Browsing by Author "Tufan, A."

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Effects of Age and Co-Morbidities on Complication Rate in Surgical Treatment of Lumbar Degenerative Diseases: a Prospective Clinical Study
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Tufan, A.; Aktaş, Ö.Y.; Eren, B.; Doruk, E.; Gulec, I.; Taş, A.; Guzey, F.K.
Surgery for lumbar degenerative diseases is increasingly more common due to ageing of the population. There were conflicting results on effects of complication rates of ageing and presence of comorbidities in these o perations in literature. Presence of systemic co-morbidities, smoking, body mass index (BMI), American Society of Anaesthesiologists score, length of hospital before and after operation and in intensive care unit (ICU), number of decompressed levels (nD), addition of instrumentation, operation time, blood loss, presence of transfusion, surgical and systemic complications seen during the operation and during one month after operation, and requirement of a new operation were recorded in 277 patients (61.6±8.8 years of age, male/female ratio 78/199) operated for lumbar degenerative diseases between 2014 and 2016. Total 96 out of 277 patients (34.6%) had complications and 1 patient died. The most frequent complications were dural tear (36 cases, 12.9%), wound problems without infection (34 cases, 12.2%), screw malposition (15 cases, 5.4%), and systemic complications (21 cases, 7.5%). The risk factors were diabetes mellitus (DM) for major complications, BMI and nD for minor complications, and nD for systemic complications. All other factors including age did not affect the complication rate. Regression analyses revealed that the only efficient factor was BMI for presence of overall and minor complications. It was found that the advanced age did not cause to increase complication rates. The efficient factors for complication rates were DM, BMI and nD. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Prophylactic Effects of Silver Nanoparticles in a Rat Model of Spinal Stabilization and Infection
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Tas, A.; Guzey, F.K.; Tufan, A.; Kuvat, N.; Aktaş, Ö.Y.; Yücel, M.; Akkalp, A.K.
Several factors increase the risk of postoperative infection. Some experimental studies have shown that silver nanoparticles (AgNP) have a protective effect from surgical infection. This study aimed to determine the effectiveness of AgNP in preventing the development of infection in the spinal stabilization rat model. In this study, 32 Sprague-Dawley rats weighing 300–350 g were used. Subjects were randomly divided into four groups. Titanium screws were placed in the spine in all groups. In Groups 2, 3, and 4, S.aureus and P.aeruginosa were cultivated in the surgical site at a concentration of 106 CFU/10 μL. Additionally, 0.5 mg/kg AgNP in maltose solution in Group 3 and maltose solution in Group 4 were used. The histopathological examinations were then done. In the fascia, muscle, bone, and screws in all groups, except in Group 1 (control group), S. aureus and P.aeruginosa reproduced. In blood cultures, there was growth of S. aureus and P. aeruginosa in 1 subject in Group 2, 6 subjects in Group 3, and 2 subjects in Group 4. The growth of S. aureus and P.aeruginosa was significantly i ncreased in Group 3. The degree of inflammation was significantly lower in Group 1. No accumulation of silver was detected in any organs histopathologically. Application of 1 eucal AgNP decreased the severity of infection. This dose was not toxic. However, administration of AgNP at this dose did not decrease the local infection rate. Therefore, new studies should be conducted to determine the ideal effective dose. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Short-Term Outcomes of Aneurysmatic/Non-aneurysmatic Patients Operated for Spontaneous Subarachnoid Hemorrhage: a Tertiary Referral Center
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Aycan, A.; Taş, A.; Arslan, M.; Tufan, A.
We aimed to retrospectively analyze patients with aneurysmal dilatation and vascular malformation who presented with spontaneous SAH. Clinical data in patients files, Preoperative and postoperative neurological and radiological findings, age, gender, and treatment results were evaluated retrospectively. The same team performed surgery on 38 (47.5%) patients. Twenty (52.6%) of the patients included in the study were female, and 18 (47.3%) were male. There were 33 patients with detected bleeding aneurysms, three with bleeding AVMs, and two patients with non-bleeding aneurysms. It was determined that 5% of the patients had a Fisher score of 1, 34% had a Fis her score of 2, 24% had a Fisher score of 3, and 37% had a Fisher score of 4. Ten patients died. There were signs of vasospasm in 18 patients. Nine (50%) of 18 patients with vasospasm survived, and 9(50%) died. Eleven patients had hydrocephalus. EVD was in serted in 10 patients. Lamina terminalis was opened in 29 patients. The vessel with the most common aneurysm was the isolated AcomA aneurysm, with a rate of 31.5% (n=12). MCA aneurysm was found with the second frequency with a rate of 23.6% (n=9) Spontaneous subarachnoid hemorrhage is a disease with high mortality and morbidity in neurosurgery. Rebleeding, vasospasm, onset GCS, Fisher score, and experienced surgical equipment are among the factors affecting the treatment outcome. Multidisciplinary treatment in centers where diagnosis, treatment, and follow-up can be made by the same team will reduce mortality and morbidity rates. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.