Browsing by Author "Tütüncü, M"

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Acute Phase Effect of Trichloroethylene Ingestion on Some Biological Markers in Dogs
(Scientific Technical Research Council Turkey, 2000) Aslan, R; Tütüncü, M; Aslan, SO; Dündar, Y
Trichloroethylene (TE) is an environmental toxic solvent hazardous to human and domestic animals and well known in the industrial sector. The purpose of this study was to determine whether oral TE plays a role in lipid oxidation and tissue damage. Fourteen dogs were treated with an oral toxic dose of 0.5 ml/kg T.E. The acute changes that occurred in creatine kimase (CK), malondialdehyte (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were investigated in blood samples taken before application and 8, 24, 48, 72 and 168 hours after treatment. SOD and GSH-Px activities decreased, protein, albumin and alcalen phosphate did not change and the others increased a and 24 h after the TE treatment. Forty-eight hours after the treatment, MDA, CK, albumin and AST increased, while SOD and GSH-Px decreased. Ail markers returned to their normal levels after 72 h. It was concluded that TE plays a role in oxidative stress and tissue damage in the acute phase, Repeated intake of oral TE can reach serious toxicity in domestic animals living around industial zones polluted with chemicals.
The Efficacy of Cloxacillin and Micanfin in Multifactorial Conjunctivitis Treatment in Van Cats
(M H Schaper Gmbh Co Kg, 2003) Akkan, HA; Ilhan, Z; Karaca, M; Tütüncü, M; Gençcelep, M; Gülhan, T
This study was performed on 121 Van Cats at the Van Cat Research Center of the Yucuncu YiI University. Out, of 121 cats 20 showed an uni- or bilateral conjunctivitis. The animals were of both sex aging between 1-9 years. The following symptoms were observed in 20 cats with conjunctivitis: serous or seromucous lacrimation, hyperemia and oedema in the conjunctiva and desquamation around their eyes. Hair samples together with hair follicules were taken from comissura medialis and used for bacteriologial and fungal culture. After cultivation, Staphylococcus spp. in 19 cats, Streptococcus spp. in 7 cats and Microsporum spp. in 2 cats were isolated. All the bacteria detected were sensitivite to cloxacillin and to some other antibiotics according to the antibiogram. Cloxacillin (Optidox opht. pom., Sanovel) was applied to both eyes of the all 20 cats. After drug application, 18 cats out of 20 (90%) showed recovery signs starting from 24 hours to 72 hours. However, clinical signs in two cats (10 %) had not disappeared at all. 1.72 hours after drug application, hair samples were taken again for bacteriological analysis. With the exception of these two samples collected from the cats with no clinical improvement, the other 18 samples did not show any bacterial growth. The 2 cats recovered after a second cloxacillin application. The conjunctivitis symptoms disappeared and bacteriological tests made 144 hours after the treatment were negative. After bacteriological elimination, the vaccine Micanfin (Micanfin flk. BioVeta) against Microsporum canis was injected intra-muscularly twice at 14 days intervals. Allergic reactions were not observed on the cats after vaccination. Fungal agents couldn't also be detected 25 and 40 days after vaccination. As a result; cloxacillin was an effective antibiotic in the conjunctivitis caused by Staphylococcus spp., and Streptococcus spp. and Micanfin can safely be used in Van cats without any side effect.
Haemobartonellosis in Van Cats
(Tubitak Scientific & Technological Research Council Turkey, 2005) Akkan, HA; Karaca, M; Tütüncü, M; Özdal, N; Yüksek, N; Agaoglu, Z; Deger, S
The present study was conducted to determine prevalence of Haemobartonella felis in Van cats. 121 Van cats (82 female, 39 male, aged 1-9 years) were the materials of the study, To determine biochemical and haematological parameters, 2 ml blood with and without anticoagulant were taken according to technique from vena cephalica antebrachii. H. felis was detected in blood smears preparations of 18 (14:88%) by Papenheim staining. Among biochemical parameters aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), creatine phosphokinase (CPK) and bilirubin were in normal range as well as the packed cell volume (PCV) and red blood cell (RBC) counts. The infected cats were treated with oxytetracycline at 10 mg/kg dose intramuscularly (Geosol((R)) flacon, Vetas) or oral oxytetracycline at 10 mg/kg dose (Neoterramycine((R)) pow. Pfizer) for 15 days. After either above treatment blood smear preparations revealed negative for the rickettsia. In conclusion, potentially lethal infection of Haemobartonelia felis is prevalent in Van cats and can successfully be cured by oral or parenteral oxytetracycline application.