Browsing by Author "Tosun, Murat"

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İntrauterin Dönemde Dişi ve Erkek Gonadal Yapıların Gelişimine Etkin Olan Faktörler
(2000) Aktan, Murad; Erdoğan, Ender; Taşkapu, Hakan; Duman, Selçuk; Tosun, Murat
İnsanlarda dişi ve erkek gonadların intrauterin dönemdeki gelişimini birçok faktör doğrudan veya dolaylı yoldan etkilemektedir. Bunların içinde en önemli olanları başta genetik olmak üzere endokrinolojik ve çevresel faktörlerdir. Genetik faktörler içinde H-Y antijeni, WT-1 geni, Sry geni gibi çok önemli genler bulunurken; endokrinolojik faktörler içinde cinsiyet farklılaşmasında çok öneme sahip Anti Müllerian Hormon (=AMH=Müllerian Inhibiting Substance=MIS)’un yanında Follikül Stimulan Hormon (=FSH), Luteinizan Hormon (=LH) ve Serotonin yer almaktadır. Bunların dışında Fibroblast Growth Faktör (=FGF), Aromataz, Aktivin, İyonize radyasyon ve Mitomisin C gibi değişik çevresel ve kimyasal faktörler de gonadal gelişimi etkilemektedir. Bu veriler bize gonadların intrauterin gelişiminin oldukça kompleks olduğunu ve sayısız faktörün bu gelişimi doğrudan veya dolaylı yoldan olumlu veya olumsuz yönde etkilediğini ortaya koymaktadır.
Some Phytochemical and Antioxidant Characteristics of Wild and Cultivated Blackberry (Rubus Caucasicus) Fruits
(Wfl Publ, 2010) Yildiz, Hilal; Sengul, Memnune; Celik, Ferit; Hegedus, Attila; Ercisli, Sezai; Tosun, Murat
Fruit weight, soluble solid content (%), vitamin C, titratable acidity, total phenolic content, total anthocyanin and total antioxidant capacity of wild and cultivated blackberry (Rubus cauctisicus) fruits were determined. Determination of antioxidant activities by beta-carotene-linoleic acid, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and ferric reducing antioxidant power (FRAP) assays resulted in average 85.17%, 34.90 mu mol/g fw DPPH and 50.70 mu mol TE/g fw FRAP, respectively. In general, wild materials exhibited higher antioxidant activity in all three methods used. The average total phenolic contents of wild genotypes were 381 mg gallic acid equivalent in 100 g fresh weight basis (GAE/g fw) indicating higher value than cv. Chester (310 mg GAE/100 g fw). The genotype ART4 had the richest amount of anthocyanin with an average of 168 mg cy-3-glu/g fw. beta-carotene-linoleic acid, FRAP, total phenolic and total anthocyanins were significantly correlated with each other. The present results suggest that blackberry fruits, in particular, wild ones, are very rich in antioxidants and indicate their importance for human healthy.
Topical Effects of Nebivolol on Wounds in Diabetic Rats
(Elsevier Science Bv, 2012) Gulcan, Erim; Kucuk, Aysegul; Cayci, Kasim; Tosun, Murat; Emre, Habib; Koral, Lokman; Avsar, Umit
Objective: Recently, it has reported that nebivolol might be useful in the treatment of diabetes mellitus foot ulcers. The aim of this study was to examine treatment of the wounds in streptozotocin-induced diabetic rats with topical nebivolol. Methods: Two 15 x 15 mm-sized wounds were created in 56 streptozotocin-induced rats. A total of 56 diabetic wounds were studied in eight groups (n = 7). No treatment was administered to the first and second groups. The third and fourth groups consisted of diabetic rats that were administered 1:1 mixture of lanolin and vaseline for 7 and 14 days, respectively. Five percent nebivolol plus 1:1 mixture of lanolin and vaseline was administered to rats in the fifth and sixth groups for 7 and 14 days, respectively, and 10% nebivolol plus 1:1 mixture of lanolin and vaseline was administered to rats in the seventh and eighth groups for 7 and 14 days, respectively. On days 7 and 14, wound healing was observed, and the percent of wound healing was determined by measuring its size and histopathologic examination. The ratio was calculated by the formula, healing ratio (%) = 100 x (1-wound area/initial wound area). Statistical analysis was performed by ANOVA with Tukey's HSD test and Mann-Whitney U test, using SPSS 15.0 software. Results: On days 7 and 14, rates of wound healing in the fifth, sixth, seventh, and eighth groups were 57.42%, 89.16%, 60.80%, and 91.80%, respectively. Multiple comparison showed that rates of wound healing were significantly higher in rats administered 5% and 10% nebivolol than those in rats administered a mixture of lanolin and vaseline and in the untreated group (P < 0.05). Conclusion: Topical nebivolol therapy may be useful for wound healing in diabetic rats. Further studies are needed to support these data. (c) 2012 Elsevier B.V. All rights reserved.