Browsing by Author "Tozlu, Deniz"

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    Article
    Synthesis of New Thiazine and Thiazole Derivatives Via Cyclization Reactions; Investigating Their Electronic Properties and Determination of Antioxidant Properties
    (Wiley, 2022) Ergan, Erdem; Tozlu, Deniz
    (4-[2,4-dimethoxyphenyl]-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(phenyl) methanone (1) have been prepared by Biginelli three-component cyclocondensation reaction of catalyzed with p-toluene sulfonic acid in ethanol. Pyrimido[2,1-b]thiazine (2) and thiazolo[3,2-a]pyrimidine (3) derivatives were obtained by a simple one-pot condensation reaction of starting compound 1 and 3-bromopropionic acid, bromoacetic acid and, respectively. By performing the reactions of compound 3 with heteroaromatic and aromatic aldehydes, arylidine-bicyclic thiazolo pyrimidine compounds (4-9) were synthesized. Theoretical calculations and molecular electrostatic potential maps of all synthesized compounds were performed using the Gaussian software package Density Functional Theory (DFT/6-31G: B3LYP). In addition, studies were carried out to determine the antioxidant properties of all the compounds obtained by the DPPH method, and compound 1 was found to be the most effective compound. The structures of the newly synthesized compounds were analyzed using spectroscopic methods such as IR, H-1, and C-13.
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    Master Thesis
    Synthesis of Thiazole and Thiazine Derivative Compounds Obtained From New Thioxopyrimidine Compound, Investigation of Their Reactions With Substituted Aldehydes and Examining of Their Theoretically Electronic Properties
    (2021) Tozlu, Deniz; Ergan, Erdem
    Çalışmamızın ilk aşamasında multikomponent reaksiyonlardan biri olan Biginelli reaksiyonuyla, 1,3-difenil-1,3-propandion, 2,4-dimetoksibenzaldehit ve tiyoüre kullanılarak (4-(2,4-dimetoksifenil)-6-fenil-2-tiyokso-1,2,3,4-tetrahidropirimidin-5-il)(fenil)metanon (D-1) bileşiği sentezlendi. D-1 bileşiğinin bromopiruvik asit, 3-bromopropiyonik asit ve bromoasetik asit ile halkalanma tepkimeleri gerçekleştirilerek, pirimidin halkasına kondense tiyazin ve tiyazol (D-2, D-3 ve D-4) bileşikleri elde edildi. Son basamakta ise 6-benzoil-5-(2,4-dimetoksifenil)-7-fenil-5H-tiyazolo[3,2-a]pirimidin-3(2H)-on (D-4) bileşiğinin, sübstitüe benzaldehit türevleri ve 2-tiyofenkarboksaldehit bileşikleriyle tepkimeleri gerçekleştirildi. Sentezlenen tüm bileşiklerin teorik hesaplamaları ve moleküler elektrostatik potansiyel haritaları Gaussian paket programı kullanılarak Density Functional Theory (DFT/6-31G) teorisi ve B3LYP fonksiyonelleri ile incelendi. Elde edilen tüm pirimidin türevi bileşiklerin yapısal karakterizasyonları, elementel analiz, IR, 1H ve 13C NMR spektroskopik yöntemler kullanılarak aydınlatıldı.