship among carbenic center and substituted heteroatom, the order of thermodynamic stability based on singlet-triplet energy differences (Delta Es-t) for fused rings is ortho-pyrrole > furan > thiophene > phosphole in a "W" arrangement; (3) The highest kinetic stability based on band gap (Delta EHOMO-LUMO) is demonstrated by substituted ortho-pyrrole carbene in a "W" arrangement; (4) Regardless of how orchestrated, the order of stabilization for fused rings is pyrrole > furan > thiophene > phosphole; (5) The ortho-phosphole ring in a "W" arrangement destabilizes carbene more than benzene ring. (C) 2020 Elsevier B.V. All rights reserved.
Zigzag and Armchair Aln Nanotubes as Anode Materials for Mg-Ion Batteries: Computational Study
(Elsevier, 2020) Yasar, Semih; Sogutlu, Inci; Mert, Handan; Mert, Nihat; Vessally, Esmail; Lin, Yuan
We studied the potential application of a zigzag and an armchair AlN nanotube (AlNNT) as an anode material for the Mg-ion batteries (MIBs) using B3LYP-gCP-D3/6-31G* model chemistry. The Mg2+ adsorption energy on the zigzag or armchair AlNNTs is -217.2 or -234.9 kcal/mol, but the Mg atom interaction is much weaker and the adsorption energy is -10.5 or -5.3 kcal/mol. The dispersion term is much more important for the Mg interaction compared to the Mg2+. This term includes 68.6% of the Mg atom adsorption energy on the zigzag tube while its contribution for Mg cation adsorption is about 3.8%. The maximum energy barrier for an Mg2+ migration and cell voltage are 6.1 kcal/mol and 4.47 V for zigzag and 5.3 kcal/mol and 4.95 V for armchair AlNNT, respectively. Thus, the AlNNTs provide a great ion mobility leading to a faster charge/discharge rate because of small energy barriers. The larger cell voltage, and higher ion mobility suggest the armchair AlNNTs as a plausible anode material for application in the anode of MIBs, compared to the zigzag AlNNT. The effect of Mg/Mg2+ adsorption on the electronic properties of AlNNTs is also discussed.