Browsing by Author "Solgun, Derya Gungordu"

Now showing 1 - 20 of 24

Design of Novel Substituted Phthalocyanines; Synthesis and Fluorescence, Dft, Photovoltaic Properties
(Tubitak Scientific & Technological Research Council Turkey, 2020) Agirtas, Mehmet Salih; Solgun, Derya Gungordu; Yildiko, Umit; Ozkartal, Abdullah
The 4-(2[3,4-dimethoxyphenoxy] phenoxy) phthalonitrile was synthesized as the starting material of new syntheses. Zinc, copper, and cobalt phthalocyanines were achieved by reaction of starting compound with Zn(CH3 COO)(2), CuCl2, and CoCl2 metal salts. Basic spectroscopic methods such as nuclear magnetic resonance electronic absorption, mass and infrared spectrometry were used in the structural characterization of the compounds. Absorption, excitation, and emission measurements of the fluorescence zinc phthalocyanine compound were also investigated in THE. Then, structural, energy, and electronic properties for synthesized metallophthalocyanines were determined by quantum chemical calculations, including the DFT method. The bandgap of HOMO and LUMO was determined to be chemically active. Global reactivity (I, A, eta, s, mu, chi, omega) and nonlinear properties were studied. In addition, molecular electrostatic potential (MEP) maps were drawn to identify potential reactive regions of metallophthalocyanine (M-Pc) compounds. Photovoltaic performances of phthalocyanine compounds for dye sensitive solar cells were investigated. The solar conversion efficiency of DSSC based on copper, zinc, and cobalt phthalocyanine compounds was 1.69%, 1.35%, and 1.54%, respectively. The compounds have good solubility and show nonlinear optical properties. Zinc phthalocyanine gave fluorescence emission.
Dft Analysis and Electronic Properties, and Synthesis of Tetra (9-Phenyl Oxy Peripheral-Substituted Zinc Phthalocyanine
(Springer int Publ Ag, 2020) Solgun, Derya Gungordu; Keskin, Mehmet Salih; Yildiko, Umit; Agirtas, Mehmet Salih
The 4-((9-phenyl-9H-xanthene-9-yl) oxy) phthalonitrile compound was synthesized and characterized as starting material. Zinc phthalocyanine was obtained by reaction of 4-((9-phenyl-9H-xanthen-9-yl) oxy) phthalonitrile with Zn(CH3COO)(2). Novel compounds were characterized using mass spectra, UV-Vis spectroscopy, H-1-NMR, C-13 NMR, and infrared spectroscopy. The fluorescence, emission, excitation, and absorption spectra of the zinc phthalocyanine compound were studied in tetrahydrofuran (THF). The determination of these properties is very useful for photodynamic therapy applications. Also, zinc phthalocyanine (Zn-Pc) was optimized with the basic set of 6-311G and LanL2DZ of the Density functional theory (DFT). The energy band-gap HOMO-LUMO of the molecule was determined. Chemical indices were calculated using HOMO-LUMO energies. The electrophilic region and the nucleophilic region were defined from the molecular electrostatic potential (MESP) maps. Dipole moment components have been calculated and can be considered as potential candidates for the design of non-linear optical materials.
Dna Binding Studies of the 2,10,16,24-Tetrakis (phenoxy-3 Acid)phthalocyaninato) Co(Ii) and Cu(Ii) Compounds
(Springer int Publ Ag, 2020) Balli, Zekeriya; Arslantas, Ali; Solgun, Derya Gungordu; Agirtas, Mehmet Salih
Tetra phenoxy-3-methoxybenzoic acid substituted Co(II) and Cu(II) metal phthalocyanine compounds were reported for the first time. The structures of these compounds were elucidated by NMR, FT-IR, UV-vis spectroscopy, and elemental analysis. The UV/Vis, fluorescence spectra, viscosity and the thermal melting point techniques were implemented to analyze the DNA bonding activities of cobalt (II) and copper (II) complexes of phthalocyanine by calf thymus DNA. These techniques showed that the phthalocyanine complexes interacted with the DNA molecule through the intercalation mechanism. Additionally, among the methods above, the binding properties of DNA with the compounds 4 and 5 were studied by means of the agarose gel electrophoresis method. The complexes 4 and 5 bonded to the DNA molecule in the buffer system at a pH of 7.02. The findings of these methods proved that the Co(II) and Cu(II) complexes of phthalocyanine could be evaluated as potential cancer medicine for cancer treatment in the near future.
