Browsing by Author "Sunnetcioglu, A."

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A Case of Lung Adenocarcinoma Presenting as Miliary Appearance
(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Çilingir, B.M.; Sunnetcioglu, A.; Özgökçe, M.; Bayram, I.
Multiple benign conditions may be the cause of miliary nodules, but the most common cause is metastatic disease. Even so miliary metastasis of lung cancer is rarely seen. The most common lung cancer with a miliary distribution is adenocarcinoma. It is often difficult to diagnose adenocarcinomas with a progressive course. Anamnesis, physical examination, imaging methods can give an idea but diagnosis should be confirmed histopathologically. As in our case, tissue biopsy should be performed for diagnosis. We aimed to present this case because we performed a tru cut biopsy which is rarely used for histopathologic diagnosis and the miliary nodules in the lung of adenocarcinoma is a rare condition. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Circulating Betatrophin Levels Are Associated With the Apnea-Hypopnea Index and Lipid Profile in Subjects With Obstructive Sleep Apnea
(Wiley-blackwell, 2016) Sertogullarindan, B.; Komuroglu, A. U.; Ucler, R.; Gunbatar, H.; Sunnetcioglu, A.; Bozan, N.; Dalli, A.
Clinical and Prognostic Features of Patients With Pandemic 2009 Influenza a (H1n1) Virus in the Intensive Care Unit
(Makerere Univ, Fac Med, 2011) Sertogullarindan, B.; Ozbay, B.; Gunini, H.; Sunnetcioglu, A.; Arisoy, A.; Bilgin, H. M.; Baran, A., I
Objective: To investigate the clinical and prognostic features of patients admitted to intensive care unit (ICU) with pandemic 2009 influenza A (H1N1) virus. Methods: Patients admitted to the intensive care unit for severe pneumonia associated with pandemic 2009 influenza A (H1N1) virus were evaluated. Results: The study included 20 patients with the mean age of 36 +/- 13. Of the 20 subjects, 17 (85%) had underlying conditions. Of the 20 patients, 11(55%) were discharged and 9 (45%) died. Cardinal symptoms were fever, myalgia, and hemoptysis with the rates of 85 %, 75 % and 45 %, respectively. All patients had pneumonic infiltrations in their chest roentgenograms. Main laboratory findings were lymphopenia, high creatin phosphokinase (CPK) and Lactate dehydrogenase (LDH) levels. All patients had positivity on real time reverse transcription-polymerase chain reaction (RT-PCR). None of the patients had pandemic 2009 influenza A (H1N1) virus vaccination. None of them had taken oseltamivir within 48 hours. Main reasons for mortality were cardiovascular complications and ventilatory associated pneumonia due to Acynetobacter baumannii. Conclusion: Early diagnosis and antiviral treatment in these cases seem to be the best approach to avoid serious illness. Special attention should be given to patients having underlying conditions such as cardiovascular and pulmonary diseases and pregnancy.
Could a New Measurement, a New Body Shape Index, Determine the Role of Obesity and Depression in Asthma Control
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Çilingir, B.M.; Ekin, S.; Yildiz, H.; Sunnetcioglu, A.; Günbatar, H.
Obesity is common in asthma. Depression is thought to be one of the risk factors that increase obesi ty. It is known that depression has an effect on poor asthma control. Body Mass Index (BMI) is mostly used to define obesity. In recent years, however, the ‘A Body Shape Index’ (ABSI) based on waist circumference (WC) measurement has been developed and th e higher ABSI corresponds to a more central body volume concentration. Our aim was to examine the effect of obesity and depression on asthma control in a way that questions the usability of ABSI, which is new in abdominal obesity measurement. A total of 99 asthmatic patients aged between 18-80 years who were followed up in Chest Diseases outpatient clinics were included in the study. Demographic and medical history of the patients were recorded. Waist circumference /BMI2/3 X Length(m) 2/3 was calculated for ABSI measurement. Beck Depression Scale (BDS) and Asthma Control Test (ACT) were applied. Pulmonary Function Test was applied to all patients by the same trained person. Obese and morbidly obese patients had poor asthma control. We found that the presence of depression caused poor asthma control in all BMI groups. The poorly controlled asthma group and the obese and morbidly obese patients had higher depression scores. BMI and waist circumference were higher in the poorly controlled asthma group (p=0.002, 0.033 respectively). However, there was no significant difference between the asthma groups in terms of ABSI (p=0.529). The findings of this study indicate that depressive symptoms, increased BMI and WC were significantly associated with poor asthma control. But ABSI is no superior to BMI in detecting asthma control and depressive mood. However, we should prompt our patients to treatment and exercise, especially for abdominal obesity. We should recommend that asthma patients with depression consult a psychiatrist. In this way, we can control our asthma patients more effectively by minimizing the existing risks. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Does Hypoxia Only Importan for Fatty Liver in Osa Patients
(Amer Thoracic Soc, 2016) Sertogullarindan, B.; Bulut, D.; Gunbatar, H.; Sunnetcioglu, A.; Ekin, S.; Arisoy, A.
