Browsing by Author "Tütüncü, M."

Now showing 1 - 3 of 3

Comparative Efficacy of Rituximab Versus Azathioprine in the Treatment of MOG Antibody-Associated Disease (MOGAD)
(Elsevier B.V., 2025) Şen, S.; Kürtüncü, M.; Demir, S.; Gündüz, T.; Demirel, E.; Tütüncü, M.; Tuncer, A.
Background: Azathioprine (AZA) and rituximab (RTX) are frequently used drugs in the treatment of Myelin Oligodendrocyte Glycoprotein Associated Disease (MOGAD). Objectives: The aim of this study was to evaluate the efficacy and safety data of AZA and RTX treatments in MOGAD. Methods: Patients diagnosed according to the 2023 MOGAD diagnostic criteria and receiving AZA or RTX treatment were included in the study. Results: In 142 patients included in the study, the female/male value was 1.2. The rate of OCB positivity in MOGAD patients was 22.6 %. Patients on RTX had higher EDSS values than patients on AZA. However, the RTX group demonstrated a more pronounced improvement in disability, reflected by a greater negative trend in the ΔEDSS values. The attack-free rate was 78 % in the RTX group and 68 % in the AZA group during their treatment period. Both groups had no difference in the time of the first attack. The main factor affecting the time to first attack was having a higher EDSS at the time of treatment initiation. The survival analysis found that EDSS scores improved significantly in patients treated with RTX. Conclusion: Although survival analyses for both treatments appear to be similar, using RTX provides better EDSS scores. © 2025
Investigation of Anti-Inflammatory Activity of Bergamot Oil
(TIP ARASTIRMALARI DERNEGI, 2007) Karaca, M.; Özbek, H.; Him, A.; Tütüncü, M.; Akkan, H.A.; Kaplanoǧlu, V.
Aim: Essential oil of Bergamot (BO) was investigated for anti-inflammatory activity using carrageenan-induced rat paw oedema test. Methods: For the anti-inflammatory activity measurement six different groups were established and BO was administered in three different doses: 0.025, 0.05 and 0.10 mL/kg. Indomethacin was used as a reference agent. Results: It was found that reduction in the inflammation was 95.70% with indomethacin, 27.56% with 0.025 mL/kg BO, 30.77% with 0.05 mL/kg BO and 63.39% with 0.10 mL/kg BO. Indomethacin showed the strongest anti-inflammatory activity among the drugs used. The strongest anti-inflammatory activity of BO was seen with 0.10 mL/kg dosage. Median effective dose (ED50) value of BO was found to be 0.079 mL/kg. Conclusion: The results showed that BO posseses promising anti-inflammatory effect.
Investigation of the Anti-Inflammatory and Analgesic Activities of Β-Caryophyllene
(2008) Bakir, B.; Him, A.; Özbek, H.; Düz, E.; Tütüncü, M.
The aim of this study was to investigate the anti-inflammatory and analgesic activities of β-caryophyllene (trons-caryophyllene) in rats and mice. In our previous work, we demonstrated the anti-inflammatory activity of Eugenia caryophyllata essential oil. We performed this study in order to determine the component(s) (such as eugenol, β-caryophyllene, α-humuiene, eugenyl acetate) responsible for these activities. For the anti-inflammatory activity measurement, five different groups were established and β-caryophyllene was administered in three different doses: 0.025, 0.05 and 0.1 ml/kg. Etodolac was used as reference agent. For the analgesic activity measurement, four different groups were established and β-caryophyllene was administered in two different doses: 0.05 and 0.1 ml/kg. Morphine was used as reference agent. Etodolac showed the strongest anti-inflammatory activity among the drugs used.The strongest anti-inflammatory activity of β-caryophyllene was seen with 0.1 ml/kg dosage. The median effective dose (ED50) value of β-caryophyllene was found to be 0.0745 ml/kg. Morphine showed the strongest analgesic activity, but β-caryophyllene did not show analgesic activity at any of the dosages. As a result, it is concluded that β-caryophyllene is a molecule having anti-inflammatory activity, but with no analgesic properties. © Essential Oil Resource Consultants. All rights reserved.