Effect of Silver Nanoparticles Prepared by Green Chemistry on the Photovoltaic Properties of Zinc Phthalocyanine
(Springer int Publ Ag, 2024) Odemis, Omer; Agirtas, Mehmet Salih; Solgun, Derya Gungordu; Ozkartal, Abdullah
The use of silver nanoparticles (AgNPs) produced from sustainable resources to improve photovoltaic properties of dye-sensitized solar cells is gaining interest due to the growing demand for clean and green energy sources. In this study, leaf (HY) and flower (HC) extracts of Golden Grass (Helichrysum italicum) were used to produce AgNPs with a low cost and easy method. The enhancement in power conversion efficiency by adding AgNPs phthalocyanine produced from biomaterials was investigated. The formation of AgNPs is indicated by a strong surface plasmon resonance (SPR) at 441 nm for HY-AgNPs and 448 nm for HC-AgNPs. Spherical AgNPs were formed with an estimated diameter of 22.59 +/- 0.71 nm for HY-AgNPs and 21.06 +/- 0.95 nm for HC-AgNs, both with a face center cubic crystal structure. On the other hand, the zinc phthalocyanine complex designed for dye-sensitized solar cells was synthesized and characterized. At the same time, the aggregation and fluorescence properties of zinc phthalocyanine were investigated. The photovoltaic properties of the phthalocyanine compound used in the study were examined without and with silver nanoparticle additives. With this doping, the power conversion efficiency percentage increased from 2.32 to 3.41 for HY-AgNPs and from 2.32 to 2.92 for HC-AgNPs. Evaluation of the results reveals that the phthalocyanine compound gains more efficient photovoltaic properties with the doping of AgNPs for dye-sensitized solar cells.
Photovoltaic Performance Properties, Dft Studies, and Synthesis of (e)-3 Acrylic Acid Substituted Phthalocyanine Complexes
(Springer int Publ Ag, 2021) Solgun, Derya Gungordu; Yildiko, Umit; Ozkartal, Abdullah; Agirtas, Mehmet Salih
In this study, firstly, a new phthalonitrile derivative was synthesized from the reaction of caffeic acid with phthalonitrile. Then, metal phthalocyanine complexes were obtained from the reaction of this phthalonitrile derivative with metal salts. Compounds were characterized by UV, NMR, IR and Mass spectroscopy methods. In addition, the fluorescence and electronic properties of the diamagnetic zinc phthalocyanine compound were investigated. The performances of dye-sensitized solar cells of compounds were examined. The calculated power conversion efficiencies (eta %) of the complexes using the obtained current density (J)-voltage (V) curves were determined that these compounds can be used as promising sensitizers in solar cell applications. The calculated power conversion efficiencies (% eta) of the complexes were found to be at a reasonable level. Molecular orbital properties such as HOMO-LUMO energy gap, Fermi Energies, state density spectrum, and molecular electrostatic potential surfaces were calculated for each phthalocyanine molecule. In addition, the amount of phthalocyanine required for ideal dye sensitivity was investigated.
Sensor Properties for Fe3+and Synthesis of New a Bis - (3-(benzhydryloxy) Propanoate) Phthalocyaninato Silicon (Iv)
(Elsevier Science Sa, 2024) Solgun, Derya Gungordu; Agirtas, Mehmet Salih
In this study, 3-(benzhydryloxy) propanoic acid (2) and bis -(3-(benzhydryloxy) propanoate) phthalocyaninato silicon (IV) (3) compounds were synthesized. Their compound structures were characterized with the help of IR, UV-visible, mass and 1 H NMR spectroscopy. Aggregation and solubility of the compounds were tested. Finally, the metal sensor property of the axial phthalocyanine compound was investigated against Cu2+, Fe3+, Mg2+, Mn2+, Na+, Zn2+, Ag+, Ba2+, Cd2+ ions. It was determined that the compound was selectively sensitive to Fe3+. The optical detection of Fe3+ ions in the presence of Cu2+, Fe3+, Mg2+, Mn2+, Na+, Zn2+, Ag+, Ba2+, Cd2+ ions shows that this material can be used for easy and practical analysis.
