Browsing by Author "Tat, Necati Muhammed"
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Article Evaluation of the Quality and Reliability of Exercise and Physiotherapy Videos Shared on Youtube for Patients With Hemophilia: a Cross Sectional Study(Turkey Assoc Physiotherapists, 2023) Tat, Necati Muhammed; Tat, Ayse MervePurpose: To evaluate the quality and reliability of shared on YouTube videos pertaining to exercises and physiotherapy in haemophilia. Methods: The terms "exercise in haemophilia" and ''physiotherapy in hemophilia'' were entered on YouTube, First 300 videos were independently analyzed by two physiotherapists and were classified as reliable or non-reliable. Video demographics were analyzed according to speakers and uploaders of the video. Video Power Index (VPI) was calculated for each video. Modified DISCERN and Global Quality Scores (GQS) were used to assess the reliability and overall quality of the videos. Results: Eighty-five videos were included and 51.7 % were non-reliable. The median GQS and DISCERN scores of the videos were significantly higher in the reliable group and where the speakers were physician and physiotherapist (p<0.001). According to the video source, the GQS and DISCERN scores of the videos shared by haemophilia patients and personal trainers were found to be significantly lower in all pairwise comparisons of other groups (p<0.001). Although the VPI was higher in the reliable group, no significant difference was found in all group comparisons (p=0.185). Conclusions: It was determined that most of the exercise and physiotherapy videos shared on YouTube in hemophilia were non-reliable and quite low quality. Although the popularity of the videos shared by Haemophilia Associations/Universities/physician or physiotherapists is not high, their reliability and quality are relatively higher. Considering the difficulties of hemophilic individuals in reaching physiotherapist who maintains their joint health, it may be recommended that musculoskeletal specialist physiotherapists share original, detailed and interesting videos.Master Thesis Investigation of Biochemical and Histopathological Effects of Vitamin C, Selenium and Therapeuthical Ultrasound Application on Muscular Injury Formed in Rats(2013) Tat, Necati Muhammed; Tülüce, Yasin; Kara, MehmetTat MN. Sıçanlarda oluşturulan kas yaralanmasında yalnız ve kombine uygulanan vitamin C, selenyum ve terapötik ultrason tedavisinin biyokimyasal ve histopatolojik etkilerinin araştırılması. Yüzüncü Yıl Üniversitesi Sağlık Bilimleri Enstitüsü, Fizyoloji Anabilim Dalı Yüksek Lisans Tezi, Van, 2013. Kas yaralanmaları sıklıkla görülen yumuşak doku yaralanmalarıdır. Kas yaralanmaları sunucunda oksidatif hasarın arttığı bildirilmektedir. Terapötik ultrason tedavisi bu tür yaralanmalarda sıklıkla uygulanmaktadır. Bu çalışmada, deneysel olarak oluşturulan kas yaralanmasında ultrason tedavisi ile bazı antioksidan maddelerin tedavi etkinliği karşılaştırıldı. Bu amaçla bazı serum enzimleri, oksidatif stres belirteçleri, nötrofil infiltrasyon belirteci olan miyeloperoksidaz (MPO) aktivitesi, enflamasyon belirteci olarak interlökin-6 ve tümör nekroz faktör-? ölçülmesinin yanısıra histolojik inceleme gerçekleştirildi. Herbiri altı adet Wistar türü albino erkek sıçandan oluşan toplam 6 grup oluşturuldu. Bu gruplar kontrol (K), yalnız kesi (YK), ultrason (U), vitamin C (Vit C), selenyum (S) ve miks (M) olarak isimlendirildi. K grubu dışındaki bütün hayvanlarda gastroknemius kasının kesilmesi yoluyla kas yaralanması oluşturuldu. YK grubundaki sıçanlara tedavi uygulanmadı. Geriye kalan 4 gruptaki hayvanlara ise yaralanma oluşturulduktan 24 saat sonra 2 günde bir toplam 3 defa tedavi uygulandı. Bu gruplardaki sıçanlara terapötik ultrason tedavisi, vitamin C, selenyum veya bunların kombine olarak verilmesi uygulandı. Altıncı günde bütün hayvanlar sakrifiye edildi. Biyokimyasal