Browsing by Author "Subasi, Yaver"

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Development of a Pvc Membrane Potentiometric Sensor With Low Detection Limit and Wide Linear Range for the Determination of Maprotiline in Pharmaceutical Formulations
(Wiley-v C H verlag Gmbh, 2022) Tekce, Serkan; Subasi, Yaver; Coldur, Fatih; Kanberoglu, Gulsah Saydan; Zahmakiran, Mehmet
Maprotiline (MAP), is an active ingredient of some antidepressants which has been broadly used for the therapy of depression. The overdose of MAP in the treatment of patients with depression can lead to significant side effects, even lethal intoxication. Therefore, it is very important to develop simple, inexpensive, fast and reliable detection methods for MAP in interested samples. In our present study, we have offered a novel poly(vinylchloride) (PVC) membrane maprotiline-selective potentiometric sensor based on a type of MOFs, known as MIL-53(Al), as electroactive ionophore substance. The sensor prepared at the optimum membrane composition exhibited a linear response for maprotiline hydrochloride in the concentration range of 1,0x10(-9) M-1,0x10(-2) M with a slope of 59,1 mV/decade and detection limit of 9,0x10(-10) M. The pH working range of the sensor was determined as 2,0-9,5. The response time of the sensor was very fast and less than 5 s. With these performance features, it has been shown that the current sensor has quite superior features compared to the potentiometric MAP-selective sensor available in the literature. The potentiometric application of the sensor was successfully carried out with the detection of MAP in pharmaceutical tablets containing MAP-HCl.
Development of Mof-Based Pvc Membrane Potentiometric Sensor for Determination of Imipramine Hydrochloride
(Springer int Publ Ag, 2022) Subasi, Yaver; Kanberoglu, Gulsah S.; Coldur, Fatih; Cubuk, Osman; Zahmakiran, Mehmet
Imipramine hydrochloride (IMIP) is a tricyclic antidepressant utilized in the treatment of depression and chronic pain in some certain cases together with pain medication. The side effects of anxiety, insomnia, crying attacks, personality change and tachycardia are seen in imipramine overdose; therefore, determination of imipramine is an important issue. In this study, a novel potentiometric PVC membrane ion-selective sensor (ISE) was developed for monitoring of IMIP. MIL-53(Al) metal-organic framework was utilized for the first time as an electroactive material in the construction of imipramine-selective PVC membrane sensor. The sensor membrane consisting of 3.0% MIL-53(Al), 64.0% dibutylphthalate (DBP), 32.0% polyvinylchloride (PVC) and 1.0% potassium tetrakis(4-chlorophenyl)borate (KTpClPB) exhibited the most satisfied potentiometric performance characteristics. The sensor displayed a linear response for imipramine hydrochloride in the concentration range of 1.0 x 10(-7) M-1.0 x 10(-1) M with a slope of 57.7 mV/decade and detection limit of 5.0 x 10(-8) M. The operational pH range of the sensor was determined as 3.7-8.5. The sensor showed highly reproducible and stable potentiometric responses with the response time of less than 5 s. The IMIP content of a pharmaceutical used in the treatment of depression was successfully determined with the proposed imipramine-selective sensor. Additionally, the analytical applicability of the sensor in real biological samples was demonstrated by performing imipramine determinations in spiked human blood serum and urine samples. [GRAPHICS] .