Several Biological Properties and Synthesis of 2-(4 Ethoxy Substitute Zinc Phthalocyanine
(Wiley, 2024) Solgun, Derya Gungordu; Ozdemir, Sadin; Dundar, Abdurrahman; Agirtas, Mehmet Salih
In this study, 4-(2-(4-methylthiazol-5-yl) ethoxy) phthalonitrile (3) and zinc phthalocyanine complex (4) were synthesized and characterized. UV-vis and fluorescence spectra, aggregation, and fluorescence parameters of the zinc phthalocyanine compound were investigated. As biological properties, DPPH radical capture, antidiabetic, DNA cutting, antimicrobial, photodynamic antimicrobial, anti-biofilm activities, and microbial cell viability parameters of the compounds were determined. The highest antioxidant activity was found as 62.80% at 100 mg/L concentration with compound 4, and compound 4 also showed the best antidiabetic activity as 65.17% at 400 mg/L concentration. In DNA cutting activity, it was determined that 3 and 4 cut DNA at all concentrations. For compounds 3-4, the minimum inhibitory concentration (MIC) values were found to be 32 and 16 mg/L for Enterococcus hirae and Enterococcus feacalis, respectively. The strongest MIC value of photodynamic antimicrobial activity was achieved as 4 mg/L for E. feacalis with 4. It was observed that both compounds inhibited the microbial viability activity of Escherichia coli by 100% at concentrations of 100 mg/L. Compound 4 inhibited biofilms of Pseudomonas aureginosa and Staphylococcus aureus as 92.48% and 98.56% at 50 mg/L concentration, respectively. In this study, the synthesis and characterization of the new zinc phthalocyanate complex and the investigation of many biological properties are included.image
Spectroscopic Evaluation of Dna Binding Activities of Copper (II) Phthalocyanine Complex Consisting of Tetrakis-(4 Ligand)
(Gazi Univ, 2025) Arslantas, Ali; Agirtas, Mehmet Salih; Solgun, Derya Gungordu
The structure and basic properties of Cu(II) phthalocyanine compound possessing tetrakis-(4-tritylphenoxy) group were elucidated in a past study with the help of absorption and infrared spectroscopic equipments. The electronic spectra, emission spectroscopy, gel agarose electrophoresis and thermal melting were employed to reveal the DNA interaction functions of this complex at changing concentrations of CT-DNA. In this experiment, the binding constant for the Cu(II) phthalocyanine compound which contains the tetrakis(4-tritylphenoxy) group was computed to be 1.53 x 106 M-1. The data obtained from absorption and fluorescence spectroscopic studies revealed that the CuPc compound reacted with CT-DNA through an intercalating mechanism. Well as the above methods, melting temperature and electrophoresis were also employed to analyse the interaction feature of CuPc with DNA. The interaction of the CuPc compound with DNA was also confirmed by data from melting temperature and electrophoresis experiments. Within the framework of the results obtained, it is predicted that CuPc compound may be a possible cancer therapeutic agent.
Synthesis and Biological Activity, Photophysical, Photochemical Properties of Tetra Substituted Magnesium Phthalocyanine
(Springernature, 2025) Ozdemir, Sadin; Solgun, Derya Gungordu; Giray, Gulay; Agirtas, Mehmet Salih
The compound 4-(2-((1H-benzo[d]imidazol-2-yl) thio) phenoxy) phthalonitrile was obtained from the reaction of 2-nitrophenol, 4-nitrophthalonitrile and 2-mercaptobenzimidazole. This compound was reacted with magnesium Chloride (MgCl2) to yield tetrakis-[(2-((1H-benzo[d]imidazol-2-yl) thio) phenoxy) phthalocyaninato] magnesium II. New compounds were characterized by UV-vis, 1H NMR, 13C NMR, FTIR and Mass spectra. Electronic spectra aggregation study of magnesium phthalocyanine compound in various concentrations and diverse solvents was performed. Photoluminescence spectra of magnesium phthalocyanine in different solvents were investigated. The biological activities of 3 and 4 compounds were investigated. The results showed that 4 had excellent antioxidant and antidiabetic activities as 75.71% and 81.83%, respectively. 3 and 4 had deoxyribonucleic acid (DNA) cleavage ability and 4 caused a double-strand fracture in plasmid DNA at 100 and 200 mg/L. Both compounds showed antimicrobial activity and also 4 was more effective against pathogenic microorganisms than 3. Photodynamic antimicrobial therapy of test compound was also more effective than without irradiation. The highest biofilm inhibition of 3 and 4 was 78.28% and 98.49% for S. aureus and also 73.95% and 91.13% for P. aeruginosa, respectively. Finally, both compounds demonstrated %100 microbial cell viability inhibition at 100 mg/L. Overall, the study suggests that both 3 and 4 have potential for further development as therapeutic agents.
