Browsing by Author "Taylan-Ozkan, Aysegul"

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Evaluation of Th1/Th2 Balance in Pulmonary Cystic Echinococcosis Patients
(Springer int Publ Ag, 2024) Gazi, Umut; Beyhan, Yunus Emre; Tosun, Ozgur; Karasartova, Djursun; Cobanoglu, Ufuk; Taylan-Ozkan, Aysegul
PurposeCystic echinococcosis (CE) is a neglected tropical disease prevalent worldwide, particularly in rural areas. Previous studies evaluated immune responses in patients with hepatic CE, however none had assessed Th1, Th2 and Th17 levels simultaneously in pulmonary CE patients. This study aimed to fill this gap in literature by using flow cytometry analysis.MethodsPeripheral blood mononuclear cells (PBMCs) were isolated from blood samples collected from healthy control (HC) volunteers and patients with active pulmonary CE cysts. The PBMCs were analysed to evaluate Th1, Th2, and Th17 cell levels within the CD3 + CD4 + T-cell population, using antibodies against interferon (IFN)-gamma, interleukin (IL)-4, and IL-17, respectively.ResultsOur analysis revealed elevated Th2 levels in CE patients, while Th1 and Th17 cell counts showed no significant difference between HC volunteers and patients with pulmonary CE.ConclusionThe results indicate an imbalanced Th1/Th2/Th17 cell regulation in the pathogenesis of pulmonary CE. Future studies are recommended to compare immune responses between pulmonary and hepatic CE to confirm these findings and evaluate any potential difference in the immunopathology associated with the two clinical forms of CE.
A Pediatric Case of Fascioliasis With Eosinophilic Pneumonia
(Turkish J Pediatrics, 2016) Bayhan, Gulsum Iclal; Batur, Abdulsamet; Taylan-Ozkan, Aysegul; Demiroren, Kaan; Beyhan, Yunus Emre
Fasciolia spp. are common trematode infestations worldwide. Fasciolia spp. may lead to hepatic diseases in the acute phase and may cause biliary diseases in the chronic phase. In addition, Fasciolia spp. may rarely cause extrahepatic signs and symptoms. The clinical manifestations of fascioliasis are divided into three groups: typical, atypical, and ectopic. Eosinophilic pneumonia is an atypical presentation of acute fascioliasis and it has been reported very rarely. Herein, we report a boy with marked blood eosinophilia and eosinophilic pneumonia who was diagnosed with fascioliasis by serologic tests and abdominal USG. The patient recovered completely following triclabendazole treatment.