ve histolojik analizler için kan ve kas dokuları alındı. Yalnız kesi grubu serum enzimleri yönünden kontrol grubu ile kıyaslandığında CK, AST ve ALT akvitesinde istatistiksel olarak anlamlı (p<0.05) artışlar görülürken LDH?da görülen yükselme anlamlı değildi. Neredeyse bütün tedavi gruplarında CK, ALT ve AST seviyesi kontrol grubuna anlamlı olarak yaklaşırken (p<0.05), LDH seviyesindeki düşüşler anlamlı değildi. Hem kan hem de kas dokusunda gerçekleştirilen biyokimyasal analizlerin çoğunun gruplardaki değişimi birbirine paraleldi. Gruplardaki total antioksidan seviye (TAS)?deki değişimlerin anlamsız olduğu görüldü. Total oksidan seviye (TOS) ve oksidatif stres indeksi (OSİ)?nin yalnız kesi grubunda arttığı, tedavi gruplarından S ve M?de ise azaldığı görüldü. Ancak değişimlerden sadece kas dokusunda bakılan TOS?un tedavi gruplarındaki düşüşünün istatistiksel olarak anlamlı olduğu bulundu (p<0.05). MPO aktivitesi yalnız kesi grubunda artmış, tedavi gruplarının neredeyse hepsinde azaltılmıştır. Bununla beraber sadece kan dokusu MPO enzim aktivitesinde, YK grubundaki artış ve tedavi gruplarından Vit C grubundandaki azalış istatistiksel olarak anlamlıydı (p<0.05). Serum enflamasyon belirteçlerinin (İL-6 ve TNF-?) değişimi ile histolojik bulgular incelendiğinde ise gruplar arasında önemli bir fark olmadığı görülmüştür. Bu çalışma ultrason tedavisinin dışında vitamin C ve selenyum tedavilerinin de kas yaralanmasında faydalı olduğunu ortaya çıkarmıştır. Burada elde edilen bulguların desteklenmesi için daha ileri çalışmalara ihtiyaç vardır.Article Investigation of the Biochemical and Histopathological Effects of Vitamin C, Selenium, and Therapeutic Ultrasound on Muscle Damage in Rats(Springer, 2023) Tuluce, Yasin; Tat, Necati Muhammed; Kara, Mehmet; Tat, Ayse MerveMuscle injury is a common type of soft tissue injury. Increased oxidative damage has been reported after muscle injuries. Therapeutic ultrasound is commonly used for such injuries. This study compared the efficacy of therapeutic ultrasound treatment and various antioxidant agents in experimental muscle injuries. For this purpose, some serum enzymes, oxidative stress, and inflammatory markers were evaluated together with histopathological examinations. Six groups were formed with 6 male Wistar albino rats in each group. These groups were control, only injury (OI), ultrasound (U), vitamin C (Vit C), selenium (S), and mixture (M). Muscle injury was caused by a laceration of the gastrocnemius muscle in all groups except the control group. No treatment was performed in the OI group. At the end of the 6-day application, all rats were sacrificed. As for serum enzymes, CK, ALT, and AST levels returned to control values in almost all treatment groups. Total oxidative status (TOS) and oxidative stress index (OSI) increased in the OI group, while they decreased in the S and M groups. In addition, the decrease in MPO activity in the blood tissue of the Vit C group was statistically significant. There were no significant changes between groups in terms of serum inflammatory markers and histological findings. This study has shown that the ingestion of vitamin C and selenium may contribute to the treatment of muscle injury in addition to therapeutic ultrasound treatment. However, further studies are needed to support these results.Article Low Frequency Physiotherapy on Joint Health, Hemarthrosis, Walking, Balance and Reaction Time in Hemophilic Arthropathy: a Controlled Trial(Bmc, 2025) Tat, Ayse Merve; Tat, Necati Muhammed; Sekeroz, Serbay; Buke, Meryem; Karaman, KamuranBackgroundPhysiotherapy is recommended for people with hemophilic arthropathy (PwHA) to improve musculoskeletal health and is typically administered in 2 or 3 sessions per week. We aimed to investigate the effects of once a week comprehensive physiotherapy and home exercise on musculoskeletal system of PwHA.MethodsIn this study 19 