Synthesis and Biological Properties of Axially Bis(3,4,5-Trimethoxybenzyloxy) Phthalocyaninato Silicon (Iv)
(Elsevier Science Sa, 2024) Solgun, Derya Gungordu; Ozdemir, Sadin; Dundar, Abdurrahman; Agirtas, Mehmet Salih
In this study, bis(3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV) was obtained from the reaction of 3,4,5-trimethoxybenzyl alcohol with SiPcCl 2 . This phthalocyanine was characterized using 1 H NMR, FTIR, UV - vis and mass spectra. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, antidiabetic, deoxyribonucleic acid (DNA) cutting, biofilm inhibition, anti -microbial and antimicrobial photodynamic therapy (aPDT) activities of newly synthesized bis(3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV) molecule were studied. The best activities were 41.58 % at 100 mg/L for antioxidant and 41.66 % for antidiabetic at 400 mg/L concentration. The molecule degraded the biofilm matrix formed by Pseudomonas aeruginosa and Staphylococcus aureus as 78.61 % and 89.26 %, at 50 mg/L concentration, respectively. It was observed that E. coli , which was used as a model microorganism, was inhibited at a level close to 100 % even at the lowest concentration of 50 mg/L. While double strand break was observed at 50 mg/L DNA cutting activity, it was determined that DNA was reduced to nucleotides at 100 and 200 mg/L. The Pc also displayed effective antimicrobial and aPDT abilities against pathogens. With the application of aPDT, the effectiveness of antimicrobial activity increased 2 to 4 times. These increase rates are very important. The main conclusion of the study was that the newly synthesized compound exhibited various effective biological activities such as effective antioxidant, antidiabetic, DNA cleavage, antimicrobial, aPDT, biofilm inhibition and microbial cell viability inhibition.
Synthesis and Sensor Properties of Silicon Phthalocyanine Axially Substituted With Bis-(prop Groups and Polymeric Phthalocyanines Bearing Peg Substituent by "click" Chemistry
(Taylor & Francis Ltd, 2023) Agirtas, Mehmet Salih; Solgun, Derya Gungordu; Savas, Bedrettin; Ozturk, Temel
Synthesis and characterization of new axially substituted phthalocyanine complexes were done. Bis - (prop-2-ynyloxy) phthalocyaninato silicon (IV) compound was obtained from the reaction of 2-propin-1-ol with SiPcCl2. Polymeric phthalocyanine containing axially substituted PEG was obtained from the reaction of bis - (prop-2-ynyloxy) phthalocyaninato silicon (IV) compound and polyethylene glycol azido. The structure of the compounds was justified by FT-IR, H-1 NMR, C-13 NMR, UV-Vis, and mass spectra. The photophysical and photochemical properties of the phthalocyanine compound axially substituted with bis-(prop-2-ynyloxy) was investigated. Properties of the compounds were examined in terms of fluorescence quantum efficiency and singlet oxygen generating capacity, and the potential photosensitizer capacity of the compound was determined. In addition, polyethylene glycol group was added to the phthalocyanine compound by click reaction. The polymer product was obtained in blue color. Phthalocyanine(Pc) containing PEG polymeric units is soluble in dimethyl sulfoxide (DMSO). Absorption measurements of the compound at different concentrations were made. Both polyethylene glycol (PEG) and phthalocyanine compounds can be used in the manufacture of medical supplies due to their non-toxicity. UV-visible study of Bis-(prop-2-ynyloxy) phthalocyaninato silicon (IV) compound revealed its high selectivity for Fe3+ ion recognition.
