Browsing by Author "Topal, C."

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Hepatitis C Virus Positivity in Patients With Neoplastic Lymphoproliferative Disorders
(2004) Dilek, I.; Durmuş, A.; Akdeniz, H.; Topal, C.; Demir, C.; Topcu, N.
Several studies have suggested that infection with hepatitis C virus (HCV), that is a hepatotropic and neoplastic virus, has a role in the aetiology of neoplastic lymphoproliferative disorders. The results of some studies, however, failed to establish such an association in the aetiology of these disorders. In this study, hepatitis C virus (HCV) antibodies were searched in 116 patients with lymphoproliferative disorders (LPD) by a third-generation macro ELISA technique. Fifty two of the patients had been suffering from non-Hodgkin's lymphoma (NHL), 38 from Hodgkin's disease (HD), 15 from chronic lymphocytic leukaemia (CLL), 6 from Waldenstrψm macroglobulinaemia (WM) and 5 from multiple myeloma (MM). Voluntary blood donors were taken as a control group. The results showed that anti-HCV positivity in all cases was significantly higher than the control group (8.6% vs 0.8%). The rates of anti-HCV positivity were 33.3%, 5.7%, 7.8%, 6.6% and 20% respectively in WM, NHL, HD, CLL and MM cases. In conclusion, the findings of our study demonstrate the probable role of HCV infection in the development of neoplastic LPD in our region.
Relationship Between Leptin Levels and Body Indexes in Patients With Haematologic Malignancy
(2001) Mete, R.; Dilek, I.; Algün, E.; Erkoç, R.; Ayakta, H.; Topal, C.; Aksoy, H.
Leptin is a recently found hormone regulating body weight. In human obesity, this weight-regulating hormone level is in a positive correlation with FMI (fat mass index) and BMI (body mass index). In this study, we aimed to investigate the relation between serum leptin levels and BMI, PF (percentage fat), LMI (lean mass index), FMI and some other parameters of patients with haematologic malignant diseases. Fourty-four patients with haematologic malignant diseases and 25 healthy control group were taken into the study. In the comparison, there were no significant between the PF and FMI values of both groups, while the mean BMI and LMI values of the control group were significantly higher than that of the patient group. There was a positive correlation between leptin levels and BMI and FMI among parameters studied in our control group, whereas we couldn't demonstrate any such correlation in patient group. We estimate that the alteration may be due to disturbances in the feed back mechanism developing in patient with haematologic malignancy.
The Serum Levels of Il-1β, Il-6, Il-8 and Tnf-Α in Nonalcoholic Fatty Liver
(2003) Tuncer, I.; Özbek, H.; Topal, C.; Uygan, I.
Nonalcoholic fatty liver (NAFL) has an extensive clinical spectrum ranging from simple fatty liver to steatohepatitis and cirrhosis. Its pathogenesis is multifactorial. The aim of our study was to measure the serum levels of some cytokines (IL-1β, IL-6, IL-8 and TNF-α), which are thought to play a role in the pathogenesis of NAFL. Thirty subjects (18 males, 12 females) with clinical and laboratory features of hepatosteatosis were enrolled in the study as the patient group (group 1) and 30 healthy subjects (21 males, 9 females) served as controls (group 2). The levels of hepatic transaminases, gamma-glutamyltransferase, alkaline phosphatase, total cholesterol, IL-1β, IL-6, IL-8 and TNF-α were studied in both patients and controls. Serum IL-1β, IL-6, and TNF-α levels did not display significant differences between the patients and the controls (P > 0.05). On the other hand, the IL-8 level was significantly elevated in the patient group (P < 0.05). This increased level may play a more active role in the pathogenesis of fatty liver than IL-1β, IL-6 and TNF-α. Further studies are needed to elucidate to what extent the proinflammatory cytokines (especially IL-8 and TNF-α) are involved in the pathogenesis of NAFL.