Browsing by Author "Taskin, Cem"

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Effects of Injectable Platelet-Rich Fibrin in Experimental Periodontitis in Rats
(Springer, 2021) Aydinyurt, Hacer Sahin; Sancak, Tunahan; Taskin, Cem; Basbugan, Yildiray; Akinci, Levent
Injectable platelet-rich fibrin (i-PRF) is an effective biological material that positively contributes to angiogenesis, wound healing, inflammation, regeneration processes, etc. This research aimed to evaluate the effect of i-PRF in rats with experimental periodontitis. Following the development of ligature-induced periodontitis, 24 Wistar albino rats were divided into three groups. Group-1: scaling and root planing (only-SRP); Group-2: SRP + i-PRF; Group-3: only- i-PRF. Heart blood from six donors was used for the i-PRF application. i-PRF was administered as a subgingival injection in the relevant groups on the 1st, 3rd, and 7th days. The tissues were evaluated histopathologically and immunohistochemically. Also, bone structures were examined using micro-CT. According to the data obtained, no statistically significant difference was observed among the groups in terms of bone resorption, inflammation, bone volume, bone levels (mesial/distal), and IL-1 beta, IFN-r, TNF-alpha, VEGF values (p > 0.05). However, bone mineral density was statistically significantly different among the groups (Group3 > Group2 > Group1) (p < 0.0001). Subgingival injection of only-i-PRF showed promising results in periodontitis treatment but contribution to SRP has not been proved according to this study results. The study results suggested that the i-PRF application was as effective as SRP in reducing bone loss, modulating inflammatory process, and effecting cytokines in experimental periodontitis. The significant effect of i-PRF on bone mineral density was the most remarkable result.
Evaluation of Periodontal Status and Interleukin Levels in Pregnant Women With Hellp Syndrome
(Kerman Univ Medical Sciences, 2022) Aydinyurt, Hacer Sahin; Cetin, Orkun; Aydogdu, Hasan Murat; Karaman, Erbil; Taskin, Cem; Sahin, Hanim Guler; Alkhatib, Mohammed F. A.
BACKGROUND AND AIM: Hemolysis, elevated liver enzymes and low platelet (HELLP) syndrome is a pregnancy-specific disease that affects many systems of the body. Its etiopathogenesis has not been fully elucidated. HELLP syndrome is characterized by hemolysis, elevated liver enzymes, and low platelet counts. It has a prevalence of 0.2%-0.8% in pregnant women. This study aimed to compare periodontal status as well as interleukin (IL)-6 and IL-37 levels in gingival crevicular fluid (GCF) of healthy pregnant women and pregnant women with HELLP syndrome. METHODS: This study included 20 patients with HELLP and 20 healthy pregnant women. The clinical periodontal parameters [plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL)] were recorded and GCF samples were collected. IL-6 and IL-37 levels were measured in GCF samples using the enzyme linked immunosorbent assay (ELISA) method. The data collected from healthy pregnant women and patients with HELLP were compared with statistical analysis. RESULTS: There was no statistically significant difference between healthy pregnant women and pregnant women with HELLP in terms of periodontal clinical parameters. There was a statistically significant difference in terms of IL-6 levels (P < 0.05); however, no statistically significant difference was determined in terms of IL-37 levels in GCF. CONCLUSION: This is the first study to evaluate periodontal status as well as IL-6 and IL-37 levels in GCF in pregnant women with HELLP syndrome. The results of the study showed that IL-6 levels were significantly higher in pregnant women with HELLP syndrome, but there was no significant difference in terms of other parameters. Further research is needed to evaluate the relationship between HELLP syndrome and periodontal disease.