young PwHA with knee and/or ankle were non-randomly divided into two groups: The Home Exercise Group (HEG) and the Comprehensive Physiotherapy Group (CPG). Joint health was evaluated with the Hemophilia Joint Health Score (HJHS), muscle strength (MS) with manual muscle tester, range of motion (ROM) with universal goniometer, pain with Numerical Pain Scale (NPS). The following functional tests were used: 6 min Walking Test (6MWT) for walking capacity, Functional Reach Test (FRT) for dynamic balance and Fitlight (R) system for visuomotor reaction time (VMRT). The frequency of hemarthrosis (FoH) in the last 6 weeks was obtained from the self-recorded data. The CPG received comprehensive physiotherapy once a week, including manual therapy, neuromuscular electrical stimulation and supervised exercises, and they performed home exercises for the other two days of the week. The HEG only performed home exercises 3 days a week. All the treatments lasted 6 weeks and evaluations were repeated.ResultsCompared with the HEG, the CPG significantly ameliorated for NPS, FoH, HJHS, VMRT (time and mean), 6MWT, all MS and several ROMs. CPG significantly improved in all outcomes except for 1 ROM. The HEG significantly improved in FoH, HJHS, VMRT (time), 6MWT and MS, but not in the ROMs.ConclusionComprehensive physiotherapy once a week and continuing home exercise significantly improve joint health, functionality and balance, and reduce pain and hemarthrosis in PwHA.Trial registrationThe study was registered at Clinicaltrials.gov (Study ID NCT06331091, retrospectively registered).Article Muscle Strength and Joint Health in Children With Hemophilia: a Cross-Sectional Study(Turkish J Pediatrics, 2020) Tat, Necati Muhammed; Tat, Ayse Merve; Can, Filiz; Antmen, Bulent; Oner, Ahmet FayikBackground and objectives. We aimed to evaluate joint health in children with hemophilia (CwH) and to investigate the effects of hemarthrosis on the musculoskeletal system. Method. Forty-one CwH aged between 6-18 years participated in the study. Joint health status was evaluated according to Hemophilia Joint Health Score (HJHS). Pain intensity level was assessed in resting and in activity using Visual Analog Scale. Range of motion was measured with goniometer and musde strength was assessed with digital dynamometer. Arthropathic joints were examined in three groups named knee, elbow and ankle. Results. Physical examination revealed arthropathy findings to be found in 29 knee, 19 elbow and 18 ankle joints. The median of flexion angle of the affected side were 120 degrees, 122 degrees and 12 degrees for the knee, elbow and ankle and extension losses of these joints were 5 degrees, 7 degrees and 0, respectively. In CwH having knee and elbow arthropathy, index joint HJHS was found to be significantly higher than those with ankle arthropathy (p <0.01). The flexor and extensor muscle strength significantly decreased in 11 CwH with unilateral elbow arthropathy compared to the non-arthropatic side (p <0.05). In 15 CwH with unilateral ankle arthropathy decreased in the extensor muscle strength (plantarflexors) (p <0.05). Extension loss showed a good correlation with index HJHS of elbow, knee and ankle joints, respectively. (r(s) = 0.599, 0.576, 0.606, p <0.01). We observed that the muscle strength of elbow flexors/extensors and ankle extensors were significantly decreased compared to the non-arthropathic side. However this situation was not detected in knee joint despite having highest index HJHS. Conclusion. Our findings indicate that hemarthrosis may cause more muscle strength loss in the upper extremity than the lower extremity. Furthermore, extension loss was found to be an important parameter in physical examination of hemophilic arthropathy. Musculoskeletal system should be evaluated comprehensively at regular intervals and when necessary rehabilitative treatment should be planned.