Browsing by Author "Timurkan, Mehmet Ozkan"

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Characterisation of Env and Gag Gene Fragments of Bovine Leukemia Viruses (Blvs) From Cattle in Turkey
(Springer Wien, 2011) Alkan, Feray; Oguzoglu, Tuba Cigdem; Timurkan, Mehmet Ozkan; Karapinar, Zeynep
The aim of this work was to investigate the molecular characteristics of bovine leukemia viruses (BLVs) in Turkey. The variability of env and gag fragments of BLVs was examined using DNA from blood samples obtained for sequence analysis of BLVs in four cattle herds from three different geographical areas in Turkey. The env gene sequences were highly similar to those of Brasilian, Argentine, and Japanese BLV strains, while gag genes from Turkish BLV isolates showed greatest similarity to those of Iranian isolates. This paper is the first report on the partial characterisation of env and gag genetic fragments of BLVs from Turkey.
Several Tick-Borne Pathogenic Viruses in Circulation in Anatolia, Turkey
(Mary Ann Liebert, inc, 2022) Dincer, Ender; Timurkan, Mehmet Ozkan; Oguz, Bekir; Sahindokuyucu, Ismail; Sahan, Adem; Ekinci, Mustafa; Ergunay, Koray
Introduction: We screened host-collected ticks for tick-borne viruses, including those recently documented as human pathogens.Methods: During 2020-2021, ticks removed form cattle, sheep, dogs, and cats in 11 provinces in 5 geographically distinct regions of Anatolia were identified, pooled, and screened using pan-nairovirus, pan-flavivirus and individual assays for Jingmen tick virus (JMTV), and Tacheng tick virus 1 and 2 (TcTV-1 and TcTV-2).Results: A total of 901 tick specimens, comprising 6 species were included. Rhipicephalus sanguineus complex was the most abundant species (44.1%), followed by Rhipicephalus bursa (38.3%), Haemaphysalis parva (7.2%), and others. The specimens were screened in 158 pools with 12 pools (7.6%) being positive. Crimean-Congo hemorrhagic fever virus (CCHFV) lineage Europe 2 (genotype VI) sequences were detected in R. bursa in five (3.2%) of the pools, with similar prevalences in central and Mediterranean Anatolian provinces. JMTV was identified in four R. bursa and one Rhipicephalus turanicus pools, collected from Mediterranean and southeastern Anatolia, with a CCHFV and JMTV coinfected R. bursa pool. The JMTV segment 1 sequences formed a separate cluster with those from Turkey and the Balkan peninsula in the maximum likelihood analysis. TcTV-2 was detected in two Dermacentor marginatus specimens (1.3%) collected in central Anatolia, with nucleocapsid sequences forming a phylogenetically segregated group among viruses from humans and ticks from China and Kazakhstan.Discussion: CCHFV Europe 2 was initially documented in ticks from central Anatolian locations, where related orthonairoviruses had been previously recorded. Ongoing activity and a wider distribution of JMTV and TcTV-2 were observed. These viruses should be screened as potential etiological agents in human infections associated with tick bites.