Is İt İn Our Genes That We're Going To Have Pulmonary Embolism
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Uney, İ.H.; Arisoy, A.; Sunnetcioglu, A.; Mermit Çilingir, B.; Yıldız, H.; Gunbatar, H.; Asker, S.
Pulmonary thromboembolism is a disease with high mortality and morbidity, which can be recurrent, difficult to diagnose, yet preventable and treatable. In this study, our aim was to evaluate comorbidities, risk factors, laboratory results, and clinical scoring in patients diagnosed with pulmonary embolis m. Our primary goal was to detect genetic mutations in cases of pulmonary embolism with acquired risk factors. Our study is a prospective study that includes clinical information, laboratory tests, Wells scoring, admission, and the prospective history of 60 patients with no previous history of venous thromboembolism (VTE) and no history of anticoagulation use. These patients were admitted to the chest diseases outpatient clinic, emergency department, or hospitalized for another reason and diagnosed with pul monary thromboembolism. The mean age of the patients was 59.9 ± 18.7 years. The most common presenting complaints were shortness of b reath and sharp chest pain. Nearly half of the patients had at least one comorbid disease. There was at least one genetic/congenital risk factor in all cases, and at least two risk factors were present in more than half of the cases. The most common mutati ons were plasminogen activator inhibitor type 1 (PAI-1) and Methylenetetrahydrofolate Reductase (MTHFR) heterozygote mutations. Pulmonary embolism continues to be a more prevalent disease with increasing age and associated risk factors. Since there is at least one acquired risk factor in all of our cases, we believe that almost every patient may have an acquired risk factor if the history is thoroughly investigated. We also believe that genetic or thrombophilic conditions may be detected in almost all cases diagnosed with pulmonary embolism. It has been concluded that immobilization and obesity are the most common preventable risk factors associated with VTE. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Mean Platelet Volume as an Indicator of Disease in Patients With Acute Pulmonary Embolisms
(Yuzuncu Yil Universitesi Tip Fakultesi, 2014) Sunnetcioglu, A.; Karadas, S.
Mean platelet volume (MPV) is a simple and easy method of assessing platelet function in routine clinical practice. The data concerning MPV in pulmonary embolism are controversial. Therefore, the aim of this study was to evaluate MPV levels and platelet numbers in patients with acute pulmonary embolisms. This retrospective study was conducted in the emergency department of the Medical Faculty Hospital of Yuzuncu Yil University between January 2010 and April 2012. The study enrolled 67 patients with acute PE (36 females and 31 males) and 53 healthy controls (31 females and 22 males). The platelet number and MPV values in patients with acute pulmonary embolism were reviewed. There were no statistically significant differences between the acute PE patients and the controls with respect to the MPV values and platelet numbers (both, p>0.05). The MPV values were inversely correlated with the platelet number in the patients with acute PE (r:0.388; p<0.001). These results suggest that MPV is not a reliable indicator for diagnosing acute pulmonary embolism. Further studies are necessary to confirm these findings. © 2014, Yuzuncu Yil Universitesi Tip Fakultesi, Universitas Indonesia. All rights reserved.
Pai-1 and Tpa Gene Polymorphisms and Susceptibility To Chronic Obstructive Pulmonary Disease in a Sample of Turkish Population
(Pakistan Medical Association, 2020) Sunnetcioglu, A.; Berkoz, M.; Yildirim, M.; Bora, G.; Yalin, S.