Synthesis of Axial Bis(benzo[d][1,3]dioxol-5 Silicon (Iv): Photophysical and Photochemical Properties and Docking Studies on Dna-Sipc Interactions
(Wiley-v C H verlag Gmbh, 2022) Solgun, Derya Gungordu; Yildiko, Umit; Agirtas, Mehmet Salih
The synthesis of an axial phthalocyanine compound by the reaction of piperonyl alcohol and SiPcCl2 has been reported. Its structure was characterized by compound (HNMR)-H-1,(CNMR)-C-13, Mass, FTIR and UV visible spectroscopy. Photophysical and photochemical properties of the compound were investigated by fluorescence spectroscopy. The photosensitizer performance of the compound was determined. In addition, with the quantum chemical study, the HOMO - LUMO band gap and the optimized structure of the compound were investigated with two basic sets of the TD-DFT B3LYP method. The band gap (Delta E) was found to be in the range of 0.6-0.7 eV, and it was determined that the compound would require low energy in the chemotherapeutic interaction with light and in its stimulation. As a chemotherapy drug candidate, its adhesion to protein and DNA structure has been evaluated as in-silico. In this context, the potential binding and interaction aspects of the new chemotherapeutically effective phthalocyanine compound with two kinds of homo sapiens protein-DNA complexes were investigated by molecular docking approach. It bonded with the phthalocyanine compound in both crystal structures. A docking score of 6.315 kcal/mol was obtained in the 6DIA encoded DNA polymerase beta substrate complex.
Synthesis of Axially Silicon Phthalocyanine Substituted With Bis- (3,4-Dimethoxyphenethoxy) Groups, Dft and Molecular Docking Studies
(Springer, 2022) Solgun, Derya Gungordu; Tanriverdi, Aslihan Aycan; Yildiko, Umit; Agirtas, Mehmet Salih
Axially bis-substituted silicon phthalocyanine was synthesized from the reaction of 2-(3,4-dimethoxy phenyl) ethanol and SiPcCl2. The structure of the compound was justified by FT-IR, (1) H NMR, (13) C NMR, UV-Vis, and mass spectra. The conglomeration action of the phthalocyanine compound was determined by UV-visible spectra at different concentrations and in different solvents. Some parameters of this axial silicon phthalocyanine compound were investigated by computational chemistry. Structural optimization of axial silicon phthalocyanine substituted with compound, HOMO-LUMO energies and MEP maps was performed by density functional theory (DFT) studies. In addition, a chemical bond analysis of the molecule was performed with quantum theory atom in molecules (QTAIM). Finally, a molecular docking study was applied to this new phthalocyanine molecule in its binding mechanism. [GRAPHICS] .
Synthesis of Bis-(benzhydryloxy) Substituted Axially Silicon(Iv) Phthalocyanine: Investigation of Photophysical, Photochemical, and Computational Electronic Properties
(Taylor & Francis Ltd, 2024) Solgun, Derya Gungordu; Yildiko, Umit; Agirtas, Mehmet Salih
Synthesis of axially disubstituted silicon(IV) phthalocyanine bearing benzhydryloxy groups obtained by reaction of SiPcCl2 with diphenylmethanol is reported. Characterization of the compound was performed by H-1 and C-13 NMR, UV-Vis, mass spectrometry, and FT-IR spectroscopy. Photophysical and photochemical properties were investigated. Fluorescence spectra measurements were performed in DMSO as solvent. A preferred chemical method was used to determine the amount of singlet oxygen production. Optimizations were calculated for the single-molecule Si-Pc with the 6-311 G (d, p) basis set at the B3LYP and B3PW91 levels of density functional theory (DFT). The charge transfer (or) charge delocalization between intramolecular donor-acceptor groups was determined by NBO analysis. Furthermore, molecular electrostatic potential, Fukui functions, electrophilic and nucleophilic character maps were calculated. The electronic structure and energy parameters of the investigated compound were determined to be Delta E-calc = 2.19 eV by DFT calculation and Delta E-opt = 1.84 by experimental UV spectrum.
Synthesis of Novel an Axially Substituted Silicon Phthalocyanine and Determination of Its Selectivity for Fe 3+
(Elsevier, 2023) Solgun, Derya Gungordu; Agirtas, Mehmet Salih
This study includes the synthesis and characterization of an axial phthalocyanine complex. This phthalocyanine was characterized with the aid of NMR, FT-IR, Mass spectrum and UV-vis spectroscopy. The solubility scale of this compound in solvents and its absorption in different solvents were determined. In addition, axial phthalocyanine absorption measurements were made in the same solvent and at different concentrations. The compound was determined to be non-aggregation within the range of measured parameters. Fluorescence absorption, excitation and emission measurements were made in different solvents. The selectivity of Bis-2((4phenoxyphenyl) diazenyl)benzoic acid) phthalocyaninato silicon (IV) compound to metal ions was investigated by UV-visible absorption spectra. Fe3+ ion selectively differed among the studied metals. This method reveals that it can be used for the optical determination of Fe3+ ion in the fields of environment, food and health.
