Browsing by Author "Temur, A."

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The Association of Hbv With Immigrant Subjects
(Comenius Univ, 2018) Temur, A.; Dulger, A. C.
Biochemical and Histochemical Study on the Hypothalamus at Some Periods of Starvation and Refeeding After Starvation
(Asian Journal of Chemistry, 2007) Temur, A.; Atli, M.; Karadag, H.; Donmez, H. H.; Askerov, F.
This study was carried out to determine biochemical and histochemical alterations in the lateral (feeding centre) and ventro-medial (satiety centre) nuclei of hypothalamus in rats starved and refed after some periods of starvation. 180 Wistar albino rats were used in the investigation. The rats were starved for a periods of 1, 3, 5 and 7 d. The rats starved 5 d were refed for a periods of 5, 10, 15 and 30 d. The activity of the neutral peptide hydrolase was biochemically determined in the hypothalamus. In addition, histochemical investigation was made in the feeding and satiety centres. It was observed that the activity of the neutral peptide hydrolase became closer to the levels of the control group at 30th d of refeeding after 5 d starvation. It was concluded that the feeding centre was more sensitive to starvation than the satiety centre and the satiety centre was restored earlier than the feeding centre.
Effect of Solvent Variation on Polyphenolic Profile and Total Phenolic Content of Olive Leaf Extract
(Centenary University, 2017) Temiz, M.A.; Temur, A.
Olive tree is one of the oldest plants, evergreen and of which fruits, leaves and trunk can be used for many different purposes. Olive has become a nutritional source widely used for especially in the Mediterranean diet and due to its extensive metabolic effects attracting everyone's attention recently. Olive and olive leaves are rich in polyphenolic compounds. Oleuropein is the most available and most active polyphenolic compound. Hydroxytyrosol, tyrosol and verbascoside are other important active compounds. Oleuropein has antioxidant, antidiabetic and antimicrobial effects. This study was investigated the effects of solvent variation on the amount of polyphenolic compounds and total phenolic content in olive leaves. The olive leaves were extracted using water, methanol/water and methanol solvents. The content of olive leaves extract was investigated by chromatographic analysis. Also total phenolic content was determined using Folin-Ciocalteu method by spectrophotometric method. The chromatographic analysis showed that methanolic solvents more effectively extracted oleuropein from olive leaf. However, when water was used as a solvent, hydroxytyrosol, tyrosol and verbascoside were extracted better from olive leaf. When solvents were compared in respect to their total phenolic content; the order from highest to lower was respectively methanol, methanol/water, and water. Consequently, due to their high hydrophilic character; polyphenolic compounds can more efficiently be extracted in methanolic solvents with high polarity. © 2017, Centenary University. All rights reserved.
The Effects of Melatonin and Vitamin E on Antioxidant Parameters in Copper Nephrotoxicity
(Ataturk Universitesi, 2018) Temiz, M.A.; Temur, A.
Copper (Cu) compounds have been widely used in various fields especially industrial processes and agriculture. Although trace amounts of Cu are essential to sustain life, excessive Cu is toxic for living organisms. This study aims to investigate the effects of vitamin E and melatonin on antioxidant enzymes activities in kidney against acute Cu toxicity. In this study, 28 Wistar albino rats were divided four equal groups (n=7) as control, Cu, Cu+Vitamin E, and Cu+Melatonin groups. Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) enzymes activities and protein carbonyl content were analyzed. Also, kidney function tests were evaluated. While Cu administration increased creatinine, blood urea nitrogen (BUN), uric acid, Na, K and Mg levels, vitamin E and melatonin was effective reduction on these levels. Carbonyl level significantly decreased in Cu+Vitamin E and Cu+melatonin groups compared to Cu group. Although SOD, GPx and CAT activities in tissue decreased by Cu exposure, vitamin E and melatonin treatment showed significant increase on their activities. Consequently, vitamin E and melatonin supplements may provide prevention Cu -based oxidation by strengthening the antioxidant defense system. In this respect, it may show a protective effect by preventing the development of nephrotoxicity. © Ataturk Universitesi. All rights reserved.