Objective: The aim of this study was to assess the influence of plasminogen activator inhibitor-1 (PAI-1) 4G/5G or tissue plasminogen activator (tPA) I/D polymorphisms in chronic obstructive pulmonary disease (COPD) cases in a sample of Turkish population. Methods: PAI-1 4G/5G and tPA Alu-repeat I/D genetic polymorphisms in 153 COPD subjects and 160 controls were investigated using PCR-RFLP and PCR methods, respectively. Results: 4G allele frequency was 0.62 and 0.39 for COPD and control groups, respectively. 4G allele had an estimated 2.56-fold [95% CI = 1.85-3.53] increased risk of COPD. tPA I allele frequency was 0.55 and 0.50, for COPD and control groups, respectively. I allele had an estimated 1.19-fold [95% CI = 0.87-1.62] increased risk of COPD Conclusions: PAI-1 4G/4G and 4G/5G genotypes seemed to play a key role in the pathophysiology of COPD in Turkish individuals. © 2020 Pakistan Medical Association. All rights reserved.
Predictive Risk Factors for Intensive Care Unit Mortality in Acute Exacerbations of Copd Requiring Invasive Mechanical Ventilation
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Sunnetcioglu, A.; Çilingir, B.M.; Çelikel, M.; Bedirhanoğlu, S.; Demirkiran, H.
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) frequently necessitate intensive care unit (ICU) admissions. The purpose of this study is to determine risk factors for ICU mortality in AECOPD who required invasive mechanical ventilation (IMV). Patients requiring IMV for AECOPD between January 2013 and March 2019 were retros pectively reviewed. Patients’ characteristics, comorbidities, and laboratory results were reviewed from the medical charts. Subjects’ acute physiology and chronic health evaluation (APACHE) II score, Glasgow Coma Scale (GCS), IMV (days), and mortality were recorded. As an output or dependent variable, ICU mortality was considered. Other variables were considered to independent factors or risk factors. Then, Logistic regression analysis was performed to determine risk factors for ICU mortality in AECOPD. The study, 134 patients were included. The mean duration of IMV were 11.6 ± 12.2 days. The ICU mortality were 51.4 %. On admission to ICU, patients had APACHE-II scores of 23.0 ± 6.2. Nonsurvivors had lower blood Mg levels ( 1.8 ± 0.2 mmol/L, p = 0.002), lower blood Ca levels (8.0 ± 0.7 mg/dL, p = 0.005), higher Uric Acid, (8.5±3.8 mg/dl, p = 004), higher CRP levels (87.2 ± 71.8 mg/dl, p = 0.048), higher leukocyte count (14.7 ± 10.2 103L, p= 0.040), higher serum lactate (2.3 ± 1.7 mmol, p = 0.003) compared to survivors. APACHI score and uric acid level were found statististically significant risk factors for ICU mortality. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
What Is the Case of More Accessibl E Treatment Options in Covid 19: Comparison of Hydroxychloroquine and Favipiravir Based on Laboratory Values
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Çilingir, B.M.; Sunnetcioglu, A.; Yildiz, H.; Erçek, B.M.; Baykal, N.D.
Two of the drugs are frequently used in COVID-19 treatment algorithm because of their low cost, easy availabil ity and application; Hydroxychloroquine (HCQ) and Favipiravir. Our aim in this study is to compare the laboratory parameters of patients diagnosed with COVID-19 Pneumonia in whom HCQ and Favipiravir treatment was initiated, and to reveal the difference in the effectiveness of the treatments. 64 COVID-19 patients whose diagnoses were confirmed by real-time polymerase chain reaction test (RT-PCR) of nasopharyngeal swab samples and pneumonia image compatible with COVID-19 on Thorax CT were included in the study. Patients were divided into three groups: treated with HCQ, treated with favipiravir, and who were switched to favipiravir treatment when they did not benefit from HCQ. We compared the laboratory values on Day 1, Day 5 and at discharge. When compared in terms of laboratory values, there was no significant difference between the groups in which HCQ and Favipiravir was initiated. In the patient group who did not improve with HCQ and switched to favipiravi r treatment, lymphocyte levels increased and ferritin, CRP and d-dimer values decreased. The decrease in D-dimer and CRP values was statistically significant (p= 0.029, p= 0.048). PLT, Hemoglobin, RDW, MPV, NLR, PLR, INR values did not change significantly in any patient group. Our study with the most commonly used drugs in our country reveals that HCQ and Favipiravir are not superior to each other. When we changed the treatment with favipiravir in the group of patients receiving HCQ whose clinical an d / or laboratory values deteriorated, D-dimer and CRP values decreased during discharge. This finding shows how effective the timely treatment change is in the recovery of the patient by closely following the patient clinically and interpreting the laboratory values correctly. In COVID-19, we should direct the treatment of our patients by following the symptoms, risk factors and especially laboratory values. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.