Synthesis of Novel Tetra (4-Tritylphenoxy) Substituted Metallophthalocyanines and Investigation of Their Aggregation, Photovoltaic, Solar Cell Properties
(Taylor & Francis inc, 2018) Solgun, Derya Gungordu; Horoz, Sabit; Agirtas, Mehmet Salih
4-(4-tritylphenoxy) phthalonitrile was synthesized and characterized. Copper, zinc and cobalt phthalocyanines were obtained by reaction of 4-(4-tritylphenoxy)phthalonitrile with CuCl2, ZnCl2, CoCl2 metal salts. New compounds were characterized by using electronic absorption, nuclear magnetic resonance spectroscopy, infrared. The aggregation investigation for phthalocyanine complexes carried out in different concentrations tetrahydrofuran. Copper, cobalt and zinc phthalocyanines were used as sensitizers in dye-sensitized solar cell structures (DSSC) by growing on TiO2 coated on FTO (Fluorine doped Tin Oxide) conductive glass substrates. Current density (J) versus voltage (V) measurements were applied to investigate the photovoltaic properties of the synthesized complexes. The calculated power conversion efficiencies (%) of the complexes using the obtained current density (J) versus voltage (V) curves show that these devices can be used as promising sensitizers in solar cell applications.
Synthesis of Phthalocyanine Complexes Carrying Caffeic Acid Groups: Increasing Photovoltaic Performance by Doping Silver Nanoparticles
(Taylor & Francis inc, 2023) Solgun, Derya Gungordu; Ozkartal, Abdullah; Agirtas, Mehmet Salih
Recently, phthalocyanines with carboxyl group have attracted attention for dye-sensitive solar cells. For this purpose, the caffeic acid unit was first reacted with phthalonitrile. Phthalocyanine complexes bearing carboxyl groups were obtained by reacting the synthesized phthalonitrile compound with different metal salts. The structures of the synthesized compounds were characterized using nukleer manyetik rezonans (NMR), UV-VIS Spektrofotometre(UV-Vis), Fourier-transform infrared spectroscopy (FTIR) and Mass spectroscopy (MS) methods. Fluorescence and aggregation properties were investigated. The efficiencies (%eta) of dye-sensitized solar cells are obtained by measurements of voltage (V) curves-current density (J). In this study, phthalocyanine compounds carrying carboxyl groups were used. Photovoltaic values were measured again by adding silver nanoparticles to the same compounds. It was observed that the power conversion efficiencies increased much more when the same compounds were doped with silver nanoparticles (AgNPs). This shows that the efficacy of phthalocyanine compounds for dye-sensitized solar cells can be significantly improved by AgNP doping. Power conversion efficiency was measured as 1.92, 2.11, and 2.20 for compounds 4,5 and 6, respectively, without doping to phthalocyanine compounds. Doping with silver nanoparticles showed an increase of 58%, 59%, and 56% for the same compounds, respectively. This shows that the power conversion effect of phthalocyanines can be made more efficiently with AgNPs doping.
Synthesis of Silver Nanoparticles Formed by Chaerophyllum Macrospermum and Eremurus Spectabilis Biomaterial and Investigation of Photovoltaic Parameters by Adding Silicon Phthalocyanine
(Taylor & Francis Ltd, 2023) Agirtas, Mehmet Salih; Odemis, Omer; Solgun, Derya Gungordu; Tanriverdi, Aslihan Aycan; Ozkartal, Abdullah
Silver nanoparticles (AgNPs) were obtained by green synthesis using Chaerophyllum macrospermum (CM) and Eremurus spectabilis (ES). These particles were characterized by TEM, XRD, IR, UV, mass, and NMR spectra. TEM images show that the mean particle size of CM-AgNPs was 30 nm and the diameter of ES-AgNPs was 14.2 nm. XRD measurements showed that CM-AgNPs were 30.85 nm and ES-AgNPs 18.80 nm in a perfect face-centered cubic crystal structure. CM-AgNP showed maximum absorption at 453 nm and ES-AgNP at 455 nm; AgNPs exhibited a strong surface plasmon resonance (SPR) and played a role in stabilization. A silicon phthalocyanine compound was synthesized and characterized. The photovoltaic properties of the axial phthalocyanine compound with and without doping of Chaerophyllum macrospermum and Eremurus spectabilis silver nanoparticles were investigated. Better dye-sensitive solar cells were formed by doping silver nanoparticles to phthalocyanine compounds with an increase in the percentage of energy conversion efficiency by 0.26 with ESAgNP doping and 0.76 with CMAgNP doping.
