Browsing by Author "Tas, Abdurrahim"

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Embolization After Internal Carotid Artery Injury Secondary to Transsphenoidal Pituitary Surgery and Delayed Intranasal Coil Protrusion: Illustrative Case
(Amer Assoc Neurological Surgeons, 2022) Tas, Abdurrahim; Bozan, Nazim; Akin, Ramazan; Aycan, Abdurrahman
BACKGROUND The authors presented a case of spontaneous nasopharyngeal coil migration that occurred 3 years after a patient had undergone transsphenoidal resection due to pituitary macroadenoma and was treated with coil application because of internal carotid artery injury secondary to transsphenoidal resection of the pituitary macroadenoma. OBSERVATIONS In the literature, eight cases of coil migration that occurred between 2 and 120 months after coil application have been reported, most of which were treated with surgical removal of the coil in a same-day surgery setting. LESSONS The case presented emphasized that coil protrusion and migration may lead to destruction in the skull base, thereby leading to serious consequences if left untreated, even in the absence of history of trauma. To the authors' knowledge, this is the first case in the literature that required additional invasive procedures due to recurrent bleeding that occurred several months after surgical removal of coils. Also, this report underlined the need for careful and long-term follow-up of coil materials used for the treatment of pseudoaneurysms caused by vascular injuries secondary to skull base injury during surgery.
Evaluation of Cholinergic Enzymes and Selected Biochemical Parameters in the Serum of Patients With a Diagnosis of Acute Subarachnoid Hemorrhage
(de Gruyter Poland Sp Z O O, 2023) Aycan, Abdurrahman; Tas, Abdurrahim; Yeltekin, Asli Cilingir; El-Tekreti, Sama Amer Abbas; Arslan, Ayse; Arslan, Mustafa; Aycan, Nur
Background: Spontaneous subarachnoid hemorrhage (SAH) is the most severe form of hemorrhagic stroke and accounts for 5-7% of all strokes. Several chemical enzymes and cytokines are thought to cause reactions that may affect the mortality and morbidity of SAH patients. This study aimed to examine the possible relationships between these parameters and the occurrence of SAH and the clinical-radiological parameters in patients with acute SAH. Methods: This study evaluated 44 patients, including 20 with SAH and 24 controls. We obtained blood from the patients and control groups, which was stored in heparinized tubes and used in determining tumor necrosis factor alpha (TNF-alpha), brain-derived neurotrophic factor (BDNF), acetylcholinesterase (AChE), caspase-3, and butyrylcholinesterase (BChE) enzymes. Results: TNF-alpha, BDNF, AChE, and BChE enzyme levels were not related to the Glasgow Coma scale (GCS) score in the patient group (p > 0.05), whereas higher enzyme levels of caspase-3 were associated with lower GCS scores (p < 0.05). The difference between the control and patient groups in terms of mean TNF-alpha levels was statistically significant (p < 0.01). The BDNF levels were statistically insignificant in the patient groups (p > 0.05). Caspase-3, AChE, and BChE levels were significantly different between the control and patient groups (p < 0.01). Conclusions: Our results may be valuable for predicting the prognosis, diagnosis, and follow-up of patients with SAH. However, further studies are required to elucidate the relationship between the clinical and radiological results in patients with SAH and certain enzymes, cytokines, and growth factors.
Prophylactic Effects of Hesperidin on Spinal Cord Injury in Rats
(Sci Printers & Publ inc, 2021) Tas, Abdurrahim; Cetin, Abdurrahman
OBJECTIVE: To investigate how inflammation after spinal cord injury affects the apoptotic process in neu-ron glial cells and to investigate the antioxidative effect of hesperidin in developing inflammation. STUDY DESIGN: Twenty Wistar Albino rats were categorized as control and SCI group. At T10-T11 vertebras, a steel rod was dropped from 10 cm to create a spinal cord injury under anesthesia. A cylindrical tube of 10 cm length was fixed to the area to undergo laminectomy. Spinal damage was created by dropping a 15-g metal weight down the tube. Immediately after the trauma, 30 mg/kg hesperidin was administered for 7 days. At the end of experiment, blood samples were taken from the animals and analyzed with various bio-chemical markers. The spinal cord was excised for routine paraffin tissue protocol. Hematoxylineosin stain was used for histological examination, and APAF-1 and NF-kappa B anti bodies were used for immunohistochemistry. RESULTS: Both MDA and MPO values were increased in the SCI group as compared to the control and SCI+ Hesperidin groups, and the increase was statistically significant. GSH content was decreased in the SCI group as compared to the control and SCI+ Hesperidin groups, and the decrease was statistically significant. In the SCI group, some of the ependymal cells were degenerative and hyperplastic, degeneration and pyk-nosis in the nuclei of neurons in the substantia grisea region, and loss of structural integrity in the exten-sions were observed. In the SCI+ Hesperidin group, mild degeneration of the ependymal cells, some of the neurons in substantia grisea continued to have an apoptotic appearance, while the integrity of the neuron cytoplasm and nucleus was preserved. In the SCI group, APAF-1 expression was positive in some of the ependymal cells. APAF-1 expression was weak in neu-ron structures and glial cells in the substantia alba and substantia grisea region in the SCI+ Hesperidin group. After SCI, there was a significant increase in NF-kappa B expression in endothelial cells and perivascular glial cells and degenerated neurons. In the SCI+Hesperidin group, mild NF-kappa B expression was observed in glial cells, some neu rons in the substantia grisea and sub-stantia alba region, and blood vessel endothelial cells. CONCLUSION: Hesperidin administration after spinal cord injury was thought to inhibit neuronal cell apo-ptosis (APAF-1) by reducing oxidative stress, inflamma-tory mediators, and NF-kappa B.