Immunohistochemical Detection of Leptospiral Antigens in Cases of Naturally Occurring Abortions in Sheep
(Elsevier Science Bv, 2008) Saglam, Y. S.; Yener, Z.; Temur, A.; Yalcin, E.
This study was carried out to determine the leptospiral antigens in naturally occurring 108 abort sheep fetuses. To determine the antigen localizations in tissue sections (kidney, liver, lung and spleen) of each fetus were stained with immunoperoxidase (IP) technique and then were examined under light microscope. The results of this study showed that 19 (17%) out of 108 fetuses were positive for the presence of leptospiral antigens. In the 19 positive cases, leptospiral antigens were found in lung (n = 10; 9%), liver (n = 7; 6%), kidney (n = 12; 11%) and spleen (n = 2; 2%) samples. Microscopic studies demonstrated that leptospiral antigens were located in the cytoplasm of macrophages in interalveolar and interlobular septum of the lung; in the cytoplasm of macrophages in the portal regions and hepatocytes of the liver; in the cytoplasm of epithelial cells of renal pelvis, in the cytoplasm of epithelial cells of cortical and medullar tubules, and macrophages of intertubular region in the kidney. In the spleen, antigens were detected in the cytoplasm of macrophages throughout the parenchymal tissue. In conclusion, the results of this study demonstrate that leptospirosis could be a major disease causing abortions in sheep. (C) 2007 Elsevier B.V. All rights reserved.
Morphological and Functional Changes in Rat Brain Under Total Sleep Deprivation
(Istanbul University, 2015) Abushov, B.; Temur, A.; Temiz, M.A.
In this article the effect of 36 h total sleep deprivation (TSD) on behavioural reactions of rats (rearing, grooming and sexual activity) and on ultrastructure of brain neurons have been studied. A group of somnogenic structures (III-V layers of the frontal limbic cortex, CA1 area of the dorsal hippocampus, reticular formation of pons varolli, nucleus raphe dorsalis and locus coeruleus) of the brain of 6 month-old Wistar rats has been analized in this study. It has been revealed that dystrophic changes (chromatolysis of cytoplasm and vacuolization) enveloping a group of medium-sized neurons (20-30 (μ) micron in diameter) are accompanied by decrease of numbers of rearing, grooming and sexual activity. It is supposed that dystrophic changes revealed in medium-sized neurons result in partial disturbances of integrative and behavioral reactions of animals.
The Prevalence of Helicobacter Pylori in Patients With Oesophageal Stenosis
(Malaysian Soc Parasitology Tropical Medicine, 2018) Yilmaz, O.; Temur, A.; Almali, N.; Dulger, A. C.; Sasmaz, M., I
Oesophageal strictures often occur following esophagectomy which is performed for cases of oesophageal cancer. These patients require repeated dilation procedures. The aim of this study is to investigate the effects of dietary regimens, which are changed because of stenosis, caused by Helicobacter pylori (H. pylori). In this retrospective study, 28 patients who had operation for oesophageal cancer and underwent dilation due to development of stricture were studied. 30 female and 30 male patients who were admitted to the Gastroenterology Clinic with complaints of dyspepsia and did not receive treatment for the eradication of H. pylori were randomly selected and included in this study as a control group. Patients' histopathological records on the hemogram, biochemistry, and endoscopic biopsy were analysed. There were 26 H. pylori (+) cases (92.8 %) in the stenosis group consisting of 28 patients, and 37 H. pylori (+) cases (61.6%) in the control group consisting of 60 patients. These results were found to be statistically significant (P=0.003). The albumin level in the stenosis group was reported to be statistically low (P=0.002). The incidence of H. pylori was found to be significantly higher in patients with stenosis. We ascribed this outcome due to changes in dietary regimens. Our findings showed that the dietary regimens of all patients who underwent esophagectomy should be regulated during the postoperative period considering H. pylori. The relationship between H. pylori and stenosis was significant, there is a need for further research with a larger sample size to enrich the findings.