Synthesis of Zinc Phthalocyanine Complex Containing Tetra Propanoic Acid Groups: Electronic Properties and Inhibitory Effects on Some Metabolic Enzymes
(Elsevier, 2024) Solgun, Derya Gungordu; Sadeghian, Nastaran; Taslimi, Parham; Taskin-Tok, Tugba; Agirtas, Mehmet Salih
In the new study, first the synthesis and characterization of 2, 10, 16, 24-Tetrakis-3-(phenoxy) propanoic acid phthalocyaninato zinc (II)(4) and its starting compound are presented. The aggregation properties of compound (4) were investigated with the UV-visible spectrum, and the excitation and emission properties were investigated with the fluorescence spectra. The new compounds were characterized by IR, UV-visible, Mass and 1H NMR spectroscopy. These 3-(3,4-dicyanophenoxy) propanoic acid (3) and compound (4) had effective inhibition against alpha-glycosidase, alpha-amylase, butyrylcholinesterase and acetylcholinesterase. IC50 values were found as 4.21-6.57 mu M for AChE, 0.32-1.88 mu M for BChE, 47.14-62.07 mu M for alpha-amylase, and 13.41-21.82 mu M for alpha-glycosidase. By molecular docking study, compared to reference compounds (tacrine and acarbose) of compound (4) [-9.25 kcal/mol for AChE; -9.30 kcal/mol for BChE; -6.50 kcal/mol for alpha-amylase and -8.49 kcal/mol for alpha-glycosidase seem to be more effective and promising. Drug development for the treatment of diabetes, hyperglycemia, and obesity has as one of its design goals the creation of molecules that are alpha-amylase and alpha-glycosidase inhibitors. As a result, compound (4) can have promising anti Alzheimer drug potential and record as novel anti-diabetic inhibitors.
Synthesis of Zinc Phthalocyanine Containing 1,2-Phenylene Bis (3-Chloropropanoate) Substituted Groups and Investigation of Their Metabolic Enzyme Inhibitory Effects
(Pergamon-elsevier Science Ltd, 2024) Solgun, Derya Gungordu; Sadeghian, Nastaran; Taslimi, Parham; Taskin-Tok, Tugba; Agirtas, Mehmet Salih
In this study, 4,5-dicyano-1,2-phenylene dinicotinate compound was obtained as a result of the reaction of 4,5dichlorophthalonitrile and nicotinic acid. This compound was reacted with the zinc chloride salt to obtain the original zinc phthalocyanine compound bearing 1,2-phenylene bis(3-chloropropanoate) substituted groups. This compound and its starting material were characterized with the assist of 1 H NMR, IR, UV-vis, Mass spectrum. In the docking study of compounds (3) 3 ) and (4) 4 ) against each target (AChE, BChE, alpha-Amy and alpha-Gly), Zn complex (4) 4 ) exhibits more binding affinity with the target models considered compared to ligand structure (3). 3 ). Especially, AChE protein and complex (4) 4 ) form the best binding affinity with a binding energy value of-10.55 kcal/mol. They are compatible and supportive with the data obtained as a result of in vitro analysis. These 4,5-dicyano-1,2phenylene dinicotinate (3) 3 ) and 2, 10, 16, 24 - tetrakis 1,2-phenylene bis(3-chloropropanoate) phthalocyaninato) zinc(II) (4) 4 ) complexes had effective inhibition against alpha-glucosidase, alpha-amylase, butyrylcholinesterase and AChE. Also, IC50 50 amounts were found as 7.84 and 12.36 mu M for AChE, 3.80 and 4.56 mu M for BChE, 27.08 and 38.14 mu M for alpha-amylase, and 5.30 and 9.73 mu M for alpha-glucosidase.